The staggered InGaN quantum well (QW) structure and the conventional InGaN QW structure for the emission at a particu-lar wavelength of 400 nm are designed and theoretically investigated,including the distribution of ...The staggered InGaN quantum well (QW) structure and the conventional InGaN QW structure for the emission at a particu-lar wavelength of 400 nm are designed and theoretically investigated,including the distribution of the carriers’ concentration,the radiative recombination rate,the Shockley-Read-Hall (SRH) recombination rate as well as the output performance and the internal quantum efficiency. The theoretical result indicates that the staggered QW structure offers significant improve-ment of carriers’ concentration in the QW,especially the hole concentration. The output power and the internal quantum efficiency also show 32.6 % and 32.5 % enhancement,respectively,in comparison with that of the conventional InGaN QW structure. The reduction of the electron overflow can be the main factor for the improvement of the optical perfor-mance for novel staggered InGaN QW structure.展开更多
目的评估婴幼儿孤独症筛查量表(checklist for autism in toddlers-23,CHAT-23)在江西省儿童中的临床应用效果。方法选取于2015年1月至2016年6月在江西省儿童医院就诊的儿童,以CHAT-23量表为筛查工具对其进行孤独症谱系障碍(autism spec...目的评估婴幼儿孤独症筛查量表(checklist for autism in toddlers-23,CHAT-23)在江西省儿童中的临床应用效果。方法选取于2015年1月至2016年6月在江西省儿童医院就诊的儿童,以CHAT-23量表为筛查工具对其进行孤独症谱系障碍(autism spectrum disorder,ASD)的早期筛查。58例年龄为18～48月龄在心理行为门诊确诊为ASD的儿童为ASD组,同期同年龄在儿童保健科就诊的110例健康儿童为对照组。以美国精神障碍诊断与统计手册第5版(the diagnostic and statistical manual of mental disorders-5,DSM-5)中ASD诊断标准联合儿童孤独症评定量表(childhood autism rating scale,CARS)为ASD诊断标准,对CHAT-23量表进行筛查指标的评价。结果 2组儿童共168例,CHAT-23量表评定为阳性有73例,其中CHAT-23量表并联筛查法评定阳性ASD组为57例,对照组为16例。CHAT-23量表筛查法评估结果:灵敏度=0.98,特异度=0.85,阳性预测值=0.79,Kappa值=0.78。家长问卷条目、核心条目和观察条目ROC曲线下面积(AUC)分别是0.990(P<0.001)、0.979(P<0.001)和0.973(P<0.001)。结论 CHAT-23量表筛查法用时少、成本低、灵敏度高,有较强的筛出ASD患儿的能力,适用于江西省ASD早期筛查。展开更多
The effects of salt stress on photosynthesis,Mehler-peroxidase reaction(MPR)and the susceptibility of PS ll to photoinhibition were investigated in Rumex K-1 leaves.Salt stress resulted in dramatic decrease in photosy...The effects of salt stress on photosynthesis,Mehler-peroxidase reaction(MPR)and the susceptibility of PS ll to photoinhibition were investigated in Rumex K-1 leaves.Salt stress resulted in dramatic decrease in photosynthesis,but had no significant effect on maximal photochemistry of PS ll(Fv/Fm).During photosynthetic induction,a considerable electron flow was transported to oxygen in MPR both in control and salt-stressed leaves.Under steady state photosynthesis,enhanced electron flow to oxygen in MPR was observed only in salt-stressed leaves.The enhanced MPR in salt-stressed leave was accompanied by enhanced activities of scavenging enzymes,i.e.superoxidase dismutase(SOD)and ascor-bate peroxidase(APX).In the presence of saturating CO_(2).decreasing oxygen concentration from 21%to 2%did not affect the susceptibility to photoinhibition in control leaves,but largely increased the suscep-tibility to photoinhibition in salt-stressed leaves.Based on these results,it is concluded that the enhanced MPR in salt-stressed Rumex leaves serves as a sink to drain the excess electrons off the electron chain and thus mitigates photoinhibition.展开更多
目的明确1例特殊面容、生长迟缓、肢体异常患儿的致病基因变异及来源,为疾病的诊断和遗传咨询提供依据。方法采集患儿及其父母外周血样并提取DNA,进行全外显子组测序检测,结合生物信息学分析方法进行数据分析,获取致病性基因变异位点,...目的明确1例特殊面容、生长迟缓、肢体异常患儿的致病基因变异及来源,为疾病的诊断和遗传咨询提供依据。方法采集患儿及其父母外周血样并提取DNA,进行全外显子组测序检测,结合生物信息学分析方法进行数据分析,获取致病性基因变异位点,最后利用Sanger测序进行验证。结果全外显子组测序结果显示位于5号染色体的NIPBL基因42号外显子上发现错义变异c.7177T>C(p.Ser2393Pro),该变异各人群数据库中未见收录。经父母Sanger验证显示,父母均无携带,属于新发变异(de novo mutation)。结合临床症状和基因检测结果,该患儿确诊为经典型德朗热综合征(Cornelia de Lange syndrome,CdLS)。结论对于特殊面容、生长迟缓、肢体异常的患儿应考虑CdLS可能,并常规进行基因检测明确诊断,有助于患儿随访管理、预后评估及遗传咨询等。展开更多
基金the National Natural Science Foundation of China (Grant No.10474020)Knowledge Innovation Program of the Chinese Academy of Sciences (No.C2-14)
文摘The staggered InGaN quantum well (QW) structure and the conventional InGaN QW structure for the emission at a particu-lar wavelength of 400 nm are designed and theoretically investigated,including the distribution of the carriers’ concentration,the radiative recombination rate,the Shockley-Read-Hall (SRH) recombination rate as well as the output performance and the internal quantum efficiency. The theoretical result indicates that the staggered QW structure offers significant improve-ment of carriers’ concentration in the QW,especially the hole concentration. The output power and the internal quantum efficiency also show 32.6 % and 32.5 % enhancement,respectively,in comparison with that of the conventional InGaN QW structure. The reduction of the electron overflow can be the main factor for the improvement of the optical perfor-mance for novel staggered InGaN QW structure.
