Endometriosis is one of the refractory and common disease in gynaecology, which the main manifestations are dysmenorrhea and infertility. Professor Cheng considers it's the deficiency-excess mixing illness whose p...Endometriosis is one of the refractory and common disease in gynaecology, which the main manifestations are dysmenorrhea and infertility. Professor Cheng considers it's the deficiency-excess mixing illness whose pathological base is blood stasis and root is the deficiency of Yin and Yang, Qi and blood. So in terms of treatment, Professor Cheng praises highly the way of strengthening the body resistance to eliminate pathogenic factors. Strengthening the body resistance and expelling evil at the same time can achieve the purpose of treatment. In the adjustment of Yin and Yang ,Qi and blood, Professor Cheng attaches importance to treating middle burner. On the treatment of dysmenorrhea, Professor Cheng is able to capture xuefu zhuyu decoction and bazhen decoction and pays attention to menstrual cycle therapy. In addition, Professor Cheng often uses jingui wenjing decoction for infertility and re-understands the decoction by meridians theory and circular motion theory. Furthermore, Professor Cheng's treatment in reserving follicle, promoting ovulation and developing follicle is distinctive by traditional Chinese medicine.展开更多
To determine the value of dissecting the recurrent laryngeal nerve during thyroid surgery with respect to preventing recurrent laryngeal nerve injury, we retrospectively analyzed clinical data from 5 344 patients unde...To determine the value of dissecting the recurrent laryngeal nerve during thyroid surgery with respect to preventing recurrent laryngeal nerve injury, we retrospectively analyzed clinical data from 5 344 patients undergoing thyroidectomy. Among these cases, 548 underwent dissection of the recurrent laryngeal nerve, while 4 796 did not. There were 12 cases of recurrent laryngeal nerve injury following recurrent laryngeal nerve dissection （injury rate of 2.2%） and 512 cases of recurrenl laryngeal nerve injury in those not undergoing nerve dissection （injury rate of 10.7%）. This difference remained statistically significant between the two groups in terms of type of thyroid disease, type of surgery, and number of surgeries. Among the 548 cases undergoing recurrent laryngeal nerve dissection, 128 developed anatomical variations of the recurrent laryngeal nerve （incidence rate of 23.4%）, but no recurrent laryngeal nerve injury was found. In addition, the incidence of recurrent laryngeal nerve injury was significantly lower in patients with the infedor parathyroid gland and middle thyroid veins used as landmarks for locating the recurrent laryngeal nerve compared with those with the entry of the recurrent laryngeal nerve into the larynx as a landmark. These findings indicate that anatomical variations of the recurrent laryngeal nerve are common, and that dissecting the recurrent laryngeal nerve during thyroid surgery is an effective means of preventing nerve injury.展开更多
The objective of this study was to evaluate the diagnostic value of 128-slice spiral CT combined with virtual colonoscopy in diagnosis of colorectal cancer.We retrospectively analyzed 45 patients of colorectal disease...The objective of this study was to evaluate the diagnostic value of 128-slice spiral CT combined with virtual colonoscopy in diagnosis of colorectal cancer.We retrospectively analyzed 45 patients of colorectal diseases who underwent definition AS+128-slice spiral CT combined with virtual colonoscopy after bowel preparation and gas injection to evaluate the clinical diagnostic value of this technology.All the patients received electronic colonoscopy and were confirmed by pathology.In total,colorectal cancer was confirmed in 42 cases and inflammation in 3 cases.Diagnostic results shows:there were 17 cases of lump,10 cases of infiltration,6 cases of ulcer,9 cases of mixed type,4 cases of liver metastases,and 36 cases of lymph node metastasis.There was no significant difference between 128-slice spiral CT combined with virtual colonoscopy and electronic colonoscopy in detection,localization and characterization of colorectal tumors.CT virtual endoscopy has great advantages in observing the invasion around the lesion and the presence or absence of metastasis in distant organs and lymph node metastasis.It is also possible to understand the shape of the lesion in the intestinal lumen and the length of the lesion involving the lumen of the intestine.展开更多
Beijing Daxing International Airport Beijing Daxing International Airport,the world’s biggest airport,officially became operational on September 25,2019.Beijing,the capital of the People’s Republic of China,is also ...Beijing Daxing International Airport Beijing Daxing International Airport,the world’s biggest airport,officially became operational on September 25,2019.Beijing,the capital of the People’s Republic of China,is also an ancient capital with a history of more than 3,000 years.In 1421,Zhu Di,an emperor of the Ming Dynasty,moved the capital to Beijing.From then on,Beijing was the capital of the Ming and Qing dynasties and left a great and splendid legacy of historical and cultural heritage.展开更多
