In response to the actual demands of the energy storage type organic Rankine power generation cycle,this study proposes a new type of jacketed shell and tube heat exchanger with integrated cold storage and heat exchan...In response to the actual demands of the energy storage type organic Rankine power generation cycle,this study proposes a new type of jacketed shell and tube heat exchanger with integrated cold storage and heat exchange.N-tedecane is selected as the phase change material for cold storage,low-temperature water as the cold source,and R134a as the heat source.The phase change material for cold storage is filled inside the jacket tube of the heat exchanger.Cold fluid is introduced into the inner tube to cause the phase change material to condense and store cold.After the cold storage is completed,R134a flows in from the shell side and condenses through heat exchange with the solidified phase change material for energy storage.This study discusses the influence laws of different cold water mass flow rates and temperatures on the cold storage performance of this heat exchanger,and analyzes the condensation effect of R134a.The results show that when the mass flow rate is 0.5 kg/s and the cold water temperature is between 3 and 4℃,the average power of the energy storage heat exchanger in the condensation experiment is 80W,and the average convective heat transfer coefficient is 110.73 W/(m^(2)⋅K).This research provides an experimental basis for the development of energy storage organic Rankine power generation cycles.展开更多
目的 探讨重组人生长激素(recombinant human growth hormone,rh-GH)治疗特发性矮小症(idiopathic short stature,ISS)的基础上实施适龄化心身干预的临床疗效及对患儿不良反应的影响。方法 选取儿科2022年2月至2024年2月收治的ISS患儿96...目的 探讨重组人生长激素(recombinant human growth hormone,rh-GH)治疗特发性矮小症(idiopathic short stature,ISS)的基础上实施适龄化心身干预的临床疗效及对患儿不良反应的影响。方法 选取儿科2022年2月至2024年2月收治的ISS患儿96例,随机数字表法分为对照组和试验组,每组48例。对照组予以rh-GH治疗,试验组在对照组基础上实施适龄化心身干预,治疗时间均为12个月。比较2组25羟基维生素D3[25-(OH)D3],胰岛素样生长因子1(IGF-1),生长发育指标、临床疗效及不良反应。结果 试验组总有效率显著高于对照组(P<0.05)。试验组干预后的身高、生长速度显著高于对照组(P<0.05)。试验组干预后的25-(OH)D3、IGF-1表达水平显著高于对照组(P<0.05)。试验组干预后的BSAP、OC表达水平显著高于对照组(P<0.05)。2组总不良反应发生率差异无统计学意义(P>0.05)。结论 适龄化心身干预用于rh-GH治疗ISS有较好的临床疗效,可促进ISS患儿生长发育,提高身体生长速度,纠正25-(OH)D3、IGF-1异常表达水平,改善骨代谢,安全性较高。展开更多
Carbon dioxide (CO_(2)) mineralization technology has attracted significant attention, due tothe synergistic terminal treatment of CO_(2) and industrial waste. The combined CO_(2) mineralizationprocess with steel ente...Carbon dioxide (CO_(2)) mineralization technology has attracted significant attention, due tothe synergistic terminal treatment of CO_(2) and industrial waste. The combined CO_(2) mineralizationprocess with steel enterprises is a promising route to simultaneously address CO_(2)emissions and SS treatment. Recently, a serial of the relevant work focus on a single type ofsteel slag (SS), and the understanding of CO_(2) absorption by mineralization of various SS isvery lacking.Meanwhile, it is urgent requirement for systematic summary and discussion onhow to make full use of the mineralized products produced after the mineralization of CO_(2)in SS. This review aims to investigate the progress of CO_(2) mineralization using SS, includingthe potential applications of mineralization products, as well as the environmental impactand risk assessment ofmineralization product applications. Currently, the application of SSmineralization products is primarily focused on their use as construction materials with loweconomic value. With usage of the mineralization products for ecological restoration (e.g.sandy soil remediation) was treated as an advanced route, but still remaining challenge infunctional materials preparation, and its technical economy and possible hazards need tobe further explored by long-term experimental tests.展开更多
A prediction model leveraging machine learning was developed to forecast the tensile strength of wear-resistant steels,focusing on the relationship between composition,hot rolling process parameters and resulting prop...A prediction model leveraging machine learning was developed to forecast the tensile strength of wear-resistant steels,focusing on the relationship between composition,hot rolling process parameters and resulting properties.Multiple machine learning algorithms were compared,with the deep neural network(DNN)model outperforming others including random forests,gradient boosting regression,support vector regression,extreme gradient boosting,ridge regression,multi-layer perceptron,linear regression and decision tree.The DNN model was meticulously optimized,achieving a training set mean squared error(MSE)of 14.177 with a coefficient of determination(R2)of 0.973 and a test set MSE of 21.573 with an R2 of 0.960,reflecting its strong predictive capabilities and generalization to unseen data.In order to further confirm the predictive ability of the model,an experimental validation was carried out,involving the preparation of five different steel samples.The tensile strength of each sample was predicted and then compared to actual measurements,with the error of the results consistently below 5%.展开更多
