目的评估儿童先天性小耳畸形患者自体肋软骨耳郭再造术后效果及生活质量(quality of life,QOL)。方法收集2013年7月至2020年7月昆明医科大学第二附属医院整形外科在全扩张法耳郭再造术后发放两份问卷的256例患者。第一份问卷评估再造耳...目的评估儿童先天性小耳畸形患者自体肋软骨耳郭再造术后效果及生活质量(quality of life,QOL)。方法收集2013年7月至2020年7月昆明医科大学第二附属医院整形外科在全扩张法耳郭再造术后发放两份问卷的256例患者。第一份问卷评估再造耳郭手术效果,涉及再造耳的大小、位置、颅耳角、亚单位结构等方面,总分100分,根据评分结果分为四个等级,即优、良、一般、差。第二份问卷为中文版格拉斯格儿童受益量表评分(glasgow children’s benefit inventory,GCBI),用于评价术后QOL的变化。得分为0表示QOL无变化,+100表示最大的改善,-100表示最大的恶化。并探讨再造耳手术效果和患者生活质量评分之间的关联性。结果共收回190份完整问卷,患儿手术效果评分:优69例(36.32%),良67例(35.26%),一般33例(17.37%),差21例(11.05%)。再造耳亚单位评分中,评分均值外耳轮最高(4.66分),耳屏最低(2.63分)。中文版GCBI量表得分均为正值,说明患儿术后QOL均得到不同程度的改善,其中在学习方面的改善最显著,其次是日常行为方面。相关性分析显示,再造耳手术效果与中文版GCBI总评分之间呈中等程度相关(r=0.57,P<0.01)。结论全扩张法联合自体肋软骨耳郭再造术可显著改善儿童的生活质量,并且更高质量的手术效果评分与更高的生活质量评分显著相关。展开更多
OBJECTIVE: To investigate the effects on the brain using three needling manipulations(twirling, lifting-thrusting, and twirling plus lifting-thrusting)when the right-side Zusanli(ST 36) acupoint was stimulated with ne...OBJECTIVE: To investigate the effects on the brain using three needling manipulations(twirling, lifting-thrusting, and twirling plus lifting-thrusting)when the right-side Zusanli(ST 36) acupoint was stimulated with needles.METHODS: Seventeen healthy subjects accepted three needling manipulations stimulating the right Zusanli(ST 36) over separate days. Functional magnetic resonance imaging was used to detect changes in the brain during the manipulations, and then the needling sensations were recorded using the MGH acupuncture sensation scale(MASS) after each scan. f MRI data were processed using Statistical Parametric Mapping 8 to analyze the positiveand negative activation in the brain induced by different acupuncture manipulations.RESULTS: The individual needling sensations showed no statistically significant differences among the three manipulations. However, the MASS index showed that lifting-thrusting > twirling plus lifting-thrusting > twirling. Lifting-thrusting activated left premotor cortex, left postcentral,right middle frontal gyrus, left inferior frontal gyrus,right lingual gyrus, left insula, right putamen, bilateral cingulate gyrus and right cerebellum; and deactivated bilateral hippocampus and left caudate.Twirling activated bilateral orbital middle frontal gyrus, left opercular and triangular inferior frontal gyrus, and right middle occipital gyrus; and deactivated bilateral precuneus, right amygdala, left anterior cingulate gyrus, right inferior temporal gyrus,right middle frontal gyrus, right supplementary motor gyrus, and left postcentral. Twirling plus lifting-thrusting activated bilateral postcentral, left inferior occipital gyrus, left insula, left thalamus, left cingulate gyrus, and right putamen; and deactivated right superior frontal gyrus, right superior parietal gyrus, right temporal gyrus, right middle occipital gyrus, right insula, and left lingual gyrus. Pairwise comparisons of the three manipulations showed that signals induced by lifting-thrusting were the strongest, especially in the limbic system,followed by twirling plus lifting-thrusting; twirling alone was the weakest.CONCLUSION: Three methods of needling manipulations similarly activated areas associated with the somatosensory system, vision, cognition, and emotional regulation. This may have significant implications for acupuncture in clinical practice.展开更多
The feature selection in analogy-based software effort estimation （ASEE） is formulized as a multi-objective optimization problem. One objective is designed to maximize the effort estimation accuracy and the other ob...The feature selection in analogy-based software effort estimation （ASEE） is formulized as a multi-objective optimization problem. One objective is designed to maximize the effort estimation accuracy and the other objective is designed to minimize the number of selected features. Based on these two potential conflict objectives, a novel wrapper- based feature selection method, multi-objective feature selection for analogy-based software effort estimation （MASE）, is proposed. In the empirical studies, 77 projects in Desharnais and 62 projects in Maxwell from the real world are selected as the evaluation objects and the proposed method MASE is compared with some baseline methods. Final results show that the proposed method can achieve better performance by selecting fewer features when considering MMRE （mean magnitude of relative error）, MdMRE （median magnitude of relative error）, PRED （ 0. 25 ）, and SA （ standardized accuracy） performance metrics.展开更多
