Reviews The Dectin-1 cluster comprises seven members:CLEC-12A,CLEC-12B,CLEC-1A,CLEC-7A,CLEC-2,CLEC-9A and OLR1.These members have been demonstrated to be involved in the tumorigenesis,progression,and metastasis of sev...Reviews The Dectin-1 cluster comprises seven members:CLEC-12A,CLEC-12B,CLEC-1A,CLEC-7A,CLEC-2,CLEC-9A and OLR1.These members have been demonstrated to be involved in the tumorigenesis,progression,and metastasis of several cancers.However,little is known about their roles in human lung adenocarcinoma(LUAD).The expression patterns of the Dectin-1 cluster were analyzed via the ONCOMINE and GEPIA databases.We evaluated the prognostic value of the Dectin-1 cluster in patients with LUAD using the Kaplan-Meier plotter and GEPIA.Differential expression was validated with the EMBL-EBI database,and protein expression was analyzed with the HPA database.In addition,protein-protein interaction network,GO,and KEGG analyses were conducted.Finally,the correlations between CLEC-12A and immune molecules(immune inhibitors and MHC molecules)were investigated via TISIDB and GEPIA.The expression levels of Dectin-1 cluster genes were downregulated in LUAD tissues compared to those in normal lung tissues.The expression levels of CLEC-12A,CLEC-12B,CLEC-2,and CLEC-9A correlated with tumor stage,and CLEC-12A and CLEC-12B were significantly associated with survival in patients with LUAD.The seven genes mostly participated in immune regulation processes and were involved in autoimmune disorders and hematological malignancies.Finally,correlation analyses revealed CLEC-12A expression was associated with most immune inhibitors and MHCs.CLEC-12A was positively related to PD-1,PD-L1,PD-L2,CTLA4,TIM3,and LAG3.In conclusion,our findings suggest that CLEC-12A and CLEC-12B can be used as prognostic biomarkers in LUAD.CLEC-12A expression was associated with immune checkpoint molecules,and CLEC-12A may be a potential assistant target to improve the efficacy of immune checkpoint inhibitors immunotherapy.展开更多
To the Editor:Immune checkpoint inhibitors(ICIs)have shown remarkable clinical responses;however,their efficacy remains limited to a small subset of patients.Peripheral blood mononuclear cells(PBMCs)offer an effective...To the Editor:Immune checkpoint inhibitors(ICIs)have shown remarkable clinical responses;however,their efficacy remains limited to a small subset of patients.Peripheral blood mononuclear cells(PBMCs)offer an effective,accessible,and minimally invasive approach to assess tumor immune status and identify ICI responders.In this study,we aimed to elucidate the role of PBMC gene expression in ICI treatment response and prognosis.This study received approval from the Biomedical Ethics Committee of West China Hospital,Sichuan University(No.2019[1045])and the requirement to obtain informed consent was waived.展开更多
Microbiome research has extended into the cancer area in the past decades.Microbes can affect oncogenesis,progression,and treatment response through various mechanisms,including direct regulation and indirect impacts....Microbiome research has extended into the cancer area in the past decades.Microbes can affect oncogenesis,progression,and treatment response through various mechanisms,including direct regulation and indirect impacts.Microbiota-associated detectionmethods and agents have been developed to facilitate cancer diagnosis and therapy.Additionally,the cancermicrobiome has recently been redefined.The identification of intra-tumoral microbes and cancer-related circulating microbial DNA(cmDNA)has promoted novel research in the cancer–microbiome area.In this review,we define the human system of commensal microbes and the cancer microbiome from a brand-new perspective and emphasize the potential value of cmDNA as a promising biomarker in cancer liquid biopsy.We outline all existing studies on the relationship between cmDNA and cancer and the outlook for potential preclinical and clinical applications of cmDNA in cancer precision medicine,as well as critical problems to be overcome in this burgeoning field.展开更多
In this paper,the authors study the multiplicity of solutions to the weighted p-Laplacian with isolated singularity and diffusion suppressed by convection-div(|x|^(α)|■u|^(p-2)■u)+λ^(1)/|x|β|■u|^(p-2)■u·x=...In this paper,the authors study the multiplicity of solutions to the weighted p-Laplacian with isolated singularity and diffusion suppressed by convection-div(|x|^(α)|■u|^(p-2)■u)+λ^(1)/|x|β|■u|^(p-2)■u·x=|x|^(γ)g(|x|)in B{0}subject to nonlinear Robin boundary value condition|x|^(α)|■u|^(p-2)■u·n=A-ρu on■B,whereλ>0,B■RN(N≥2)is the unit ball centered at the origin,α>0,p>1,β∈R,γ>-N,g∈C(0,1])with g(0)>0,A∈R,ρ>0 and n is the unit outward normal.The same problem with diffusion promoted by convection,namely λ≤0,has already been discussed by the last two authors(Song-Yin(2012)),where the existence,nonexistence and classification of singularities for solutions are presented.Completely different from[Song,H.J.and Yin,J.X.,Removable isolated singularities of solutions to the weighted p-Laplacian with singular convection,Math.Meth.Appl.Sci.,35,2012,1089-1100],in the present caseλ>0,namely the diffusion is suppressed by the convection,non-singular solutions are not only existent but also may be infinite which vary according only to the values of solutions at the isolated singular point.At the same time,the singular solutions may exist only if the diffusion dominates the convection.展开更多
基金supported by the China Postdoctoral Science Foundation[Grant No.2018M643495]Technology Department of Sichuan Province[Grant No.2020YJ0049].
