目的设计制造一种考虑假体尺寸的全膝关节置换术截骨导板(简称截骨导板),实现术中快速、精准定位、辅助截骨的目的。方法截骨导板采用德国EOS公司的FORMIGA P 110三维(3D)打印设备制造,打印材料为聚十二内酰胺(PA12)。通过CT、股骨3D重...目的设计制造一种考虑假体尺寸的全膝关节置换术截骨导板(简称截骨导板),实现术中快速、精准定位、辅助截骨的目的。方法截骨导板采用德国EOS公司的FORMIGA P 110三维(3D)打印设备制造,打印材料为聚十二内酰胺(PA12)。通过CT、股骨3D重建、假体逆向重建获得股骨远端与假体的数字模型,用计算机手术预演确定合理尺寸的假体,固定股骨远端与假体的接触面作为截骨平面,以该平面为基准逐步装配其他部件。3D打印设备模型输入格式为病理性股骨标准模板库(STL),采用选择性激光烧结(SLS)技术生产截骨导板,打印主体材料为聚十二内酰胺(PA12)。制造成品灭菌消毒后,于2019年至2021年用于3例因严重骨关节炎实施的截骨手术,其中男性2例,女性1例;患处位于左侧1例,右侧2例;年龄54~67岁,平均年龄59岁。术中医生严格按照截骨导板使用指南实施截骨手术。统计术中和术后失血量、手术时间、髋膝踝角、胫股角、美国膝关节协会评分(AKS)与美国特种外科医院(HSS)膝关节功能评分对手术结果进行评估。结果成功打印制造截骨导板,主要尺寸:固定钉钉孔到截骨平面的垂直距离10.17~12.51 mm,前髁固定钉钉孔直径3.18 mm;截骨槽宽度1.42 mm,固定钉中心点距离45.44 mm,固定钉钉孔直径3.16 mm。临床试用表明,在截骨手术中使用截骨导板定位股骨远端面,切面呈规则“8”字形状,无明显过切或少切现象,能保证截骨的准确性。未发生摆锯与截骨导板干涉或截骨导板破裂等需要中断手术的事件。术后患者膝关节功能恢复良好,随访过程中未出现假体松动、下沉、膝内外翻畸形、移位、股骨端骨折、脂肪栓塞等不良反应。结论实验研究设计制造的截骨导板能够准确定位,相较于普通截骨工具具有无需开髓、一次安装、多次定位的功能。基于3D打印技术的手术预演有利于医生术前根据患者骨形确定假体规格,提前熟悉截骨参数,预估手术难度,考虑术中可能出现的各种问题,从而制订适合患者的个体化、最优化手术方案。展开更多
Using chromium oxide (CrO3) as an oxidant, the immobilization of simulating radioactive waste in perovskite (CaTiO3) structure by a combustion synthesis (CS) method was tested. The products were characterized by Archi...Using chromium oxide (CrO3) as an oxidant, the immobilization of simulating radioactive waste in perovskite (CaTiO3) structure by a combustion synthesis (CS) method was tested. The products were characterized by Archimedes liquid displacement technique, microhardness technique, X-ray diffraction, and scanning electron microscopy. The leaching rate was measured by the method of MCC-1 or MCC-2. The primary results show that the CS method can be used to solidify the immobilizate waste effectively.展开更多
To obtain a primary overview of gene diversity and expression pattern inLycoris longituba, 4,992 ESTs (Expressed Sequence Tags) from L. longituba bud were se-quenced and4,687 cleaned ESTs were used for gene expression...To obtain a primary overview of gene diversity and expression pattern inLycoris longituba, 4,992 ESTs (Expressed Sequence Tags) from L. longituba bud were se-quenced and4,687 cleaned ESTs were used for gene expression analysis. Clustered by the PHRAP program, 967contigs and 1,343 singlets were obtained. Blast search showed that 179 contigs and 227 singlets(totally 1,066 ESTs) had homologues in GenBank and 3,621 ESTs were novel.展开更多
基金This project was financially supported by the National Natural Science Foundation of China (No. 20476008).
文摘Using chromium oxide (CrO3) as an oxidant, the immobilization of simulating radioactive waste in perovskite (CaTiO3) structure by a combustion synthesis (CS) method was tested. The products were characterized by Archimedes liquid displacement technique, microhardness technique, X-ray diffraction, and scanning electron microscopy. The leaching rate was measured by the method of MCC-1 or MCC-2. The primary results show that the CS method can be used to solidify the immobilizate waste effectively.
基金Hi-tech Research &Development Program of China (863 Program, No. 2002AA241051) and Science & Technology Program for Agriculture Development of Shanghai.
文摘To obtain a primary overview of gene diversity and expression pattern inLycoris longituba, 4,992 ESTs (Expressed Sequence Tags) from L. longituba bud were se-quenced and4,687 cleaned ESTs were used for gene expression analysis. Clustered by the PHRAP program, 967contigs and 1,343 singlets were obtained. Blast search showed that 179 contigs and 227 singlets(totally 1,066 ESTs) had homologues in GenBank and 3,621 ESTs were novel.
