Ciprofloxacin loaded microspheres were prepared by spray drying technique, with bovine serum albumin as the natural biodegradable wall materials. The obtained microspheres, using aqueous system, were organic solvent-f...Ciprofloxacin loaded microspheres were prepared by spray drying technique, with bovine serum albumin as the natural biodegradable wall materials. The obtained microspheres, using aqueous system, were organic solvent-free. The diameters of the spherical microspheres were in the range of 1-5 1:4. The drug entrapment of microspheres, formulated with different ciprofloxacin/albumin ratios as 1:1, 1:2 and 1:4, were 46.93%, 32.96% and 20.56% (n=3). And the encapsulation efflciencies for ciprofloxacin during spray drying were higher than 90%. Thermal denaturation programs at different temperatures (100-120℃) for different time intervals (3-6-12 h) were further processed to stabilize the spray-dried microspheres. The higher the extent for thermal denaturation, the slower the rate of ciprofloxacin released from microspheres in vitro. So the release rate of ciprofloxacin from microspheres can be controlled by modifing the conditions of thermal denaturation.展开更多
"Machinery Manufacturing Process and Fixture Design" is an important professional core course of machinery related majors in higher vocational colleges, with strong theory, practice and application. This cou..."Machinery Manufacturing Process and Fixture Design" is an important professional core course of machinery related majors in higher vocational colleges, with strong theory, practice and application. This course is the intersection and integration point of several mechanical professional courses, and the content of the course conforms to the connotation of made in China and the spirit of craftsmen in great countries, and it is a "natural experimental field" for the reform of ideological and political education. Through thinking and exploring education teaching, further refine political connotation of machinery manufacturing process and fixture course, system design, the ideological education of element organic into the professional teaching, thinking based on the "course education" under the background of the new course teaching mode, and improve the students' spirit of patriotism and national pride and craftsmen.展开更多
文摘Ciprofloxacin loaded microspheres were prepared by spray drying technique, with bovine serum albumin as the natural biodegradable wall materials. The obtained microspheres, using aqueous system, were organic solvent-free. The diameters of the spherical microspheres were in the range of 1-5 1:4. The drug entrapment of microspheres, formulated with different ciprofloxacin/albumin ratios as 1:1, 1:2 and 1:4, were 46.93%, 32.96% and 20.56% (n=3). And the encapsulation efflciencies for ciprofloxacin during spray drying were higher than 90%. Thermal denaturation programs at different temperatures (100-120℃) for different time intervals (3-6-12 h) were further processed to stabilize the spray-dried microspheres. The higher the extent for thermal denaturation, the slower the rate of ciprofloxacin released from microspheres in vitro. So the release rate of ciprofloxacin from microspheres can be controlled by modifing the conditions of thermal denaturation.
文摘"Machinery Manufacturing Process and Fixture Design" is an important professional core course of machinery related majors in higher vocational colleges, with strong theory, practice and application. This course is the intersection and integration point of several mechanical professional courses, and the content of the course conforms to the connotation of made in China and the spirit of craftsmen in great countries, and it is a "natural experimental field" for the reform of ideological and political education. Through thinking and exploring education teaching, further refine political connotation of machinery manufacturing process and fixture course, system design, the ideological education of element organic into the professional teaching, thinking based on the "course education" under the background of the new course teaching mode, and improve the students' spirit of patriotism and national pride and craftsmen.