Catalytic amine-solvent regeneration has been validated as an energy-saving strategy for CO_(2) chemisorption by boosting reaction kinetics under mild conditions.The upscale performance evaluation and longterm durabil...Catalytic amine-solvent regeneration has been validated as an energy-saving strategy for CO_(2) chemisorption by boosting reaction kinetics under mild conditions.The upscale performance evaluation and longterm durability are indispensable steps for industrial application but have been scarcely reported thus far.Here,we report a ZrO_(2)/Al_(2)O_(3) pack catalyst that possesses strong metal oxide-support interactions,a porous structure,active and stable Zr-O-Al coordination,promoted proton transfer and a 40.7% decrease in the energy activation of carbamate decomposition,which significantly accelerates CO_(2) desorption kinetics.The upscale experiment and cost evaluation based on industrial flue gas revealed that the use of packing catalysts can reduce energy consumption by 27.56% and optimize the overall cost by 10.49%.The active sites present excellent stability in alkaline solvents.This work is the first to investigate the ability of high-technology readiness(technology readiness level at 6(TRL 6))for catalytic aminesolvent regeneration,providing valuable insights for potential applications involving efficient CO_(2) capture with catalyst assistance.展开更多
Background:Accumulating studies have shown the important role of circular RNAs(circRNAs)in the oncogenesis and metastasis of various cancers.We previously reported that circACTN4 could bind with FUBP1 to promote tumor...Background:Accumulating studies have shown the important role of circular RNAs(circRNAs)in the oncogenesis and metastasis of various cancers.We previously reported that circACTN4 could bind with FUBP1 to promote tumorigenesis and the development of breast cancer(BC)by increasing the expression of MYC.However,its exact molecular mechanism and biological function have not been fully elucidated.Methods:Here,Circular RNA microarray analysis was conducted in 3 pairs of BC and paracancerous tissues.The expression of circACTN4 in BC cells and tissues was detected via reverse transcription‒quantitative PCR(RT‒qPCR).Cell Counting Kit-8(CCK-8),5-ethynyl-2-deoxyuridine(EdU),transwell migration,and invasion assays were performed to further detect the biological functions of circACTN4 in BC cells.Xenograft models were used to investigate the in vivo role of circACTN4.Fluorescence in situ hybridization,Chromatin immunoprecipitation(ChIP)‒qPCR,coimmunoprecipitation,fluorometric,western blot,and rescue experiments were performed to explore the mechanism of circACTN4.Results:Our results revealed that circACTN4 was highly expressed in BC cells and tissues.The upregulated expression of circACTN4 was significantly related to the T stage and TNM stage and poor prognosis of patients with BC.circACTN4 was located primarily in the nucleus of BC cells.Upregulation of circACTN4 significantly increased the proliferation,invasion,and growth of BC cells,whereas the downregulation of circACTN4 exerted the opposite effects and induced G1/S cell cycle arrest.Mechanistically,we showed that circACTN4 could upregulate the expression of MYC and that MYC might interact with TIP60 histone acetyltransferase to increase the recruitment of TIP60 to MYC target genes and histone H4 acetylation(AcH4),thus promoting the progression of the breast cancer cell cycle and tumorigenesis.Conclusion:Taken together,our findings reveal for the first time a new mechanism by which circACTN4 could promote oncogenesis and the development of BC by increasing the AcH4 of MYC target genes via TIP60.Therefore,circACTN4 could be a novel target for BC diagnosis and remedy.展开更多
Full waveform inversion methods evaluate the properties of subsurface media by minimizing the misfit between synthetic and observed data.However,these methods omit measurement errors and physical assumptions in modeli...Full waveform inversion methods evaluate the properties of subsurface media by minimizing the misfit between synthetic and observed data.However,these methods omit measurement errors and physical assumptions in modeling,resulting in several problems in practical applications.In particular,full waveform inversion methods are very sensitive to erroneous observations(outliers)that violate the Gauss–Markov theorem.Herein,we propose a method for addressing spurious observations or outliers.Specifically,we remove outliers by inverting the synthetic data using the local convexity of the Gaussian distribution.To achieve this,we apply a waveform-like noise model based on a specific covariance matrix definition.Finally,we build an inversion problem based on the updated data,which is consistent with the wavefield reconstruction inversion method.Overall,we report an alternative optimization inversion problem for data containing outliers.The proposed method is robust because it uses uncertainties.This method enables accurate inversion,even when based on noisy models or a wrong wavelet.展开更多
基金the the basic scientific research Funds project of Heilongjiang Universities[grant numbers 2024-KYYWF-0554].
