The high-temperature sensitivity of the silicon material index limits the applications of silicon-based micro-ring resonators in integrated photonics. To realize a low but broadband temperature-dependent-wavelength-sh...The high-temperature sensitivity of the silicon material index limits the applications of silicon-based micro-ring resonators in integrated photonics. To realize a low but broadband temperature-dependent-wavelength-shift microring resonator, designing a broadband athermal waveguide becomes a significant task. In this work,we propose a broadband athermal waveguide that shows a low effective thermo-optical coefficient of1 × 10^(-6)∕K from 1400 to 1700 nm. The proposed waveguide shows a low-loss performance and stable broadband athermal property when it is applied to ring resonators, and the bending loss of ring resonators with a radius of >30 μm is 0.02 dB/cm.展开更多
Klebsiella pneumoniae is a Gram-negative opportunistic pathogenic bacterium that occasionally inhabits the human gastrointestinal tracts.Gut-colonized K.pneumoniae may then metastasize to other organs and tissues,thus...Klebsiella pneumoniae is a Gram-negative opportunistic pathogenic bacterium that occasionally inhabits the human gastrointestinal tracts.Gut-colonized K.pneumoniae may then metastasize to other organs and tissues,thus causing severe infections.In this study,we identified three cpxA mutations in K.pneumoniae that experimentally evolved to show reduced adhesive ability.CpxA is a sensor histidine kinase that rendered reduced surface adhesion and gut colonization ability in K.pneumoniae.Interestingly,one experimentally gained CpxA mutant(L168del)also commonly occurs in nature.K.pneumoniae containing CpxA variants showed different colonization potentials through altered type 3 fimbriae expression.Lastly,we demonstrated that CpxA contributes to amino acid sensing,thus regulating the colonization of K.pneumoniae both on solid surfaces and in mouse intestines.The polymorphism of CpxA may help to broaden the environmental adaptation of the bacterium.These findings together reveal a Cpx-mediated regulation to diversify intestinal colonization in K.pneumoniae.展开更多
基金National Basic Research Program of China(973)(2014CB340104/3)National Natural Science Foundation of China(NSFC)(61775164,61335005,61377076,61575142,61431009)Tianjin University
文摘The high-temperature sensitivity of the silicon material index limits the applications of silicon-based micro-ring resonators in integrated photonics. To realize a low but broadband temperature-dependent-wavelength-shift microring resonator, designing a broadband athermal waveguide becomes a significant task. In this work,we propose a broadband athermal waveguide that shows a low effective thermo-optical coefficient of1 × 10^(-6)∕K from 1400 to 1700 nm. The proposed waveguide shows a low-loss performance and stable broadband athermal property when it is applied to ring resonators, and the bending loss of ring resonators with a radius of >30 μm is 0.02 dB/cm.
基金partially supported by the National Key R&D Program of China(Grant no.2023YFC2308403)the National Natural Science Foundation of China(Grant no.32430002)+5 种基金the Natural Science Foundation of Zhejiang Province of China(Grant no.LRG25C010001)the Westlake University-Muyuan Joint Research Institute(Program no.WU2024MY001)the Westlake Center for Genome Editing(Program no.21200000A992410)the Zhejiang Provincial Key Laboratory Construction Project(2024ZY01026)the“Pioneer”and“Leading Goose”R&D Program of Zhejiang(Grant no.2024SSYS0029)support from the Westlake Laboratory of Life Sciences and Biomedicine and the Westlake Education Foundation.
文摘Klebsiella pneumoniae is a Gram-negative opportunistic pathogenic bacterium that occasionally inhabits the human gastrointestinal tracts.Gut-colonized K.pneumoniae may then metastasize to other organs and tissues,thus causing severe infections.In this study,we identified three cpxA mutations in K.pneumoniae that experimentally evolved to show reduced adhesive ability.CpxA is a sensor histidine kinase that rendered reduced surface adhesion and gut colonization ability in K.pneumoniae.Interestingly,one experimentally gained CpxA mutant(L168del)also commonly occurs in nature.K.pneumoniae containing CpxA variants showed different colonization potentials through altered type 3 fimbriae expression.Lastly,we demonstrated that CpxA contributes to amino acid sensing,thus regulating the colonization of K.pneumoniae both on solid surfaces and in mouse intestines.The polymorphism of CpxA may help to broaden the environmental adaptation of the bacterium.These findings together reveal a Cpx-mediated regulation to diversify intestinal colonization in K.pneumoniae.