文摘目的评估婴幼儿孤独症筛查量表(checklist for autism in toddlers-23,CHAT-23)在江西省儿童中的临床应用效果。方法选取于2015年1月至2016年6月在江西省儿童医院就诊的儿童,以CHAT-23量表为筛查工具对其进行孤独症谱系障碍(autism spectrum disorder,ASD)的早期筛查。58例年龄为18～48月龄在心理行为门诊确诊为ASD的儿童为ASD组,同期同年龄在儿童保健科就诊的110例健康儿童为对照组。以美国精神障碍诊断与统计手册第5版(the diagnostic and statistical manual of mental disorders-5,DSM-5)中ASD诊断标准联合儿童孤独症评定量表(childhood autism rating scale,CARS)为ASD诊断标准,对CHAT-23量表进行筛查指标的评价。结果 2组儿童共168例,CHAT-23量表评定为阳性有73例,其中CHAT-23量表并联筛查法评定阳性ASD组为57例,对照组为16例。CHAT-23量表筛查法评估结果:灵敏度=0.98,特异度=0.85,阳性预测值=0.79,Kappa值=0.78。家长问卷条目、核心条目和观察条目ROC曲线下面积(AUC)分别是0.990(P<0.001)、0.979(P<0.001)和0.973(P<0.001)。结论 CHAT-23量表筛查法用时少、成本低、灵敏度高,有较强的筛出ASD患儿的能力,适用于江西省ASD早期筛查。
文摘The effects of salt stress on photosynthesis,Mehler-peroxidase reaction(MPR)and the susceptibility of PS ll to photoinhibition were investigated in Rumex K-1 leaves.Salt stress resulted in dramatic decrease in photosynthesis,but had no significant effect on maximal photochemistry of PS ll(Fv/Fm).During photosynthetic induction,a considerable electron flow was transported to oxygen in MPR both in control and salt-stressed leaves.Under steady state photosynthesis,enhanced electron flow to oxygen in MPR was observed only in salt-stressed leaves.The enhanced MPR in salt-stressed leave was accompanied by enhanced activities of scavenging enzymes,i.e.superoxidase dismutase(SOD)and ascor-bate peroxidase(APX).In the presence of saturating CO_(2).decreasing oxygen concentration from 21%to 2%did not affect the susceptibility to photoinhibition in control leaves,but largely increased the suscep-tibility to photoinhibition in salt-stressed leaves.Based on these results,it is concluded that the enhanced MPR in salt-stressed Rumex leaves serves as a sink to drain the excess electrons off the electron chain and thus mitigates photoinhibition.
文摘目的明确1例特殊面容、生长迟缓、肢体异常患儿的致病基因变异及来源,为疾病的诊断和遗传咨询提供依据。方法采集患儿及其父母外周血样并提取DNA,进行全外显子组测序检测,结合生物信息学分析方法进行数据分析,获取致病性基因变异位点,最后利用Sanger测序进行验证。结果全外显子组测序结果显示位于5号染色体的NIPBL基因42号外显子上发现错义变异c.7177T>C(p.Ser2393Pro),该变异各人群数据库中未见收录。经父母Sanger验证显示,父母均无携带,属于新发变异(de novo mutation)。结合临床症状和基因检测结果,该患儿确诊为经典型德朗热综合征(Cornelia de Lange syndrome,CdLS)。结论对于特殊面容、生长迟缓、肢体异常的患儿应考虑CdLS可能,并常规进行基因检测明确诊断,有助于患儿随访管理、预后评估及遗传咨询等。
