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广域电磁法在洞庭盆地北部生物气勘探中应用及远景靶区预测 被引量:4
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作者 孙春岩 唐侥 +6 位作者 赵浩 张仕强 王栋琳 贺会策 凌帆 李建华 贺岩 《地学前缘》 EI CAS CSCD 北大核心 2018年第4期210-225,共16页
洞庭盆地地处湘西古生界边缘,经历了中生代晚白垩世盆地基本成型和新生代断块运动为主的两期构造旋回,为终成于燕山(中生代)延续于喜马拉雅(新生代)的断陷盆地。盆内局部凹陷白垩系之上存在着持续砂泥岩沉积及第四纪河流湖泊相现代沉积... 洞庭盆地地处湘西古生界边缘,经历了中生代晚白垩世盆地基本成型和新生代断块运动为主的两期构造旋回,为终成于燕山(中生代)延续于喜马拉雅(新生代)的断陷盆地。盆内局部凹陷白垩系之上存在着持续砂泥岩沉积及第四纪河流湖泊相现代沉积,具备了形成一定规模生物气藏的地质条件。2013—2015年笔者通过洞庭盆地浅层沉积物系统地球化学勘探,基本搞清了盆地内渗漏甲烷气体异常的分布状况。根据各指标地球化学异常特征,发现洞庭盆地北部沅江凹陷北部斜坡、青树嘴—河坝镇一带是洞庭盆地内生物气资源最有可能突破的远景区。为了追索渗漏甲烷气体来源,深化地球化学异常解释评价以及浅层生物气系统研究,2015—2016年在发现的生物气远景区,部署完成5条广域电磁测深和两条汞气测量剖面。本研究旨在通过实测地球物理和地球化学综合剖面的对比研究,揭示本区第四系构造分布和地球化学异常机制,为洞庭盆地生物气资源远景和气藏靶区的预测划分提供科学依据,也为勘探第四系生物气资源方法技术的选择提供了建议。勘探成果表明:(1)本区第四系能够满足生物气系统"生储盖"条件,具有生物气资源潜力;(2)沉积物游离烃甲烷地球化学异常是下伏第四系内气体聚集沿断裂带或沉积层向表层渗漏运移所致。酸解烃指标是识别有利于生物气体生储环境的敏感因子之一;(3)洞庭盆地工区西北部,P2剖面南段和P2线北部与P3、P4剖面交汇区域,具有良好的"自生自储"型生物气藏资源远景,是本区勘探生物资源天然气最有希望的靶区;(4)洞庭湖北部工区东部,P6测线南部接近沅江凹陷中心的四季红一带,是本区寻找"自生自储"和"下生上储"型气藏的有利地带和资源远景区;(5)浅层沉积物地球化学勘探,有利于发现与生物气有关的气体渗漏、评价下伏沉积体系特性、缩小地球物理勘探靶区。地球化学与广域电磁剖面测量的结合是勘探生物成因天然气经济快速的方法技术。 展开更多
关键词 洞庭盆地 生物气 广域电磁法 汞气测量 地球化学异常 第四系 游离烃 酸解烃
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城市强干扰环境地下空间探测技术与应用 被引量:18
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作者 何继善 李帝铨 +2 位作者 胡艳芳 凌帆 王金海 《工程地球物理学报》 2022年第5期559-567,共9页
城市地下空间开发利用是我国城市发展的重要研究课题,如何实现城市强干扰环境地下地质结构“透明化”是科学、合理、安全开发利用城市地下空间的关键。我国地质环境条件复杂,特殊的地质构造给城市地下空间透明化带来了严峻的挑战。地球... 城市地下空间开发利用是我国城市发展的重要研究课题,如何实现城市强干扰环境地下地质结构“透明化”是科学、合理、安全开发利用城市地下空间的关键。我国地质环境条件复杂,特殊的地质构造给城市地下空间透明化带来了严峻的挑战。地球物理勘探的无损探测特点使其在城市地下空间探测中得到了广泛的应用。本文在介绍微重力探测、地质雷达、高密度电法、广域电磁法以及天然源面波勘探在城市地下空间探测应用的基础上,分析了不同地球物理探测技术在复杂地质背景下的应用效果及可行性,最后针对传统地球物理探测技术瓶颈提出了改进方案及建议,以期为城市强干扰环境地下空间透明化发展提供技术支撑。 展开更多
关键词 城市地下空间 透明化 地球物理勘探 合理规划
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深海甲烷电化学原位长期监测技术及其在海洋环境调查和天然气水合物勘探中的意义 被引量:6
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作者 孙春岩 王栋琳 +4 位作者 张仕强 贺会策 赵浩 凌帆 尹文斌 《物探与化探》 CAS 北大核心 2019年第1期1-16,共16页
深海溶解甲烷浓度数据连续获取的方法技术,对于海洋环境和天然气水合物开发过程中甲烷扩散作用及通量的动态监测,具有重要的科学意义和实际应用价值。本文较详细地介绍了依据"海水脱气、气体样品定量输入、电化学高精度检测"... 深海溶解甲烷浓度数据连续获取的方法技术,对于海洋环境和天然气水合物开发过程中甲烷扩散作用及通量的动态监测,具有重要的科学意义和实际应用价值。本文较详细地介绍了依据"海水脱气、气体样品定量输入、电化学高精度检测"技术思路,采用"增压排液整机系统控制的海水循环、减压稳流、气液分离、烃类组分高精度检测技术改进"方法,研发"深海甲烷电化学原位长期监测技术"的关键环节和技术方法。结合原位传感器在胶州湾港口为期94天底水长期监测实验获取的数据成果,对原位传感器的技术性能、数据质量、地质效果进行了研究评价。结果表明:(1)原位传感器量程甲烷指标达到0.01~10 000 nmol/L,灵敏度达到0.01 nmol/L,对烃类组分检测具有较好的稳定性和选择性;(2)监测水域溶解甲烷数值范围19.01~106.87 nmol/L,正常甲烷背景32.41 nmol/L,局部异常甲烷背景80.60 nmol/L,资料显示异常与污水排放过程对海水环境污染有关;(3)实测甲烷数据成果地球化学特征与胶州湾海域海水环境以往调查研究成果符合,证明了实测数据的客观性和科学性;(4)海试监测试验成果证明,原位传感器测试性能可靠、结构设计合理、设计思路科学,基本具备了海洋科学调查中对海水甲烷浓度数据获取的能力,在未来海洋天然气水合物开发过程中对甲烷扩散作用的动态监测及深海甲烷浓度通量的长期监测中,具有实际应用价值和科学意义。 展开更多
关键词 深海环境 长期监测 甲烷原位传感器 海水甲烷浓度 海洋天然气水合物 胶州湾
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基于ISSA优化EEMD的用户侧电力负荷预测方法
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作者 石文娟 凌凡 +2 位作者 张俊权 宋振世 李力 《信息技术》 2025年第2期97-103,共7页
为减少负荷预测结果误差,提出基于混合改进麻雀搜索算法(ISSA)优化集合经验模态分解(EEMD)的电力负荷预测方法。获取用户历史用电信息,通过奇异值分解算法去除噪声数据,并利用差分自回归滑动平均模型完成平滑处理。针对集合经验模态分... 为减少负荷预测结果误差,提出基于混合改进麻雀搜索算法(ISSA)优化集合经验模态分解(EEMD)的电力负荷预测方法。获取用户历史用电信息,通过奇异值分解算法去除噪声数据,并利用差分自回归滑动平均模型完成平滑处理。针对集合经验模态分解所需的参数建立优化目标函数,依托于ISSA算法求出最优参数组合。通过分析历史电力负荷数据,将其输入基于广义回归神经网络的预测模型,输出电力负荷预测值。实验结果表明:所提方法预测结果的相对误差控制在0.1以下,可满足用户侧电力负荷预测要求。 展开更多
