目的了解年轻男男性行为者(young men who have sex with men,YMSM)偶遇性伴现状,分析关联因素。方法2016年9月—2019年9月用“滚雪球”抽样法,对绵阳市YMSM偶遇性伴现状进行问卷调查和人类免疫缺陷病毒(HIV)、梅毒血清学检测,用χ^(2)...目的了解年轻男男性行为者(young men who have sex with men,YMSM)偶遇性伴现状,分析关联因素。方法2016年9月—2019年9月用“滚雪球”抽样法,对绵阳市YMSM偶遇性伴现状进行问卷调查和人类免疫缺陷病毒(HIV)、梅毒血清学检测,用χ^(2)检验,多因素二分类Logistics回归分析偶遇性伴的关联因素。结果共调查351人,最近6个月有肛交250人,其中有偶遇性伴者112人,占44.8%(112/250),平均性伴(1.9±1.6)人,每次使用安全套者92人。最近6个月有无偶遇性伴者HIV、梅毒阳性率差异均无统计学意义(P>0.05)。多因素分析发现,性角色均可(OR=2.921,95%CI:1.079~4.864)、最近6个月多性伴(OR=9.424,95%CI:4.494~19.762)、最近6个月群交(OR=25.537,95%CI:2.098~310.891)、自我接纳得分越高(OR=1.627,95%CI:1.104~2.398)者有偶遇性伴的可能更大,最近6个月有固定性伴者(OR=0.082,95%CI:0.035~0.188)有偶遇性伴的可能更小(P<0.05)。结论YMSM偶遇性伴普遍,其偶遇性伴与性角色、性行为和自我接纳相关联,行为风险较大,应针对性开展行为干预。展开更多
The nitro-substituted derivatives of guanine are designed and calculated to explore novel high energy density materials.To explore the thermal stability of title molecules,the heat of formation(HOF),bond dissociation ...The nitro-substituted derivatives of guanine are designed and calculated to explore novel high energy density materials.To explore the thermal stability of title molecules,the heat of formation(HOF),bond dissociation energy(BDE),and bond order of the trigger bond are calculated.To predict the possibility used as high energy density compounds,the detonation pressure(P),detonation velocity(D),explosive heat(Q),and crystal density(ρ)are calculated by using the classical Kamlet-Jacobs(K-J)equation.Based on our calculations,E(D=8.93 km/s,P=37.21 GPa)is confirmed as the potential high energy density compound.展开更多
目的了解男男性行为人群(men who have sex with men,MSM)应对方式的现状,分析不同人口学特征应对方式差异。方法2015年3~10月采用滚雪球抽样法,选取简易应付方式问卷(SCSQ)对四川省绵阳市MSM进行匿名问卷调查和艾滋病病毒(HIV)、梅毒(...目的了解男男性行为人群(men who have sex with men,MSM)应对方式的现状,分析不同人口学特征应对方式差异。方法2015年3~10月采用滚雪球抽样法,选取简易应付方式问卷(SCSQ)对四川省绵阳市MSM进行匿名问卷调查和艾滋病病毒(HIV)、梅毒(TP)血清学检测。结果调查对象各维度分值分别为:积极应对(1.64±0.46)分、消极应对(1.21±0.51)分,差异有统计学意义(t=32.492,P=0.000),均高于常模(P均〈0.01)。HIV阳性率6.06%,TP阳性率6.49%;HIV感染与否消极应对得分差异有统计学意义(P〈0.05),感染者消极应对得分较高。年龄与积极应对、消极应对均呈负相关(P均〈0.01)。不同文化程度、婚姻状况、户籍、性取向、本地居住时间、居住地区积极应对得分,不同婚姻状况、户籍、性取向消极应对得分差异有统计学意义(P均〈0.05)。结论MSM应对方式倾向积极,应对方式与人口学特征相关,消极应对增大了HIV感染风险。展开更多
A series of derivatives of pyridazine were designed through substituting hydrogens on the pyridazine ring with nitro groups.To explore the thermal stability of the title molecules,heats of formation,bond dissociation ...A series of derivatives of pyridazine were designed through substituting hydrogens on the pyridazine ring with nitro groups.To explore the thermal stability of the title molecules,heats of formation,bond dissociation energies,and bond orders were calculated at the B3PW91/6-311+G(d,p)level.To confirm the potential usage as high energy density compounds,the detonation pressure and detonation velocity were predicted by using the empirical Kamlet-Jacobs(K-J)equation.Based on our calculated results,both thermal and kinetic stabilities of the title molecules are confirmed with good detonation characters.Especially,3,4,5-trinitropyridazide and 3,4,6-trinitropyridazide represent excellent detonation parameters better than 1,3,5-trinitro-1,3,5-triazacyclohexane(RDX)and are screened out as potential high energy density compounds.展开更多
At the B3PW91/6-311+G(d,p)//MP2/6-311+G(d,p)level,molecular densities,detonation velocities,and detonation pressures of nitroso substituted derivatives of azetidine with their thermal stabilities were investigated to ...At the B3PW91/6-311+G(d,p)//MP2/6-311+G(d,p)level,molecular densities,detonation velocities,and detonation pressures of nitroso substituted derivatives of azetidine with their thermal stabilities were investigated to look for high energy density compounds(HEDCs).It was found that the azetidine derivatives had high heat of formation(HOF)and large bond dissociation energy(BDE).Intramolecular hydrogen bonds were located in three molecules(1,4,and 5),and the molecular stability were improved markedly as well.For 5 and 6,the detonation performances(D=9.36km/s and 10.80km/s,P=44.42GPa and 60.70GPa,respectively)meet requirements as high energy density compounds.This work may provide basic information for further study of title compounds.展开更多
