Deforestation is one of the most serious environmental problems facing humankind.It continues to escalate rapidly across many regions of the world,thereby deteriorating the forest soil quality.This has prompted a larg...Deforestation is one of the most serious environmental problems facing humankind.It continues to escalate rapidly across many regions of the world,thereby deteriorating the forest soil quality.This has prompted a large number of field-based studies aimed at understanding the impacts of deforestation on soil properties.However,the lack of comprehensive meta-analyses that utilized these studies has limited our deeper understanding of how different soil properties,including the soil organic carbon(SOC)pool,respond to deforestation.To address this critical knowledge gap,we conducted a meta-analysis of 144 studies to explore the impacts of deforestation on soil chemical,physical,and biological properties,with special emphasis on the long-term changes in SOC,such as concentrations,stocks,and sequestration.The results revealed that deforestation significantly decreased soil organic matter,electrical conductivity,and base saturation by 52%,50%,and 98%,respectively.While deforestation increased soil total nitrogen content and decreased available phosphorus content by 51%and 99%,respectively,it resulted in slight decreases in some chemical properties,including soil pH(1%)and base cations(1%–13%).Deforestation significantly increased bulk density by 27%and soil erosion by 47%,but significantly decreased soil aggregate stability by 39%and saturated hydraulic conductivity by 63%.Soil microbial biomass C and N concentrations and enzyme activities were significantly decreased as a consequence of deforestation.Soil biological properties were much more affected by deforestation than soil physical and chemical properties.Regarding the SOC,the land use conversion from forest to pasture significantly increased SOC concentrations,stocks,and sequestration rates(11%–13%),whereas the land use conversions from forest to both plantation and cropland significantly decreased SOC concentrations,stocks,and sequestration rates(10%–43%).This observed decline in SOC accumulations decreased with increasing years after deforestation.The SOC dynamics following deforestation were predominantly regulated by microbial biomass concentrations,dehydrogenase activity,soil erosion,saturated hydraulic conductivity,aggregate stability,as well as concentrations of total organic carbon,total nitrogen,total phosphorus and organic matter.The present meta-analytical study provides compelling evidence that deforestation can induce profound changes in soil characteristics,including soil C contents,and has significant implications for soil health sustainability and climate change mitigation.展开更多
Ionic Polymer-Metal Composite （IPMC） is a new electro-active polymer, which has the advantages of light weight, flexibility, and large stroke with low driving voltage. Because of these features, IPMC can be applied ...Ionic Polymer-Metal Composite （IPMC） is a new electro-active polymer, which has the advantages of light weight, flexibility, and large stroke with low driving voltage. Because of these features, IPMC can be applied to bionic robotic actuators, artificial muscles, as well as dynamic sensors. However, IPMC has the major drawback of low generative blocking force. In this paper, in order to enhance the blocking force, the Nation membranes with thickness of 0.22 mm, 0.32 mm, 0.42 mm, 0.64 mm and 0.8 mm were prepared by casting from liquid solution. By employing these Nation membranes, IPMCs with varying thickness were fabricated by electroless plating. The elastic modulus of the casted Nation membranes were obtained by a nano-indenter, and the current, the displacement and the blocking force were respectively measured by the apparatus for actuation test. Finally, the effects of the thickness on the performance of IPMC were analyzed with an electromechanical model. Experimental study and theory analysis indicate that as the thickness increases, the elastic modulus of Nation membrane and the blocking force of IPMC increase, however, the current and the displacement decrease.展开更多
While China’s Air Pollution Prevention and Control Action Plan on particulate matter since 2013 has reduced sulfate significantly,aerosol ammonium nitrate remains high in East China.As the high nitrate abundances are...While China’s Air Pollution Prevention and Control Action Plan on particulate matter since 2013 has reduced sulfate significantly,aerosol ammonium nitrate remains high in East China.As the high nitrate abundances are strongly linked with ammonia,reducing ammonia emissions is becoming increasingly important to improve the air quality of China.Although satellite data provide evidence of substantial increases in atmospheric ammonia concentrations over major agricultural regions,long-term surface observation of ammonia concentrations are sparse.In addition,there is still no consensus on whether agricultural or non-agricultural emissions dominate the urban ammonia budget.Identifying the ammonia source by nitrogen isotope helps in designing a mitigation strategy for policymakers,but existing methods have not been well validated.Revisiting the concentration measurements and identifying source apportionment of atmospheric ammonia is thus an essential step towards reducing ammonia emissions.展开更多
