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血清HE4、B7H4表达水平及全身免疫炎症指数与卵巢癌患者临床病理特征及肿瘤转移的关系 被引量:2
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作者 朱琳 杨柳 +3 位作者 卞军 李蕊 程晓丽 辛毅娟 《现代生物医学进展》 CAS 2024年第18期3460-3464,共5页
目的:探讨血清附睾蛋白4(HE4)、B7同源体4(B7H4)表达水平及全身免疫炎症指数(SII)与卵巢癌患者临床病理特征及肿瘤转移的关系。方法:选取我院2017年1月到2020年1月收治的80例卵巢癌患者,将其分为恶性组,另选取同期80例良性卵巢病变患者... 目的:探讨血清附睾蛋白4(HE4)、B7同源体4(B7H4)表达水平及全身免疫炎症指数(SII)与卵巢癌患者临床病理特征及肿瘤转移的关系。方法:选取我院2017年1月到2020年1月收治的80例卵巢癌患者,将其分为恶性组,另选取同期80例良性卵巢病变患者分为良性组,80名健康者作为对照组。对比三组受检者血清HE4、B7H4及SII表达水平。分析不同临床病理特征及肿瘤转移患者HE4、B7H4及SII表达水平,并采用Spearman相关性分析HE4、B7H4及SII与卵巢癌临床病理特征及肿瘤转移的相关性。并随访3年,记录总生存时间,分析HE4、B7H4及SII与卵巢癌生存期的关系。结果:三组患者HE4、B7H4及SII表达水平对比差异显著,恶性组明显高于良性组与对照组(P<0.05);不同年龄、组织学类型卵巢癌患者HE4、B7H4及SII表达水平对比无明显差异(P>0.05),不同FIGO分期、淋巴结转移、远处转移、肿瘤分化程度患者HE4、B7H4及SII表达水平对比差异显著(P<0.05);Spearman相关分析结果表明,HE4、B7H4及SII与卵巢癌组织学类型无明显相关性,与FIGO分期、淋巴结转移、远处转移及肿瘤分化程度呈正相关(P<0.05);所有患者进行4年随访,HE4高水平患者中位总生存时间为23.53(6.42~42.13)个月个月明显低于低水平患者中位总生存时间32.54(14.53~42.13)个月。B7H4高水平患者中位总生存时间为21.32(6.42~42.13)个月明显低于低水平患者中位总生存时间31.32(14.63~42.13)个月。SII高水平患者中位总生存时间为20.36(6.42~42.13)个月明显低于低水平患者中位总生存时间34.68(13.56~42.13)个月(P<0.05)。结论:血清HE4、B7H4、SII表达与卵巢癌临床分期、淋巴结转移、远处转移及肿瘤分化程度相关,且三者高表达可能意味着患者预后不良。 展开更多
关键词 附睾蛋白4 B7同源体4 全身免疫炎症指数 卵巢癌
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昆明市一线医护人员焦虑、抑郁、睡眠及事件影响状况的相关性研究 被引量:5
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作者 李晓霞 李琪勇 +3 位作者 全映波 李蕊 合浩 向盈盈 《世界睡眠医学杂志》 2020年第5期751-752,共2页
目的:了解新冠疫情期间昆明市一线医务人员心理健康状况及其相关性。方法:对昆明市9家市属医院550名医护人员进行调查研究,通过电子问卷方式,对其进行焦虑筛查量表(GAD-7)、抑郁筛查量表(PHQ-9)、失眠严重指数问卷(ISI)及事件影响量表... 目的:了解新冠疫情期间昆明市一线医务人员心理健康状况及其相关性。方法:对昆明市9家市属医院550名医护人员进行调查研究,通过电子问卷方式,对其进行焦虑筛查量表(GAD-7)、抑郁筛查量表(PHQ-9)、失眠严重指数问卷(ISI)及事件影响量表修订版(IES-R)测评,并对上述4个因子测评结果进行相关性分析。结果:IES-R评分与PHQ-9、GAD-7、ISI呈正相关,相关系数r分别为0. 92、0. 93、0. 95,P <0. 05,差异有统计学意义。IES-R≥35分者焦虑抑郁及失眠严重程度明显高于IES-R <35分者(P <0. 05)。结论:面对COVID-19事件,参与抗疫的一线医护人员心理健康均受到不同程度的影响。在繁重且存在感染风险的抗疫战斗中,有必要对一线医护人员心理健康进行关注。 展开更多
关键词 新冠肺炎 心理健康 睡眠
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证据图谱的制作与报告 被引量:46
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作者 李艳飞 李秀霞 +6 位作者 李睿 曹柳娇 李美萱 李慧娟 后亮瑛 张维益 杨克虎 《中国循证医学杂志》 CSCD 北大核心 2020年第9期1098-1103,共6页
证据图谱是通过对现有证据的系统收集、评价和综合,明确研究现状和差距,进而促进科学研究和决策的一种新型证据综合研究方法。经过近20年的发展,证据图谱的制作与报告方法不断完善,获得了国际社会的广泛关注与认可。我国对于证据图谱的... 证据图谱是通过对现有证据的系统收集、评价和综合,明确研究现状和差距,进而促进科学研究和决策的一种新型证据综合研究方法。经过近20年的发展,证据图谱的制作与报告方法不断完善,获得了国际社会的广泛关注与认可。我国对于证据图谱的关注较早,但相关理论和实践研究相对较少,证据图谱概念的定义尚不统一。本文系统梳理了证据图谱的起源发展和定义演化,全面介绍了证据图谱的制作与报告,供研究者借鉴参考,以期进一步促进证据图谱在我国的研究与发展。 展开更多
关键词 证据图谱 证据图 差距图 制作 报告
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经皮后路内镜术前臂丛MRN定位突出的颈椎间盘的准确性 被引量:2
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作者 黄镇 孙宁 +5 位作者 任佳彬 李瑞 刘鑫 李岳飞 刘乃国 孙兆忠 《中国矫形外科杂志》 CAS CSCD 北大核心 2019年第14期1259-1263,共5页
