Neurodegeneration shows regional and cell-type-specific patterns in ageing and disease1,but the underlying mechanisms for cell-type-specific neuronal losses remain poorly understood.Previous studies have shown that up...Neurodegeneration shows regional and cell-type-specific patterns in ageing and disease1,but the underlying mechanisms for cell-type-specific neuronal losses remain poorly understood.Previous studies have shown that upper cortical layer thinning occurs in progressive human multiple sclerosis(MS)and that cortical layer 2 and layer 3(L2/3)excitatory neurons(L2/3ENs)that express CUT-like homeobox 2(CUX2)are selectively vulnerable to degeneration2.展开更多
文摘Neurodegeneration shows regional and cell-type-specific patterns in ageing and disease1,but the underlying mechanisms for cell-type-specific neuronal losses remain poorly understood.Previous studies have shown that upper cortical layer thinning occurs in progressive human multiple sclerosis(MS)and that cortical layer 2 and layer 3(L2/3)excitatory neurons(L2/3ENs)that express CUT-like homeobox 2(CUX2)are selectively vulnerable to degeneration2.