关键词 ISSA 集合经验模态分解 用户侧 负荷 参数优化
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蒽与马来酸酐Diels-Alder反应的量化计算研究——介绍一个计算化学实验 被引量:1
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作者 樊玲 庞美丽 +2 位作者 张业云 王彦美 尚贞锋 《大学化学》 CAS 2024年第4期133-139,共7页
蒽与马来酸酐的Diels-Alder反应是基础有机化学实验课程中普遍开展的一个经典实验。本文推荐蒽与马来酸酐Diels-Alder反应的计算化学实验,该实验采用Gaussian 16程序中的密度泛函方法对蒽和马来酸酐Diels-Alder反应的反应机理进行了研... 蒽与马来酸酐的Diels-Alder反应是基础有机化学实验课程中普遍开展的一个经典实验。本文推荐蒽与马来酸酐Diels-Alder反应的计算化学实验,该实验采用Gaussian 16程序中的密度泛函方法对蒽和马来酸酐Diels-Alder反应的反应机理进行了研究。旨在通过本实验激发学生对有机化学和计算化学的兴趣,加深学生对化学学科的理解,提升学生在科研工作中学以致用的能力。 展开更多
关键词 计算化学实验 有机实验 Gaussian软件 反应机理
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用SolidWorks软件辅助设计物理化学实验设备 被引量:2
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作者 樊玲 尚贞锋 《大学化学》 CAS 2020年第3期89-93,共5页
结合实例介绍采用SolidWorks软件设计物理化学实验仪器设备。证明SolidWorks软件用于设计仪器设备不仅大大节省了设计的时间和成本,并且还能提高了设计的效率和效果。
关键词 物理化学实验 SOLIDWORKS软件 辅助设备设计
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朱溪钨铜矿的广域电磁法深部探测 被引量:15
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作者 陈后扬 李帝铨 +7 位作者 凌帆 吴西全 危志峰 张斌 田红军 游文兵 邹其峰 刘献满 《中国有色金属学报》 EI CAS CSCD 北大核心 2022年第10期3227-3243,共17页
朱溪钨铜矿是近年发现的超大型矽卡岩型钨铜矿床,刷新了钨矿资源量的世界纪录,主矿体埋深普遍超过1000 m。2017年,矿体在倾向和走向上没有完全封闭,主要控岩控矿构造的深部产状未知,亟需开展深部探测工作。本研究尝试将广域电磁法应用... 朱溪钨铜矿是近年发现的超大型矽卡岩型钨铜矿床,刷新了钨矿资源量的世界纪录,主矿体埋深普遍超过1000 m。2017年,矿体在倾向和走向上没有完全封闭,主要控岩控矿构造的深部产状未知,亟需开展深部探测工作。本研究尝试将广域电磁法应用到朱溪矿区深部探测;利用物性资料和井旁视电阻率测深曲线建立了目标地质体电性、密度、磁性与岩性之间的联系;开展了重磁电多参数对比分析,结合已知地质资料绘制了骨干剖面的二维地质−地球物理断面,依据广域电磁法反演断面拟三维切片图构建了三维地质找矿模型。结果表明:这些工作较好地揭示了区内主控岩控矿构造、赋矿层位的展布形态,获取了与深部隐伏岩体有关的热液蚀变活动信息。广域电磁法为朱溪矿区深部500~3000 m“第二找矿空间”的成矿规律研究、下一步找矿方向等提供了有力依据,是金属矿产深部找矿的有效方法技术。 展开更多
关键词 朱溪钨铜矿 广域电磁法 矽卡岩 深部探测
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建筑工程项目施工进度影响因素分析 被引量:7
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作者 令凡 吕国敏 +2 位作者 陈利雄 朱李春 李新凯 《黑龙江科学》 2021年第10期162-164,共3页
本文对影响施工进度的各个因素和主要原因加以阐述和分析,并结合自身实践有针对性地提出以事前控制、动态管理为主的对策,对提高施工进度管理水平,确保建筑工程项目按时保质保量完工,促进施工进度管理更加科学化、规范化、制度化具有较... 本文对影响施工进度的各个因素和主要原因加以阐述和分析,并结合自身实践有针对性地提出以事前控制、动态管理为主的对策,对提高施工进度管理水平,确保建筑工程项目按时保质保量完工,促进施工进度管理更加科学化、规范化、制度化具有较大的意义。 展开更多
关键词 建筑工程项目 施工进度 影响因素
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小切口微创治疗难复型股骨转子间骨折的疗效观察 被引量:4
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作者 凌樊 朱光宏 +4 位作者 卜光昌 胡天鑫 谭士凯 彭青松 孙贵平 《生物骨科材料与临床研究》 CAS 2022年第6期42-46,共5页
目的探讨髋部前外侧小切口手术入路复位方式利用PFNA内固定治疗难复型股骨转子间骨折患者的临床疗效。方法选取2017年5月至2021年5月湖南省湘西自治州人民医院的老年难复型股骨转子间骨折患者共34例,其中髋部前外侧小切口组19例(行髋部... 目的探讨髋部前外侧小切口手术入路复位方式利用PFNA内固定治疗难复型股骨转子间骨折患者的临床疗效。方法选取2017年5月至2021年5月湖南省湘西自治州人民医院的老年难复型股骨转子间骨折患者共34例,其中髋部前外侧小切口组19例(行髋部前外侧小切口PFNA内固定手术),常规外侧大切口组15例(行常规外侧大切口PFNA内固定手术)。比较两组患者的手术时间、切口长度、术中出血量、早期下床活动时间、术后疼痛评分等相关数据。结果所有患者均获得随访6~10个月,平均随访(8.12±1.64)个月。髋部前外侧小切口组患者的手术时间、术中出血量、手术切口长度、早期下床活动时间、术后疼痛评分优于常规外侧大切口组,两组间比较差异有统计学意义(P<0.05)。结论对于老年难复型股骨转子间骨折患者,髋部前外侧微创切口PFNA手术治疗难复位型股骨转子间骨折的方式术中出血量少,手术创伤小,患者的术后疼痛低,术后下床活动时间早,安全性大大提高。 展开更多
关键词 微创 股骨转子间骨折 难复型 PFNA
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300 t 级渔业资源调查船建设项目的全过程管理 被引量:2
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作者 令凡 冯震华 +2 位作者 朱李春 李新凯 陈利雄 《广东造船》 2020年第6期101-104,共4页
本文主要阐述了我所300 t级海洋渔业资源调查船新建项目,从立项审批、设计、招投标、建造、监造、海试、完工交船、工程结算、财务决算、档案整理、项目验收、项目后评价等全过程的管理。通过加强各关键节点的有效管理,对项目的建造周... 本文主要阐述了我所300 t级海洋渔业资源调查船新建项目,从立项审批、设计、招投标、建造、监造、海试、完工交船、工程结算、财务决算、档案整理、项目验收、项目后评价等全过程的管理。通过加强各关键节点的有效管理,对项目的建造周期、质量监督控制、施工安全防护、基建财务管理以及船舶正常营运、后续维护等方面具有非常重要的意义。 展开更多
