目的可视化分析葛根质量控制研究文献,总结该领域研究现状及研究热点,为后续研究提供参考。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)和Web of Science(WOS)1993年1月1日-2023年7月29日...目的可视化分析葛根质量控制研究文献,总结该领域研究现状及研究热点,为后续研究提供参考。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)和Web of Science(WOS)1993年1月1日-2023年7月29日收录的葛根质量控制研究文献,利用Citespace6.2.R4软件可视化分析作者、发文机构、关键词。结果纳入中文文献1188篇,英文文献550篇。中、英文文献发文总体呈上升趋势。中文文献作者以王钰乐、何艳发文量较高(5篇),英文文献发文量最高的作者为Putalun Waraporn(13篇),研究机构以北京中医药大学为主。高频关键词为“葛根素”“质量控制”“含量测定”“葛根”“指纹图谱”,中文文献关键词聚为13类,英文文献关键词聚为11类,分别探测到20个突现关键词。结论当前研究围绕葛根化学成分、指纹图谱、提取与制备工艺、药理作用展开,葛根质量控制多采用多成分定性定量研究。经典名方质量控制研究、中药整体性研究、药理作用相关性研究及作用机制研究将成为该领域研究趋势。展开更多
Objective To explore the transitive regularity of holistic constituents from the crude slices of the medicinal raw materials(MCS)to the formula granules(FG),fufang decoction(FD),and finally,the concentrated pills(CP)o...Objective To explore the transitive regularity of holistic constituents from the crude slices of the medicinal raw materials(MCS)to the formula granules(FG),fufang decoction(FD),and finally,the concentrated pills(CP)of Liuwei Dihuang Fufang(六味地黄复方,LWDHF).Methods Samples for MCS,FG,FD,and CP of LWDHF were obtained,and a fingerprint data-base was established using high-performance liquid chromatography(HPLC),by separating the samples in an XB-C18 column and analyzing the transitive regularity of components us-ing the total quantum statistical moment(TQSM),including total quantum zero moment(AUCT),total quantum first moment(MRTT),total quantum second moment(VRTT),and its similarity approach.The AUCT,MRTT,and VRTT were calculated based on the representative HPLC chromatograms of FG,FD,and CP of LWDHF.Results AUCT of FG,FD,and CP of LWDHF was 71804,46553,and 144646μV·s,respectively;MRTT was 14.43,14.54,and 18.85 min,respectively;and VRTT was 106.98,112.84,and 269.12 min^(2),respectively.Comparing the similarity of FG/FD,FG/CP and FD/CP of LWDHF,the TQSM similarity values were 98.66%,76.62%,and 75.37%,respectively,whereas the tradi-tional similarity evaluation values were 98.68%,85.43%,and 85.60%,respectively.Conclusion The results perform little distinction in the total composition between FG and FD,whereas some distinction existed between FD and CP.Experimental evidence,therefore indicates that FG could be used as the alternative of MCS in clinical applications.展开更多
山银花Lonicerae Flos作为一种常用的药食两用中药,具有清热解毒、疏散风热的功效,广泛应用于中成药、食品和保健品。近年来,市场需求的增加使山银花的成分、药效和质量成为研究焦点。山银花的质量受到基原、产地、批次和加工方式等多...山银花Lonicerae Flos作为一种常用的药食两用中药,具有清热解毒、疏散风热的功效,广泛应用于中成药、食品和保健品。近年来,市场需求的增加使山银花的成分、药效和质量成为研究焦点。山银花的质量受到基原、产地、批次和加工方式等多种因素的影响,其化学成分复杂、不稳定,给质量控制带来严峻挑战。通过系统梳理中国知网(China national knowledge infrastructure,CNKI)与Web of Science(WOS)中山银花的基原、成分、生物效应质量评控相关文献,明确山银花的变异成分、活性成分,并通过计算变异系数(coefficient of variation,CV)预测山银花可能的Ⅰ类质控指标。通过网络药理学和分子对接技术,将预测的I类质控指标与清热解毒功效相关联。以绿原酸为例,分析了Ⅰ类质控指标在山银花的“基原鉴别-生产过程监控-制剂药效保障”全产业链的参与方式,为后续山银花在生产加工以及制剂过程中关键监控成分提供参考,也为其质量标准优化提供理论依据。展开更多
