Raman imaging,as a molecular spectroscopy technique,has been widely studied and applied in research fields such as life sciences and food safety due to its excellent specificity and high resolution.However,its develop...Raman imaging,as a molecular spectroscopy technique,has been widely studied and applied in research fields such as life sciences and food safety due to its excellent specificity and high resolution.However,its development still faces challenges such as weak signals,slow acquisition speed,and insufficient penetration depth.In recent years,the rapid development of aggregate science has provided new insights for addressing these limitations.Aggregation-induced emission(AIE)materials exhibit enhanced signals in the aggregated state,which may compensate for the inherent weak Raman signals.This article reviews the cutting-edge progress of Raman imaging technology and its current status in cross-disciplinary research with aggregate science,emphasizing the strategy of constructing AIE-Raman dual-responsive probes through molecular engineering to achieve functional complementarity between fluorescence localization and Raman quantification,thereby significantly improving detection sensitivity and specificity.These probes have demonstrated single-cell resolution and high spatiotemporal accuracy in applications such as tumor surgical navigation,diagnosis and treatment of drug-resistant bacteria,and dynamic monitoring of organelles.We also analyze the bottlenecks in this field,such as biological safety and the complexity of molecular design,and outline the future development directions,including intelligent responsive probes,artificial intelligence-assisted analysis,and multimodal fusion platforms.The integration of Raman imaging and AIE sheds new light in the field of medical imaging.展开更多
目的分析糖尿病肾病氧化应激的研究现状、热点和发展趋势。方法检索中国知网、万方数据知识服务平台、维普网及Web of Science核心合集数据库中关于糖尿病肾病氧化应激研究的相关文章,检索时限为2015年9月1日至2025年9月1日;使用CiteSpa...目的分析糖尿病肾病氧化应激的研究现状、热点和发展趋势。方法检索中国知网、万方数据知识服务平台、维普网及Web of Science核心合集数据库中关于糖尿病肾病氧化应激研究的相关文章,检索时限为2015年9月1日至2025年9月1日;使用CiteSpace V6.4.R1软件绘制可视化图谱并对其进行分析。结果共纳入2040篇文献,其中中文文献1004篇,英文文献1036篇。中文文献发文量最多的作者为刘华、刘圣君;英文文献发文量最多的作者为Sun Lin。中文文献发文量最多的机构是山东中医药大学;英文文献发文量最多的机构是Central South University。中英文文献使用频次前3位的关键词均是糖尿病肾病、氧化应激、炎症。关键词聚类分析共得到16个中、英文聚类,关键词突现分析共得到25个中文突现词和25个英文突现词。结论糖尿病肾病氧化应激研究逐渐成熟,对其进行深入探讨有望为糖尿病肾病的诊治提供新策略。展开更多
文摘Raman imaging,as a molecular spectroscopy technique,has been widely studied and applied in research fields such as life sciences and food safety due to its excellent specificity and high resolution.However,its development still faces challenges such as weak signals,slow acquisition speed,and insufficient penetration depth.In recent years,the rapid development of aggregate science has provided new insights for addressing these limitations.Aggregation-induced emission(AIE)materials exhibit enhanced signals in the aggregated state,which may compensate for the inherent weak Raman signals.This article reviews the cutting-edge progress of Raman imaging technology and its current status in cross-disciplinary research with aggregate science,emphasizing the strategy of constructing AIE-Raman dual-responsive probes through molecular engineering to achieve functional complementarity between fluorescence localization and Raman quantification,thereby significantly improving detection sensitivity and specificity.These probes have demonstrated single-cell resolution and high spatiotemporal accuracy in applications such as tumor surgical navigation,diagnosis and treatment of drug-resistant bacteria,and dynamic monitoring of organelles.We also analyze the bottlenecks in this field,such as biological safety and the complexity of molecular design,and outline the future development directions,including intelligent responsive probes,artificial intelligence-assisted analysis,and multimodal fusion platforms.The integration of Raman imaging and AIE sheds new light in the field of medical imaging.
文摘目的分析糖尿病肾病氧化应激的研究现状、热点和发展趋势。方法检索中国知网、万方数据知识服务平台、维普网及Web of Science核心合集数据库中关于糖尿病肾病氧化应激研究的相关文章,检索时限为2015年9月1日至2025年9月1日;使用CiteSpace V6.4.R1软件绘制可视化图谱并对其进行分析。结果共纳入2040篇文献,其中中文文献1004篇,英文文献1036篇。中文文献发文量最多的作者为刘华、刘圣君;英文文献发文量最多的作者为Sun Lin。中文文献发文量最多的机构是山东中医药大学;英文文献发文量最多的机构是Central South University。中英文文献使用频次前3位的关键词均是糖尿病肾病、氧化应激、炎症。关键词聚类分析共得到16个中、英文聚类,关键词突现分析共得到25个中文突现词和25个英文突现词。结论糖尿病肾病氧化应激研究逐渐成熟,对其进行深入探讨有望为糖尿病肾病的诊治提供新策略。
