To explore the clinical characteristics,pathogenesis,and treatment efficacy of patients with stroke warning syndrome(SWS).Methods:Ten patients with internal capsule early warning syndrome who visited the Neurology Dep...To explore the clinical characteristics,pathogenesis,and treatment efficacy of patients with stroke warning syndrome(SWS).Methods:Ten patients with internal capsule early warning syndrome who visited the Neurology Department of our hospital from 2019 to 2023 were enrolled.Their clinical data were summarized,and the etiology,pathogenesis,imaging features,and treatment outcomes were discussed in light of previous literature.Results:Among the patients,there were 5 males and 5 females,with an average age of 60 years.The number of attacks ranged from 4 to 9,and the duration of each attack varied from 3 to 60 minutes.Five patients underwent intravenous thrombolysis.Four patients still experienced recurrent attacks after thrombolysis.They were then provided with volume expansion,anticoagulation,antiplatelet aggregation,vasospasm-relief therapies,and symptomatic treatment as appropriate.Three months later,the mRs score of all patients was≤2 points.Conclusion:Although SWS is not common,it is associated with a high risk of early infarction and a poor clinical prognosis.Clinicians should be fully aware of stroke warning syndrome and strive to prevent its clinical progression.展开更多
目的 报道1例有输血史和妊娠史的产生抗-Jr^(a)的孕妇的抗体鉴定、妊娠期间血液管理与胎儿新生儿溶血病(hemolytic disease of fetus and newborn,HDFN)的监测过程。方法 利用盐水凝集技术和抗人球蛋白技术完成孕妇血型鉴定、意外抗体...目的 报道1例有输血史和妊娠史的产生抗-Jr^(a)的孕妇的抗体鉴定、妊娠期间血液管理与胎儿新生儿溶血病(hemolytic disease of fetus and newborn,HDFN)的监测过程。方法 利用盐水凝集技术和抗人球蛋白技术完成孕妇血型鉴定、意外抗体筛查与鉴定、抗体效价及IgG亚类检测;利用PCR-SSP技术完成孕妇18个血型系统基因分型,利用二代测序技术完成38个血型系统基因测序,利用一代测序技术验证二代测序检出的稀有血型突变位点并对家系成员完成对应稀有血型基因测序调查。通过孕期门诊贫血管理和自体血采集为孕妇完成备血。对新生儿完成HDFN三项试验及新生儿血浆IgG亚类检测。结果 孕妇血型为B型RhD阳性,意外抗体筛查阳性,抗体鉴定符合高频抗原抗体格局。基因测序发现孕妇为ABCG2 c.376C>T纯合突变所致Jr(a-)表型,血浆中存在抗-Jr^(a)。家系成员中未找到与孕妇相合的Jr(a-)血液。孕妇孕期IgG抗体效价基本维持256,未检测到针对Jr^(a)抗原的IgG1和IgG3亚类抗体。孕期两次储备自体血液800 mL。新生儿为B型RhD阳性,Jr(a+),意外抗体筛查阳性(抗-Jr^(a)),IgG抗体亚类分型未检出IgG1和IgG3,直接抗人球蛋白试验阳性,酸放散阴性。结论 血清学和血型基因分析技术结合可为高频抗原抗体鉴定提供诊断依据,围产期贫血管理和阶段性储备自体血的方式保障患者围术期用血,IgG抗体亚类分型可为临床评估及预防HDFN提供参考依据。展开更多
目的分析健康素养和久坐行为在老年维持性血液透析(maintenance hemodialysis,MHD)患者孤独感对衰弱的链式中介作用。方法2022年1月至2023年12月,采用便利抽样法选取江苏省人民医院收治的216例老年MHD患者为研究对象,采用Tilburg衰弱量...目的分析健康素养和久坐行为在老年维持性血液透析(maintenance hemodialysis,MHD)患者孤独感对衰弱的链式中介作用。方法2022年1月至2023年12月,采用便利抽样法选取江苏省人民医院收治的216例老年MHD患者为研究对象,采用Tilburg衰弱量表(tilburg frailty index,TFI)、孤独感量表(University of California at Los Angeles loneliness scale,UCLA-LS)、慢性病患者健康素养量表(health literacy management scale,HeLMS)、老年人久坐行为问卷对其进行调查。结果老年MHD患者,久坐行为时间为(7.24±0.67)h/d。衰弱与孤独感、久坐行为之间呈正相关,与健康素养之间呈负相关(均P<0.05)。健康素养、久坐行为以及健康素养-久坐行为在孤独感与衰弱之间发挥部分中介效应,效应值分别为0.21、0.20、0.08,占总效应的20.39%、19.42%、7.76%。结论孤独感可以通过调节健康素养和久坐行为,间接影响老年MHD患者衰弱程度。展开更多
The aviation industry has become one of the top ten greenhouse gas emission industries in the world. China’s aviation carbon emissions continue to increase, but the analysis of its influencing factors at the provinci...The aviation industry has become one of the top ten greenhouse gas emission industries in the world. China’s aviation carbon emissions continue to increase, but the analysis of its influencing factors at the provincial level is still incomplete. This paper firstly uses Stochastic Impacts by Regression on Population, Affluence and Technology model(STIRPAT) model to analyze the time series evolution of China’s aviation carbon emissions from 2000 to 2019. Secondly, it uses the Logarithmic Mean Divisia Index(LDMI) model to analyze the influencing characteristics and degree of four factors on China’s aviation