关键词 海洋渔业 船舶建造 全过程管理
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Effect of hospital discharge plan for children with type 1 diabetes on discharge readiness,discharge education quality,and blood glucose control 被引量:14
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作者 Hui-Juan Tong Feng Qiu ling fan 《World Journal of Clinical Cases》 SCIE 2021年第4期774-783,共10页
BACKGROUND Type 1 diabetes is one of the most common chronic diseases in childhood.The number of type 1 diabetes patients in China still ranks fourth in the world.Therefore,children with type 1 diabetes in China are a... BACKGROUND Type 1 diabetes is one of the most common chronic diseases in childhood.The number of type 1 diabetes patients in China still ranks fourth in the world.Therefore,children with type 1 diabetes in China are a group that needs attention.The management of type 1 diabetes mellitus(T1DM)involves many aspects of daily life.It is extremely challenging for children and their families.T1DM children have complex medical care needs.Despite the continuous development of therapeutic medicine and treatment technologies,blood glucose control in children with T1DM is still not ideal.They and their parents need to acquire more knowledge and skills before being discharged.AIM To explore the influence of hospital discharge plan based on parental care needs of children with T1DM on discharge readiness,quality of discharge education and blood glucose control level.METHODS In total,102 parents of children with type 1 diabetes were divided into control group and intervention group according to admission time.Fifty cases from February to June 2019 were selected as the control group,and 52 cases from July to October 2019 were selected as the intervention group to implement the discharge plan.The Readiness for Hospital Discharge Scale,Hospital Discharged Education Quality Scale and children's blood glucose metabolism indicators were used to compare the differences in discharge preparation,discharge education quality and blood glucose control between the two groups of children and their parents.RESULTS On the day of discharge,the two groups of children had the following scores of readiness for discharge:The intervention group score was 225.34±32.47,and the control group score was 208.68±29.31.The P value was 0.007,and the difference was statistically significant.The discharge education quality scores were as follows:The intervention group score was 135.11±19.86,the control group score was 124.13±15.56,the P value was 0.002 and the difference was statistically significant.Three months after discharge,the blood glucose metabolism indicator showed that the glycosylated hemoglobin value of the two groups was(7.45%±1.04%),and that of the control group was(8.04%±1.27%),P=0.012.Therefore,the improvement of parents'readiness for discharge,quality of discharge education and blood glucose metabolism indicators(glycosylated hemoglobin,fasting blood glucose and postprandial blood glucose)in the intervention group were better than those in the control group(P<0.05),and the difference was statistically significant.CONCLUSION The discharge plan for children with T1DM can help the children and their families realize the transition from hospital care to home self-management and improve the parents'readiness for discharge,thereby improving children’s blood glucose control levels. 展开更多
