Apical periodontitis(AP)is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of the tooth(i.e.,dental pulp tissue),resulting in inflammation and apical bone resorption affectin...Apical periodontitis(AP)is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of the tooth(i.e.,dental pulp tissue),resulting in inflammation and apical bone resorption affecting 50%of the worldwide population,with more than 15 million root canals performed annually in the United States.Current treatment involves cleaning and decontaminating the infected tissue with chemo-mechanical approaches and materials introduced years ago,such as calcium hydroxide,zinc oxide–eugenol,or even formalin products.Here,we present,for the first time,a nanotherapeutics based on using synthetic highdensity lipoprotein(sHDL)as an innovative and safe strategy to manage dental bone inflammation.sHDL application in concentrations ranging from 25μg to 100μg/mL decreases nuclear factor Kappa B(NF-κB)activation promoted by an inflammatory stimulus(lipopolysaccharide,LPS).Moreover,sHDL at 500μg/mL concentration markedly decreases in vitro osteoclastogenesis(P<0.001),and inhibits IL-1α(P=0.027),TNF-α(P=0.004),and IL-6(P<0.001)production in an inflammatory state.Notably,sHDL strongly dampens the Toll-Like Receptor signaling pathway facing LPS stimulation,mainly by downregulating at least 3-fold the pro-inflammatory genes,such as Il1b,Il1a,Il6,Ptgs2,and Tnf.In vivo,the lipoprotein nanoparticle applied after NaOCl reduced bone resorption volume to(1.3±0.05)mm^(3) and attenuated the inflammatory reaction after treatment to(1090±184)cells compared to non-treated animals that had(2.9±0.6)mm^(3)(P=0.0123)and(2443±931)cells(P=0.004),thus highlighting its promising clinical potential as an alternative therapeutic for managing dental bone inflammation.展开更多
BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare disease of unknown etiology.The optimal treatment for CCS remains unknown.Treatment with corticosteroids is considered the mainstay treatment because of its high effi...BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare disease of unknown etiology.The optimal treatment for CCS remains unknown.Treatment with corticosteroids is considered the mainstay treatment because of its high efficacy,but the therapeutic strategy for steroid-resistant CCS is not yet established.CASE SUMMARY This is the case of an 81-year-old woman who was diagnosed with CCS.Given her severe diarrhea,nausea,vomiting,and hypoproteinemia,hormone therapy(40 mg/d)was administered,and the symptoms improved within 1 wk.After 3 mo,the patient had no obvious symptoms.The polyps were significantly reduced on review gastroscopy and colonoscopy,thus hormone reduction gradually began.The hormone level was maintained at 10 mg/d after 6 mo.Despite the age of the patient and the side effects of hormones,the patient had no obvious discomfort.However,hormone drugs were discontinued,and mesalazine was administered orally at 3 g/d.The patient's symptoms continued to improve after a follow-up of 5 years.CONCLUSION Corticosteroids and mesalazine are potential treatment options for CCS.展开更多
The feasibility of implementing distinctive agriculture insurance in Hebei Province is analyzed from the following aspects covering the support of policies and laws;agricultural products and brands with Hebei distinct...The feasibility of implementing distinctive agriculture insurance in Hebei Province is analyzed from the following aspects covering the support of policies and laws;agricultural products and brands with Hebei distinct;the rich experience of insurance companies;farmers'strong awareness on insurance and farmers'great demand on agricultural insurance.The plights faced by distinctive agricultural insurance are pointed out.It includes weak awareness of farmers on buying insurance;low enthusiasm of insurance company;poor support from the government and backward laws and regulations and so on.The countermeasures on developing distinctive agricultural insurance are put forward.The countermeasures on improving farmers'awareness on buying insurance;innovating the insurance products and services;increasing the support from the government;perfecting the legislation on agricultural insurance should be adopted to develop agricultural insurance.展开更多
On the strength of investigation,the status quo of rural micro insurance of Hebei Province is introduced.The results show that it is characterized by the following features:rapid development;continuously increased exp...On the strength of investigation,the status quo of rural micro insurance of Hebei Province is introduced.The results show that it is characterized by the following features:rapid development;continuously increased experimental types and experimental areas;increasingly improved ability of serving the economic and social development;the combination of micro insurance and small loan has achieved success.Based on the efforts of analyzing the questionnaires,the following problems of the development of rural small loan are detected.For instance,the inadequate promotion on micro insurance;peasants'weak awareness of insurance;unclear understanding of the functions of micro insurance;unitary marketing channel of micro insurance;complex reasons of peasants'unwillingness to buy micro insurance and the poor service quality of insurance company.In view of these problems,countermeasures and suggestions are put forward,which include strengthening the promotion on micro insurance,improving peasants'awareness of insurance;expanding the marketing channel and innovating operation mode;innovating the products of micro insurance and encouraging technological innovation;improving the quality of service and establishing the excellent image of insurance company;strengthening the support from government and assisting peasants to insure.展开更多