Azalea is a general designation of Rhododendron in the Ericaceae family.Rhododendron not only has high ornamental value but also has application value in ecological protection,medicine,and scientific research.In this ...Azalea is a general designation of Rhododendron in the Ericaceae family.Rhododendron not only has high ornamental value but also has application value in ecological protection,medicine,and scientific research.In this study,we used Illumina and PacBio sequencing to assemble and annotate the entire chloroplast genomes(cp genomes)of four Rhododendron species.The chloroplast genomes of R.concinnum,R.henanense subsp.lingbaoense,R.micranthum,and R.simsii were assembled into 207,236,208,015,207,233,and 206,912 bp,respectively.All chloroplast genomes contain eight rRNA genes,with either 88 or 89 protein-coding genes.The four cp genomes were compared and analyzed by bioinformatics,and the phylogenetic analysis based on chloroplast genomes of 26 species of Ericaceae,Actinidiaceae,and Primulaceae under Ericales was conducted.A comparison of the linear structure of cp genomes of four Rhododendron showed that there were substantial sequence similarities in coding regions,but high differences in non-coding regions.A phylogenetic analysis,based on chloroplast whole genome sequences,showed that all Rhododendron species are in the clade Ericaceae.This study provides valuable genetic information for the study of population genetics and evolutionary relationships in Rhododendron and other azalea species.展开更多
The critical role of calcium dyshomeostasis in the pathogenesis of Alzheimer’s disease(AD):AD is a progressive neurodegenerative disease characterized by cognitive decline,memory impairment,and behavioral changes.Wit...The critical role of calcium dyshomeostasis in the pathogenesis of Alzheimer’s disease(AD):AD is a progressive neurodegenerative disease characterized by cognitive decline,memory impairment,and behavioral changes.With an estimated 50 million people being affected worldwide,the incidence of AD is constantly increasing globally.The hallmark of AD is the accumulation of amyloid-beta protein(Aβ)in the form of amyloid plaques and hyperphosphorylated tau protein in the form of neurofibrillary tangles.However,increasing evidence suggests that calcium ion(Ca2+)dysregulation also plays a crucial role in the pathogenesis of AD(Calvo-Rodriguez and Bacskai,2021).As a key second messenger,Ca2+regulates a wide range of cellular processes,including the release of neurotransmitters,gene expression,and cell death.Ca^(2+)also regulates the activity of Calcium/calmodulin-dependent protein kinase II,which is critical for synaptic plasticity,learning,and memory(Kaushik et al.,2022).Alternation in the Ca^(2+)signal is an early event in the pathogenesis of AD,which can lead to synaptic dysfunction,neuronal loss,and cognitive impairment.展开更多
According to the requirement of New Engineering Disciplines initiated by the Ministry of Education of China,the course of Programming Fundamentals has been reformed in ethnic university to satisfy the standard of New ...According to the requirement of New Engineering Disciplines initiated by the Ministry of Education of China,the course of Programming Fundamentals has been reformed in ethnic university to satisfy the standard of New Engineering Certification.The reform is implemented in teaching content,implementation in both theoretical and experimental classes,teaching assessment and teacher training.展开更多
Lacking therapeutic targets highlights the crucial roles of chemotherapy and radiotherapy in the clinical management of triple-negative breast cancer(TNBC).To relieve the side effects of the chemoradiotherapy combinat...Lacking therapeutic targets highlights the crucial roles of chemotherapy and radiotherapy in the clinical management of triple-negative breast cancer(TNBC).To relieve the side effects of the chemoradiotherapy combination regimen,we design and develop a self-assembled micelle nanosystem consisting of perfluorocarbon chain-modified cisplatin prodrug.By incorporating perfluorodecalin,this nanosystem can effectively carry ozone and promote irradiation-derived reactive oxygen species(ROS)production.By leveraging the perfluorocarbon sidechain,the nanosystem exhibits efficient internalization by TNBC cells and effectively escapes from lysosomal entrapment.Under X-ray irradiation,ozone-generated ROS disrupts the intracellular redox balance,thereby facilitating the release of cisplatin in a reduction-responsive manner mediated by reduced glutathione.Moreover,oxygen derived from ozone decomposition enhances the efficacy of radiotherapy by alleviating tumor hypoxia.Notably,the combination of irradiation with ozone-loaded cisplatin prodrug nano system synergistically prompts antitumor efficacy and reduces cellular/systemic toxicity in vitro and in vivo.Furthermore,the combo regimen remodels the tumor microenvironment into an immune-favored state by triggering immunogenic cell death and relieving hypoxia,which provides a promising foundation for a combination regimen of immunotherapy.In conclusion,our nanosystem presents a novel strategy for integrating chemotherapy and radiotherapy to optimize the efficacy and safety of TNBC clinical treatment.展开更多
