Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of ...Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels.Methods This study utilized individual participant data from 21 cohort studies,comprising both published and unpublished data.Eligibility criteria included individual-level data on leisure-time and occupational physical activity(categorized as sedentary,low,moderate,and high)along with data on all-cause and/or cardiovascular mortality.A 2-stage individual participant data meta-analysis was conducted,with separate analysis of each study using Cox proportional hazards models(Stage 1).These results were combined using random-effects models(Stage 2).Results Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels,for both males and females.Among males with sedentary work,high compared to sedentary leisure-time physical activity was associated with lower all-cause(hazard ratios(HR)=0.77,95%confidence interval(95%CI):0.70-0.85)and cardiovascular mortality(HR=0.76,95%CI:0.66-0.87)risk.Among males with high levels of occupational physical activity,high compared to sedentary leisure-time physical activity was associated with lower all-cause(HR=0.84,95%CI:0.74-0.97)and cardiovascular mortality(HR=0.79,95%CI:0.60-1.04)risk,while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically significant.Among females,most effects were similar but more imprecise,especially in the higher occupational physical activity levels.Conclusion Higher levels of leisure-time physical activity were generally associated with lower mortality risks.However,results for workers with moderate and high occupational physical activity levels,especially women,were more imprecise.Our findings suggests that workers may benefit from engaging in high levels of leisure-time physical activity,irrespective of their level of occupational physical activity.展开更多
Background Rheumatoid arthritis(RA)is a chronic disease influenced by genetic and environmental factors,with viral infections potentially influencing the immune system and increasing the risk of autoimmune diseases li...Background Rheumatoid arthritis(RA)is a chronic disease influenced by genetic and environmental factors,with viral infections potentially influencing the immune system and increasing the risk of autoimmune diseases like RA.This study investigated the relationship between exposure to chikungunya and dengue infections,indicated by the presence of arboviral IgG antibodies,and risk of developing RA dichotomized by anti-citrullinated protein antibody(ACPA)status.Methods Serum samples from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis(MyEIRA)population-based case-control study involving 1235 RA cases and 1625 controls were assayed for IgG antibodies against chikungunya and dengue viruses.Positive results indicate previous exposure to the studied arboviral infections.Logistic regression and Mann–Whitney U test were performed to estimate the risk of developing ACPA-positive/ACPA-negative RA.Results We observed a low frequency of chikungunya IgG antibodies and a high frequency of dengue IgG antibodies in the overall RA cases and controls.No direct association was observed between previous exposure to chikungunya/dengue infection and risk of future RA in overall RA cases and controls.However,analysis by ethnicity showed a decreased risk for ACPA-positive RA in chikungunya IgG antibody positive subjects of Malay(odds ratio[OR]=0.38,95%confidence interval[CI]=0.16–0.90,p<0.05)and Chinese origins(OR=0.12,95%CI=0.01–0.93,p<0.05).Additionally,we observed a decreased risk of ACPA-positive RA in Indian among persons with positive dengue IgG antibody status(OR=0.60,95%CI=0.38–0.95,p<0.05).No significant association was observed between chikungunya/dengue infection exposures and risk of ACPA-negative RA.Conclusion This study found no overall association between chikungunya or dengue exposure,and the risk for developing RA.展开更多
基金The Trùndelag Health Study (HUNT) is a collaboration between HUNT Research Centre (Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology), Trùndelag County Council, Central Norway Regional Health Authority, and the Norwegian Institute of Public HealthThe coordination of European Prospective Investigation into Cancer and Nutrition - Spain study (EPIC) is financially supported by the International Agency for Research on Cancer (IARC)+7 种基金by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC)supported by Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andaluc 1a, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain)funded by The Netherlands Organisation for Health Research and DevelopmentZon Mw (Grant No.: 531-00141-3)Funding for the SHIP study has been provided by the Federal Ministry for Education and Research (BMBFidentification codes 01 ZZ96030, 01 ZZ0103, and 01 ZZ0701)support from the Swedish Research Council (2018-02527 and 2019-00193)financed by the Helmholtz Zentrum München - German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria.
文摘Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels.Methods This study utilized individual participant data from 21 cohort studies,comprising both published and unpublished data.Eligibility criteria included individual-level data on leisure-time and occupational physical activity(categorized as sedentary,low,moderate,and high)along with data on all-cause and/or cardiovascular mortality.A 2-stage individual participant data meta-analysis was conducted,with separate analysis of each study using Cox proportional hazards models(Stage 1).These results were combined using random-effects models(Stage 2).Results Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels,for both males and females.Among males with sedentary work,high compared to sedentary leisure-time physical activity was associated with lower all-cause(hazard ratios(HR)=0.77,95%confidence interval(95%CI):0.70-0.85)and cardiovascular mortality(HR=0.76,95%CI:0.66-0.87)risk.Among males with high levels of occupational physical activity,high compared to sedentary leisure-time physical activity was associated with lower all-cause(HR=0.84,95%CI:0.74-0.97)and cardiovascular mortality(HR=0.79,95%CI:0.60-1.04)risk,while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically significant.Among females,most effects were similar but more imprecise,especially in the higher occupational physical activity levels.Conclusion Higher levels of leisure-time physical activity were generally associated with lower mortality risks.However,results for workers with moderate and high occupational physical activity levels,especially women,were more imprecise.Our findings suggests that workers may benefit from engaging in high levels of leisure-time physical activity,irrespective of their level of occupational physical activity.
基金Universiti Kuala Lumpur,Grant/Award Number:STR16037The Swedish National Research Council,Grant/Award Number:DNR 348-2009-6468Kementerian Kesihatan Malaysia,Grant/Award Numbers:NMRR-08-820-1975,JPP-IMR 07-046,JPP-IMR 08-006,MRG-200512,NMRR-07-299-572,NMRR-17-848-35829。
文摘Background Rheumatoid arthritis(RA)is a chronic disease influenced by genetic and environmental factors,with viral infections potentially influencing the immune system and increasing the risk of autoimmune diseases like RA.This study investigated the relationship between exposure to chikungunya and dengue infections,indicated by the presence of arboviral IgG antibodies,and risk of developing RA dichotomized by anti-citrullinated protein antibody(ACPA)status.Methods Serum samples from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis(MyEIRA)population-based case-control study involving 1235 RA cases and 1625 controls were assayed for IgG antibodies against chikungunya and dengue viruses.Positive results indicate previous exposure to the studied arboviral infections.Logistic regression and Mann–Whitney U test were performed to estimate the risk of developing ACPA-positive/ACPA-negative RA.Results We observed a low frequency of chikungunya IgG antibodies and a high frequency of dengue IgG antibodies in the overall RA cases and controls.No direct association was observed between previous exposure to chikungunya/dengue infection and risk of future RA in overall RA cases and controls.However,analysis by ethnicity showed a decreased risk for ACPA-positive RA in chikungunya IgG antibody positive subjects of Malay(odds ratio[OR]=0.38,95%confidence interval[CI]=0.16–0.90,p<0.05)and Chinese origins(OR=0.12,95%CI=0.01–0.93,p<0.05).Additionally,we observed a decreased risk of ACPA-positive RA in Indian among persons with positive dengue IgG antibody status(OR=0.60,95%CI=0.38–0.95,p<0.05).No significant association was observed between chikungunya/dengue infection exposures and risk of ACPA-negative RA.Conclusion This study found no overall association between chikungunya or dengue exposure,and the risk for developing RA.
