NaCl aqueous solution（15 wt%） was used as the quenching medium to prepare amorphous Lithium-Zinc ferrite hollow microspheres（LiZn FHMs） based on self-reactive quenching technology. Investigations by scanning elect...NaCl aqueous solution（15 wt%） was used as the quenching medium to prepare amorphous Lithium-Zinc ferrite hollow microspheres（LiZn FHMs） based on self-reactive quenching technology. Investigations by scanning electro microscope, X-ray diffraction, electron diffraction of transmission electron microscope, and differential scanning calorimetry prove that LiZn FHMs are susceptible to amorphization. It is indicated that NaCl aqueous solution（15 wt%） has ultra-fast quenching speed, and the growth rate of crystals on LiZn FHMs is so large that the formation and growth of the crystal nucleus are significantly restrained. This is the main reason for the formation of amorphous LiZn FHMs.展开更多
CD4^(+)T细胞和B细胞之间的病理性相互作用是系统性自身免疫病的重要发病机制之一,其中滤泡辅助性T细胞(follicular helper T cell,Tfh)和外周辅助性T细胞(peripheral helper T cell,Tph)是辅助B细胞的关键细胞。Tph细胞是一类新发现的...CD4^(+)T细胞和B细胞之间的病理性相互作用是系统性自身免疫病的重要发病机制之一,其中滤泡辅助性T细胞(follicular helper T cell,Tfh)和外周辅助性T细胞(peripheral helper T cell,Tph)是辅助B细胞的关键细胞。Tph细胞是一类新发现的辅助性T细胞亚群,表型为PD-1highCXCR5-CD4^(+)。Tph细胞与Tfh细胞在表型、功能及作用部位上具有一定差异,其与B细胞相互作用,在促进B细胞分化为浆细胞并产生自身抗体的同时,还促进异位淋巴结构的形成以维持局部炎症和抗体反应。Tph细胞新近在类风湿关节炎、系统性红斑狼疮、干燥综合征、IgG4相关疾病等多种自身免疫病中被报道,现将Tph细胞的外周免疫应答在不同系统性自身免疫病中的研究进展予以综述,旨在探寻自身抗体产生的新机制,有助于未来开发新的诊断、治疗靶点。展开更多
基金Funded by the National Natural Science Foundation of China(No.51172282)the Hebei Natural Science Foundation of China(E2015506011)
文摘NaCl aqueous solution（15 wt%） was used as the quenching medium to prepare amorphous Lithium-Zinc ferrite hollow microspheres（LiZn FHMs） based on self-reactive quenching technology. Investigations by scanning electro microscope, X-ray diffraction, electron diffraction of transmission electron microscope, and differential scanning calorimetry prove that LiZn FHMs are susceptible to amorphization. It is indicated that NaCl aqueous solution（15 wt%） has ultra-fast quenching speed, and the growth rate of crystals on LiZn FHMs is so large that the formation and growth of the crystal nucleus are significantly restrained. This is the main reason for the formation of amorphous LiZn FHMs.
文摘CD4^(+)T细胞和B细胞之间的病理性相互作用是系统性自身免疫病的重要发病机制之一,其中滤泡辅助性T细胞(follicular helper T cell,Tfh)和外周辅助性T细胞(peripheral helper T cell,Tph)是辅助B细胞的关键细胞。Tph细胞是一类新发现的辅助性T细胞亚群,表型为PD-1highCXCR5-CD4^(+)。Tph细胞与Tfh细胞在表型、功能及作用部位上具有一定差异,其与B细胞相互作用,在促进B细胞分化为浆细胞并产生自身抗体的同时,还促进异位淋巴结构的形成以维持局部炎症和抗体反应。Tph细胞新近在类风湿关节炎、系统性红斑狼疮、干燥综合征、IgG4相关疾病等多种自身免疫病中被报道,现将Tph细胞的外周免疫应答在不同系统性自身免疫病中的研究进展予以综述,旨在探寻自身抗体产生的新机制,有助于未来开发新的诊断、治疗靶点。
