目的探讨失眠认知行为治疗(cognitive behavioral therapy for insomnia,CBT-I)对不同程度失眠障碍合并抑郁、焦虑患者的疗效。方法2020年7月至2023年1月,采用便利抽样法选取上海市精神卫生中心126例失眠障碍伴抑郁、焦虑症状的患者,分...目的探讨失眠认知行为治疗(cognitive behavioral therapy for insomnia,CBT-I)对不同程度失眠障碍合并抑郁、焦虑患者的疗效。方法2020年7月至2023年1月,采用便利抽样法选取上海市精神卫生中心126例失眠障碍伴抑郁、焦虑症状的患者,分为中度失眠组和重度失眠组,两组均接受8周的CBT-I治疗。分别在基线、2周、4周及8周时,使用匹兹堡睡眠指数量表(Pittsburgh sleep quality index,PSQI)、汉密尔顿抑郁量表(17-item Hamilton depression scale,HAMD-17)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)以及睡眠信念和态度量表(dysfunctional beliefs and attitudes about sleep scale,DBAS-16)等进行评估。结果治疗后,中度组和重度组患者的PSQI[5.00(4.00,8.00)vs.7.48(7.00,10.25)]分、HAMD-17[6.00(2.00,6.44)vs.6.44(5.00,8.00)]分、HAMA[5.10(2.00,5.20)vs.5.20(3.00,7.25)]分;两组治疗效果差异无统计学意义(P=0.216)。中度组所有指标在2周末均明显改善(均P<0.05);重度组DBAS-16后果因子和药物因子在4周末明显改善(均P<0.05),且睡眠潜伏期和生活质量存在波动现象。结论CBT-I对失眠、抑郁和焦虑均有显著疗效,但不同失眠严重程度患者的失眠改善幅度存在差异。展开更多
Through a comprehensive study of magnetostratigraphy and sedimentology of several basins in the northeastern Tibetan Plateau,we reveal that the study area mainly experienced six tectonic uplift stages at approximately...Through a comprehensive study of magnetostratigraphy and sedimentology of several basins in the northeastern Tibetan Plateau,we reveal that the study area mainly experienced six tectonic uplift stages at approximately 52 Ma,34-30 Ma,24-20 Ma,16-12 Ma,8-6 Ma,and 3.6-2.6 Ma.Comprehensive analyses of pollen assemblages from the Qaidam,Linxia,Xining,and West Jiuquan Basins show that the northeastern Tibetan Plateau has undergone six major changes in vegetation types and climate：50-40 Ma for the warm-humid forest vegetation,40-23 Ma for the warm-arid and temperate-arid forest steppe vegetation,23-18.6 Ma for the warm-humid and temperate-humid forest vegetation,18.6-8.5 Ma for the warm-humid and cool-humid forest steppe vegetation,8.6-5 Ma for the temperate sub-humid savanna steppe vegetation,and 5-1.8 Ma for the cold-arid steppe vegetation.Comprehensive comparisons of tectonic uplift events inferred from sedimentary records,climatic changes inferred from pollen,and global climate changes show that in the northeastern Tibetan Plateau the climate in the Paleogene at low altitude was mainly controlled by the global climate change,while that in the Neogene interval with high altitude landscapes of mountains and basins is more controlled by altitude and morphology.展开更多
Objective Located at the interface of terrestrial and marine ecosystems, mangroves are particularly sensitive to environmental changes. They provide a sedimentary sink for organic carbon, whereby core samples could p...Objective Located at the interface of terrestrial and marine ecosystems, mangroves are particularly sensitive to environmental changes. They provide a sedimentary sink for organic carbon, whereby core samples could provide detailed records of mangrove evolution. Human induced, rapid environmental changes in recent years require a better understanding of the mangrove ecosystems evolution in the past, by reconstructing the past mangrove dynamics using triterpenols recorded in sediments. The aim of our work is to improve the application of triterpenols as biomarkers for mangrove development in long term in China.展开更多
文摘目的探讨失眠认知行为治疗(cognitive behavioral therapy for insomnia,CBT-I)对不同程度失眠障碍合并抑郁、焦虑患者的疗效。方法2020年7月至2023年1月,采用便利抽样法选取上海市精神卫生中心126例失眠障碍伴抑郁、焦虑症状的患者,分为中度失眠组和重度失眠组,两组均接受8周的CBT-I治疗。分别在基线、2周、4周及8周时,使用匹兹堡睡眠指数量表(Pittsburgh sleep quality index,PSQI)、汉密尔顿抑郁量表(17-item Hamilton depression scale,HAMD-17)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)以及睡眠信念和态度量表(dysfunctional beliefs and attitudes about sleep scale,DBAS-16)等进行评估。结果治疗后,中度组和重度组患者的PSQI[5.00(4.00,8.00)vs.7.48(7.00,10.25)]分、HAMD-17[6.00(2.00,6.44)vs.6.44(5.00,8.00)]分、HAMA[5.10(2.00,5.20)vs.5.20(3.00,7.25)]分;两组治疗效果差异无统计学意义(P=0.216)。中度组所有指标在2周末均明显改善(均P<0.05);重度组DBAS-16后果因子和药物因子在4周末明显改善(均P<0.05),且睡眠潜伏期和生活质量存在波动现象。结论CBT-I对失眠、抑郁和焦虑均有显著疗效,但不同失眠严重程度患者的失眠改善幅度存在差异。
基金supported by Foundation of Geological Survey of China (no. 1212011121261)the State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences (no. GBL11307)
文摘Through a comprehensive study of magnetostratigraphy and sedimentology of several basins in the northeastern Tibetan Plateau,we reveal that the study area mainly experienced six tectonic uplift stages at approximately 52 Ma,34-30 Ma,24-20 Ma,16-12 Ma,8-6 Ma,and 3.6-2.6 Ma.Comprehensive analyses of pollen assemblages from the Qaidam,Linxia,Xining,and West Jiuquan Basins show that the northeastern Tibetan Plateau has undergone six major changes in vegetation types and climate：50-40 Ma for the warm-humid forest vegetation,40-23 Ma for the warm-arid and temperate-arid forest steppe vegetation,23-18.6 Ma for the warm-humid and temperate-humid forest vegetation,18.6-8.5 Ma for the warm-humid and cool-humid forest steppe vegetation,8.6-5 Ma for the temperate sub-humid savanna steppe vegetation,and 5-1.8 Ma for the cold-arid steppe vegetation.Comprehensive comparisons of tectonic uplift events inferred from sedimentary records,climatic changes inferred from pollen,and global climate changes show that in the northeastern Tibetan Plateau the climate in the Paleogene at low altitude was mainly controlled by the global climate change,while that in the Neogene interval with high altitude landscapes of mountains and basins is more controlled by altitude and morphology.
基金granted by the National Natural Science Foundation of China(grants No.41306064 and 41376075)
文摘Objective Located at the interface of terrestrial and marine ecosystems, mangroves are particularly sensitive to environmental changes. They provide a sedimentary sink for organic carbon, whereby core samples could provide detailed records of mangrove evolution. Human induced, rapid environmental changes in recent years require a better understanding of the mangrove ecosystems evolution in the past, by reconstructing the past mangrove dynamics using triterpenols recorded in sediments. The aim of our work is to improve the application of triterpenols as biomarkers for mangrove development in long term in China.