carbon emissions, which are air transportation revenue, aviation route structure, air transportation intensity and aviation energy intensity. Thirdly, it determines the various factors’ influencing direction and evolution trend of 31 provinces’ aviation carbon emissions in China(not including Hong Kong, Macao, Taiwan of China due to incomplete data). Finally, it derives the decoupling effort model and analyzes the decoupling relationship and decoupling effort degree between air carbon emissions and air transportation revenue in different provinces. The study found that from 2000 to2019, China’s total aviation carbon emissions continued to grow, while the growth rate of aviation carbon emissions showed a fluctuating downward trend. Air transportation revenue and aviation route structure promote the growth of total aviation carbon emissions, and air transportation intensity and aviation energy intensity have a restraining effect on the growth of total aviation carbon emissions. The scope of negative driving effect of air transportation revenue and air transportation intensity on total aviation carbon emissions in various provinces has increased. While the scope of positive driving influence of aviation route structure on total aviation carbon emissions of various provinces has increased, aviation energy intensity mainly has negative driving influence on total aviation carbon emissions of each province. Overall, the emission reduction trend in the areas to the west and north of the Qinling-Huaihe River Line is obvious. The decoupling mode between air carbon emissions and air transportation revenue in 31 provinces is mainly expansion negative decoupling.The air transportation intensity effect shows strong decoupling efforts in most provinces, the decoupling effort of aviation route structure effect and aviation energy intensity effect is not prominent.展开更多
OBJECTIVE:To evaluate the clinical efficacy and safety of external application of Chinese herbal medicine(exCHM)for psoriasis vulgaris(PV).METHODS:Different search portals,including the China National Knowledge Infras...OBJECTIVE:To evaluate the clinical efficacy and safety of external application of Chinese herbal medicine(exCHM)for psoriasis vulgaris(PV).METHODS:Different search portals,including the China National Knowledge Infrastructure Database,China Science and Technology Journal Database,Wanfang,Sino Med,clinicaltrials,Pub Med,Cochrane Library,and Cochrane Central Register of Controlled Trials,were searched for randomized controlled trials(RCTs)that compared the ex-CHM intervention with other treatment protocols for PV,with available data as of November 25,2020.The Review Manager 5.3 software was used for analysis.RESULTS:Nineteen RCTs involving 1988 participants were included,of which twelve RCTs qualified for the Meta-analysis.The results showed that the addition of CHM bath to narrow-band ultraviolet B(NB-UVB)had a higher response rate[RR=1.29;95%CI(1.19,1.40);P<0.00001];lower psoriasis area severity index(PASI)[MD=-3.15;95%CI(-4.79,-1.52);P=0.0002],adverse reactions rate[RR=0.32;95%CI(0.15,0.66);P=0.002],and recurrence rate[RR=0.48;95%CI(0.30,0.79);P=0.004]than NB-UVB alone.The addition of CHM fumigation to NB-UVB also showed a higher response rate[RR=1.29;95%CI(1.11,1.49);P=0.0007]and lower adverse reactions rate[RR=0.44;95%CI(0.24,0.79);P=0.006].In addition,CHM bath could reduce the adverse reactions induced by 308 nm excimer laser and improve patients’quality of life better than phototherapy.CHM fumigation could improve the efficacy of calcipotriol ointment and reduce the adverse reactions.CHM fumigation combined with external washing plus acitretin showed better results than using acitretin alone.No statistical difference was observed between CHM external washing and calcipotriol ointment or CHM ointment and retinoic acids.CONCLUSIONS:Current evidence showed that CHM bath and fumigation appeared to be efficient and safe for PV treatment.However,no definite conclusion could be drawn due to the low quality of included studies and thus more well-designed studies are needed for further assessment.展开更多