[目的]应用磁共振神经成像(MRN)技术对臂丛神经及颈髓成像,指导术中对颈神经的精确减压治疗根性颈椎病。[方法]44例神经根型颈椎病患者行经皮颈椎后路内镜颈椎间盘切除术(PPECD),术前行臂丛MRN扫描,重建三维图像,观察突出颈椎间盘压迫... [目的]应用磁共振神经成像(MRN)技术对臂丛神经及颈髓成像,指导术中对颈神经的精确减压治疗根性颈椎病。[方法]44例神经根型颈椎病患者行经皮颈椎后路内镜颈椎间盘切除术(PPECD),术前行臂丛MRN扫描,重建三维图像,观察突出颈椎间盘压迫颈神经位置,PPECD术中确认、对比二者差异。记录手术时间、术后并发症,采用VAS评分和JOA评分评价临床效果。[结果]所有患者均顺利完成手术,术中无重要血管损伤。3例术后出现上肢感觉减退,1例出现上肢肌力下降,术后3个月均完全恢复。随访时间12~36个月,VAS评分随时间延长显著减少,而JOA评分显著增加,不同时间点差异有统计学意义(P<0.05)。影像与术中观察44例患者中,突出的颈椎间盘位于肩前型占79.55%(35/44)、肩上型占11.36%(5/44)、腋下型占9.09%(4/44)。仅1例术前臂丛MRN定位与术中定位不一致。与术中所见相比,术前影像定位准确率为97.73%。[结论]臂丛MRN定位偏向侧椎管或椎间孔段突出的颈椎间盘与颈神经的位置关系是可靠的,突出的颈椎间盘绝大多数为肩前型。 展开更多
关键词 磁共振神经成像 经皮颈椎后路内镜颈椎间盘切除术 神经根型颈椎病 定位
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黄壤颗粒表面离子吸附动力学中的离子特异性效应 被引量:7
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作者 吴英博 刘新敏 +3 位作者 李睿 杜伟 田锐 李航 《土壤学报》 CAS CSCD 北大核心 2018年第6期1450-1459,共10页
基于考虑离子非经典极化作用的离子吸附动力学模型,以可变电荷黄壤颗粒为代表材料,研究了锂离子(Li+)、钠离子(Na+)和铯离子(Cs+)在黄壤颗粒表面的吸附动力学特征,进一步计算了离子在土壤/水界面的扩散距离与表面电化学参数。结果表明:(... 基于考虑离子非经典极化作用的离子吸附动力学模型,以可变电荷黄壤颗粒为代表材料,研究了锂离子(Li+)、钠离子(Na+)和铯离子(Cs+)在黄壤颗粒表面的吸附动力学特征,进一步计算了离子在土壤/水界面的扩散距离与表面电化学参数。结果表明:(1)Li+、Na+和Cs+在黄壤颗粒表面吸附仅存在一级动力学过程并存在明显的离子特异性差异,这种差异随着电解质浓度降低而增大;(2)离子非经典极化与体积效应的共同作用决定了离子在固/液界面的扩散距离,在较高浓度电解质中,Na+和Li+的离子体积和极化效应基本平衡,导致Na+和Li+离子间差异不显著,但Cs+由于强烈的非经典极化作用,扩散距离表现为:Cs+>Na+≈Li+;在低浓度电解质中,离子非经典极化作用占主导,扩散距离表现为:Cs+> Na+> Li+,表明离子扩散距离在低浓度下差异大,而高浓度下差异不显著;(3)离子扩散距离的差异导致固/液界面电位的不同,Stern电位、电荷密度和电场强度均受到离子扩散距离的影响,表面电位(绝对值)在各个浓度下均表现为:Li+> Na+> Cs+,说明表面电位仅受非经典极化作用的影响。本研究将对土壤/水界面反应理论的完善提供新思路。 展开更多
关键词 离子吸附 极化 表面电位 离子特异性效应 电场
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Studies on the Programmed Cell Death in Rice During Starchy Endosperm Development 被引量:2
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作者 lirui LANSheng-yin XUZhen-xiu 《Agricultural Sciences in China》 CAS CSCD 2004年第9期663-670,共8页
Morphological variations of the nucleus in starchy endosperm cell were observed by theelectron-transmisson microscope during endosperm development in rice. Along with thedevelopment of the starchy endosperm, the nucle... Morphological variations of the nucleus in starchy endosperm cell were observed by theelectron-transmisson microscope during endosperm development in rice. Along with thedevelopment of the starchy endosperm, the nuclei of the cells showed chromatin condensation,the typical feature of programmed cell death (PCD). The nuclei also showed nucleusdeformation, disruption of nuclear envelope, nucleoplasm leaking into the cytoplasm andnucleus disintegration resulting in nuclear residue formation. From the nucleus deformationto the nucleus disintegration, the morphological changes of the nucleus were orderlyprogressive. This indicated that the cell death of starchy endosperm in rice wasprogrammed cell death. Evans Blue staining observation showed that the cell death wasinitially detected in the central part of starchy endosperm in rice, then expandedoutward. The activities of superoxide dismutase (SOD) and catalase (CAT) in rice starchyendosperm both descended continuously as development progressed. The analysis of DNA ofrice starchy endosperm did not show the presence of DNA laddering. The above resultsshowed that the cell death of starchy endosperm in rice was a special form of PCD. 展开更多