文摘目的可视化分析葛根质量控制研究文献,总结该领域研究现状及研究热点,为后续研究提供参考。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)和Web of Science(WOS)1993年1月1日-2023年7月29日收录的葛根质量控制研究文献,利用Citespace6.2.R4软件可视化分析作者、发文机构、关键词。结果纳入中文文献1188篇,英文文献550篇。中、英文文献发文总体呈上升趋势。中文文献作者以王钰乐、何艳发文量较高(5篇),英文文献发文量最高的作者为Putalun Waraporn(13篇),研究机构以北京中医药大学为主。高频关键词为“葛根素”“质量控制”“含量测定”“葛根”“指纹图谱”,中文文献关键词聚为13类,英文文献关键词聚为11类,分别探测到20个突现关键词。结论当前研究围绕葛根化学成分、指纹图谱、提取与制备工艺、药理作用展开,葛根质量控制多采用多成分定性定量研究。经典名方质量控制研究、中药整体性研究、药理作用相关性研究及作用机制研究将成为该领域研究趋势。
基金Hunan Provincial Natural Science Foundation of China(2019JJ40220 and 2021JJ30514)Hunan Provincial Administration of Traditional Chinese Medicine(2021204and 2021073)+1 种基金Scientific Research Fund of Hunan Provincial Education Department(2021204 and 2021073)Pharmaceutical Open Fund of Domestic First-class Disciplines(Cultivation)of Hunan Province(2018YX11)。
文摘Objective To explore the transitive regularity of holistic constituents from the crude slices of the medicinal raw materials(MCS)to the formula granules(FG),fufang decoction(FD),and finally,the concentrated pills(CP)of Liuwei Dihuang Fufang(六味地黄复方,LWDHF).Methods Samples for MCS,FG,FD,and CP of LWDHF were obtained,and a fingerprint data-base was established using high-performance liquid chromatography(HPLC),by separating the samples in an XB-C18 column and analyzing the transitive regularity of components us-ing the total quantum statistical moment(TQSM),including total quantum zero moment(AUCT),total quantum first moment(MRTT),total quantum second moment(VRTT),and its similarity approach.The AUCT,MRTT,and VRTT were calculated based on the representative HPLC chromatograms of FG,FD,and CP of LWDHF.Results AUCT of FG,FD,and CP of LWDHF was 71804,46553,and 144646μV·s,respectively;MRTT was 14.43,14.54,and 18.85 min,respectively;and VRTT was 106.98,112.84,and 269.12 min^(2),respectively.Comparing the similarity of FG/FD,FG/CP and FD/CP of LWDHF,the TQSM similarity values were 98.66%,76.62%,and 75.37%,respectively,whereas the tradi-tional similarity evaluation values were 98.68%,85.43%,and 85.60%,respectively.Conclusion The results perform little distinction in the total composition between FG and FD,whereas some distinction existed between FD and CP.Experimental evidence,therefore indicates that FG could be used as the alternative of MCS in clinical applications.
文摘山银花Lonicerae Flos作为一种常用的药食两用中药,具有清热解毒、疏散风热的功效,广泛应用于中成药、食品和保健品。近年来,市场需求的增加使山银花的成分、药效和质量成为研究焦点。山银花的质量受到基原、产地、批次和加工方式等多种因素的影响,其化学成分复杂、不稳定,给质量控制带来严峻挑战。通过系统梳理中国知网(China national knowledge infrastructure,CNKI)与Web of Science(WOS)中山银花的基原、成分、生物效应质量评控相关文献,明确山银花的变异成分、活性成分,并通过计算变异系数(coefficient of variation,CV)预测山银花可能的Ⅰ类质控指标。通过网络药理学和分子对接技术,将预测的I类质控指标与清热解毒功效相关联。以绿原酸为例,分析了Ⅰ类质控指标在山银花的“基原鉴别-生产过程监控-制剂药效保障”全产业链的参与方式,为后续山银花在生产加工以及制剂过程中关键监控成分提供参考,也为其质量标准优化提供理论依据。