基金Project of Chengde Municipal Science and Technology Bureau,Project Name:A Comparative Study on the Efficacy and Safety of Tirofiban and Argatroban in the Treatment of Acute Cerebral Infarction.Project Code:202402A045.
文摘To explore the clinical characteristics,pathogenesis,and treatment efficacy of patients with stroke warning syndrome(SWS).Methods:Ten patients with internal capsule early warning syndrome who visited the Neurology Department of our hospital from 2019 to 2023 were enrolled.Their clinical data were summarized,and the etiology,pathogenesis,imaging features,and treatment outcomes were discussed in light of previous literature.Results:Among the patients,there were 5 males and 5 females,with an average age of 60 years.The number of attacks ranged from 4 to 9,and the duration of each attack varied from 3 to 60 minutes.Five patients underwent intravenous thrombolysis.Four patients still experienced recurrent attacks after thrombolysis.They were then provided with volume expansion,anticoagulation,antiplatelet aggregation,vasospasm-relief therapies,and symptomatic treatment as appropriate.Three months later,the mRs score of all patients was≤2 points.Conclusion:Although SWS is not common,it is associated with a high risk of early infarction and a poor clinical prognosis.Clinicians should be fully aware of stroke warning syndrome and strive to prevent its clinical progression.
文摘目的分析健康素养和久坐行为在老年维持性血液透析(maintenance hemodialysis,MHD)患者孤独感对衰弱的链式中介作用。方法2022年1月至2023年12月,采用便利抽样法选取江苏省人民医院收治的216例老年MHD患者为研究对象,采用Tilburg衰弱量表(tilburg frailty index,TFI)、孤独感量表(University of California at Los Angeles loneliness scale,UCLA-LS)、慢性病患者健康素养量表(health literacy management scale,HeLMS)、老年人久坐行为问卷对其进行调查。结果老年MHD患者,久坐行为时间为(7.24±0.67)h/d。衰弱与孤独感、久坐行为之间呈正相关,与健康素养之间呈负相关(均P<0.05)。健康素养、久坐行为以及健康素养-久坐行为在孤独感与衰弱之间发挥部分中介效应,效应值分别为0.21、0.20、0.08,占总效应的20.39%、19.42%、7.76%。结论孤独感可以通过调节健康素养和久坐行为,间接影响老年MHD患者衰弱程度。
基金Under the auspices of the National Natural Science Foundation of China(No.42071266)the Third Batch of Hebei Youth Top Talent ProjectNatural Science Foundation of Hebei Province(No.D2021205003)。
文摘The aviation industry has become one of the top ten greenhouse gas emission industries in the world. China’s aviation carbon emissions continue to increase, but the analysis of its influencing factors at the provincial level is still incomplete. This paper firstly uses Stochastic Impacts by Regression on Population, Affluence and Technology model(STIRPAT) model to analyze the time series evolution of China’s aviation carbon emissions from 2000 to 2019. Secondly, it uses the Logarithmic Mean Divisia Index(LDMI) model to analyze the influencing characteristics and degree of four factors on China’s aviation carbon emissions, which are air transportation revenue, aviation route structure, air transportation intensity and aviation energy intensity. Thirdly, it determines the various factors’ influencing direction and evolution trend of 31 provinces’ aviation carbon emissions in China(not including Hong Kong, Macao, Taiwan of China due to incomplete data). Finally, it derives the decoupling effort model and analyzes the decoupling relationship and decoupling effort degree between air