In this paper, we suggest and analyze a modified Thakur three-step iterative algorithm to approximate a common element of the set of common fixed points of Garcia-Falset mappings and the set of solutions of some varia...In this paper, we suggest and analyze a modified Thakur three-step iterative algorithm to approximate a common element of the set of common fixed points of Garcia-Falset mappings and the set of solutions of some variational inequalities in Banach spaces. We also establish strong convergence theorems for a common solution of the above-said problems by the proposed iterative algorithm without the compactness assumption. The methods in this paper are novel and different from those given in many other papers. And the results are the extension and improvement of the recent results announced by many others.展开更多
ATP binding cassette subfamily C member 8(ABCC8)encodes a protein regulating the ATP-sensitive potassium channel.Whether the level of ABCC8 mRNA in lower grade glioma(LGG)correlates with immune cell infiltration and p...ATP binding cassette subfamily C member 8(ABCC8)encodes a protein regulating the ATP-sensitive potassium channel.Whether the level of ABCC8 mRNA in lower grade glioma(LGG)correlates with immune cell infiltration and patient outcomes has not been evaluated until now.Comparisons of ABCC8 expression between different tumors and normal tissues were evaluated by exploring publicly available datasets.The association between ABCC8 and tumor immune cell infiltration,diverse gene mutation characteristics,tumor mutation burden(TMB),and survival in LGG was also investigated in several independent datasets.Pathway enrichment analysis was conducted to search for ABCC8-associated signaling pathways.Through an online database,we found that ABCC8 expression in LGG was lower than in normal tissues.Then,the association of ABCC8 expression and immune cell infiltration in LGG was discussed.As we expected,the ABCC8 mRNA levels were negatively associated with non-T immune cell infiltration levels in all datasets.Consistently,TCGA_LGG RNA-seq data revealed that ABCC8 downregulated several non-T immune cell-associated signaling pathways in gene set enrichment analysis.Different ABCC8 expression groups showed diverse gene mutation characteristics and TMB.The high expression of ABCC8 was linked to improved survival of LGG patients.A pathway enrichment analysis of ABCC8-associated genes indicated that the GABAergic synapse signaling pathway might be involved in regulating immunity in LGG.Our findings show that ABCC8 reflects LGG tumor immunity and is an ideal prognostic biomarker for LGG.展开更多
The split common fixed point problem is an inverse problem that consists in finding an element in a fixed point set such that its image under a bounded linear operator belongs to another fixed-point set. In this paper...The split common fixed point problem is an inverse problem that consists in finding an element in a fixed point set such that its image under a bounded linear operator belongs to another fixed-point set. In this paper, we present new iterative algorithms for solving the split common fixed point problem of demimetric mappings in Hilbert spaces. Moreover, our algorithm does not need any prior information of the operator norm. Weak and strong convergence theorems are given under some mild assumptions. The results in this paper are the extension and improvement of the recent results in the literature.展开更多
The principle of optical trapping is conventionally based on the interaction of optical fields with linear-induced polarizations. However, the optical force originating from the nonlinear polarization becomes signific...The principle of optical trapping is conventionally based on the interaction of optical fields with linear-induced polarizations. However, the optical force originating from the nonlinear polarization becomes significant when nonlinear optical nanoparticles are trapped by femtosecond laser pulses. Herein we develop the time-averaged optical forces on a nonlinear optical nanoparticle using high-repetition-rate femtosecond laser pulses, based on the linear and nonlinear polarization effects. We investigate the dependence of the optical forces on the magnitudes and signs of the refractive nonlinearities. It is found that the self-focusing effect enhances the trapping ability, whereas the self-defocusing effect leads to the splitting of the potential well at the focal plane and destabilizes the optical trap. Our results show good agreement with the reported experimental observations and provide theoretical support for capturing nonlinear optical particles.展开更多
We investigate femtosecond laser trapping dynamics of two-photon absorbing hollow-core nanoparticles with different volume fractions and two-photon absorption(TPA)coefficients.Numerical simulations show that the hollo...We investigate femtosecond laser trapping dynamics of two-photon absorbing hollow-core nanoparticles with different volume fractions and two-photon absorption(TPA)coefficients.Numerical simulations show that the hollow-core particles with low and high-volume fractions can easily be trapped and bounced by the tightly focused Gaussian laser pulses,respectively.Further studies show that the hollow-core particles with and without TPA can be identified,because the TPA effect enhances the radiation force,and subsequently the longitudinal force destabilizes the trap by pushing the particle away from the focal point.The results may find direct applications in particle sorting and characterizing the TPA coefficient of single nanoparticles.展开更多