文摘In response to the actual demands of the energy storage type organic Rankine power generation cycle,this study proposes a new type of jacketed shell and tube heat exchanger with integrated cold storage and heat exchange.N-tedecane is selected as the phase change material for cold storage,low-temperature water as the cold source,and R134a as the heat source.The phase change material for cold storage is filled inside the jacket tube of the heat exchanger.Cold fluid is introduced into the inner tube to cause the phase change material to condense and store cold.After the cold storage is completed,R134a flows in from the shell side and condenses through heat exchange with the solidified phase change material for energy storage.This study discusses the influence laws of different cold water mass flow rates and temperatures on the cold storage performance of this heat exchanger,and analyzes the condensation effect of R134a.The results show that when the mass flow rate is 0.5 kg/s and the cold water temperature is between 3 and 4℃,the average power of the energy storage heat exchanger in the condensation experiment is 80W,and the average convective heat transfer coefficient is 110.73 W/(m^(2)⋅K).This research provides an experimental basis for the development of energy storage organic Rankine power generation cycles.
文摘目的 探讨重组人生长激素(recombinant human growth hormone,rh-GH)治疗特发性矮小症(idiopathic short stature,ISS)的基础上实施适龄化心身干预的临床疗效及对患儿不良反应的影响。方法 选取儿科2022年2月至2024年2月收治的ISS患儿96例,随机数字表法分为对照组和试验组,每组48例。对照组予以rh-GH治疗,试验组在对照组基础上实施适龄化心身干预,治疗时间均为12个月。比较2组25羟基维生素D3[25-(OH)D3],胰岛素样生长因子1(IGF-1),生长发育指标、临床疗效及不良反应。结果 试验组总有效率显著高于对照组(P<0.05)。试验组干预后的身高、生长速度显著高于对照组(P<0.05)。试验组干预后的25-(OH)D3、IGF-1表达水平显著高于对照组(P<0.05)。试验组干预后的BSAP、OC表达水平显著高于对照组(P<0.05)。2组总不良反应发生率差异无统计学意义(P>0.05)。结论 适龄化心身干预用于rh-GH治疗ISS有较好的临床疗效,可促进ISS患儿生长发育,提高身体生长速度,纠正25-(OH)D3、IGF-1异常表达水平,改善骨代谢,安全性较高。
基金supported by the National Key Research and Development Program(Nos.2023YFC3707101 and 2023YFF0614301)the Tsinghua University Initiative Scientific Research Program(No.2023Z02JMP001)the Linghang Project of School of Environment(No.025108011).
文摘Carbon dioxide (CO_(2)) mineralization technology has attracted significant attention, due tothe synergistic terminal treatment of CO_(2) and industrial waste. The combined CO_(2) mineralizationprocess with steel enterprises is a promising route to simultaneously address CO_(2)emissions and SS treatment. Recently, a serial of the relevant work focus on a single type ofsteel slag (SS), and the understanding of CO_(2) absorption by mineralization of various SS isvery lacking.Meanwhile, it is urgent requirement for systematic summary and discussion onhow to make full use of the mineralized products produced after the mineralization of CO_(2)in SS. This review aims to investigate the progress of CO_(2) mineralization using SS, includingthe potential applications of mineralization products, as well as the environmental impactand risk assessment ofmineralization product applications. Currently, the application of SSmineralization products is primarily focused on their use as construction materials with loweconomic value. With usage of the mineralization products for ecological restoration (e.g.sandy soil remediation) was treated as an advanced route, but still remaining challenge infunctional materials preparation, and its technical economy and possible hazards need tobe further explored by long-term experimental tests.
基金support of the National Natural Science Foundation of China(Nos.52161008 and 51961030)the Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region of China(NJYT23003)+1 种基金the Project of Central Government Guiding Local Science and Technology Development(Nos.2022ZY0035 and 2022ZY0072)the Special Fund for Talent Revitalisation Plan of Yangjiang Key Industries of Alloy Materials and Hardware Knives and Scissors(RCZX2022020).
文摘A prediction model leveraging machine learning was developed to forecast the tensile strength of wear-resistant steels,focusing on the relationship between composition,hot rolling process parameters and resulting properties.Multiple machine learning algorithms were compared,with the deep neural network(DNN)model outperforming others including random forests,gradient boosting regression,support vector regression,extreme gradient boosting,ridge regression,multi-layer perceptron,linear regression and decision tree.The DNN model was meticulously optimized,achieving a training set mean squared error(MSE)of 14.177 with a coefficient of determination(R2)of 0.973 and a test set MSE of 21.573 with an R2 of 0.960,reflecting its strong predictive capabilities and generalization to unseen data.In order to further confirm the predictive ability of the model,an experimental validation was carried out,involving the preparation of five different steel samples.The tensile strength of each sample was predicted and then compared to actual measurements,with the error of the results consistently below 5%.