关键词 Type 1 diabetes Hospital discharge plan Hospital discharge readiness Blood glucose control CHILDREN PARENTS
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布鲁顿酪氨酸激酶抑制剂介导的出血机制及临床管理
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作者 宋丽霞 康虹阳 +3 位作者 韩国将 刘洁 范凌(综述) 佟长青(审校) 《中国肿瘤临床》 CAS CSCD 北大核心 2024年第14期737-741,共5页
布鲁顿酪氨酸激酶(Bruton's tyrosine kinase,BTK)抑制剂是治疗B细胞淋巴瘤的新型靶向药物,尤其在套细胞淋巴瘤(mantle cell lymphoma,MCL)、慢性淋巴细胞白血病/小淋巴细胞淋巴瘤(chronic lymphocytic leukemia/small lymphocytic ... 布鲁顿酪氨酸激酶(Bruton's tyrosine kinase,BTK)抑制剂是治疗B细胞淋巴瘤的新型靶向药物,尤其在套细胞淋巴瘤(mantle cell lymphoma,MCL)、慢性淋巴细胞白血病/小淋巴细胞淋巴瘤(chronic lymphocytic leukemia/small lymphocytic lymphoma,CLL/SLL)、华氏巨球蛋白血症(Waldenstr?m's macroglobulinaemia,WM)的治疗中显示出良好的疗效。随着BTK抑制剂在临床上的广泛使用,出血的不良反应逐渐显现。出血事件是由于BTK抑制剂的脱靶效应引起,在使用过程中通过多条信号通路来影响血小板功能,导致出血的发生。出血一旦发生将影响患者的治疗,严重会危机生命,应该加强出血的临床管理,本文就BTK抑制剂引起出血的作用机制及临床管理进行综述。 展开更多
关键词 BTK抑制剂 出血 不良事件 临床管理
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小型复叠式空气源热泵采暖系统性能影响因素的实验研究 被引量:10
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作者 鲁祥友 凌帆 +2 位作者 唐景春 谢远来 张进新 《低温与超导》 CAS 北大核心 2020年第4期47-51,共5页
本文探讨了循环水流量﹑热水温度及环境温度等参数对小型复叠式空气源热泵采暖系统性能的影响。实验结果表明:在一定温度范围内,随着制取热水温度的升高,热泵的制热量逐渐降低,热泵的输入功率逐渐增大,系统COP呈下降趋势;当制取的热水... 本文探讨了循环水流量﹑热水温度及环境温度等参数对小型复叠式空气源热泵采暖系统性能的影响。实验结果表明:在一定温度范围内,随着制取热水温度的升高,热泵的制热量逐渐降低,热泵的输入功率逐渐增大,系统COP呈下降趋势;当制取的热水温度相同、环境温度较高时,热泵的制热量、热泵平均COP值较高;在一定流量范围内,循环流量越大,热泵的制热能力越高,当制取热水的温度相同时,大循环流量下高温环路的压缩机排气温度越低,运行越稳定。 展开更多
关键词 热泵 水箱 制热量 传热 流量
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Electrophysiological changes of autonomic cells in left ventricular outflow tract in guinea pigs with iron deficiency anemia complicated with chronic heart failure 被引量:4
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作者 ling fan Li-Feng Chen Jing fan 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2017年第12期1197-1200,共4页
Objective: To investigate the electrophysiological changes of autonomic cells in left ventricular outflow tract in guinea pigs with iron deficiency anemia complicated with chronic heart failure.Methods: Guinea pigs mo... Objective: To investigate the electrophysiological changes of autonomic cells in left ventricular outflow tract in guinea pigs with iron deficiency anemia complicated with chronic heart failure.Methods: Guinea pigs model of iron deficiency anemia complicated with chronic heart failure in 10 guinea pigs of the experimental group was made by feeding a low iron diet,pure water and subcutaneous injection of isoproterenol. The control group consisting of 11 guinea pigs was given normal food, normal water and injected with normal saline. The left ventricular outflow tract model specimen was also prepared. The standard microelectrode technique was used to observe electrophysiological changes of autonomic cells in the outflow tract of left ventricular heart failure complicated with iron deficiency anemia in guinea pig model. The indicators of observation were maximal diastolic potential, action potential amplitude, 0 phase maximal depolarization velocity, 4 phase automatic depolarization velocity, repolarization 50% and 90%, and spontaneous discharge frequency.Results: Compared with the control group, 4 phase automatic depolarization velocity,spontaneous discharge frequency and 0 phase maximal depolarization velocity decreased significantly(P < 0.01) and action potential amplitude reduced(P < 0.01) in model group. Moreover, repolarization 50% and 90% increased(P < 0.01).Conclusions: There are electrophysiological abnormalities of the left ventricular outflow tract in guinea pigs with iron deficiency anemia complicated with heart failure. 展开更多