Severe bone defects remain a significant clinical challenge,necessitating the development of advanced bone repair scaffolds with excellent biocompatibility,precise immune modulation,and robust support for vascularizat...Severe bone defects remain a significant clinical challenge,necessitating the development of advanced bone repair scaffolds with excellent biocompatibility,precise immune modulation,and robust support for vascularization and osteogenesis.Silk fibroin(SF),a polymer renowned for its outstanding biocompatibility,has been widely used in bone repair scaffold materials.However,its complex fabrication process limits its broader clinical application.In this study,flat silkworm cocoon(FSC),characterized by continuous silk fibers,a porous hierarchical structure,and superior mechanical properties,was utilized for the first time to fabricate bio-scaffolds(TH-PDA@Mg)designed for sustained magnesium ion release in bone repair applications.FSC scaffolds featuring surface pores and extracellular matrix-like structures were successfully prepared using hot-press and surface modification techniques.Magnesium ions were effectively assembled onto FSC scaffolds via polydopamine(PDA)-mediated adhesive interactions.The resulting TH-PDA@Mg scaffolds demonstrated enhanced osteogenic properties,exceptional mechanical strength,superior surface characteristics,and excellent biocompatibility.In vitro analyses revealed that these scaffolds supported cell adhesion,promoted stem cell proliferation,and facilitated osteogenic differentiation due to the synergistic effects of SF and magnesium ions.Furthermore,they exhibited immunomodulatory properties by promoting M2 macrophage polarization while suppressing M1 macrophage activity.In vivo studies using a rat model of critical-sized cranial bone defects showed that the TH-PDA@Mg scaffolds accelerated bone regeneration,enhanced angiogenesis,and mitigated inflammation.These findings highlight the remarkable osteogenic and immunomodulatory potential of functional bio-spinning silk fiber scaffolds,underscoring their promise as a therapeutic strategy for the clinical treatment of bone defects.展开更多
Background Microbial colonization in the nasopharynx and nasal cavity plays a defensive role in children.The coronavirus disease 2019(COVID-19)pandemic may have an influence on the nasopharynx and nasal cavity microbi...Background Microbial colonization in the nasopharynx and nasal cavity plays a defensive role in children.The coronavirus disease 2019(COVID-19)pandemic may have an influence on the nasopharynx and nasal cavity microbiota.This study aimed to identify and compare the microbiota in the nasopharynx and nasal cavity before and during the COVID-19 pandemic in a healthy pediatric population.Methods Separate mucosal swabs were collected from the nasopharynx and nasal cavity of healthy children before and during the COVID-19 pandemic.A 16S ribosomal RNA-based metagenomic approach was employed to characterize and analyze alterations in the nasopharyngeal and nasal microbiota to determine whether isolation measures,such as mask wearing,influence microbial ecology.Results The richness and diversity of the nasopharyngeal and nasal microbiota decreased during the COVID-19 pandemic compared with before the pandemic.Firmicutes and Proteobacteria were the most abundant phyla in the nasopharyngeal and nasal microbiota,respectively,both before and during the pandemic.Corynebacterium and Moraxella were the dominant genera in the nasopharyngeal and nasal microbiota during the COVID-19 pandemic,whereas Pseudomonas and Corynebacterium were dominant before the pandemic.Compared with pre-pandemic conditions,microbial colonization differed significantly for Cyanobacteria/Chloroplast and Bacteroidetes in the nasopharynx and for Planctomycetes in the nasal cavity during the COVID-19 pandemic.Conclusions This study revealed a lower microbiota diversity during COVID-19,possibly accompanied by microbiota dysbiosis,increased risk of respiratory infections and inflammatory responses in healthy children.This study underscores the importance of reestablishing microbiota balance and highlights the need for personalized treatment and prophylactic strategies in routine public health practice.展开更多
This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease(PD)reflected by fractional anisotropy(FA),addressing clinical profiles and methodology-related heterogeneit...This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease(PD)reflected by fractional anisotropy(FA),addressing clinical profiles and methodology-related heterogeneity.Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls(HC)using the anisotropic effect size–signed differential mapping.A total of 808 patients with PD and 760 HC coming from 27 databases were finally included.Subgroup analyses were conducted considering heterogeneity with respect to medication status,disease stage,analysis methods,and the number of diffusion directions in acquisition.Compared with HC,patients with PD had decreased FA in the left middle cerebellar peduncle,corpus callosum(CC),left inferior fronto-occipital fasciculus,and right inferior longitudinal fasciculus.Most of the main results remained unchanged in subgroup metaanalyses of medicated patients,early stage patients,voxel-based analysis,and acquisition with˂30 diffusion directions.The subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory cortex.The cerebellum and CC,associated with typical motor impairment,showed the most consistent FA decreases in PD.Medication status,analysis approaches,and the number of diffusion directions have an important impact on the findings,needing careful evaluation in future meta-analyses.展开更多