Constipation is common in the diseases of the digestive system in clinics.With the change in diet structure and the increase in life pressure,the prevalence rate increases year by year.In traditional Chinese medicine(...Constipation is common in the diseases of the digestive system in clinics.With the change in diet structure and the increase in life pressure,the prevalence rate increases year by year.In traditional Chinese medicine(TCM),the location of the disease of constipation is in the large intestine,which is related to the dysfunction of lung,spleen,liver,kidney and other viscera.Its pathogenesis is conductive dysfunction of large intestine.Based on the theory,Shouhui Tongbian Capsule(SHTB)is composed of eight traditional Chinese medicines,including Polygoni multiflori Radix(Heshouwu in Chinese),Aloe(Luhui in Chinese),Cassiae Semen(Juemingzi in Chinese),Ginseng Radix et Rhizoma(Renshen in Chinese),Lycii Fructus(Gouqizi in Chinese),Asini Corii Colla(Ejiao in Chinese),Aurantii Fructus Immaturus(Zhishi in Chinese),and Atractylodis Macrocephalae Rhizoma(Baizhu in Chinese),which could help to release excessive turbid,and nourishing yin and supplementing qi in the treatment.This study has been carried out to review the latest advances of SHTB in the treatment of constipation.The results showed that significant effect of SHTB was found in the treatment of constipation,such as functional constipation,and constipation associated with tumor chemotherapy,colitis,type 2 diabetes and chronic cardiac failure.Besides,obvious adverse reactions were not observed.SHTB could effectively treat five types of constipation,provide direction for the future exploration of SHTB in the treatment of other types of constipation。展开更多
Constipation is a common and prevalent digestive system disease in clinical practice, which seriously affects human physical and mental health. Currently, chemical drugs have good short-term therapeutic effects. Howev...Constipation is a common and prevalent digestive system disease in clinical practice, which seriously affects human physical and mental health. Currently, chemical drugs have good short-term therapeutic effects. However, because of their adverse reactions, easy recurrence after drug discontinuation, and dependence with long-term use, the long-term efficacy is unsatisfactory. The pathogenesis of constipation is mainly attributed to dysfunction of zang-fu organs and imbalance of qi-blood and yin-yang, with the syndrome being asthenia in origin and asthenia in superficiality. Aloe is a traditional Chinese medicine with cold properties and a bitter taste, and one of the most commonly used herbs for constipation.Based on Aloe and its monomer components, combined with the existing compatibility studies of Aloe and several Chinese patent drugs represented by Aloe, this paper comprehensively and systematically introduced the research progress of Aloe and its compatibility prescriptions in the treatment of constipation from basic experiments to clinical observations, providing theoretical basis and medication guidance for the clinical rational application of Aloe and its prescriptions in the treatment of constipation. At the same time, it also provides the direction for future research on the mechanism of Aloe in the treatment of constipation.展开更多
Small-scale pumps for controlling microfluidics have promising applications in drug delivery and chemical assays.Liquid metal(LM)demonstrates excellent flow pumping performance due to its simple structure and the elec...Small-scale pumps for controlling microfluidics have promising applications in drug delivery and chemical assays.Liquid metal(LM)demonstrates excellent flow pumping performance due to its simple structure and the electrocapillary effect under an electric field.However,LM droplets risk escaping from constrained structures,which can lead to pump failure.Temperature regulation is also a critical parameter in optimizing chemical reactions in fluidic systems,however,integrating it into a compact system remains challenging.Here,we develop a temperature-triggered gallium-based actuator(TTGA)by introducing a gallium(Ga)droplet wetted on a copper(Cu)plate as the core element for flow actuation.The Cu plate prevents the Ga droplet from escaping the chamber and significantly increases the flow rate.By leveraging the electrochemical method to inhibit the supercooling effect of Ga,the TTGA enables activation/deactivation for flow actuation at different temperatures.We investigate the impact of electrode position,solution concentration,and applied voltage on TTGA’s pumping efficiency.By dynamically tuning the Ga droplet’s temperature to control phase transition,TTGA allows for accurate flow actuation control.Furthermore,placing Ga and eutectic Ga-indium(EGaIn)droplets in different channels enables the expected flow divergence for fluids with different temperatures.The development of TTGA presents new opportunities in microfluidics and biomedical treatment.展开更多
文摘In this paper, we suggest and analyze a modified Thakur three-step iterative algorithm to approximate a common element of the set of common fixed points of Garcia-Falset mappings and the set of solutions of some variational inequalities in Banach spaces. We also establish strong convergence theorems for a common solution of the above-said problems by the proposed iterative algorithm without the compactness assumption. The methods in this paper are novel and different from those given in many other papers. And the results are the extension and improvement of the recent results announced by many others.