carbon emissions and air transportation revenue in different provinces. The study found that from 2000 to2019, China’s total aviation carbon emissions continued to grow, while the growth rate of aviation carbon emissions showed a fluctuating downward trend. Air transportation revenue and aviation route structure promote the growth of total aviation carbon emissions, and air transportation intensity and aviation energy intensity have a restraining effect on the growth of total aviation carbon emissions. The scope of negative driving effect of air transportation revenue and air transportation intensity on total aviation carbon emissions in various provinces has increased. While the scope of positive driving influence of aviation route structure on total aviation carbon emissions of various provinces has increased, aviation energy intensity mainly has negative driving influence on total aviation carbon emissions of each province. Overall, the emission reduction trend in the areas to the west and north of the Qinling-Huaihe River Line is obvious. The decoupling mode between air carbon emissions and air transportation revenue in 31 provinces is mainly expansion negative decoupling.The air transportation intensity effect shows strong decoupling efforts in most provinces, the decoupling effort of aviation route structure effect and aviation energy intensity effect is not prominent.
基金Supported by the National Natural Science Foundation of China:to Study the Immunoanti-inflammatory Mechanism of Cooling Blood Detoxification Methods for Psoriasis Treatment from Influence of S1P/S1PRs to Th17/KC Inflammatory Axis(No.81874393)
文摘OBJECTIVE:To evaluate the clinical efficacy and safety of external application of Chinese herbal medicine(exCHM)for psoriasis vulgaris(PV).METHODS:Different search portals,including the China National Knowledge Infrastructure Database,China Science and Technology Journal Database,Wanfang,Sino Med,clinicaltrials,Pub Med,Cochrane Library,and Cochrane Central Register of Controlled Trials,were searched for randomized controlled trials(RCTs)that compared the ex-CHM intervention with other treatment protocols for PV,with available data as of November 25,2020.The Review Manager 5.3 software was used for analysis.RESULTS:Nineteen RCTs involving 1988 participants were included,of which twelve RCTs qualified for the Meta-analysis.The results showed that the addition of CHM bath to narrow-band ultraviolet B(NB-UVB)had a higher response rate[RR=1.29;95%CI(1.19,1.40);P<0.00001];lower psoriasis area severity index(PASI)[MD=-3.15;95%CI(-4.79,-1.52);P=0.0002],adverse reactions rate[RR=0.32;95%CI(0.15,0.66);P=0.002],and recurrence rate[RR=0.48;95%CI(0.30,0.79);P=0.004]than NB-UVB alone.The addition of CHM fumigation to NB-UVB also showed a higher response rate[RR=1.29;95%CI(1.11,1.49);P=0.0007]and lower adverse reactions rate[RR=0.44;95%CI(0.24,0.79);P=0.006].In addition,CHM bath could reduce the adverse reactions induced by 308 nm excimer laser and improve patients’quality of life better than phototherapy.CHM fumigation could improve the efficacy of calcipotriol ointment and reduce the adverse reactions.CHM fumigation combined with external washing plus acitretin showed better results than using acitretin alone.No statistical difference was observed between CHM external washing and calcipotriol ointment or CHM ointment and retinoic acids.CONCLUSIONS:Current evidence showed that CHM bath and fumigation appeared to be efficient and safe for PV treatment.However,no definite conclusion could be drawn due to the low quality of included studies and thus more well-designed studies are needed for further assessment.