The catalytic transferred of small molecules into high-value chemical products in green methods are highly perused,and has obtained huge attention.In this field,great progress has been achieved during the past five ye...The catalytic transferred of small molecules into high-value chemical products in green methods are highly perused,and has obtained huge attention.In this field,great progress has been achieved during the past five years.Followed by the roadmap(Chinese Chemical Letters,2019,30,2089-2109)written by us before five years,we think that it should be updated to give more insights in this field.Thus,we write the present roadmap based on the fast changed background.In this roadmap,oxygen and carbon dioxide reduction reactions(including at high temperature),photocatalytic hydrogen generation and carbon dioxide reduction reactions,(photo)electrocatalytic reduction of O_(2)to H_(2)O_(2)and NH_(3)generated from N_(2) are discussed.The progress and challenges in above catalytic processes are given.We believe this manuscript will give the researchers more suggestions and help them to obtain useful information in this field.展开更多
Aerosol ammonium(NH_(4)^(+)),mainly produced from the reactions of ammonia(NH_(3))with acids in the atmosphere,has significant impacts on air pollution,radiative forcing,and human health.Understanding the source and f...Aerosol ammonium(NH_(4)^(+)),mainly produced from the reactions of ammonia(NH_(3))with acids in the atmosphere,has significant impacts on air pollution,radiative forcing,and human health.Understanding the source and formation mechanism of NH_(4)^(+)can provide scientific insights into air quality improvements.However,the sources of NH_(3)in urban areas are not well understood,and few studies focus on NH_(3)/NH_(4)^(+)at different heights within the atmospheric boundary layer,which hinders a comprehensive understanding of aerosol NH_(4)^(+).In this study,we perform both field observation and modeling studies(the Community Multiscale Air Quality,CMAQ)to investigate regional NH_(3)emission sources and vertically resolved NH_(4)^(+)formation mechanisms during the winter in Beijing.Both stable nitrogen isotope analyses and CMAQ model suggest that combustion-related NH_(3)emissions,including fossil fuel sources,NH_(3)slip,and biomass burning,are important sources of aerosol NH_(4)^(+)with more than 60%contribution occurring on heavily polluted days.In contrast,volatilization-related NH_(3)sources(livestock breeding,N-fertilizer application,and human waste)are dominant on clean days.Combustion-related NH_(3)is mostly local from Beijing,and biomass burning is likely an important NH_(3)source(~15%–20%)that was previously overlooked.More effective control strategies such as the two-product(e.g.,reducing both SO_(2)and NH_(3))control policy should be considered to improve air quality.展开更多
Human health is deteriorating due to the effluent containing heavy metal ions and organic dyes.Hence,photoreduction of Cr(Ⅵ)to Cr(Ⅲ)and degradation of rhodamine B(RhB)using a novel photocatalyst is particularly impo...Human health is deteriorating due to the effluent containing heavy metal ions and organic dyes.Hence,photoreduction of Cr(Ⅵ)to Cr(Ⅲ)and degradation of rhodamine B(RhB)using a novel photocatalyst is particularly important.In this work,h-BN/NiS_(2)/NiS composites were prepared via a simple solvothermal method and a double Z-scheme heterojunction was constructed for efficiently removing RhB and Cr(Ⅵ).The 7 wt-%h-BN/NiS_(2)/NiS composites were characterized via a larger specific surface area(15.12 m^(2)·g^(−1)),stronger light absorption capacity,excellent chemical stability,and high yield of electrons and holes.The experimental result indicated that the photoreduction efficiency of the 7 wt-%h-BN/NiS_(2)/NiS photocatalyst achieved 98.5%for Cr(Ⅵ)after 120 min,which was about 3 times higher than that of NiS_(2)/NiS(34%).However,the removal rate of RhB by the 7 wt-%h-BN/NiS_(2)/NiS photocatalyst reached 80%.This is due to the double Z-scheme heterojunction formed between NiS_(2)/NiS and h-BN,which improved the charge separation efficiency and transmission efficiency.Besides,the influence of diverse photogenerated electron and hole scavengers upon the photoreduction of Cr(Ⅵ)was studied,the results indicated that graphene-like h-BN promoted transportation of photoinduced charges on the surface of the h-BN/NiS_(2)/NiS photocatalyst via the interfacial effects.展开更多