Combinatorial optimization(CO)on graphs is a classic topic that has been extensively studied across many scientific and industrial fields.Recently,solving CO problems on graphs through learning methods has attracted g...Combinatorial optimization(CO)on graphs is a classic topic that has been extensively studied across many scientific and industrial fields.Recently,solving CO problems on graphs through learning methods has attracted great attention.Advanced deep learning methods,e.g.,graph neural networks(GNNs),have been used to effectively assist the process of solving COs.However,current frameworks based on GNNs are mainly designed for certain CO problems,thereby failing to consider their transferable and generalizable abilities among different COs on graphs.Moreover,simply using original graphs to model COs only captures the direct correlations among objects,which does not consider the mathematical logicality and properties of COs.In this paper,we propose a unified pre-training and adaptation framework for COs on graphs with the help of the maximum satisfiability(Max-SAT)problem.We first use Max-SAT to bridge different COs on graphs since they can be converted to Max-SAT problems represented by standard formulas and clauses with logical information.Then we further design a pre-training and domain adaptation framework to extract the transferable and generalizable features so that different COs can benefit from them.In the pre-training stage,Max-SAT instances are generated to initialize the parameters of the model.In the fine-tuning stage,instances from CO and Max-SAT problems are used for adaptation so that the transferable ability can be further improved.Numerical experiments on several datasets show that features extracted by our framework exhibit superior transferability and Max-SAT can boost the ability to solve COs on graphs.展开更多
基金Scientific Research Project of Guangdong bureau of traditional Chinese medicine(No.20171106).
文摘Endometriosis is one of the refractory and common disease in gynaecology, which the main manifestations are dysmenorrhea and infertility. Professor Cheng considers it's the deficiency-excess mixing illness whose pathological base is blood stasis and root is the deficiency of Yin and Yang, Qi and blood. So in terms of treatment, Professor Cheng praises highly the way of strengthening the body resistance to eliminate pathogenic factors. Strengthening the body resistance and expelling evil at the same time can achieve the purpose of treatment. In the adjustment of Yin and Yang ,Qi and blood, Professor Cheng attaches importance to treating middle burner. On the treatment of dysmenorrhea, Professor Cheng is able to capture xuefu zhuyu decoction and bazhen decoction and pays attention to menstrual cycle therapy. In addition, Professor Cheng often uses jingui wenjing decoction for infertility and re-understands the decoction by meridians theory and circular motion theory. Furthermore, Professor Cheng's treatment in reserving follicle, promoting ovulation and developing follicle is distinctive by traditional Chinese medicine.
基金supported by the National Natural Science Foundation of China, No. 81271088the Natural Science Foundation of Shanghai, No. 11ZR1423600
文摘To determine the value of dissecting the recurrent laryngeal nerve during thyroid surgery with respect to preventing recurrent laryngeal nerve injury, we retrospectively analyzed clinical data from 5 344 patients undergoing thyroidectomy. Among these cases, 548 underwent dissection of the recurrent laryngeal nerve, while 4 796 did not. There were 12 cases of recurrent laryngeal nerve injury following recurrent laryngeal nerve dissection （injury rate of 2.2%） and 512 cases of recurrenl laryngeal nerve injury in those not undergoing nerve dissection （injury rate of 10.7%）. This difference remained statistically significant between the two groups in terms of type of thyroid disease, type of surgery, and number of surgeries. Among the 548 cases undergoing recurrent laryngeal nerve dissection, 128 developed anatomical variations of the recurrent laryngeal nerve （incidence rate of 23.4%）, but no recurrent laryngeal nerve injury was found. In addition, the incidence of recurrent laryngeal nerve injury was significantly lower in patients with the infedor parathyroid gland and middle thyroid veins used as landmarks for locating the recurrent laryngeal nerve compared with those with the entry of the recurrent laryngeal nerve into the larynx as a landmark. These findings indicate that anatomical variations of the recurrent laryngeal nerve are common, and that dissecting the recurrent laryngeal nerve during thyroid surgery is an effective means of preventing nerve injury.