Nitro and amino groups were introduced into piperidine skeleton to design derivatives of piperidine(labeled asα,β1,β2,β3,γandδ).Heats of formation(HOFs)are calculated in detail at the B3PW91/6-311+G(d,p)level fo...Nitro and amino groups were introduced into piperidine skeleton to design derivatives of piperidine(labeled asα,β1,β2,β3,γandδ).Heats of formation(HOFs)are calculated in detail at the B3PW91/6-311+G(d,p)level for these aminonitropiperidines.The results show that all derivatives have negative heats of formation,which were affected by the positions of substituted groups.The molecular stability is estimated and analyzed based on bond dissociation energies(BDE)and characteristic heights(H50).All derivatives designed in this paper are confirmed with lower impact sensitivity than 1,3,5-trinitro-1,3,5-triazinane(RDX)and 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX).Furthermore,the detonation velocities(D)and the detonation pressures(P)are predicted via the Kamlet-Jacobs equation.In all these molecules,δhas comparable detonation character with that of RDX and HMX and can be the candidate of high-energy-density compounds(HEDCs).展开更多
The azide oxiranes were studied at the CCSD(T)/cc-PVDZ//MP2/cc-PVDZ level in this paper.The sublimation enthalpies and heats of formation both in gas phase and solid state were calculated.The thermodynamics stability ...The azide oxiranes were studied at the CCSD(T)/cc-PVDZ//MP2/cc-PVDZ level in this paper.The sublimation enthalpies and heats of formation both in gas phase and solid state were calculated.The thermodynamics stability was predicted by using the bond dissociation energy and characteristic height,through which all title compounds are confirmed to be more stable than hexanitrohexaazaisowurtzitane(CL-20)and A,B1 and D are less sensitive than hexahydro-1,3,5,-trinitro-1,3,5-triazine(RDX).Furthermore,the detonation property was measured by the specific impulse.The detonation performance of the title compounds is comparable to that of RDX.Our results can provide basic information for the molecular design of novel high-energy-density compounds.展开更多
文摘目的了解年轻男男性行为者(young men who have sex with men,YMSM)偶遇性伴现状,分析关联因素。方法2016年9月—2019年9月用“滚雪球”抽样法,对绵阳市YMSM偶遇性伴现状进行问卷调查和人类免疫缺陷病毒(HIV)、梅毒血清学检测,用χ^(2)检验,多因素二分类Logistics回归分析偶遇性伴的关联因素。结果共调查351人,最近6个月有肛交250人,其中有偶遇性伴者112人,占44.8%(112/250),平均性伴(1.9±1.6)人,每次使用安全套者92人。最近6个月有无偶遇性伴者HIV、梅毒阳性率差异均无统计学意义(P>0.05)。多因素分析发现,性角色均可(OR=2.921,95%CI:1.079~4.864)、最近6个月多性伴(OR=9.424,95%CI:4.494~19.762)、最近6个月群交(OR=25.537,95%CI:2.098~310.891)、自我接纳得分越高(OR=1.627,95%CI:1.104~2.398)者有偶遇性伴的可能更大,最近6个月有固定性伴者(OR=0.082,95%CI:0.035~0.188)有偶遇性伴的可能更小(P<0.05)。结论YMSM偶遇性伴普遍,其偶遇性伴与性角色、性行为和自我接纳相关联,行为风险较大,应针对性开展行为干预。
基金supported by the Natural Science Foundation of Guizhou Province(Nos.QKHPTRC[2018]5778-09 and QKHJC[2020]1Y038)the Natural Science Foundation of Guizhou Education University(Nos.14BS017 and 2019ZD001)。
文摘The nitro-substituted derivatives of guanine are designed and calculated to explore novel high energy density materials.To explore the thermal stability of title molecules,the heat of formation(HOF),bond dissociation energy(BDE),and bond order of the trigger bond are calculated.To predict the possibility used as high energy density compounds,the detonation pressure(P),detonation velocity(D),explosive heat(Q),and crystal density(ρ)are calculated by using the classical Kamlet-Jacobs(K-J)equation.Based on our calculations,E(D=8.93 km/s,P=37.21 GPa)is confirmed as the potential high energy density compound.