关键词 Iron deficiency anemia Chronic heart failure Guinea pig model Autonomic cells Left ventricular outflow tract ELECTROPHYSIOLOGY
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Effect of motivational interviewing on postoperative weight control in patients with obstructive sleep apnea-hypopnea syndrome 被引量:6
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作者 Xiang-Hong Sun Peng-Shi Xue +1 位作者 Xiang-Xiu Qi ling fan 《World Journal of Clinical Cases》 SCIE 2020年第15期3209-3217,共9页
BACKGROUND Obesity is an important factor to cause the obstructive sleep apnea-hypopnea syndrome(OSAHS).Higher body mass index(BMI)often results in more severe OSAHS.Currently,the common measures for controlling the w... BACKGROUND Obesity is an important factor to cause the obstructive sleep apnea-hypopnea syndrome(OSAHS).Higher body mass index(BMI)often results in more severe OSAHS.Currently,the common measures for controlling the weight mainly include diet control,increase exercise and so on.Motivational interviewing(MI)could explore the patient’s internal state and make the patient realize his/her ambivalence,resulting in the change in his/her behavior.This process emphasizes respecting the patient’s autonomy.AIM To evaluate the effect of MI on the weight control of patients with OSAHS.METHODS A randomized controlled study was conducted in 100 obese OSAHS patients undergoing surgical treatment at Shengjing Hospital of China Medical University.The patients were divided into an intervention group and a control group,with 50 cases each.The control group was given routine health education after the operation;in addition to the regular health education,the intervention group was given MI according to a predetermined plan.Obesity-related indicators,postoperative complications,and the sleep status of both groups were evaluated before and 6 mo after the intervention.RESULTS Patients in the intervention group had significantly improved body weight,BMI,and waist and neck circumferences compared with patients in the control group(P<0.05).Regarding complications at 6 mo after operation,the incidence of cough and reflux in patients in the intervention group was significantly lower than that in the control group(P<0.05).In addition,the Epworth Sleepiness Scale and Self-Rating Scale of Sleep scores of patients in the intervention group were significantly lower than those in the control group,and the sleep status of patients in the intervention group was improved(P<0.05).CONCLUSION MI intervention has a significant advantage over postoperative routine health education.It can greatly change the lifestyle,further control the postoperative weight,reduce the occurrence of complications,improve the quality of sleep,and improve long-term postoperative efficacy in OSAHS patients. 展开更多
关键词 Obstructive sleep apnea-hypopnea syndrome POSTOPERATIVE Weight control Motivational interview Quality of sleep PATIENTS