文摘The objective of this study was to evaluate the diagnostic value of 128-slice spiral CT combined with virtual colonoscopy in diagnosis of colorectal cancer.We retrospectively analyzed 45 patients of colorectal diseases who underwent definition AS+128-slice spiral CT combined with virtual colonoscopy after bowel preparation and gas injection to evaluate the clinical diagnostic value of this technology.All the patients received electronic colonoscopy and were confirmed by pathology.In total,colorectal cancer was confirmed in 42 cases and inflammation in 3 cases.Diagnostic results shows:there were 17 cases of lump,10 cases of infiltration,6 cases of ulcer,9 cases of mixed type,4 cases of liver metastases,and 36 cases of lymph node metastasis.There was no significant difference between 128-slice spiral CT combined with virtual colonoscopy and electronic colonoscopy in detection,localization and characterization of colorectal tumors.CT virtual endoscopy has great advantages in observing the invasion around the lesion and the presence or absence of metastasis in distant organs and lymph node metastasis.It is also possible to understand the shape of the lesion in the intestinal lumen and the length of the lesion involving the lumen of the intestine.
文摘Beijing Daxing International Airport Beijing Daxing International Airport,the world’s biggest airport,officially became operational on September 25,2019.Beijing,the capital of the People’s Republic of China,is also an ancient capital with a history of more than 3,000 years.In 1421,Zhu Di,an emperor of the Ming Dynasty,moved the capital to Beijing.From then on,Beijing was the capital of the Ming and Qing dynasties and left a great and splendid legacy of historical and cultural heritage.
基金supported by the National Natural Science Foundation of China(No.32102613,32330102,U20A2058)China Agriculture Research System of MOF and MARA(CARS-18-ZJ0102,CARS-18-ZJ0103)+3 种基金Natural Science Foundation of Chongqing,China(No.cstc2021jcyj-cxtt0005)Yibin Academy of Southwest University(XNDX2022020015,XNDX20221302)Chongqing Exceptional Young Talents Project(cstc2022ycjh-bgzxm0019)Venture and Innovation Support Program for Chongqing Overseas Returnees(cx2024003).
文摘Severe bone defects remain a significant clinical challenge,necessitating the development of advanced bone repair scaffolds with excellent biocompatibility,precise immune modulation,and robust support for vascularization and osteogenesis.Silk fibroin(SF),a polymer renowned for its outstanding biocompatibility,has been widely used in bone repair scaffold materials.However,its complex fabrication process limits its broader clinical application.In this study,flat silkworm cocoon(FSC),characterized by continuous silk fibers,a porous hierarchical structure,and superior mechanical properties,was utilized for the first time to fabricate bio-scaffolds(TH-PDA@Mg)designed for sustained magnesium ion release in bone repair applications.FSC scaffolds featuring surface pores and extracellular matrix-like structures were successfully prepared using hot-press and surface modification techniques.Magnesium ions were effectively assembled onto FSC scaffolds via polydopamine(PDA)-mediated adhesive interactions.The resulting TH-PDA@Mg scaffolds demonstrated enhanced osteogenic properties,exceptional mechanical strength,superior surface characteristics,and excellent biocompatibility.In vitro analyses revealed that these scaffolds supported cell adhesion,promoted stem cell proliferation,and facilitated osteogenic differentiation due to the synergistic effects of SF and magnesium ions.Furthermore,they exhibited immunomodulatory properties by promoting M2 macrophage polarization while suppressing M1 macrophage activity.In vivo studies using a rat model of critical-sized cranial bone defects showed that the TH-PDA@Mg scaffolds accelerated bone regeneration,enhanced angiogenesis,and mitigated inflammation.These findings highlight the remarkable osteogenic and immunomodulatory potential of functional bio-spinning silk fiber scaffolds,underscoring their promise as a therapeutic strategy for the clinical treatment of bone defects.
基金supported by the National Natural Science Foundation of China(Grant nos.81800903,82171135,82371140,81970881,82271160)Science and Technology Innovation Plan of Shanghai Science and Technology Commission(Grant no.21Y31900504)National Key R&D Program of China(2024YFC2511100).