基金supported by the National Natural Science Foundation of China(52300134 and 22106084)the China Postdoctoral Science Foundation(2022TQ0175,2023M741931,and 2022T150350).
文摘Catalytic amine-solvent regeneration has been validated as an energy-saving strategy for CO_(2) chemisorption by boosting reaction kinetics under mild conditions.The upscale performance evaluation and longterm durability are indispensable steps for industrial application but have been scarcely reported thus far.Here,we report a ZrO_(2)/Al_(2)O_(3) pack catalyst that possesses strong metal oxide-support interactions,a porous structure,active and stable Zr-O-Al coordination,promoted proton transfer and a 40.7% decrease in the energy activation of carbamate decomposition,which significantly accelerates CO_(2) desorption kinetics.The upscale experiment and cost evaluation based on industrial flue gas revealed that the use of packing catalysts can reduce energy consumption by 27.56% and optimize the overall cost by 10.49%.The active sites present excellent stability in alkaline solvents.This work is the first to investigate the ability of high-technology readiness(technology readiness level at 6(TRL 6))for catalytic aminesolvent regeneration,providing valuable insights for potential applications involving efficient CO_(2) capture with catalyst assistance.
基金supported by National Natural Science Foundation of China(No.82173170,Junxia ChenNo.82103089,Lei Xing)Natural Science Foundation of Chongqing,China(No.CSTB2022BSXMJCX0057,Lei Xing).
文摘Background:Accumulating studies have shown the important role of circular RNAs(circRNAs)in the oncogenesis and metastasis of various cancers.We previously reported that circACTN4 could bind with FUBP1 to promote tumorigenesis and the development of breast cancer(BC)by increasing the expression of MYC.However,its exact molecular mechanism and biological function have not been fully elucidated.Methods:Here,Circular RNA microarray analysis was conducted in 3 pairs of BC and paracancerous tissues.The expression of circACTN4 in BC cells and tissues was detected via reverse transcription‒quantitative PCR(RT‒qPCR).Cell Counting Kit-8(CCK-8),5-ethynyl-2-deoxyuridine(EdU),transwell migration,and invasion assays were performed to further detect the biological functions of circACTN4 in BC cells.Xenograft models were used to investigate the in vivo role of circACTN4.Fluorescence in situ hybridization,Chromatin immunoprecipitation(ChIP)‒qPCR,coimmunoprecipitation,fluorometric,western blot,and rescue experiments were performed to explore the mechanism of circACTN4.Results:Our results revealed that circACTN4 was highly expressed in BC cells and tissues.The upregulated expression of circACTN4 was significantly related to the T stage and TNM stage and poor prognosis of patients with BC.circACTN4 was located primarily in the nucleus of BC cells.Upregulation of circACTN4 significantly increased the proliferation,invasion,and growth of BC cells,whereas the downregulation of circACTN4 exerted the opposite effects and induced G1/S cell cycle arrest.Mechanistically,we showed that circACTN4 could upregulate the expression of MYC and that MYC might interact with TIP60 histone acetyltransferase to increase the recruitment of TIP60 to MYC target genes and histone H4 acetylation(AcH4),thus promoting the progression of the breast cancer cell cycle and tumorigenesis.Conclusion:Taken together,our findings reveal for the first time a new mechanism by which circACTN4 could promote oncogenesis and the development of BC by increasing the AcH4 of MYC target genes via TIP60.Therefore,circACTN4 could be a novel target for BC diagnosis and remedy.
基金National Natural Science Foundation of China under Grant 42276055National Key Research and Development Program under Grant 2022YFC2803503Fundamental Research Funds for the Central Universities under Grant 202262008.
文摘Full waveform inversion methods evaluate the properties of subsurface media by minimizing the misfit between synthetic and observed data.However,these methods omit measurement errors and physical assumptions in modeling,resulting in several problems in practical applications.In particular,full waveform inversion methods are very sensitive to erroneous observations(outliers)that violate the Gauss–Markov theorem.Herein,we propose a method for addressing spurious observations or outliers.Specifically,we remove outliers by inverting the synthetic data using the local convexity of the Gaussian distribution.To achieve this,we apply a waveform-like noise model based on a specific covariance matrix definition.Finally,we build an inversion problem based on the updated data,which is consistent with the wavefield reconstruction inversion method.Overall,we report an alternative optimization inversion problem for data containing outliers.The proposed method is robust because it uses uncertainties.This method enables accurate inversion,even when based on noisy models or a wrong wavelet.
