目的探讨基于问题的学习(Problem-based Learning,PBL)教学法联合标准化病人(Standardized Patient,SP)在临床医学学士(Bachelor of Medicine and Bachelor of Surgry,MBBS)学生血液病实践教学中的应用效果。方法选取2023年2—6月由江...目的探讨基于问题的学习(Problem-based Learning,PBL)教学法联合标准化病人(Standardized Patient,SP)在临床医学学士(Bachelor of Medicine and Bachelor of Surgry,MBBS)学生血液病实践教学中的应用效果。方法选取2023年2—6月由江苏大学附属人民医院血液科负责血液病临床教学的39名2019级MBBS学生为对照组,选取2024年2—6月32名2021级MBBS学生为观察组。观察组采用PBL联合SP模式实施临床实践教学,对照组采用传统讲授法实施临床实践教学。对比两组理论考试、临床思维能力考核成绩及对教学方案的认可度。结果观察组理论考试、临床思维能力考核成绩均高于对照组,差异有统计学意义(P均<0.05)。观察组对教学方案的认可度为90.63%(29/32),高于对照组的69.23%(27/39),差异有统计学意义(χ^(2)=8.178,P<0.05)。结论采取PBL联合SP模式可有效提高MBBS学生的见习质量、学习兴趣和实践能力,加深学生对于血液系统疾病的认识,全面提升学生的自学能力、团队协作能力以及临床思维能力。展开更多
Objective To evaluate the predictive value of simplified geriatric assessment(sGA)in elderly Chinese patients diagnosed with diffuse large B-cell lymphoma(DLBCL).Methods It retrospectively analyzed the relationships o...Objective To evaluate the predictive value of simplified geriatric assessment(sGA)in elderly Chinese patients diagnosed with diffuse large B-cell lymphoma(DLBCL).Methods It retrospectively analyzed the relationships of sGA with the clinical characteristics,outcome,and prognosis of 219 patients aged≥60 years who were newly diagnosed with DLBCL at six hospitals in Jiangsu province between January 2018 and December 2022.Results The median age of 219 patients was 68 years(60-87 years).According to the sGA system criteria,101(46.1%),103(47.0%),and 15(6.8%)elderly patients with DLBCL were categorized as fit,unfit,and frail,respectively.The most common adverse reactions after chemotherapy were hematologic,and the incidence of grade>2 hematologic adverse reactions was similar among the three groups(47.5%vs 41.7%vs 46.7%,respectively;X=0.712,P=0.700).Compared with the fit and unfit groups,the frail group showed tendencies toward for higher proportions of grade>2 gastrointestinal,pulmonary,and infectious adverse reactions(P>0.05 for all).The fit,unfit,and frail groups had respective remission rates of 74.3%,46.6%,and 20.0%(x²=25.249,P<0.001);disease progression rates of 5.9%,11.7%,and 26.7%(X=6.763,P<0.05);2-year overall survival rates of 92.1%(95%CI 86.6%to 97.9%),77.6%(95%CI 69.5%to 86.6%),and 70.1%(95%CI 49.4%to 99.6%)(P<0.05);and 2-year progression-free survival rates of 76.8%(95%CI 67.0%to 84.8%),69.7%(95%CI 61.8%to 82.0%),and 65.7%(95%CI 53.3%to 100%)(P=0.399).Conclusion sGA can effectively predict treatment adverse effects and efficacy,disease progression,and long-term survival in elderly DLBCL.展开更多
文摘目的探讨基于问题的学习(Problem-based Learning,PBL)教学法联合标准化病人(Standardized Patient,SP)在临床医学学士(Bachelor of Medicine and Bachelor of Surgry,MBBS)学生血液病实践教学中的应用效果。方法选取2023年2—6月由江苏大学附属人民医院血液科负责血液病临床教学的39名2019级MBBS学生为对照组,选取2024年2—6月32名2021级MBBS学生为观察组。观察组采用PBL联合SP模式实施临床实践教学,对照组采用传统讲授法实施临床实践教学。对比两组理论考试、临床思维能力考核成绩及对教学方案的认可度。结果观察组理论考试、临床思维能力考核成绩均高于对照组,差异有统计学意义(P均<0.05)。观察组对教学方案的认可度为90.63%(29/32),高于对照组的69.23%(27/39),差异有统计学意义(χ^(2)=8.178,P<0.05)。结论采取PBL联合SP模式可有效提高MBBS学生的见习质量、学习兴趣和实践能力,加深学生对于血液系统疾病的认识,全面提升学生的自学能力、团队协作能力以及临床思维能力。
文摘Objective To evaluate the predictive value of simplified geriatric assessment(sGA)in elderly Chinese patients diagnosed with diffuse large B-cell lymphoma(DLBCL).Methods It retrospectively analyzed the relationships of sGA with the clinical characteristics,outcome,and prognosis of 219 patients aged≥60 years who were newly diagnosed with DLBCL at six hospitals in Jiangsu province between January 2018 and December 2022.Results The median age of 219 patients was 68 years(60-87 years).According to the sGA system criteria,101(46.1%),103(47.0%),and 15(6.8%)elderly patients with DLBCL were categorized as fit,unfit,and frail,respectively.The most common adverse reactions after chemotherapy were hematologic,and the incidence of grade>2 hematologic adverse reactions was similar among the three groups(47.5%vs 41.7%vs 46.7%,respectively;X=0.712,P=0.700).Compared with the fit and unfit groups,the frail group showed tendencies toward for higher proportions of grade>2 gastrointestinal,pulmonary,and infectious adverse reactions(P>0.05 for all).The fit,unfit,and frail groups had respective remission rates of 74.3%,46.6%,and 20.0%(x²=25.249,P<0.001);disease progression rates of 5.9%,11.7%,and 26.7%(X=6.763,P<0.05);2-year overall survival rates of 92.1%(95%CI 86.6%to 97.9%),77.6%(95%CI 69.5%to 86.6%),and 70.1%(95%CI 49.4%to 99.6%)(P<0.05);and 2-year progression-free survival rates of 76.8%(95%CI 67.0%to 84.8%),69.7%(95%CI 61.8%to 82.0%),and 65.7%(95%CI 53.3%to 100%)(P=0.399).Conclusion sGA can effectively predict treatment adverse effects and efficacy,disease progression,and long-term survival in elderly DLBCL.