基金the National Institutes of Health(NIH–National Institute of Dental and Craniofacial Research,grant R01DE031476)。
文摘Apical periodontitis(AP)is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of the tooth(i.e.,dental pulp tissue),resulting in inflammation and apical bone resorption affecting 50%of the worldwide population,with more than 15 million root canals performed annually in the United States.Current treatment involves cleaning and decontaminating the infected tissue with chemo-mechanical approaches and materials introduced years ago,such as calcium hydroxide,zinc oxide–eugenol,or even formalin products.Here,we present,for the first time,a nanotherapeutics based on using synthetic highdensity lipoprotein(sHDL)as an innovative and safe strategy to manage dental bone inflammation.sHDL application in concentrations ranging from 25μg to 100μg/mL decreases nuclear factor Kappa B(NF-κB)activation promoted by an inflammatory stimulus(lipopolysaccharide,LPS).Moreover,sHDL at 500μg/mL concentration markedly decreases in vitro osteoclastogenesis(P<0.001),and inhibits IL-1α(P=0.027),TNF-α(P=0.004),and IL-6(P<0.001)production in an inflammatory state.Notably,sHDL strongly dampens the Toll-Like Receptor signaling pathway facing LPS stimulation,mainly by downregulating at least 3-fold the pro-inflammatory genes,such as Il1b,Il1a,Il6,Ptgs2,and Tnf.In vivo,the lipoprotein nanoparticle applied after NaOCl reduced bone resorption volume to(1.3±0.05)mm^(3) and attenuated the inflammatory reaction after treatment to(1090±184)cells compared to non-treated animals that had(2.9±0.6)mm^(3)(P=0.0123)and(2443±931)cells(P=0.004),thus highlighting its promising clinical potential as an alternative therapeutic for managing dental bone inflammation.
文摘BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare disease of unknown etiology.The optimal treatment for CCS remains unknown.Treatment with corticosteroids is considered the mainstay treatment because of its high efficacy,but the therapeutic strategy for steroid-resistant CCS is not yet established.CASE SUMMARY This is the case of an 81-year-old woman who was diagnosed with CCS.Given her severe diarrhea,nausea,vomiting,and hypoproteinemia,hormone therapy(40 mg/d)was administered,and the symptoms improved within 1 wk.After 3 mo,the patient had no obvious symptoms.The polyps were significantly reduced on review gastroscopy and colonoscopy,thus hormone reduction gradually began.The hormone level was maintained at 10 mg/d after 6 mo.Despite the age of the patient and the side effects of hormones,the patient had no obvious discomfort.However,hormone drugs were discontinued,and mesalazine was administered orally at 3 g/d.The patient's symptoms continued to improve after a follow-up of 5 years.CONCLUSION Corticosteroids and mesalazine are potential treatment options for CCS.
基金Supported by Hebei Social Science Development and Research Subjects(201003127)
文摘The feasibility of implementing distinctive agriculture insurance in Hebei Province is analyzed from the following aspects covering the support of policies and laws;agricultural products and brands with Hebei distinct;the rich experience of insurance companies;farmers'strong awareness on insurance and farmers'great demand on agricultural insurance.The plights faced by distinctive agricultural insurance are pointed out.It includes weak awareness of farmers on buying insurance;low enthusiasm of insurance company;poor support from the government and backward laws and regulations and so on.The countermeasures on developing distinctive agricultural insurance are put forward.The countermeasures on improving farmers'awareness on buying insurance;innovating the insurance products and services;increasing the support from the government;perfecting the legislation on agricultural insurance should be adopted to develop agricultural insurance.
基金Supported by Hebei Research Projects on Soft Science(10457204D-19)
文摘On the strength of investigation,the status quo of rural micro insurance of Hebei Province is introduced.The results show that it is characterized by the following features:rapid development;continuously increased experimental types and experimental areas;increasingly improved ability of serving the economic and social development;the combination of micro insurance and small loan has achieved success.Based on the efforts of analyzing the questionnaires,the following problems of the development of rural small loan are detected.For instance,the inadequate promotion on micro insurance;peasants'weak awareness of insurance;unclear understanding of the functions of micro insurance;unitary marketing channel of micro insurance;complex reasons of peasants'unwillingness to buy micro insurance and the poor service quality of insurance company.In view of these problems,countermeasures and suggestions are put forward,which include strengthening the promotion on micro insurance,improving peasants'awareness of insurance;expanding the marketing channel and innovating operation mode;innovating the products of micro insurance and encouraging technological innovation;improving the quality of service and establishing the excellent image of insurance company;strengthening the support from government and assisting peasants to insure.