Background:No convincing modalities have been shown to completely prevent postdural puncture headache(PDPH)after accidental dural puncture(ADP)during obstetric epidural procedures.We aimed to evaluate the role of epid...Background:No convincing modalities have been shown to completely prevent postdural puncture headache(PDPH)after accidental dural puncture(ADP)during obstetric epidural procedures.We aimed to evaluate the role of epidural administration of hydroxyethyl starch(HES)in preventing PDPH following ADP,regarding the prophylactic efficacy and side effects.Methods:Between January 2019 and February 2021,patients with a recognized ADP during epidural procedures for labor or cesarean delivery were retrospectively reviewed to evaluate the prophylactic strategies for the development of PDPH at a single tertiary hospital.The development of PDPH,severity and duration of headache,adverse events associated with prophylactic strategies,and hospital length of stay postpartum were reported.Results:A total of 105 patients experiencing ADP received a re-sited epidural catheter.For PDPH prophylaxis,46 patients solely received epidural analgesia,25 patients were administered epidural HES on epidural analgesia,and 34 patients received two doses of epidural HES on and after epidural analgesia,respectively.A significant difference was observed in the incidence of PDPH across the groups(epidural analgesia alone,31[67.4%];HES-Epidural analgesia,ten[40.0%];HES-Epidural analgesia-HES,five[14.7%];P<0.001).No neurologic deficits,including paresthesias and motor deficits related to prophylactic strategies,were reported from at least 2 months to up to more than 2 years after delivery.An overall backache rate related to HES administration was 10%.The multivariable regression analysis revealed that the HES-Epidural analgesia-HES strategy was significantly associated with reduced risk of PDPH following ADP(OR=0.030,95%confidence interval:0.006-0.143;P<0.001).Conclusions:The incorporated prophylactic strategy was associated with a great decrease in the risk of PDPH following obstetric ADP.This strategy consisted of re-siting an epidural catheter with continuous epidural analgesia and two doses of epidural HES,respectively,on and after epidural analgesia.The efficacy and safety profiles of this strategy have to be investigated further.展开更多
Far lateral approach(FLA),together with its modified approaches,is a fundamental surgical approach for surgical resection of lesions located at the ventral or ventrolateral side of the foramen magnum.[1,2,3,4,5]The ke...Far lateral approach(FLA),together with its modified approaches,is a fundamental surgical approach for surgical resection of lesions located at the ventral or ventrolateral side of the foramen magnum.[1,2,3,4,5]The key procedure in FLA is exposing the vertebral artery(VA)especially the V3 segment.[1,5,6]When performing an FLA,most neurosurgeons choose to expose the suboccipital triangle(formed by the rectus capitis posterior major,the superior oblique,and the inferior oblique)as a key anatomical landmark initially and then expose the V3 segment.[1,2,5,6,7]However,on the one hand,this muscular anatomical landmarks-suboccipital triangle varies in depth,morphology,and location in different patients,which increases the risk of VA injury during surgery.[3]On the other hand,this procedure could lead to exposing difficulty due to the obstruction of overlying layers of muscles and the distribution of blood vessels,which could prolong the time for craniotomy fairly.The course of VA could vary,such as looping backward and bulge posteriorly between the lips of the suboccipital triangle,where it could be damaged if one expects it to be found in the depth of the suboccipital triangle.[3]Thus,neurosurgeons have the potential for VA injury and a rather prolonged time to successfully expose VA.展开更多
1 Introduction Recently,there is growing evidence that it is essential to predict the interactions between circRNAs and RBP binding sites for diagnosing diseases and providing a potential target to treat diseases[1].M...1 Introduction Recently,there is growing evidence that it is essential to predict the interactions between circRNAs and RBP binding sites for diagnosing diseases and providing a potential target to treat diseases[1].Many studies have predicted the binding sites of circRNA-RBPs by using deep learning methods based on the sequence information of circRNAs for each RBP.Furthermore,many methods focus on diversified view of sequence encoding for improving the performance of the predictive models.展开更多
基金This study was financially supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA28020300)the National Natural Science Foundation of China(Grant No.42250410332)+2 种基金the Key Foreign Cooperation Program of the Bureau of International Cooperation of the Chinese Academy of Sciences(Grant No.177GJHZ2022020BS)the‘Double-First Class’Initiative Program for Foreign Talents of Southwest University(Grant No.cstc2021ycjh-bgzxm0002)the‘Prominent Scientist Program’of Chongqing Talents(Grant No.cstc2021ycjh-bgzxm0020)。
