目的:探讨血清中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)、降钙素基因相关肽(calcitonin gene-related peptide,CGRP)、中性粒细胞计数与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)...目的:探讨血清中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)、降钙素基因相关肽(calcitonin gene-related peptide,CGRP)、中性粒细胞计数与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)对老年脑卒中并发肺部感染(stroke complicated with pulmonary infection,SCPI)患者预后转归的预测价值。方法:本研究为回顾性单中心研究,选取2020年6月至2024年6月内蒙古包钢医院收治的149例老年SCPI患者,根据预后转归分为预后不良组(n=58)和预后良好组(n=91)。收集基线资料、实验室检查指标,并计算NLR。采用酶联免疫法检测血清NGAL、CGRP水平。多因素Logistic回归分析老年SCPI患者预后不良影响因素。受试者工作特征(receiver operating characteristic,ROC)曲线分析预测价值。结果:与预后良好组比较,预后不良组年龄≥70岁、出血性脑卒中比例、血肌酐、白细胞计数、美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分、血小板计数、C反应蛋白、NGAL、NLR水平升高,神经外科重症监护室(nerosurgery intensive care unit,NICU)时间延长,CGRP水平降低(P<0.05)。CGRP升高为老年SCPI患者预后不良保护因素(OR<1,P<0.05)。年龄≥70岁、出血性脑卒中、NICU时间延长、NIHSS评分升高、NGAL水平升高、NLR升高为老年SCPI患者预后不良危险因素(OR>1,P<0.05)。NGAL、CGRP、NLR单独和三项联合预测老年SCPI患者预后转归的曲线下面积(area under the curve,AUC)分别为0.777、0.771、0.786、0.927,三项联合预测老年SCPI患者预后转归效能最高(P<0.05)。结论:年龄≥70岁、出血性脑卒中、NICU时间延长和NIHSS评分升高、NGAL水平升高、NLR升高是老年SCPI患者预后不良的危险因素,CGRP水平升高为独立保护因素。联合检测NGAL、CGRP、NLR能提升老年SCPI患者预后转归的预测价值。展开更多
O-Ethyl S-hydrogen isoquinolin-l-ylcarbonothioimidate was synthesized and its structure was characterized by IR, MS, ^1H NMR, elemental analysis and single-crystal X-ray diffraction. The crystal belongs to monoclinic,...O-Ethyl S-hydrogen isoquinolin-l-ylcarbonothioimidate was synthesized and its structure was characterized by IR, MS, ^1H NMR, elemental analysis and single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group P21/c with a = 10.9471（19）, b = 9.3968（17）, c = 10.6125（19） A, β = 100.761 （3）°, V = 1072.5（3） A^3, Z = 4, Dc = 1.439 g/cm^3, F（000） = 488 and μ = 0.279 mm^-1. A total of 7763 reflections were collected, of which 2090 were unique. The structure was refined to the final R = 0.0322 and wR = 0.0882 for 2016 observed reflections with Ⅰ 〉 2σ（Ⅰ）. The crystal structure shows that there are intramolecular N-H…S hydrogen bonds and π-π stacking interactions between adjacent molecules.展开更多
目的:研究吡拉西坦联合胞磷胆碱对急性脑梗死认知功能和神经功能的影响。方法:选择2014年1月~2018年1月我院的150例急性脑梗死患者,随机分为两组。对照组采用吡拉西坦治疗,观察组采用吡拉西坦联合胞磷胆碱治疗。采用神经功能缺损程度(Na...目的:研究吡拉西坦联合胞磷胆碱对急性脑梗死认知功能和神经功能的影响。方法:选择2014年1月~2018年1月我院的150例急性脑梗死患者,随机分为两组。对照组采用吡拉西坦治疗,观察组采用吡拉西坦联合胞磷胆碱治疗。采用神经功能缺损程度(National Institutes of Health Stroke Scale,NIHSS)、析蒙特利尔认知评估量表(Montreal cognitive assessment scale,Mo CA)和日常生活能力(Activities of daily living,ADL)评分量表,比较两组治疗前后神经功能、认识功能和日常生活能力变化。