文摘目的了解男男性行为人群(men who have sex with men,MSM)应对方式的现状,分析不同人口学特征应对方式差异。方法2015年3~10月采用滚雪球抽样法,选取简易应付方式问卷(SCSQ)对四川省绵阳市MSM进行匿名问卷调查和艾滋病病毒(HIV)、梅毒(TP)血清学检测。结果调查对象各维度分值分别为:积极应对(1.64±0.46)分、消极应对(1.21±0.51)分,差异有统计学意义(t=32.492,P=0.000),均高于常模(P均〈0.01)。HIV阳性率6.06%,TP阳性率6.49%;HIV感染与否消极应对得分差异有统计学意义(P〈0.05),感染者消极应对得分较高。年龄与积极应对、消极应对均呈负相关(P均〈0.01)。不同文化程度、婚姻状况、户籍、性取向、本地居住时间、居住地区积极应对得分,不同婚姻状况、户籍、性取向消极应对得分差异有统计学意义(P均〈0.05)。结论MSM应对方式倾向积极,应对方式与人口学特征相关,消极应对增大了HIV感染风险。
基金supported by the Foundation of Natural Science of Guizhou Education University(No.14BS017)。
文摘A series of derivatives of pyridazine were designed through substituting hydrogens on the pyridazine ring with nitro groups.To explore the thermal stability of the title molecules,heats of formation,bond dissociation energies,and bond orders were calculated at the B3PW91/6-311+G(d,p)level.To confirm the potential usage as high energy density compounds,the detonation pressure and detonation velocity were predicted by using the empirical Kamlet-Jacobs(K-J)equation.Based on our calculated results,both thermal and kinetic stabilities of the title molecules are confirmed with good detonation characters.Especially,3,4,5-trinitropyridazide and 3,4,6-trinitropyridazide represent excellent detonation parameters better than 1,3,5-trinitro-1,3,5-triazacyclohexane(RDX)and are screened out as potential high energy density compounds.
基金supported by the Natural Science Foundation of Guizhou Province(Nos.QKHPTRC[2018]5778-09 and QKHJC[2020]1Y038)the Natural Science Foundation of Guizhou Education University(Nos.14BS017 and 2019ZD001).
文摘At the B3PW91/6-311+G(d,p)//MP2/6-311+G(d,p)level,molecular densities,detonation velocities,and detonation pressures of nitroso substituted derivatives of azetidine with their thermal stabilities were investigated to look for high energy density compounds(HEDCs).It was found that the azetidine derivatives had high heat of formation(HOF)and large bond dissociation energy(BDE).Intramolecular hydrogen bonds were located in three molecules(1,4,and 5),and the molecular stability were improved markedly as well.For 5 and 6,the detonation performances(D=9.36km/s and 10.80km/s,P=44.42GPa and 60.70GPa,respectively)meet requirements as high energy density compounds.This work may provide basic information for further study of title compounds.
基金supported by the Natural Science Foundation of Guizhou Education University(Nos.14BS017 and 2019ZD001)the Natural Science Foundation of Guizhou Province(No.QKHPTRC20185778-09)。
文摘Nitro and amino groups were introduced into piperidine skeleton to design derivatives of piperidine(labeled asα,β1,β2,β3,γandδ).Heats of formation(HOFs)are calculated in detail at the B3PW91/6-311+G(d,p)level for these aminonitropiperidines.The results show that all derivatives have negative heats of formation,which were affected by the positions of substituted groups.The molecular stability is estimated and analyzed based on bond dissociation energies(BDE)and characteristic heights(H50).All derivatives designed in this paper are confirmed with lower impact sensitivity than 1,3,5-trinitro-1,3,5-triazinane(RDX)and 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX).Furthermore,the detonation velocities(D)and the detonation pressures(P)are predicted via the Kamlet-Jacobs equation.In all these molecules,δhas comparable detonation character with that of RDX and HMX and can be the candidate of high-energy-density compounds(HEDCs).
基金supported by the Natural Science Foundation of Guizhou Education University(No.14BS017)the Natural Science Foundation of Guizhou Province(No.QKHPTRC20185778-09)。
文摘The azide oxiranes were studied at the CCSD(T)/cc-PVDZ//MP2/cc-PVDZ level in this paper.The sublimation enthalpies and heats of formation both in gas phase and solid state were calculated.The thermodynamics stability was predicted by using the bond dissociation energy and characteristic height,through which all title compounds are confirmed to be more stable than hexanitrohexaazaisowurtzitane(CL-20)and A,B1 and D are less sensitive than hexahydro-1,3,5,-trinitro-1,3,5-triazine(RDX).Furthermore,the detonation property was measured by the specific impulse.The detonation performance of the title compounds is comparable to that of RDX.Our results can provide basic information for the molecular design of novel high-energy-density compounds.
