Objective:To systematically evaluate the main risk factors of post-transplant diabetes mellitus(PTDM)after renal transplantation in China in the past 10 years.Methods:CNKI,Wanfang,VIP,and PubMed were searched to colle...Objective:To systematically evaluate the main risk factors of post-transplant diabetes mellitus(PTDM)after renal transplantation in China in the past 10 years.Methods:CNKI,Wanfang,VIP,and PubMed were searched to collect the related literatures on risk factors of PTDM after renal transplantation published by Chinese scholars from January 2010 to October 2020.The data were extracted and Meta-analysis was performed by Revman 5.3 software.Results:A total of 18 case-control studies were included,involving 5458 patients.There were 1106 PTDM cases after kidney transplantation and 4352 cases without PTDM after kidney transplantation.Meta-analysis results showed age[MD=6.09,P<0.00001],gender[OR=1.22,P=0.02],family history of diabetes[OR=5.56,P<0.0001],source of donor kidney[OR=1.87,P<0.0001],BMI[MD=1.76,P<0.00001],HBV infection[OR=2.52,P=0.04],HCV infection[OR=2.55,P<0.0001],CMV infection[OR=1.81,P=0.008],Cyclosporin A[OR=0.51,P=0.04],tacrolimus[OR=2.34,P=0.003],acute rejection[OR=2.72,P<0.00001],and smoking history[OR=2.01,P=0.0006]were associated with PTDM after renal transplantation in China.Conclusion:Age,gender,family history of diabetes,source of kidney donors,BMI,HBV,HCV,CMV,tacrolimus,acute rejection,and smoking history are risk factors for PTDM after kidney transplantation in China.Cyclosporin A is protective factors of PTDM after kidney transplantation in China.These factors are worthy of attention by relevant clinical workers in our country.展开更多
基金Graduate Education Innovation Project of Shanxi Province in 2020(No.2020SY256)。
文摘Objective:To systematically evaluate the main risk factors of post-transplant diabetes mellitus(PTDM)after renal transplantation in China in the past 10 years.Methods:CNKI,Wanfang,VIP,and PubMed were searched to collect the related literatures on risk factors of PTDM after renal transplantation published by Chinese scholars from January 2010 to October 2020.The data were extracted and Meta-analysis was performed by Revman 5.3 software.Results:A total of 18 case-control studies were included,involving 5458 patients.There were 1106 PTDM cases after kidney transplantation and 4352 cases without PTDM after kidney transplantation.Meta-analysis results showed age[MD=6.09,P<0.00001],gender[OR=1.22,P=0.02],family history of diabetes[OR=5.56,P<0.0001],source of donor kidney[OR=1.87,P<0.0001],BMI[MD=1.76,P<0.00001],HBV infection[OR=2.52,P=0.04],HCV infection[OR=2.55,P<0.0001],CMV infection[OR=1.81,P=0.008],Cyclosporin A[OR=0.51,P=0.04],tacrolimus[OR=2.34,P=0.003],acute rejection[OR=2.72,P<0.00001],and smoking history[OR=2.01,P=0.0006]were associated with PTDM after renal transplantation in China.Conclusion:Age,gender,family history of diabetes,source of kidney donors,BMI,HBV,HCV,CMV,tacrolimus,acute rejection,and smoking history are risk factors for PTDM after kidney transplantation in China.Cyclosporin A is protective factors of PTDM after kidney transplantation in China.These factors are worthy of attention by relevant clinical workers in our country.
