为了解决有机食品鉴别需要多种参数指标进行综合判定,制样过程繁琐,判别正确率偏低的问题,本研究提出一种基于稳定同位素比例质谱和液相色谱-高分辨质谱分析技术,结合偏最小二乘法判别分析(partial least squares-discriminant analysis...为了解决有机食品鉴别需要多种参数指标进行综合判定,制样过程繁琐,判别正确率偏低的问题,本研究提出一种基于稳定同位素比例质谱和液相色谱-高分辨质谱分析技术,结合偏最小二乘法判别分析(partial least squares-discriminant analysis,PLS-DA)的有机番茄鉴别方法。将采集的94个番茄样品(有机番茄50个,普通番茄44个)匀浆破碎、冷冻干燥后,分析并采集氮同位素比值(δ^(15)N)和液相色谱-高分辨质谱数据,应用PLS-DA方法提取数据信息,建立有机番茄判别模型,筛选并确证出其中判别的标志因子,包括氮同位素比值以及有机酸、黄酮类等13个特征化合物。所建立的模型对有机番茄的判别正确率为93.4%,基本可以满足有机番茄判别的需要。该研究为有机西红柿的快速判定提供了一种新的技术手段。展开更多
Excavated from the Western Han tomb in Tianhui Town(天回镇),Jinniu District(金牛区),Chengdu,China,Tian Hui Yi Jian(《天回医简》Tianhui Medical Slips)were penned during the Warring States period by the renowned physici...Excavated from the Western Han tomb in Tianhui Town(天回镇),Jinniu District(金牛区),Chengdu,China,Tian Hui Yi Jian(《天回医简》Tianhui Medical Slips)were penned during the Warring States period by the renowned physician Bian Que(扁鹊)and his students.Since their discovery,the medical,historical,and archaeological communities have given them considerable attention.This paper sorts out the diagnostic content of Tian Hui Yi Jian from various aspects of inspection,palpation,inquiry,listening and smelling examination and provides a summary and analysis of four features:the concept of the correspondence between heaven and man is the foundation,the idea of the five elements throughout the whole process,extremely focus on pulse diagnosis,emphasize a comprehensive analysis of four examinations.These analyses can investigate the value and significance of Tian Hui Yi Jian in developing traditional Chinese medicine(TCM)diagnosis history.In this way,we aim to reproduce the overview and level of TCM diagnostics at that time,clear up some ambiguous understanding of its development history,and provide a reference for further research on the origin and development of TCM.展开更多
文摘脓毒症急性肾损伤(Sepsis-associated acute kidney injury,S-AKI)是脓毒症最常见的器官功能障碍。中医学认为,S-AKI的根本病机为正虚毒损、瘀滞络脉,治疗上宜扶正益气,辅以活血化瘀、行气通腑。文中就中医药对S-AKI早期炎症反应调控作用的概况进行综述,认为炎症反应、微循环功能障碍、代谢重编程可能是S-AKI的3个基本发病机制,并且提出中医药治疗S-AKI的优势明显,可通过调控核因子κB(Nuclear factor kappa-light-chain-enhancer of activated B cells,NF-κB)、磷脂酰肌醇3-激酶/蛋白激酶B信号通路(Phosphatidylinositol 3-kinase/protein kinase B signaling pathway,PI3K/AKT)等信号通路,改善微循环、抑制炎症介质释放,以降低炎性因子的水平,从而改善S-AKI早期炎症反应。但目前S-AKI的生理病理机制仍不明确,还需要加强有针对性的研究,为S-AKI的临床治疗创造更多新思路。
文摘为了解决有机食品鉴别需要多种参数指标进行综合判定,制样过程繁琐,判别正确率偏低的问题,本研究提出一种基于稳定同位素比例质谱和液相色谱-高分辨质谱分析技术,结合偏最小二乘法判别分析(partial least squares-discriminant analysis,PLS-DA)的有机番茄鉴别方法。将采集的94个番茄样品(有机番茄50个,普通番茄44个)匀浆破碎、冷冻干燥后,分析并采集氮同位素比值(δ^(15)N)和液相色谱-高分辨质谱数据,应用PLS-DA方法提取数据信息,建立有机番茄判别模型,筛选并确证出其中判别的标志因子,包括氮同位素比值以及有机酸、黄酮类等13个特征化合物。所建立的模型对有机番茄的判别正确率为93.4%,基本可以满足有机番茄判别的需要。该研究为有机西红柿的快速判定提供了一种新的技术手段。
基金financed by the grant from the Research Center of China Unearthed Medical Literature and Cultural Relics(No.CTYX17)。
文摘Excavated from the Western Han tomb in Tianhui Town(天回镇),Jinniu District(金牛区),Chengdu,China,Tian Hui Yi Jian(《天回医简》Tianhui Medical Slips)were penned during the Warring States period by the renowned physician Bian Que(扁鹊)and his students.Since their discovery,the medical,historical,and archaeological communities have given them considerable attention.This paper sorts out the diagnostic content of Tian Hui Yi Jian from various aspects of inspection,palpation,inquiry,listening and smelling examination and provides a summary and analysis of four features:the concept of the correspondence between heaven and man is the foundation,the idea of the five elements throughout the whole process,extremely focus on pulse diagnosis,emphasize a comprehensive analysis of four examinations.These analyses can investigate the value and significance of Tian Hui Yi Jian in developing traditional Chinese medicine(TCM)diagnosis history.In this way,we aim to reproduce the overview and level of TCM diagnostics at that time,clear up some ambiguous understanding of its development history,and provide a reference for further research on the origin and development of TCM.
