Liver metastases occur commonly in many solid malignancies.With advances in systemic therapies and increased life expectancy,the role of using local therapies in oligo-metastases is rapidly increasing.Stereotactic bod...Liver metastases occur commonly in many solid malignancies.With advances in systemic therapies and increased life expectancy,the role of using local therapies in oligo-metastases is rapidly increasing.Stereotactic body ra-diotherapy(SBRT)is an emerging precision therapy that is being used more frequently in the treatment for un-resectable liver metastases.This review focuses on the role of SBRT for liver metastases,principles of treatment,clinical outcomes,toxicity,and optimal patient selection.展开更多
Hepatocellular carcinoma(HCC)is a common malignancy with high mortality rates.While surgery can be curative in early-stage disease,80% of patients cannot undergo surgical resection.Stereotactic body radiotherapy(SBRT)...Hepatocellular carcinoma(HCC)is a common malignancy with high mortality rates.While surgery can be curative in early-stage disease,80% of patients cannot undergo surgical resection.Stereotactic body radiotherapy(SBRT),an emerging,non-invasive,precision treatment,has shown promising results across various stages of HCC and has thus been adopted in practice to varying degrees around the world.This article aims to review current guideline recommendations on SBRT,clinical evidence,and outcome comparisons with other local treatment modalities.Attempts are also made to compare the differences in clinical trials between Asian and Western countries.展开更多
文摘Liver metastases occur commonly in many solid malignancies.With advances in systemic therapies and increased life expectancy,the role of using local therapies in oligo-metastases is rapidly increasing.Stereotactic body ra-diotherapy(SBRT)is an emerging precision therapy that is being used more frequently in the treatment for un-resectable liver metastases.This review focuses on the role of SBRT for liver metastases,principles of treatment,clinical outcomes,toxicity,and optimal patient selection.
基金supported in part by Shenzhen Science and Technol-ogy Program(grant number KQTD20180411185028798)a Varian Medical Systems Research Grant.
文摘Hepatocellular carcinoma(HCC)is a common malignancy with high mortality rates.While surgery can be curative in early-stage disease,80% of patients cannot undergo surgical resection.Stereotactic body radiotherapy(SBRT),an emerging,non-invasive,precision treatment,has shown promising results across various stages of HCC and has thus been adopted in practice to varying degrees around the world.This article aims to review current guideline recommendations on SBRT,clinical evidence,and outcome comparisons with other local treatment modalities.Attempts are also made to compare the differences in clinical trials between Asian and Western countries.