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Effect of iron overload on electrophysiology of slow reaction autorhythmic cells of left ventricular outflow tract in guinea pigs 被引量:4
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作者 ling fan Li-Feng Chen +2 位作者 Jing fan Lan-Ping Zhao Xiao-Yun Zhang 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2018年第2期151-154,共4页
Objective: To investigate the electrophysiology effects and mechanism of iron overload on the slow response autorhythmic cells in the left ventricular outflow tract of guinea pigs.Methods: Standard microelectrode cell... Objective: To investigate the electrophysiology effects and mechanism of iron overload on the slow response autorhythmic cells in the left ventricular outflow tract of guinea pigs.Methods: Standard microelectrode cell recording techniques were adopted to observe the electrophysiological effects of different concentrations of Fe^(2+)(100 μmol/L, 200 μmol/L) on the left ventricular outflow tract autorhythmic cells.Heart tissues were perfused with FeSO_4(200 μmol/L) combing with CaCl_2(4.2 mmol/L), Verapamil,(1 μmol/L), and nickel chloride(200μmol/L) respectively to observe the influences of these contents on electrophysiology of FeSO_4(200μmol/L) on the left ventricular outflow tract autorhythmic cells.Results: Fe^(2+)at both 100 μmol/L and 200 μmol/L could change the electrophysiological parameters of the slow response autorhythmic cells of the left ventricular outflow tract in a concentrationdependent manner resulting into decrease in Vmax, APA and MDP, slower RPF and VDD, and prolonged APD_(50) and APD_(90)(P all <0.05).Besides, perfusion of increased Ca^(2+) concentration could partially offset the electrophysiological effects of Fe^(2+)(200 μmol/L).The L-type calcium channel(LTCC) blocker Verapamil(1 μmol/L) could block the electrophysiological effects of Fe^(2+)(200 μmol/L).But the T-type calcium channel(TTCC) blocker nickel chloride(NiCl_2, 200 μmol/L) could not block the electrophysiological effects of Fe^(2+)(200 μmol/L).Conclusions: Fe^(2+) can directly change the electrophysiological characteristics of the slow response autorhythmic cells of the left ventricular outflow tract probably through the L-type calcium channel. 展开更多
关键词 Iron overload Iron poisoning Left ventricular outflow tract Slow reaction autorhythmic cell ELECTROPHYSIOLOGY
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动力学反应瓶的研制及其在物理化学实验教学中的应用
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作者 张业云 樊玲 +1 位作者 王彦美 尚贞锋 《大学化学》 CAS 2024年第4期100-106,共7页
化学反应速率常数受温度影响很大,动力学实验教学中常先预热后取液,溶液转移过程中的室温暴露使体系温度失衡,易导致初始数据误差大,动力学曲线变形;定量移液、启动计时、混合溶液等需同步操作,学生不熟练易忙乱出错;溶液预热时试剂过量... 化学反应速率常数受温度影响很大,动力学实验教学中常先预热后取液,溶液转移过程中的室温暴露使体系温度失衡,易导致初始数据误差大,动力学曲线变形;定量移液、启动计时、混合溶液等需同步操作,学生不熟练易忙乱出错;溶液预热时试剂过量,易造成浪费等。针对上述问题,本实验室自制了“裤型”动力学反应瓶及其配套装置,使溶液的移取、预热和混合逐步进行,实验步骤更加合理,减少了温度失衡引起的实验误差及学生的操作失误,并可节约试剂。该瓶已实际应用于本校的物理化学实验教学中,改进和丰富了实验内容,更好地锻炼了学生的操作能力,并对培养学生综合分析与解决问题的能力、提高学生科研素养、提升实验教学效果起到了一定作用。 展开更多
关键词 “裤型”反应瓶 化学动力学 实验教学
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Acupuncture and moxibustion for the elderly patients with depression:A randomized controlled trial 被引量:2
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作者 Juanfen GONG ling fan +1 位作者 Zhao CHEN Wenbin FU 《World Journal of Acupuncture-Moxibustion》 CSCD 2019年第3期169-173,共5页