关键词 Seed development Programmed cell death RICE Starchy endosperm
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The Brief Introduction to the Sino-US Joint Centers for Soil and Water Conservation and Environmental Protection 被引量:1
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作者 LIJing lirui ZHENGFen-li 《水土保持研究》 CSCD 2004年第4期174-176,共3页
Erosion and transport of soil has worldwide implications for agriculture, landscape stability, climate, natural hazards, and clean, renewable resources of water and air. Assured access to clean water and a healthy and... Erosion and transport of soil has worldwide implications for agriculture, landscape stability, climate, natural hazards, and clean, renewable resources of water and air. Assured access to clean water and a healthy and safe environment requires an ethic of conservation and protection. The minimum scale in which these principles apply successfully is basin wide. These are the fundamental concerns of the Sino-US Centers for Soil and Water Conservation and Environmental Protection. 展开更多
关键词 水土保持 土壤侵蚀 环境保护 中国 美国
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Anomalous Scaling Behaviors in a Rice-Pile Model with Two Different Driving Mechanisms
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作者 ZHANGDuan-Ming SUNHong-Zhang +4 位作者 LIZhi-Hua PANGui-Jun YUBo-Ming lirui YINYan-Ping 《Communications in Theoretical Physics》 SCIE CAS CSCD 2005年第1X期99-102,共4页
The moment analysis is applied to perform large scale simulations of the rice-pile model. We find that this model shows different scaling behavior depending on the driving mechanism used. With the noisy driving, the r... The moment analysis is applied to perform large scale simulations of the rice-pile model. We find that this model shows different scaling behavior depending on the driving mechanism used. With the noisy driving, the rice-pile model violates the finite-size scaling hypothesis, whereas, with fixed driving, it shows well defined avalanche exponents and displays good finite size scaling behavior for the avalanche size and time duration distributions. 展开更多
关键词 组织危险程度 米堆模型 不规则比例 有限尺寸比例
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A Decomposition Theorem on Herz Spaces over Locally Compact Vilenkin Groups
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作者 LANSen-hua lirui 《Chinese Quarterly Journal of Mathematics》 CSCD 北大核心 2005年第2期141-146,共6页
In this paper, by applying a vector-valued inequality we obtained a decomposition theorem on Herz spaces over locally compact Vilenkin groups with new range 0<q≤1.