The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, i...The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene.展开更多
基金Supported by China Academy of Chinese Medical Sciences Foundation(No.ZZ08010)General Program of National Natural Science Foundation of China(No.81273674)
文摘OBJECTIVE: To investigate the effects on the brain using three needling manipulations(twirling, lifting-thrusting, and twirling plus lifting-thrusting)when the right-side Zusanli(ST 36) acupoint was stimulated with needles.METHODS: Seventeen healthy subjects accepted three needling manipulations stimulating the right Zusanli(ST 36) over separate days. Functional magnetic resonance imaging was used to detect changes in the brain during the manipulations, and then the needling sensations were recorded using the MGH acupuncture sensation scale(MASS) after each scan. f MRI data were processed using Statistical Parametric Mapping 8 to analyze the positiveand negative activation in the brain induced by different acupuncture manipulations.RESULTS: The individual needling sensations showed no statistically significant differences among the three manipulations. However, the MASS index showed that lifting-thrusting > twirling plus lifting-thrusting > twirling. Lifting-thrusting activated left premotor cortex, left postcentral,right middle frontal gyrus, left inferior frontal gyrus,right lingual gyrus, left insula, right putamen, bilateral cingulate gyrus and right cerebellum; and deactivated bilateral hippocampus and left caudate.Twirling activated bilateral orbital middle frontal gyrus, left opercular and triangular inferior frontal gyrus, and right middle occipital gyrus; and deactivated bilateral precuneus, right amygdala, left anterior cingulate gyrus, right inferior temporal gyrus,right middle frontal gyrus, right supplementary motor gyrus, and left postcentral. Twirling plus lifting-thrusting activated bilateral postcentral, left inferior occipital gyrus, left insula, left thalamus, left cingulate gyrus, and right putamen; and deactivated right superior frontal gyrus, right superior parietal gyrus, right temporal gyrus, right middle occipital gyrus, right insula, and left lingual gyrus. Pairwise comparisons of the three manipulations showed that signals induced by lifting-thrusting were the strongest, especially in the limbic system,followed by twirling plus lifting-thrusting; twirling alone was the weakest.CONCLUSION: Three methods of needling manipulations similarly activated areas associated with the somatosensory system, vision, cognition, and emotional regulation. This may have significant implications for acupuncture in clinical practice.
基金The National Natural Science Foundation of China(No.61602267,61202006)the Open Project of State Key Laboratory for Novel Software Technology at Nanjing University(No.KFKT2016B18)
文摘The feature selection in analogy-based software effort estimation （ASEE） is formulized as a multi-objective optimization problem. One objective is designed to maximize the effort estimation accuracy and the other objective is designed to minimize the number of selected features. Based on these two potential conflict objectives, a novel wrapper- based feature selection method, multi-objective feature selection for analogy-based software effort estimation （MASE）, is proposed. In the empirical studies, 77 projects in Desharnais and 62 projects in Maxwell from the real world are selected as the evaluation objects and the proposed method MASE is compared with some baseline methods. Final results show that the proposed method can achieve better performance by selecting fewer features when considering MMRE （mean magnitude of relative error）, MdMRE （median magnitude of relative error）, PRED （ 0. 25 ）, and SA （ standardized accuracy） performance metrics.
基金supported by National Basic Research Program of China (Grants Nos. 2010CB833400, 2004CB720200)Innovation Program of Chinese Academy of Sciences (Grant No. KZCX2-YW-Q09-04)+1 种基金National Natural Science Foundation of China (Grants Nos. 41072142, 40921120406 and 40772116)State Key Laboratory of Loess and Quaternary Geology (SKLLQG)
文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene.