文摘Deforestation is one of the most serious environmental problems facing humankind.It continues to escalate rapidly across many regions of the world,thereby deteriorating the forest soil quality.This has prompted a large number of field-based studies aimed at understanding the impacts of deforestation on soil properties.However,the lack of comprehensive meta-analyses that utilized these studies has limited our deeper understanding of how different soil properties,including the soil organic carbon(SOC)pool,respond to deforestation.To address this critical knowledge gap,we conducted a meta-analysis of 144 studies to explore the impacts of deforestation on soil chemical,physical,and biological properties,with special emphasis on the long-term changes in SOC,such as concentrations,stocks,and sequestration.The results revealed that deforestation significantly decreased soil organic matter,electrical conductivity,and base saturation by 52%,50%,and 98%,respectively.While deforestation increased soil total nitrogen content and decreased available phosphorus content by 51%and 99%,respectively,it resulted in slight decreases in some chemical properties,including soil pH(1%)and base cations(1%–13%).Deforestation significantly increased bulk density by 27%and soil erosion by 47%,but significantly decreased soil aggregate stability by 39%and saturated hydraulic conductivity by 63%.Soil microbial biomass C and N concentrations and enzyme activities were significantly decreased as a consequence of deforestation.Soil biological properties were much more affected by deforestation than soil physical and chemical properties.Regarding the SOC,the land use conversion from forest to pasture significantly increased SOC concentrations,stocks,and sequestration rates(11%–13%),whereas the land use conversions from forest to both plantation and cropland significantly decreased SOC concentrations,stocks,and sequestration rates(10%–43%).This observed decline in SOC accumulations decreased with increasing years after deforestation.The SOC dynamics following deforestation were predominantly regulated by microbial biomass concentrations,dehydrogenase activity,soil erosion,saturated hydraulic conductivity,aggregate stability,as well as concentrations of total organic carbon,total nitrogen,total phosphorus and organic matter.The present meta-analytical study provides compelling evidence that deforestation can induce profound changes in soil characteristics,including soil C contents,and has significant implications for soil health sustainability and climate change mitigation.
基金Acknowledgement The authors thank the financial support from the National Natural Science Foundation of China （Grant No. 50705043, 60535020 and 60910007）.
文摘Ionic Polymer-Metal Composite （IPMC） is a new electro-active polymer, which has the advantages of light weight, flexibility, and large stroke with low driving voltage. Because of these features, IPMC can be applied to bionic robotic actuators, artificial muscles, as well as dynamic sensors. However, IPMC has the major drawback of low generative blocking force. In this paper, in order to enhance the blocking force, the Nation membranes with thickness of 0.22 mm, 0.32 mm, 0.42 mm, 0.64 mm and 0.8 mm were prepared by casting from liquid solution. By employing these Nation membranes, IPMCs with varying thickness were fabricated by electroless plating. The elastic modulus of the casted Nation membranes were obtained by a nano-indenter, and the current, the displacement and the blocking force were respectively measured by the apparatus for actuation test. Finally, the effects of the thickness on the performance of IPMC were analyzed with an electromechanical model. Experimental study and theory analysis indicate that as the thickness increases, the elastic modulus of Nation membrane and the blocking force of IPMC increase, however, the current and the displacement decrease.
基金supported by the National Key Research and Development Program of China(Grant No.2017YFC0210100)National Research Program for Key Issues in Air Pollution Control(Grant No.DQGG0208)+1 种基金the National Natural Science Foundation of China(Grant No.41405144)WWW acknowledges support from the Atmospheric and Geospaces Sciences U.S.National Science Foundation(Grant No.AGS 1351932)。
文摘While China’s Air Pollution Prevention and Control Action Plan on particulate matter since 2013 has reduced sulfate significantly,aerosol ammonium nitrate remains high in East China.As the high nitrate abundances are strongly linked with ammonia,reducing ammonia emissions is becoming increasingly important to improve the air quality of China.Although satellite data provide evidence of substantial increases in atmospheric ammonia concentrations over major agricultural regions,long-term surface observation of ammonia concentrations are sparse.In addition,there is still no consensus on whether agricultural or non-agricultural emissions dominate the urban ammonia budget.Identifying the ammonia source by nitrogen isotope helps in designing a mitigation strategy for policymakers,but existing methods have not been well validated.Revisiting the concentration measurements and identifying source apportionment of atmospheric ammonia is thus an essential step towards reducing ammonia emissions.
基金supported by the National Natural Science Foundation of China[Grant No.31870697].