文摘Reviews The Dectin-1 cluster comprises seven members:CLEC-12A,CLEC-12B,CLEC-1A,CLEC-7A,CLEC-2,CLEC-9A and OLR1.These members have been demonstrated to be involved in the tumorigenesis,progression,and metastasis of several cancers.However,little is known about their roles in human lung adenocarcinoma(LUAD).The expression patterns of the Dectin-1 cluster were analyzed via the ONCOMINE and GEPIA databases.We evaluated the prognostic value of the Dectin-1 cluster in patients with LUAD using the Kaplan-Meier plotter and GEPIA.Differential expression was validated with the EMBL-EBI database,and protein expression was analyzed with the HPA database.In addition,protein-protein interaction network,GO,and KEGG analyses were conducted.Finally,the correlations between CLEC-12A and immune molecules(immune inhibitors and MHC molecules)were investigated via TISIDB and GEPIA.The expression levels of Dectin-1 cluster genes were downregulated in LUAD tissues compared to those in normal lung tissues.The expression levels of CLEC-12A,CLEC-12B,CLEC-2,and CLEC-9A correlated with tumor stage,and CLEC-12A and CLEC-12B were significantly associated with survival in patients with LUAD.The seven genes mostly participated in immune regulation processes and were involved in autoimmune disorders and hematological malignancies.Finally,correlation analyses revealed CLEC-12A expression was associated with most immune inhibitors and MHCs.CLEC-12A was positively related to PD-1,PD-L1,PD-L2,CTLA4,TIM3,and LAG3.In conclusion,our findings suggest that CLEC-12A and CLEC-12B can be used as prognostic biomarkers in LUAD.CLEC-12A expression was associated with immune checkpoint molecules,and CLEC-12A may be a potential assistant target to improve the efficacy of immune checkpoint inhibitors immunotherapy.
基金National Natural Science Foundation of China(No.NSFC82372331)Project of Science and Technology Department of Sichuan Province(Nos.2024NSFSC1551 and 2023NSFSC0716)
文摘To the Editor:Immune checkpoint inhibitors(ICIs)have shown remarkable clinical responses;however,their efficacy remains limited to a small subset of patients.Peripheral blood mononuclear cells(PBMCs)offer an effective,accessible,and minimally invasive approach to assess tumor immune status and identify ICI responders.In this study,we aimed to elucidate the role of PBMC gene expression in ICI treatment response and prognosis.This study received approval from the Biomedical Ethics Committee of West China Hospital,Sichuan University(No.2019[1045])and the requirement to obtain informed consent was waived.
基金Thisworkwas supported by the National Natural Science Foundation Regional Innovation and Development(grant No.U20A20394)the Project of Science and Technology Department of Sichuan Province(grant No.2020YJ0106).
文摘Microbiome research has extended into the cancer area in the past decades.Microbes can affect oncogenesis,progression,and treatment response through various mechanisms,including direct regulation and indirect impacts.Microbiota-associated detectionmethods and agents have been developed to facilitate cancer diagnosis and therapy.Additionally,the cancermicrobiome has recently been redefined.The identification of intra-tumoral microbes and cancer-related circulating microbial DNA(cmDNA)has promoted novel research in the cancer–microbiome area.In this review,we define the human system of commensal microbes and the cancer microbiome from a brand-new perspective and emphasize the potential value of cmDNA as a promising biomarker in cancer liquid biopsy.We outline all existing studies on the relationship between cmDNA and cancer and the outlook for potential preclinical and clinical applications of cmDNA in cancer precision medicine,as well as critical problems to be overcome in this burgeoning field.
基金supported by the National Natural Science Foundation of China(Nos.12171166,11601200,11771156,11861038,12161045,12026220)。
文摘In this paper,the authors study the multiplicity of solutions to the weighted p-Laplacian with isolated singularity and diffusion suppressed by convection-div(|x|^(α)|■u|^(p-2)■u)+λ^(1)/|x|β|■u|^(p-2)■u·x=|x|^(γ)g(|x|)in B{0}subject to nonlinear Robin boundary value condition|x|^(α)|■u|^(p-2)■u·n=A-ρu on■B,whereλ>0,B■RN(N≥2)is the unit ball centered at the origin,α>0,p>1,β∈R,γ>-N,g∈C(0,1])with g(0)>0,A∈R,ρ>0 and n is the unit outward normal.The same problem with diffusion promoted by convection,namely λ≤0,has already been discussed by the last two authors(Song-Yin(2012)),where the existence,nonexistence and classification of singularities for solutions are presented.Completely different from[Song,H.J.and Yin,J.X.,Removable isolated singularities of solutions to the weighted p-Laplacian with singular convection,Math.Meth.Appl.Sci.,35,2012,1089-1100],in the present caseλ>0,namely the diffusion is suppressed by the convection,non-singular solutions are not only existent but also may be infinite which vary according only to the values of solutions at the isolated singular point.At the same time,the singular solutions may exist only if the diffusion dominates the convection.
