遗体资源对于医学进步有重要意义,当前我国的遗体捐献工作不容乐观,一定程度限制了医学教学的开展[1-2]。目前国内对遗体捐献的认知多局限于从捐献者登记到遗体接受的流程,而医学院校接受遗体后开展解剖学教学和人文教育也是捐献工作的...遗体资源对于医学进步有重要意义,当前我国的遗体捐献工作不容乐观,一定程度限制了医学教学的开展[1-2]。目前国内对遗体捐献的认知多局限于从捐献者登记到遗体接受的流程,而医学院校接受遗体后开展解剖学教学和人文教育也是捐献工作的重要部分,如何在这一阶段充分发挥遗体的价值有待进一步研究。笔者一行于2018年在加拿大英属哥伦比亚大学(The University of British Columbia,简称UBC)进修解剖学。作为加拿大著名高等学府,UBC集教学和科研于一身,在国际上享有盛誉,其医学院更是跻身全球顶尖水平。展开更多
组织学与胚胎学作为临床医学专业中不可或缺的基础课程,在致力于打造一流本科课程和推进新医科发展的背景下,该课程已采用了多种先进的教学理念来提高质量,如BOPPPS教学、PBL教学、线上线下混合式教学和成果导向教育等。成果导向教育(ou...组织学与胚胎学作为临床医学专业中不可或缺的基础课程,在致力于打造一流本科课程和推进新医科发展的背景下,该课程已采用了多种先进的教学理念来提高质量,如BOPPPS教学、PBL教学、线上线下混合式教学和成果导向教育等。成果导向教育(outcome based education,OBE)是以目标为导向,以学生为中心,引导知识结构与职业需求相适应的先进的教育理念[1]。而《中国本科医学教育标准—临床医学专业(2016版)》(以下简称《标准》)反映医学教育的国际趋势、国内现状和社会期待,是制定教育目标、教育计划、教育评价体系的重要依据。展开更多
In recent years the evolution of olfactory bulb periglomerular cells,as well as the function of periglomerular cells in olfactory encoding,has attracted increasing attention.Studies of neural information encoding base...In recent years the evolution of olfactory bulb periglomerular cells,as well as the function of periglomerular cells in olfactory encoding,has attracted increasing attention.Studies of neural information encoding based on the analysis of simulation and modeling have given rise to electrophysiological models of periglomerular cells,which have an important role in the understanding of the biology of these cells.In this review we provide a brief introduction to the anatomy of the olfactory system and the cell types in the olfactory bulb.We elaborate on the latest progress in the study of the heterogeneity of periglomerular cells based on different classification criteria,such as molecular markers,structure,ion channels and action potentials.Then,we discuss the several existing electrophysiological models of periglomerular cells,and we highlight the problems and defects of these models.Finally,considering our present work,we propose a future direction for electrophysiological investigations of periglomerular cells and for the modeling of periglomerular cells and olfactory information encoding.展开更多
The aim of the present study was to investigate the electrophysiological characteristics of the different layers of the olfactory bulb (OB). We used an in vitro OB slice coupled onto a microelectrode array (MEA) for s...The aim of the present study was to investigate the electrophysiological characteristics of the different layers of the olfactory bulb (OB). We used an in vitro OB slice coupled onto a microelectrode array (MEA) for simultaneous detection of spontaneous activities of OB neurons at different sites. Different frequency oscillations dominated the different layers of the OB slice, and the gamma frequency oscillations mainly appeared in the glomerular layer. The waves consisted of negative, positive, and bidirectional spikes, and were distributed at the different layers of the OB slice. Thus, combination of the OB slice with MEA is a useful technique for identifying signal oscillations by multi-site synchronous measurement, and will allow further studies on olfactory information coding and processing function.展开更多
文摘遗体资源对于医学进步有重要意义,当前我国的遗体捐献工作不容乐观,一定程度限制了医学教学的开展[1-2]。目前国内对遗体捐献的认知多局限于从捐献者登记到遗体接受的流程,而医学院校接受遗体后开展解剖学教学和人文教育也是捐献工作的重要部分,如何在这一阶段充分发挥遗体的价值有待进一步研究。笔者一行于2018年在加拿大英属哥伦比亚大学(The University of British Columbia,简称UBC)进修解剖学。作为加拿大著名高等学府,UBC集教学和科研于一身,在国际上享有盛誉,其医学院更是跻身全球顶尖水平。
文摘组织学与胚胎学作为临床医学专业中不可或缺的基础课程,在致力于打造一流本科课程和推进新医科发展的背景下,该课程已采用了多种先进的教学理念来提高质量,如BOPPPS教学、PBL教学、线上线下混合式教学和成果导向教育等。成果导向教育(outcome based education,OBE)是以目标为导向,以学生为中心,引导知识结构与职业需求相适应的先进的教育理念[1]。而《中国本科医学教育标准—临床医学专业(2016版)》(以下简称《标准》)反映医学教育的国际趋势、国内现状和社会期待,是制定教育目标、教育计划、教育评价体系的重要依据。
基金supported by the National Natural Science Foundation of China (Grant Nos. 30300083,30800248,60875078,and 81171416)the Natural Science Foundation of Zhejiang Province (Grant No.Z1080300)
文摘In recent years the evolution of olfactory bulb periglomerular cells,as well as the function of periglomerular cells in olfactory encoding,has attracted increasing attention.Studies of neural information encoding based on the analysis of simulation and modeling have given rise to electrophysiological models of periglomerular cells,which have an important role in the understanding of the biology of these cells.In this review we provide a brief introduction to the anatomy of the olfactory system and the cell types in the olfactory bulb.We elaborate on the latest progress in the study of the heterogeneity of periglomerular cells based on different classification criteria,such as molecular markers,structure,ion channels and action potentials.Then,we discuss the several existing electrophysiological models of periglomerular cells,and we highlight the problems and defects of these models.Finally,considering our present work,we propose a future direction for electrophysiological investigations of periglomerular cells and for the modeling of periglomerular cells and olfactory information encoding.
基金supported by the National Natural Science Foundation of China (81027003)the Research Fund for the Doctoral Program of Ministry of Education of China (20120101130011)
文摘The aim of the present study was to investigate the electrophysiological characteristics of the different layers of the olfactory bulb (OB). We used an in vitro OB slice coupled onto a microelectrode array (MEA) for simultaneous detection of spontaneous activities of OB neurons at different sites. Different frequency oscillations dominated the different layers of the OB slice, and the gamma frequency oscillations mainly appeared in the glomerular layer. The waves consisted of negative, positive, and bidirectional spikes, and were distributed at the different layers of the OB slice. Thus, combination of the OB slice with MEA is a useful technique for identifying signal oscillations by multi-site synchronous measurement, and will allow further studies on olfactory information coding and processing function.
