Four new polyhydroxylated steroids plaksterols A–D(1–4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol(5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol(6), were isolated from m...Four new polyhydroxylated steroids plaksterols A–D(1–4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol(5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol(6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells.展开更多
基金supported by the National Key Research and Development Program of China (No. 2018YFC-0310903)the National Natural Science Foundation of China (Nos.21572210,41776136 and 81991522)NSFC-Shandong Joint Fund for Marine Science Research Centers (No. U1606403)。
文摘Four new polyhydroxylated steroids plaksterols A–D(1–4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol(5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol(6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells.