结果:观察组基本治愈15例,显效30例,有效26例,无效4例,恶化1例,总有效率为94.67%,明显高于对照组(P<0.05);治疗后,两组的ADL和Mo CA评分明显升高,神经功能缺损量表(National Institutes of Health Stroke Scale,NHISS)评分明显降低,且观察组的ADL、Mo CA和NHISS评分明显优于对照组(均P<0.05);治疗后,两组的血清细胞凋亡蛋白酶-3(cysteinyl aspartate specific proteinase-3,Caspase-3)和低氧诱导因子-1α(Hypoxia-inducible factor 1α,HIF-1α)水平均明显降低,且观察组明显低于对照组(均P<0.05);对照组发生干呕1例(1.33%),恶心2例(2.67%),头痛1例(1.33%),头晕1例(1.33%);观察组发生干呕1例(1.33%),恶心1例(1.33%),头痛1例(1.33%),出血1例(1.33%);两组无明显差异(P>0.05)。结论:吡拉西坦联合胞磷胆碱能改善急性脑梗死的认知功能和神经功能,其机制可能与调节细胞诱导因子Caspase-3和HIF-1α的表达水平相关。展开更多
目的探讨多学科协助膳食干预追踪对肥胖冠心病患者体质指数、血脂、血糖及饮食依从性和生活质量的影响。方法选取2017年1月—2020年10月汕头市潮阳区人民医院心血管内科收治身体质量指数(body mass index,BMI)≥25的冠心病患者100例,按...目的探讨多学科协助膳食干预追踪对肥胖冠心病患者体质指数、血脂、血糖及饮食依从性和生活质量的影响。方法选取2017年1月—2020年10月汕头市潮阳区人民医院心血管内科收治身体质量指数(body mass index,BMI)≥25的冠心病患者100例,按随机数字表法分为对照组和实验组,各组50例。对照组予常规的膳食干预,实验组则在多学科协作下进行膳食干预3个月,并全程追踪,比较两组干预前后体质指数、血脂、血糖、膳食营养摄入水平、饮食依从性及生活质量。结果实验组干预后体重(70.51±6.86)kg、腰围(93.25±9.01)cm、BMI(26.01±4.17)、甘油三酯(triglyceride,TG)(1.88±0.24)mmol/L、总胆固醇(total cholesterol,TC)(5.22±0.69)mmol/L及空腹胰岛素(fasting insulin,FINS)(5.21±4.01)mIU/L指标水平均低于对照组[体重(74.22±8.05)kg、腰围(98.02±8.25)cm、BMI(28.15±4.96)、TG(2.55±0.45)mmol/L、TC(6.15±0.82)mmol/L及FINS(6.91±3.55)mIU/L],差异均有统计学意义(P<0.05);实验组干预后营养摄入总能量(1295.22±495.25)kcal、脂肪(49.56±23.28)g均低于对照组[总能量(1671.24±601.75)kcal、脂肪(68.81±45.25)g],膳食纤维(13.59±4.55)g高于对照组(11.77±4.25)g,差异均有统计学意义(P<0.05);实验组干预后饮食依从性[(25.56±4.49)分]及生活质量[(76.98±14.51)分]得分改善情况优于对照组[饮食依从性(23.19±4.73)分、生活质量(69.83±13.66)分],差异均有统计学意义(P<0.05)。结论多学科协助膳食干预追踪能在一定程度上改善肥胖冠心病患者体质指数、血脂及血糖水平,提高患者饮食依从性及生活质量。展开更多
Soil drying may induce a number of stresses on crops. This paper investigated maize（Zea mays L.） root growth as affected by drought and soil penetration resistance（PR）, which was caused by soil drying and tillage ...Soil drying may induce a number of stresses on crops. This paper investigated maize（Zea mays L.） root growth as affected by drought and soil penetration resistance（PR）, which was caused by soil drying and tillage in a clayey red soil. Compared with conventional tillage（C） and deep tillage（D）, soil compaction（P） and no-till（N） significantly increased soil PR in the 0-15 cm layer. The PR increased dramatically as the soil drying increased, particularly in soil with a high bulk density. Increased soil PR reduced the maize root mass density distribution not only in the vertical profile（0-20 cm） but also in the horizontal layer at the same distance（0-5, 5-10, 10-15 cm） from the maize plant. With an increase in soil PR in pots, the maize root length, root surface area and root volume significantly decreased. Specifically, the maize root length declined exponentially from 309 to 64 cm per plant with