关键词 Vilenkin group Herz space vector-valued inequality
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Application Value of Fast Rehabilitation Surgery Concept in Knee Arthroscopy Anterior Cruciate Ligament Reconstruction
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作者 LIGuoqin SONGDechen lirui 《外文科技期刊数据库(文摘版)医药卫生》 2022年第4期006-010,共5页
Objective: to explore the application value and effect of the concept of fast recovery surgery in arthroscopic anterior cruciate ligament reconstruction. Methods: this paper mainly selects patients who received knee a... Objective: to explore the application value and effect of the concept of fast recovery surgery in arthroscopic anterior cruciate ligament reconstruction. Methods: this paper mainly selects patients who received knee arthroscopy anterior cruciate ligament reconstruction in our hospital from January to December 2021 as the research subjects, including 112 cases, divided into control group (56 cases) and experimental group (56 cases). The main method used in the two groups was the conventional treatment concept;the experimental group was mainly treated with the concept of fast recovery surgery. After the clinical treatment, the application value and effect of the concept of fast recovery surgery were evaluated from the Judet and Lysholm scores, postoperative recovery index, satisfaction and infection rate. Results: the Judet and Lysholm scores were compared, and the excellent and good rates were compared between the two groups at 3 months and 6 months after surgery. Among them, the postoperative score of the experimental group was significantly higher than that of the control group, and the difference between the two groups was statistically significant (P<0.05). The recovery from various indicators in the control group and the experimental group, such as: the length of hospital stay in the control group was longer than that in the experimental group;the recovery time of the knee joint range of motion in the control group was relatively longer;the VAS and BI scores in the experimental group were better than those in the control group. Comparing the satisfaction of patients between the two groups, the satisfaction of patients in the experimental group was significantly higher than that in the control group, and the two groups were statistically significant (P<0.05). Comparing the infection rates of the two groups, the infection rate of the control group was 14.29%, and the infection rate of the experimental group was 1.79%, which fully demonstrated that there was a statistically significant difference in the infection rates between the two groups (P<0.05). Conclusion: in the process of patients undergoing knee arthroscopy anterior cruciate ligament reconstruction, the use of fast rehabilitation surgery concept is more effective than traditional treatment, which can effectively speed up the patients rehabilitation process, shorten the patients hospitalization time and recovery time, and improve the patients experience. Satisfactions with clinical treatment improve patients limb function and then obtain higher quality of life. 展开更多
关键词 fast recovery surgery concept knee arthroscopy anterior cruciate ligament reconstruction
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不同来源文冠果成品苗造林表现
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作者 李瑞 张瑞 +1 位作者 梁鸡保 孟新刚 《北方果树》 2020年第3期19-20,共2页
对3个不同来源地的文冠果成品苗造林后的成活率及生育指标研究表明,成活率高低依次为中神木浩泽一年生成品苗(本地自育苗)、榆林佳县3年生成品苗、甘肃西北文冠果基地3年生成品苗。就地育苗就地移栽的浩泽一年生成品苗造林成活率高达93.... 对3个不同来源地的文冠果成品苗造林后的成活率及生育指标研究表明,成活率高低依次为中神木浩泽一年生成品苗(本地自育苗)、榆林佳县3年生成品苗、甘肃西北文冠果基地3年生成品苗。就地育苗就地移栽的浩泽一年生成品苗造林成活率高达93.33%,且第1年的生长量明显高于其他两个来源的。文冠果造林应在本地育苗。 展开更多
关键词 文冠果 来源 造林
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