文摘Azalea is a general designation of Rhododendron in the Ericaceae family.Rhododendron not only has high ornamental value but also has application value in ecological protection,medicine,and scientific research.In this study,we used Illumina and PacBio sequencing to assemble and annotate the entire chloroplast genomes(cp genomes)of four Rhododendron species.The chloroplast genomes of R.concinnum,R.henanense subsp.lingbaoense,R.micranthum,and R.simsii were assembled into 207,236,208,015,207,233,and 206,912 bp,respectively.All chloroplast genomes contain eight rRNA genes,with either 88 or 89 protein-coding genes.The four cp genomes were compared and analyzed by bioinformatics,and the phylogenetic analysis based on chloroplast genomes of 26 species of Ericaceae,Actinidiaceae,and Primulaceae under Ericales was conducted.A comparison of the linear structure of cp genomes of four Rhododendron showed that there were substantial sequence similarities in coding regions,but high differences in non-coding regions.A phylogenetic analysis,based on chloroplast whole genome sequences,showed that all Rhododendron species are in the clade Ericaceae.This study provides valuable genetic information for the study of population genetics and evolutionary relationships in Rhododendron and other azalea species.
基金supported by grants from the Macao Science and Technology Development Fund(Project code:002/2023/ALC)Foshan Medicine Dengfeng Project of China 2019-2021(to BYKL).
文摘The critical role of calcium dyshomeostasis in the pathogenesis of Alzheimer’s disease(AD):AD is a progressive neurodegenerative disease characterized by cognitive decline,memory impairment,and behavioral changes.With an estimated 50 million people being affected worldwide,the incidence of AD is constantly increasing globally.The hallmark of AD is the accumulation of amyloid-beta protein(Aβ)in the form of amyloid plaques and hyperphosphorylated tau protein in the form of neurofibrillary tangles.However,increasing evidence suggests that calcium ion(Ca2+)dysregulation also plays a crucial role in the pathogenesis of AD(Calvo-Rodriguez and Bacskai,2021).As a key second messenger,Ca2+regulates a wide range of cellular processes,including the release of neurotransmitters,gene expression,and cell death.Ca^(2+)also regulates the activity of Calcium/calmodulin-dependent protein kinase II,which is critical for synaptic plasticity,learning,and memory(Kaushik et al.,2022).Alternation in the Ca^(2+)signal is an early event in the pathogenesis of AD,which can lead to synaptic dysfunction,neuronal loss,and cognitive impairment.
基金supported by the Scientific Research Foundation of Inner Mongolia of China(KCBJ2018029)the CRP of CAS Key Laboratory of Solar Activity of National Astronomical Observatories(KLSA201905).
文摘According to the requirement of New Engineering Disciplines initiated by the Ministry of Education of China,the course of Programming Fundamentals has been reformed in ethnic university to satisfy the standard of New Engineering Certification.The reform is implemented in teaching content,implementation in both theoretical and experimental classes,teaching assessment and teacher training.
基金supported by Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0502300[2023ZD0502304],China)National Guidance Fund on Developing Local Science and Technology for Sichuan Province(2023ZYD0167,China)+5 种基金the National Key Research and Development Program of China(2022YFA1207300[2022YFA1207303],China)National Natural Science Foundation of China(No.82172634,China)Key Program of the Science and Technology Bureau of Sichuan(No.2021YFSY0007,China)1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD23028,China)Sichuan Province Health Commission(JH20231197,China)Dedicated Post-doctoral R&D Fund,West China Hospital,Sichuan University(2023HXBH132,China).
文摘Lacking therapeutic targets highlights the crucial roles of chemotherapy and radiotherapy in the clinical management of triple-negative breast cancer(TNBC).To relieve the side effects of the chemoradiotherapy combination regimen,we design and develop a self-assembled micelle nanosystem consisting of perfluorocarbon chain-modified cisplatin prodrug.By incorporating perfluorodecalin,this nanosystem can effectively carry ozone and promote irradiation-derived reactive oxygen species(ROS)production.By leveraging the perfluorocarbon sidechain,the nanosystem exhibits efficient internalization by TNBC cells and effectively escapes from lysosomal entrapment.Under X-ray irradiation,ozone-generated ROS disrupts the intracellular redox balance,thereby facilitating the release of cisplatin in a reduction-responsive manner mediated by reduced glutathione.Moreover,oxygen derived from ozone decomposition enhances the efficacy of radiotherapy by alleviating tumor hypoxia.Notably,the combination of irradiation with ozone-loaded cisplatin prodrug nano system synergistically prompts antitumor efficacy and reduces cellular/systemic toxicity in vitro and in vivo.Furthermore,the combo regimen remodels the tumor microenvironment into an immune-favored state by triggering immunogenic cell death and relieving hypoxia,which provides a promising foundation for a combination regimen of immunotherapy.In conclusion,our nanosystem presents a novel strategy for integrating chemotherapy and radiotherapy to optimize the efficacy and safety of TNBC clinical treatment.