an increase in soil PR from 491 to 3 370 k Pa; the roots almost stopped elongating when the soil PR was larger than 2 200 k Pa. It appeared that fine roots（〈2.5 mm in diameter） thickened when the soil PR increased, resulting in a larger average root diameter. The average root diameter increased linearly with soil PR, regardless of soil irrigation or drought. The results suggest that differences in soil PR caused by soil drying is most likely responsible for inconsistent root responses to water stress in different soils.展开更多
The title compound, 1-4-（dimethylamino）benzylidene）-4-（naphthalene-1-yl） thiosemicarbazide （DMABNTS, C20H20N4S, Mr = 348.47）, was synthesized and characterized by elemental analysis, 1R, ^1H NMR and MS. The cry...The title compound, 1-4-（dimethylamino）benzylidene）-4-（naphthalene-1-yl） thiosemicarbazide （DMABNTS, C20H20N4S, Mr = 348.47）, was synthesized and characterized by elemental analysis, 1R, ^1H NMR and MS. The crystal structure of DMABNTS with 1,4-dioxane （Diox, C4H8O2） solvent molecules （DMABNTS·2Diox, C28H36N4O4S, Mr = 524.67） was determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic system, space group P21/c with a = 14.418（4）, b = 7.1702（19）, c = 28.350（7）°A,β= 101.154（6）°, V= 2875.4（13） °A^3, Z= 4, Dc= 1.212 g/cm^3, F（000） = 1120 and μ= 0.151 mm^-1. A total of 6458 reflections were collected, of which 4671 were unique. The structure was solved by direct methods and refined to the final R = 0.0732 and wR = 0.2127 for 3921 observed reflections （I〉 2σ（I））. There exist intermolecular hydrogen bonds （N（2）-H（2B）…S（1A）and N（1）-H（1A）…O（4B）） in the structure. The study of fluorescent properties ＇shows that DMABNTS emits bright solid-state fluorescence in the visible region and exhibits blue photoluminescence.展开更多
文摘目的:探讨血清中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)、降钙素基因相关肽(calcitonin gene-related peptide,CGRP)、中性粒细胞计数与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)对老年脑卒中并发肺部感染(stroke complicated with pulmonary infection,SCPI)患者预后转归的预测价值。方法:本研究为回顾性单中心研究,选取2020年6月至2024年6月内蒙古包钢医院收治的149例老年SCPI患者,根据预后转归分为预后不良组(n=58)和预后良好组(n=91)。收集基线资料、实验室检查指标,并计算NLR。采用酶联免疫法检测血清NGAL、CGRP水平。多因素Logistic回归分析老年SCPI患者预后不良影响因素。受试者工作特征(receiver operating characteristic,ROC)曲线分析预测价值。结果:与预后良好组比较,预后不良组年龄≥70岁、出血性脑卒中比例、血肌酐、白细胞计数、美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分、血小板计数、C反应蛋白、NGAL、NLR水平升高,神经外科重症监护室(nerosurgery intensive care unit,NICU)时间延长,CGRP水平降低(P<0.05)。CGRP升高为老年SCPI患者预后不良保护因素(OR<1,P<0.05)。年龄≥70岁、出血性脑卒中、NICU时间延长、NIHSS评分升高、NGAL水平升高、NLR升高为老年SCPI患者预后不良危险因素(OR>1,P<0.05)。NGAL、CGRP、NLR单独和三项联合预测老年SCPI患者预后转归的曲线下面积(area under the curve,AUC)分别为0.777、0.771、0.786、0.927,三项联合预测老年SCPI患者预后转归效能最高(P<0.05)。结论:年龄≥70岁、出血性脑卒中、NICU时间延长和NIHSS评分升高、NGAL水平升高、NLR升高是老年SCPI患者预后不良的危险因素,CGRP水平升高为独立保护因素。联合检测NGAL、CGRP、NLR能提升老年SCPI患者预后转归的预测价值。
