To the Editor,Gout is a chronic inflammatory arthritis resulting from the deposition of monosodium urate crystals,often presenting as an acute monoarticular flare in the lower extremities.Its incidence continues to ri...To the Editor,Gout is a chronic inflammatory arthritis resulting from the deposition of monosodium urate crystals,often presenting as an acute monoarticular flare in the lower extremities.Its incidence continues to rise globally,paralleling increasing rates of obesity and metabolic disorders.Known risk factors include obesity,hypertension,diuretic use,chronic kidney disease,high fructose consumption,and diets rich in purines.1 Type 2 diabetes mellitus(T2DM),especially when diagnosed early,has also been implicated in raising the risk of gout,likely due to shared metabolic and inflammatory pathways.2 While conventional therapies for gout center on urate‐lowering strategies and flare prevention,recent interest has emerged around how newer antidiabetic medications might modulate gout risk.展开更多
文摘To the Editor,Gout is a chronic inflammatory arthritis resulting from the deposition of monosodium urate crystals,often presenting as an acute monoarticular flare in the lower extremities.Its incidence continues to rise globally,paralleling increasing rates of obesity and metabolic disorders.Known risk factors include obesity,hypertension,diuretic use,chronic kidney disease,high fructose consumption,and diets rich in purines.1 Type 2 diabetes mellitus(T2DM),especially when diagnosed early,has also been implicated in raising the risk of gout,likely due to shared metabolic and inflammatory pathways.2 While conventional therapies for gout center on urate‐lowering strategies and flare prevention,recent interest has emerged around how newer antidiabetic medications might modulate gout risk.