基金supported by the National Natural Science Foundation of China(Nos.22268003,22102095,52204320,U20A20246 and 12275199,U22A20418,22075196,21972110,52202208)National Key Research and Development Program of China(Nos.2023YFA1507903,2022YFB3803600,2022YFB4002501)+9 种基金SINOPEC(Beijing)Research Institute of Chemical Industry Co.,Ltd.(No.223239)the Fundamental Research Funds for the Central Universities(No.CCNU22JC017)the Postdoctoral Science Foundation of China(No.2021M692535)the Natural Science Foundation of Shaanxi Province(No.2022JQ-095)the Basic Research Project Foundation of Xi’an Jiaotong University(No.xzy012024012)the Youth Foundation of State Key Laboratory of Electrical Insulation and Power Equipment(No.EIPE2131)the Russian Science Foundation(No.22-13-00035)the Ministry of Science and Higher Education within the framework of a State Assignment of the Ioffe Institute,Russian Academy of Sciences(No.FFUG-2024-0036)Yunnan Fundamental Research Projects(No.202305AF150116)the Research Project Supported by Shanxi Scholarship Council of China(No.2022-050)。
文摘The catalytic transferred of small molecules into high-value chemical products in green methods are highly perused,and has obtained huge attention.In this field,great progress has been achieved during the past five years.Followed by the roadmap(Chinese Chemical Letters,2019,30,2089-2109)written by us before five years,we think that it should be updated to give more insights in this field.Thus,we write the present roadmap based on the fast changed background.In this roadmap,oxygen and carbon dioxide reduction reactions(including at high temperature),photocatalytic hydrogen generation and carbon dioxide reduction reactions,(photo)electrocatalytic reduction of O_(2)to H_(2)O_(2)and NH_(3)generated from N_(2) are discussed.The progress and challenges in above catalytic processes are given.We believe this manuscript will give the researchers more suggestions and help them to obtain useful information in this field.
基金supported by the National Natural Science Foundation of China(42130513,41905110,and 41961130384)the Royal Society Newton Advanced Fellowship,United Kingdom(NAFR1191220)the Research Grants Council of the Hong Kong Special Administrative Region,China(T24/504/17 and A-Poly U502/16)。
文摘Aerosol ammonium(NH_(4)^(+)),mainly produced from the reactions of ammonia(NH_(3))with acids in the atmosphere,has significant impacts on air pollution,radiative forcing,and human health.Understanding the source and formation mechanism of NH_(4)^(+)can provide scientific insights into air quality improvements.However,the sources of NH_(3)in urban areas are not well understood,and few studies focus on NH_(3)/NH_(4)^(+)at different heights within the atmospheric boundary layer,which hinders a comprehensive understanding of aerosol NH_(4)^(+).In this study,we perform both field observation and modeling studies(the Community Multiscale Air Quality,CMAQ)to investigate regional NH_(3)emission sources and vertically resolved NH_(4)^(+)formation mechanisms during the winter in Beijing.Both stable nitrogen isotope analyses and CMAQ model suggest that combustion-related NH_(3)emissions,including fossil fuel sources,NH_(3)slip,and biomass burning,are important sources of aerosol NH_(4)^(+)with more than 60%contribution occurring on heavily polluted days.In contrast,volatilization-related NH_(3)sources(livestock breeding,N-fertilizer application,and human waste)are dominant on clean days.Combustion-related NH_(3)is mostly local from Beijing,and biomass burning is likely an important NH_(3)source(~15%–20%)that was previously overlooked.More effective control strategies such as the two-product(e.g.,reducing both SO_(2)and NH_(3))control policy should be considered to improve air quality.
基金supported by Program for Science&Technology Innovative Research Team in the University of Henan Province(Grant No.21IRTSTHN006)Program for Science&Technology Innovation Talents in Universities of Henan Province(Grant No.19HAS-TIT042)+1 种基金Key scientific and technological project in Henan Province(Grant No.212102210179)Program for Innovative Research Team of Henan Polytechnic University(Grant Nos.T2018-2,T2019-1).
文摘Human health is deteriorating due to the effluent containing heavy metal ions and organic dyes.Hence,photoreduction of Cr(Ⅵ)to Cr(Ⅲ)and degradation of rhodamine B(RhB)using a novel photocatalyst is particularly important.In this work,h-BN/NiS_(2)/NiS composites were prepared via a simple solvothermal method and a double Z-scheme heterojunction was constructed for efficiently removing RhB and Cr(Ⅵ).The 7 wt-%h-BN/NiS_(2)/NiS composites were characterized via a larger specific surface area(15.12 m^(2)·g^(−1)),stronger light absorption capacity,excellent chemical stability,and high yield of electrons and holes.The experimental result indicated that the photoreduction efficiency of the 7 wt-%h-BN/NiS_(2)/NiS photocatalyst achieved 98.5%for Cr(Ⅵ)after 120 min,which was about 3 times higher than that of NiS_(2)/NiS(34%).However,the removal rate of RhB by the 7 wt-%h-BN/NiS_(2)/NiS photocatalyst reached 80%.This is due to the double Z-scheme heterojunction formed between NiS_(2)/NiS and h-BN,which improved the charge separation efficiency and transmission efficiency.Besides,the influence of diverse photogenerated electron and hole scavengers upon the photoreduction of Cr(Ⅵ)was studied,the results indicated that graphene-like h-BN promoted transportation of photoinduced charges on the surface of the h-BN/NiS_(2)/NiS photocatalyst via the interfacial effects.