基金This work was supported by the Fund of Longyan College (No. Z03103)
文摘O-Ethyl S-hydrogen isoquinolin-l-ylcarbonothioimidate was synthesized and its structure was characterized by IR, MS, ^1H NMR, elemental analysis and single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group P21/c with a = 10.9471（19）, b = 9.3968（17）, c = 10.6125（19） A, β = 100.761 （3）°, V = 1072.5（3） A^3, Z = 4, Dc = 1.439 g/cm^3, F（000） = 488 and μ = 0.279 mm^-1. A total of 7763 reflections were collected, of which 2090 were unique. The structure was refined to the final R = 0.0322 and wR = 0.0882 for 2016 observed reflections with Ⅰ 〉 2σ（Ⅰ）. The crystal structure shows that there are intramolecular N-H…S hydrogen bonds and π-π stacking interactions between adjacent molecules.
文摘目的:研究吡拉西坦联合胞磷胆碱对急性脑梗死认知功能和神经功能的影响。方法:选择2014年1月~2018年1月我院的150例急性脑梗死患者,随机分为两组。对照组采用吡拉西坦治疗,观察组采用吡拉西坦联合胞磷胆碱治疗。采用神经功能缺损程度(National Institutes of Health Stroke Scale,NIHSS)、析蒙特利尔认知评估量表(Montreal cognitive assessment scale,Mo CA)和日常生活能力(Activities of daily living,ADL)评分量表,比较两组治疗前后神经功能、认识功能和日常生活能力变化。结果:观察组基本治愈15例,显效30例,有效26例,无效4例,恶化1例,总有效率为94.67%,明显高于对照组(P<0.05);治疗后,两组的ADL和Mo CA评分明显升高,神经功能缺损量表(National Institutes of Health Stroke Scale,NHISS)评分明显降低,且观察组的ADL、Mo CA和NHISS评分明显优于对照组(均P<0.05);治疗后,两组的血清细胞凋亡蛋白酶-3(cysteinyl aspartate specific proteinase-3,Caspase-3)和低氧诱导因子-1α(Hypoxia-inducible factor 1α,HIF-1α)水平均明显降低,且观察组明显低于对照组(均P<0.05);对照组发生干呕1例(1.33%),恶心2例(2.67%),头痛1例(1.33%),头晕1例(1.33%);观察组发生干呕1例(1.33%),恶心1例(1.33%),头痛1例(1.33%),出血1例(1.33%);两组无明显差异(P>0.05)。结论:吡拉西坦联合胞磷胆碱能改善急性脑梗死的认知功能和神经功能,其机制可能与调节细胞诱导因子Caspase-3和HIF-1α的表达水平相关。
文摘目的探讨多学科协助膳食干预追踪对肥胖冠心病患者体质指数、血脂、血糖及饮食依从性和生活质量的影响。方法选取2017年1月—2020年10月汕头市潮阳区人民医院心血管内科收治身体质量指数(body mass index,BMI)≥25的冠心病患者100例,按随机数字表法分为对照组和实验组,各组50例。对照组予常规的膳食干预,实验组则在多学科协作下进行膳食干预3个月,并全程追踪,比较两组干预前后体质指数、血脂、血糖、膳食营养摄入水平、饮食依从性及生活质量。结果实验组干预后体重(70.51±6.86)kg、腰围(93.25±9.01)cm、BMI(26.01±4.17)、甘油三酯(triglyceride,TG)(1.88±0.24)mmol/L、总胆固醇(total cholesterol,TC)(5.22±0.69)mmol/L及空腹胰岛素(fasting insulin,FINS)(5.21±4.01)mIU/L指标水平均低于对照组[体重(74.22±8.05)kg、腰围(98.02±8.25)cm、BMI(28.15±4.96)、TG(2.55±0.45)mmol/L、TC(6.15±0.82)mmol/L及FINS(6.91±3.55)mIU/L],差异均有统计学意义(P<0.05);实验组干预后营养摄入总能量(1295.22±495.25)kcal、脂肪(49.56±23.28)g均低于对照组[总能量(1671.24±601.75)kcal、脂肪(68.81±45.25)g],膳食纤维(13.59±4.55)g高于对照组(11.77±4.25)g,差异均有统计学意义(P<0.05);实验组干预后饮食依从性[(25.56±4.49)分]及生活质量[(76.98±14.51)分]得分改善情况优于对照组[饮食依从性(23.19±4.73)分、生活质量(69.83±13.66)分],差异均有统计学意义(P<0.05)。结论多学科协助膳食干预追踪能在一定程度上改善肥胖冠心病患者体质指数、血脂及血糖水平,提高患者饮食依从性及生活质量。
