Paclitaxel is one of the commonly used drugs in postoperative chemotherapy for ovarian cancer patients. However, affected by drug dosage and individual differences in the course of medication, patients will have diffe...Paclitaxel is one of the commonly used drugs in postoperative chemotherapy for ovarian cancer patients. However, affected by drug dosage and individual differences in the course of medication, patients will have different degrees of adverse reactions, which will cause damage to the patient’s body once they occur. This paper retrospectively analyzed the clinical data of patients with severe allergic reactions such as fecal incontinence and numbness of hands and feet caused by the use of paclitaxel liposome during postoperative chemotherapy in a case of ovarian cancer admitted to our hospital. The causes and corresponding treatment measures were analyzed, in order to provide the reference for medical staff to take effective countermeasures in advance in the future.展开更多
BACKGROUND Endoscopic full-thickness resection(EFTR)is increasingly used for treating gastrointestinal stromal tumors(GISTs)in the stomach.AIM To compare the efficacy,tolerability,and clinical outcomes of EFTR vs surg...BACKGROUND Endoscopic full-thickness resection(EFTR)is increasingly used for treating gastrointestinal stromal tumors(GISTs)in the stomach.AIM To compare the efficacy,tolerability,and clinical outcomes of EFTR vs surgical resection(SR)for gastric GISTs.METHODS We collected clinical data from patients diagnosed with GISTs who underwent either EFTR or SR at our hospital from October 2011 to July 2024.Patients were matched in a 1:1 ratio based on baseline characteristics and tumor clinical-pathological features using propensity score matching.We analyzed perioperative outcomes and follow-up data.The primary outcome measure was progressionfree survival(PFS).RESULTS Out of 912 patients,573 met the inclusion criteria.After matching,each group included 95 patients.The EFTR group demonstrated statistically significant advantages over the SR group in average operative time(P<0.001),length of hospital stay(P<0.001),time to resume liquid diet(P<0.001),incidence of adverse events(P=0.031),and hospitalization costs(P<0.001).The en bloc resection rate was significantly different,with SR group at 100%and EFTR group at 93.7%(P=0.038).The median follow-up was 2451.50 days.Recurrence occurred in 3 patients in the EFTR group and 4 patients in the SR group,with no statistically significant difference(P=1.000).Factors associated with PFS included age,tumor size,high-risk category in the modified National Institutes of Health(NIH)risk score,and resection status.Resection status was identified as an independent prognostic factor for PFS(P=0.0173,hazard ratios=0.0179,95%CI:0.000655-0.491).Notably,there was no statistically significant difference in PFS between the two groups.CONCLUSION This study is a non-inferiority design.The EFTR group significantly outperformed the SR group in terms of operative time,length of hospital stay,time to resume a liquid diet,incidence of adverse events,and hospitalization costs,demonstrating its higher economic efficiency and better tolerability.Additionally,although the en bloc resection rate was lower in the EFTR group compared to the SR group,there were no significant differences in tumor recurrence rates and progression-free survival between the two groups.This study found no statistical difference in the primary endpoint of postoperative recurrence rates between the two groups.However,due to sample size limitations,this result requires further validation in larger-scale studies.The current results should be viewed as exploratory evidence.展开更多
In practical mechanical fault detection and diagnosis,it is difficult and expensive to collect enough large-scale supervised data to train deep networks.Transfer learning can reuse the knowledge obtained from the sour...In practical mechanical fault detection and diagnosis,it is difficult and expensive to collect enough large-scale supervised data to train deep networks.Transfer learning can reuse the knowledge obtained from the source task to improve the performance of the target task,which performs well on small data and reduces the demand for high computation power.However,the detection performance is significantly reduced by the direct transfer due to the domain difference.Domain adaptation(DA)can transfer the distribution information from the source domain to the target domain and solve a series of problems caused by the distribution difference of data.In this survey,we review various current DA strategies combined with deep learning(DL)and analyze the principles,advantages,and disadvantages of each method.We also summarize the application of DA combined with DL in the field of fault diagnosis.This paper provides a summary of the research results and proposes future work based on analysis of the key technologies.展开更多
The application of artificial intelligence(AI)technology in the medical field has experienced a long history of development.In turn,some long-standing points and challenges in the medical field have also prompted dive...The application of artificial intelligence(AI)technology in the medical field has experienced a long history of development.In turn,some long-standing points and challenges in the medical field have also prompted diverse research teams to continue to explore AI in depth.With the development of advanced technologies such as the Internet of Things(IoT),cloud computing,big data,and 5G mobile networks,AI technology has been more widely adopted in the medical field.In addition,the in-depth integration of AI and IoT technology enables the gradual improvement of medical diagnosis and treatment capabilities so as to provide services to the public in a more effective way.In this work,we examine the technical basis of IoT,cloud computing,big data analysis and machine learning involved in clinical medicine,combined with concepts of specific algorithms such as activity recognition,behavior recognition,anomaly detection,assistant decision-making system,to describe the scenario-based applications of remote diagnosis and treatment collaboration,neonatal intensive care unit,cardiology intensive care unit,emergency first aid,venous thromboembolism,monitoring nursing,image-assisted diagnosis,etc.We also systematically summarize the application of AI and IoT in clinical medicine,analyze the main challenges thereof,and comment on the trends and future developments in this field.展开更多