基金supported by the Scientific and Technological Innovation Program for Clinical Medicine of Jinan(202019132)to LIPING GONG.
文摘ATP binding cassette subfamily C member 8(ABCC8)encodes a protein regulating the ATP-sensitive potassium channel.Whether the level of ABCC8 mRNA in lower grade glioma(LGG)correlates with immune cell infiltration and patient outcomes has not been evaluated until now.Comparisons of ABCC8 expression between different tumors and normal tissues were evaluated by exploring publicly available datasets.The association between ABCC8 and tumor immune cell infiltration,diverse gene mutation characteristics,tumor mutation burden(TMB),and survival in LGG was also investigated in several independent datasets.Pathway enrichment analysis was conducted to search for ABCC8-associated signaling pathways.Through an online database,we found that ABCC8 expression in LGG was lower than in normal tissues.Then,the association of ABCC8 expression and immune cell infiltration in LGG was discussed.As we expected,the ABCC8 mRNA levels were negatively associated with non-T immune cell infiltration levels in all datasets.Consistently,TCGA_LGG RNA-seq data revealed that ABCC8 downregulated several non-T immune cell-associated signaling pathways in gene set enrichment analysis.Different ABCC8 expression groups showed diverse gene mutation characteristics and TMB.The high expression of ABCC8 was linked to improved survival of LGG patients.A pathway enrichment analysis of ABCC8-associated genes indicated that the GABAergic synapse signaling pathway might be involved in regulating immunity in LGG.Our findings show that ABCC8 reflects LGG tumor immunity and is an ideal prognostic biomarker for LGG.
文摘The split common fixed point problem is an inverse problem that consists in finding an element in a fixed point set such that its image under a bounded linear operator belongs to another fixed-point set. In this paper, we present new iterative algorithms for solving the split common fixed point problem of demimetric mappings in Hilbert spaces. Moreover, our algorithm does not need any prior information of the operator norm. Weak and strong convergence theorems are given under some mild assumptions. The results in this paper are the extension and improvement of the recent results in the literature.
基金National Natural Science Foundation of China(NSFC)(11474052,11504049,11774055,61535003)Natural Science Foundation of Jiangsu Province,China(BK20171364)National Key Basic Research Program of China(2015CB352002)
文摘The principle of optical trapping is conventionally based on the interaction of optical fields with linear-induced polarizations. However, the optical force originating from the nonlinear polarization becomes significant when nonlinear optical nanoparticles are trapped by femtosecond laser pulses. Herein we develop the time-averaged optical forces on a nonlinear optical nanoparticle using high-repetition-rate femtosecond laser pulses, based on the linear and nonlinear polarization effects. We investigate the dependence of the optical forces on the magnitudes and signs of the refractive nonlinearities. It is found that the self-focusing effect enhances the trapping ability, whereas the self-defocusing effect leads to the splitting of the potential well at the focal plane and destabilizes the optical trap. Our results show good agreement with the reported experimental observations and provide theoretical support for capturing nonlinear optical particles.
基金financially supported by the National Natural Science Foundation of China(No.11774055)the Natural Science Foundation of Jiangsu Province(No.BK20171364)。
文摘We investigate femtosecond laser trapping dynamics of two-photon absorbing hollow-core nanoparticles with different volume fractions and two-photon absorption(TPA)coefficients.Numerical simulations show that the hollow-core particles with low and high-volume fractions can easily be trapped and bounced by the tightly focused Gaussian laser pulses,respectively.Further studies show that the hollow-core particles with and without TPA can be identified,because the TPA effect enhances the radiation force,and subsequently the longitudinal force destabilizes the trap by pushing the particle away from the focal point.The results may find direct applications in particle sorting and characterizing the TPA coefficient of single nanoparticles.