基金supported by the National Natural Science Foundation of China (41271240)
文摘Soil drying may induce a number of stresses on crops. This paper investigated maize（Zea mays L.） root growth as affected by drought and soil penetration resistance（PR）, which was caused by soil drying and tillage in a clayey red soil. Compared with conventional tillage（C） and deep tillage（D）, soil compaction（P） and no-till（N） significantly increased soil PR in the 0-15 cm layer. The PR increased dramatically as the soil drying increased, particularly in soil with a high bulk density. Increased soil PR reduced the maize root mass density distribution not only in the vertical profile（0-20 cm） but also in the horizontal layer at the same distance（0-5, 5-10, 10-15 cm） from the maize plant. With an increase in soil PR in pots, the maize root length, root surface area and root volume significantly decreased. Specifically, the maize root length declined exponentially from 309 to 64 cm per plant with an increase in soil PR from 491 to 3 370 k Pa; the roots almost stopped elongating when the soil PR was larger than 2 200 k Pa. It appeared that fine roots（〈2.5 mm in diameter） thickened when the soil PR increased, resulting in a larger average root diameter. The average root diameter increased linearly with soil PR, regardless of soil irrigation or drought. The results suggest that differences in soil PR caused by soil drying is most likely responsible for inconsistent root responses to water stress in different soils.
文摘The title compound, 1-4-（dimethylamino）benzylidene）-4-（naphthalene-1-yl） thiosemicarbazide （DMABNTS, C20H20N4S, Mr = 348.47）, was synthesized and characterized by elemental analysis, 1R, ^1H NMR and MS. The crystal structure of DMABNTS with 1,4-dioxane （Diox, C4H8O2） solvent molecules （DMABNTS·2Diox, C28H36N4O4S, Mr = 524.67） was determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic system, space group P21/c with a = 14.418（4）, b = 7.1702（19）, c = 28.350（7）°A,β= 101.154（6）°, V= 2875.4（13） °A^3, Z= 4, Dc= 1.212 g/cm^3, F（000） = 1120 and μ= 0.151 mm^-1. A total of 6458 reflections were collected, of which 4671 were unique. The structure was solved by direct methods and refined to the final R = 0.0732 and wR = 0.2127 for 3921 observed reflections （I〉 2σ（I））. There exist intermolecular hydrogen bonds （N（2）-H（2B）…S（1A）and N（1）-H（1A）…O（4B）） in the structure. The study of fluorescent properties ＇shows that DMABNTS emits bright solid-state fluorescence in the visible region and exhibits blue photoluminescence.