文摘Background Microbial colonization in the nasopharynx and nasal cavity plays a defensive role in children.The coronavirus disease 2019(COVID-19)pandemic may have an influence on the nasopharynx and nasal cavity microbiota.This study aimed to identify and compare the microbiota in the nasopharynx and nasal cavity before and during the COVID-19 pandemic in a healthy pediatric population.Methods Separate mucosal swabs were collected from the nasopharynx and nasal cavity of healthy children before and during the COVID-19 pandemic.A 16S ribosomal RNA-based metagenomic approach was employed to characterize and analyze alterations in the nasopharyngeal and nasal microbiota to determine whether isolation measures,such as mask wearing,influence microbial ecology.Results The richness and diversity of the nasopharyngeal and nasal microbiota decreased during the COVID-19 pandemic compared with before the pandemic.Firmicutes and Proteobacteria were the most abundant phyla in the nasopharyngeal and nasal microbiota,respectively,both before and during the pandemic.Corynebacterium and Moraxella were the dominant genera in the nasopharyngeal and nasal microbiota during the COVID-19 pandemic,whereas Pseudomonas and Corynebacterium were dominant before the pandemic.Compared with pre-pandemic conditions,microbial colonization differed significantly for Cyanobacteria/Chloroplast and Bacteroidetes in the nasopharynx and for Planctomycetes in the nasal cavity during the COVID-19 pandemic.Conclusions This study revealed a lower microbiota diversity during COVID-19,possibly accompanied by microbiota dysbiosis,increased risk of respiratory infections and inflammatory responses in healthy children.This study underscores the importance of reestablishing microbiota balance and highlights the need for personalized treatment and prophylactic strategies in routine public health practice.
基金supported by the National Natural Science Foundation(Nos.81621003,81761128023,81220108013,81227002,and 81030027)the Program for Innovative Research Team in University(No.IRT16R52)of China+1 种基金the Professorship Award(No.T2014190)of Chinathe CMB Distinguished Professorship Award(No.F510000/G16916411)administered by the Institute of International Education.
文摘This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease(PD)reflected by fractional anisotropy(FA),addressing clinical profiles and methodology-related heterogeneity.Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls(HC)using the anisotropic effect size–signed differential mapping.A total of 808 patients with PD and 760 HC coming from 27 databases were finally included.Subgroup analyses were conducted considering heterogeneity with respect to medication status,disease stage,analysis methods,and the number of diffusion directions in acquisition.Compared with HC,patients with PD had decreased FA in the left middle cerebellar peduncle,corpus callosum(CC),left inferior fronto-occipital fasciculus,and right inferior longitudinal fasciculus.Most of the main results remained unchanged in subgroup metaanalyses of medicated patients,early stage patients,voxel-based analysis,and acquisition with˂30 diffusion directions.The subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory cortex.The cerebellum and CC,associated with typical motor impairment,showed the most consistent FA decreases in PD.Medication status,analysis approaches,and the number of diffusion directions have an important impact on the findings,needing careful evaluation in future meta-analyses.
基金supported by National Natural Science Foundation of China(Grant Nos.11991021,11991020 and 12271503)。
文摘Combinatorial optimization(CO)on graphs is a classic topic that has been extensively studied across many scientific and industrial fields.Recently,solving CO problems on graphs through learning methods has attracted great attention.Advanced deep learning methods,e.g.,graph neural networks(GNNs),have been used to effectively assist the process of solving COs.However,current frameworks based on GNNs are mainly designed for certain CO problems,thereby failing to consider their transferable and generalizable abilities among different COs on graphs.Moreover,simply using original graphs to model COs only captures the direct correlations among objects,which does not consider the mathematical logicality and properties of COs.In this paper,we propose a unified pre-training and adaptation framework for COs on graphs with the help of the maximum satisfiability(Max-SAT)problem.We first use Max-SAT to bridge different COs on graphs since they can be converted to Max-SAT problems represented by standard formulas and clauses with logical information.Then we further design a pre-training and domain adaptation framework to extract the transferable and generalizable features so that different COs can benefit from them.In the pre-training stage,Max-SAT instances are generated to initialize the parameters of the model.In the fine-tuning stage,instances from CO and Max-SAT problems are used for adaptation so that the transferable ability can be further improved.Numerical experiments on several datasets show that features extracted by our framework exhibit superior transferability and Max-SAT can boost the ability to solve COs on graphs.