基金supported by National Key R&D Program of China(No.2022YFC3502100)Cutting Edge Development Fund of Advanced Medical Research Institute,Lunan Hope Pharmaceutical Co.,Ltd.(No.1520019013)+1 种基金the Scientific and Technological Innovation Program for Clinical Medicine of Jinan(No.202019132)Cultivation Fund Program of the Second Hospital of Shandong University(No.2022YP14).
文摘Constipation is common in the diseases of the digestive system in clinics.With the change in diet structure and the increase in life pressure,the prevalence rate increases year by year.In traditional Chinese medicine(TCM),the location of the disease of constipation is in the large intestine,which is related to the dysfunction of lung,spleen,liver,kidney and other viscera.Its pathogenesis is conductive dysfunction of large intestine.Based on the theory,Shouhui Tongbian Capsule(SHTB)is composed of eight traditional Chinese medicines,including Polygoni multiflori Radix(Heshouwu in Chinese),Aloe(Luhui in Chinese),Cassiae Semen(Juemingzi in Chinese),Ginseng Radix et Rhizoma(Renshen in Chinese),Lycii Fructus(Gouqizi in Chinese),Asini Corii Colla(Ejiao in Chinese),Aurantii Fructus Immaturus(Zhishi in Chinese),and Atractylodis Macrocephalae Rhizoma(Baizhu in Chinese),which could help to release excessive turbid,and nourishing yin and supplementing qi in the treatment.This study has been carried out to review the latest advances of SHTB in the treatment of constipation.The results showed that significant effect of SHTB was found in the treatment of constipation,such as functional constipation,and constipation associated with tumor chemotherapy,colitis,type 2 diabetes and chronic cardiac failure.Besides,obvious adverse reactions were not observed.SHTB could effectively treat five types of constipation,provide direction for the future exploration of SHTB in the treatment of other types of constipation。
基金supported by National Key Research and Development Program (No. 2022YFC3502100, 2022YFC3502102-05)Joint Fund of Natural Fund of Shandong Province (No. ZR2021LZY036)Lunan Hope Pharmaceutical Co., Ltd. (No. 1520019013)。
文摘Constipation is a common and prevalent digestive system disease in clinical practice, which seriously affects human physical and mental health. Currently, chemical drugs have good short-term therapeutic effects. However, because of their adverse reactions, easy recurrence after drug discontinuation, and dependence with long-term use, the long-term efficacy is unsatisfactory. The pathogenesis of constipation is mainly attributed to dysfunction of zang-fu organs and imbalance of qi-blood and yin-yang, with the syndrome being asthenia in origin and asthenia in superficiality. Aloe is a traditional Chinese medicine with cold properties and a bitter taste, and one of the most commonly used herbs for constipation.Based on Aloe and its monomer components, combined with the existing compatibility studies of Aloe and several Chinese patent drugs represented by Aloe, this paper comprehensively and systematically introduced the research progress of Aloe and its compatibility prescriptions in the treatment of constipation from basic experiments to clinical observations, providing theoretical basis and medication guidance for the clinical rational application of Aloe and its prescriptions in the treatment of constipation. At the same time, it also provides the direction for future research on the mechanism of Aloe in the treatment of constipation.
基金funded by the Australian Research Council Discovery Project(DP230100823)the research funded by the Australian Research Council Future Fellowship(FT230100257).
文摘Small-scale pumps for controlling microfluidics have promising applications in drug delivery and chemical assays.Liquid metal(LM)demonstrates excellent flow pumping performance due to its simple structure and the electrocapillary effect under an electric field.However,LM droplets risk escaping from constrained structures,which can lead to pump failure.Temperature regulation is also a critical parameter in optimizing chemical reactions in fluidic systems,however,integrating it into a compact system remains challenging.Here,we develop a temperature-triggered gallium-based actuator(TTGA)by introducing a gallium(Ga)droplet wetted on a copper(Cu)plate as the core element for flow actuation.The Cu plate prevents the Ga droplet from escaping the chamber and significantly increases the flow rate.By leveraging the electrochemical method to inhibit the supercooling effect of Ga,the TTGA enables activation/deactivation for flow actuation at different temperatures.We investigate the impact of electrode position,solution concentration,and applied voltage on TTGA’s pumping efficiency.By dynamically tuning the Ga droplet’s temperature to control phase transition,TTGA allows for accurate flow actuation control.Furthermore,placing Ga and eutectic Ga-indium(EGaIn)droplets in different channels enables the expected flow divergence for fluids with different temperatures.The development of TTGA presents new opportunities in microfluidics and biomedical treatment.