文摘Background:No convincing modalities have been shown to completely prevent postdural puncture headache(PDPH)after accidental dural puncture(ADP)during obstetric epidural procedures.We aimed to evaluate the role of epidural administration of hydroxyethyl starch(HES)in preventing PDPH following ADP,regarding the prophylactic efficacy and side effects.Methods:Between January 2019 and February 2021,patients with a recognized ADP during epidural procedures for labor or cesarean delivery were retrospectively reviewed to evaluate the prophylactic strategies for the development of PDPH at a single tertiary hospital.The development of PDPH,severity and duration of headache,adverse events associated with prophylactic strategies,and hospital length of stay postpartum were reported.Results:A total of 105 patients experiencing ADP received a re-sited epidural catheter.For PDPH prophylaxis,46 patients solely received epidural analgesia,25 patients were administered epidural HES on epidural analgesia,and 34 patients received two doses of epidural HES on and after epidural analgesia,respectively.A significant difference was observed in the incidence of PDPH across the groups(epidural analgesia alone,31[67.4%];HES-Epidural analgesia,ten[40.0%];HES-Epidural analgesia-HES,five[14.7%];P<0.001).No neurologic deficits,including paresthesias and motor deficits related to prophylactic strategies,were reported from at least 2 months to up to more than 2 years after delivery.An overall backache rate related to HES administration was 10%.The multivariable regression analysis revealed that the HES-Epidural analgesia-HES strategy was significantly associated with reduced risk of PDPH following ADP(OR=0.030,95%confidence interval:0.006-0.143;P<0.001).Conclusions:The incorporated prophylactic strategy was associated with a great decrease in the risk of PDPH following obstetric ADP.This strategy consisted of re-siting an epidural catheter with continuous epidural analgesia and two doses of epidural HES,respectively,on and after epidural analgesia.The efficacy and safety profiles of this strategy have to be investigated further.
基金This work is financially supported by the grants from the Program of Science and Technology Department of Sichuan Province(No.2021YFS0205 and No.2020YFS0222)the Program of Health Commission of Sichuan Province(No.20PJ051)。
文摘Far lateral approach(FLA),together with its modified approaches,is a fundamental surgical approach for surgical resection of lesions located at the ventral or ventrolateral side of the foramen magnum.[1,2,3,4,5]The key procedure in FLA is exposing the vertebral artery(VA)especially the V3 segment.[1,5,6]When performing an FLA,most neurosurgeons choose to expose the suboccipital triangle(formed by the rectus capitis posterior major,the superior oblique,and the inferior oblique)as a key anatomical landmark initially and then expose the V3 segment.[1,2,5,6,7]However,on the one hand,this muscular anatomical landmarks-suboccipital triangle varies in depth,morphology,and location in different patients,which increases the risk of VA injury during surgery.[3]On the other hand,this procedure could lead to exposing difficulty due to the obstruction of overlying layers of muscles and the distribution of blood vessels,which could prolong the time for craniotomy fairly.The course of VA could vary,such as looping backward and bulge posteriorly between the lips of the suboccipital triangle,where it could be damaged if one expects it to be found in the depth of the suboccipital triangle.[3]Thus,neurosurgeons have the potential for VA injury and a rather prolonged time to successfully expose VA.
基金supported by the National Natural Science Foundation of China (Grant Nos.62072206,62102158)the Fundamental Research Funds for the Centra Universities (No.2662022JC004)2021 Foshan Support Project for Promoting the Development of University Scientific and Technological Achievements Service Industry (2021DZXX05).
文摘1 Introduction Recently,there is growing evidence that it is essential to predict the interactions between circRNAs and RBP binding sites for diagnosing diseases and providing a potential target to treat diseases[1].Many studies have predicted the binding sites of circRNA-RBPs by using deep learning methods based on the sequence information of circRNAs for each RBP.Furthermore,many methods focus on diversified view of sequence encoding for improving the performance of the predictive models.