Objective:To identify the effects of acupuncture and moxibustion therapy by soothing liver and regulating mind on the quality of life among the elders with depression.Methods:This was a single-blind,randomized,control... Objective:To identify the effects of acupuncture and moxibustion therapy by soothing liver and regulating mind on the quality of life among the elders with depression.Methods:This was a single-blind,randomized,controlled trial of 75 elders with depression conducted in Guangdong Province,China,in January to December 2010.Eligible patients were randomly divided into three treatment groups.22 patients received acupuncture and moxibustion treatment of soothing liver and regulating mind[group A,in acupuncture procedure:Hegu(合谷L14),Taichong(太冲LR3),Baihui(百会GV20)and Yinting(印堂GV29)were selected,in moxibustion procedure,bilateral Geshu(膈俞BL17)and Danshu(胆俞BL19)were selected,the moxibustion cones was placed on the acupoints,five cones were given to each point.In intradermal needling procedure,Xinshu(心俞BL15),and Ganshu(肝俞BL18)were selected].28 patients received acupoint shallow puncturing treatment(group B,patients received the same acupoints as in the group A,with a 2-3 mm needling depth and no needle sensation was required.A shorter duration of moxibustion and only 1-2 mm of needle body was inserted into the points when intradermal needling).25 patients received non-acupoint shallow puncturing treatment(group C,patients received non-acupoint shallow puncturing at points 10 mm lateral to LI4 and LR3,10 mm left side of GV20 and GV29 in acupuncture procedure;10 mm lateral to BL17 and BL19 in moxibustion procedure;10 mm lateral to BL15 and BL18 in intradermal needling procedure,with the same manipulation method as that in the group B).In all three groups,the treatment was given twice a week for 12 weeks.The Short Form(36)Health Survey(SF36)and TCM Symptom Scale Score as clinical efficacy and quality of life were used to quantitatively assess patients'outcomes before and after treatment.Results:The TCM Symptom Scale scores showed significant differences between the group A and C,and between group B and C(both P<0.05),while there was no significant difference between group A and B(P>0.05).An item-by-item analysis of the SF36 showed the elders in group A obtained the highest scores at each time point after treatment(all P<0.05).Among the results,mental health and report health transition items showed no significant differences between the group A and group B at time point of after treatment(all P>0.05).Vitality and social functioning items at a month after treatment time point,social functioning and report:health transition items at 3 months after treatment time point,role emotional item at after treatment time point showed no significant differences between the group B and group C(all P>0.05).Conclusions:The therapeutic effect of acupuncture and moxibustion by soothing liver and regulating mind can obviously improve the quality of life of depression elders. 展开更多
关键词 Elderly DEPRESSION Acupuncture and MOXIBUSTION Short Form(36)Health Survey TCM SYMPTOM scale
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Magnetically recoverable Fe3O4@polydopamine nanocomposite as an excellent co-catalyst for Fe^3+ reduction in advanced oxidation processes 被引量:2
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作者 ling fan Jinliang Xie +3 位作者 Zhilin Zhang Yaping Zheng Dongdong Yao Ting Li 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2020年第6期69-78,共10页
Advanced oxidation processes are widely applied to removal of persistent toxic substances from wastewater by hydroxyl radicals(·OH),which is generated from hydrogen peroxide(H2O2)decomposition.However,their pract... Advanced oxidation processes are widely applied to removal of persistent toxic substances from wastewater by hydroxyl radicals(·OH),which is generated from hydrogen peroxide(H2O2)decomposition.However,their practical applications have been hampered by many strict conditions,such as iron sludge,rigid pH condition,large doses of hydrogen peroxide and Fe^2+,etc.Herein,a magnetically recyclable Fe3O4@polydopamine(Fe3O4@PDA)coreshell nanocomposite was fabricated.As an excellent reducing agent,it can convert Fe^3+to Fe^2+.Combined with the coordination of polydopamine and ferric ions,the production of iron sludge is inhibited.The minimum concentration of hydrogen peroxide(0.2 mmol/L and Fe^2+(0.18 mmol/L))is 150-fold and 100-fold lower than that of previous reports,respectively.It also exhibits excellent degradation performance over a wide pH range from 3.0 to 9.0.Even after the tenth recycling,it still achieves over 99%degradation efficiency with the total organic carbon degradation rate of 80%,which is environmentally benign and has a large economic advantage.This discovery paves a way for extensive practical application of advanced oxidation processes,especially in environmental remediation. 展开更多
关键词 Fe3O4@polydopamine nanocomposites Fenton-like catalysts Fe^3+/Fe^2+cycle Magnetically reusable
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An all-organic aqueous potassium dual-ion battery 被引量:2
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作者 Junmin Ge Xianhui Yi +1 位作者 ling fan Bingan Lu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第6期28-33,I0002,共7页
Benefiting from the environmental friendliness of organic electrodes and the high security of aqueous electrolyte,an all-organic aqueous potassium dual-ion full battery(APDIB) was assembled with 21 M potassium bis(flu... Benefiting from the environmental friendliness of organic electrodes and the high security of aqueous electrolyte,an all-organic aqueous potassium dual-ion full battery(APDIB) was assembled with 21 M potassium bis(fluoroslufonyl)imide(KFSI) water-in-salt as the electrolyte.The APDIB could deliver a reversible capacity of around 50 mAh g^(-1) at 200 mA g^(-1)(based on the weight of total active materials),a long cycle stability over 900 cycles at 500 mA g^(-1) and a high coulombic efficiency of 98.5%.The reaction mechanism of APDIB during the charge/discharge processes is verified:the FSI-could associate/disassociate with the nitrogen atom in the polytriphenylamine(PTPAn) cathode,while the K^(+) could react with C=O bonds in the 3,4,9,10-perylenetetracarboxylic diimide(PTCDI) anode reversibly.Our work contributes toward the understanding the nature of water-into-salt electrolyte and successfully constructed all-organic APDIB. 展开更多
关键词 All-organic electrode Potassium ion battery Dual-ion full battery Aqueous high concentration electrolyte High safety
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