Objectives:To retrospectively analyze the clinical results of the treatment of pulmonary multifocal adenocarcinoma presenting as ground glass opacity(GGO)by surgery and thermal ablation.Methods:87 GGO-type pulmonary a...Objectives:To retrospectively analyze the clinical results of the treatment of pulmonary multifocal adenocarcinoma presenting as ground glass opacity(GGO)by surgery and thermal ablation.Methods:87 GGO-type pulmonary adenocarcinomas of 48 patients(14 males and 34 females;mean age:59.7 years old±9.9,range:33-79 years old)had been treated from March 2015 to March 2019.Treatment means included 43 wedge resections,7 segmentectomy,17 lobectomies,and 20 thermal ablations.The indication selected for treatment means,safety,and local tumor progression rate were evaluated.Results:No operation-related death occurred in all patients.42 times of surgery were performed and 67 carcinomas were resected in 42 patients.23 times of single-port Video-assisted thoracoscopic surgery(VATS),8 times of two-port VATS and 11 times of three-port VATS were performed in total.There were 2 cases of air leak(exceeding 1 week),1 case of chylothorax and 1 case of massive pleural effusion.Time duration of surgery was between 60 and 300 mins(mean:167 mins).Intraoperative blood loss was between 5 and 300 mL(mean:44 mL).Time of chest drainage was between 2 and 23 d(mean 4.9 d).Chest drainage volume was between 14 and 4633 mL(mean:872 mL).Post-operation LOS(length of stay)was between 3 and 25 d(mean:6.2 d).15 times of thermal ablation were performed(1 case of air leak)and 20 carcinomas were ablated in 14 patients.The ablation time was between 30 and 120 min(mean:43 min);post-operation LOS was between 1 and 10 d(mean:3.5 d).During the mean follow-up period(16 months±13)(range:5-60 months),no local tumor progression occurred.Conclusions:Surgery and thermal ablation are safe and effective options for the treatment of pulmonary multifocal GGO-type adenocarcinoma.展开更多
The dissolved oxygen content in water is an important indicator for assessing the quality of the water environment,and maintaining a certain amount of dissolved oxygen is essential for the healthy development of the e...The dissolved oxygen content in water is an important indicator for assessing the quality of the water environment,and maintaining a certain amount of dissolved oxygen is essential for the healthy development of the ecological environment.When a water body is anoxic,the activity of anaerobic microorganisms increases and organic matter is decomposed to produce a large number of blackening and odorizing substances,resulting in black and odorous water bodies,which is a very common and typical phenomenon in China.Presently,there is still a relatively universal occurrence of illicitly connected stormwater and sewage pipes in the urban drainage pipe network in China,which makes oxygen-consuming substances be directly discharged into rivers through stormwater pipes and consume the dissolved oxygen in the water bodies,resulting in an oxygen deficiency of the water.This induces seasonal or year-round black and stink phenomena in urban rivers.Hence,identifying high oxygen-consuming substances,which lays the foundation for the subsequent removal of oxygen-consuming substances,is essential.Through a series of comparisons of water quality indicators and analysis of organic characteristics,it was found that the oxygen consumption capacity of domestic sewage was higher than that of industrial wastewater in the selected area of this study,and the oxygen-consuming substances of domestic sewage were small molecular amino acids.By comparing 20 conventional free amino acids,it was found that seven of them consumed oxygen easily,and compared with chemical oxygen consumption,biological oxygen consumption was in a leading position.展开更多
Vibration measurements can be used to evaluate the operation status of power equipment and are widely applied in equipment quality inspection and fault identification.Event-sensing technology can sense the change in s...Vibration measurements can be used to evaluate the operation status of power equipment and are widely applied in equipment quality inspection and fault identification.Event-sensing technology can sense the change in surface light intensity caused by object vibration and provide a visual description of vibration behavior.Based on the analysis of the principle underlying the transformation of vibration behavior into event flow data by an event sensor,this paper proposes an algorithm to reconstruct event flow data into a relationship correlating vibration displacement and time to extract the amplitude-frequency characteristics of the vibration signal.A vibration measurement test platform is constructed,and feasibility and effectiveness tests are performed for the vibration motor and other power equipment.The results show that event-sensing technology can effectively perceive the surface vibration behavior of power and provide a wide dynamic range.Furthermore,the vibration measurement and visualization algorithm for power equipment constructed using this technology offers high measurement accuracy and efficiency.The results of this study provide a new noncontact and visual method for locating vibrations and performing amplitude-frequency analysis on power equipment.展开更多
Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis.To provide clinical practice recommendations on the immune function in sepsis,an expert consensus focusing ...Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis.To provide clinical practice recommendations on the immune function in sepsis,an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was developed.Literature related to the immune monitoring and treatment of sepsis were retrieved from PubMed,Web of Science,and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online questionnaire.Then,the Delphi method was used to form consensus opinions,and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus opinions.This consensus achieved satisfactory results through two rounds of questionnaire survey,with 2 statements rated as perfect consistency,13 as very good consistency,and 9 as good consistency.After summarizing the results,a total of 14 strong recommended opinions,8 weak recommended opinions and 2 non-recommended opinions were produced.Finally,a face-to-face discussion of the consensus opinions was performed through an online meeting,and all judges unanimously agreed on the content of this consensus.In summary,this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.展开更多
In the quasi-free electron model,the Fermi surface spreads into a sphere in the Brillouin zone,i.e.,the Fermi sphere.The Fermi sphere exists widely in metal systems,no matter whether the crystal is in a body-center cu...In the quasi-free electron model,the Fermi surface spreads into a sphere in the Brillouin zone,i.e.,the Fermi sphere.The Fermi sphere exists widely in metal systems,no matter whether the crystal is in a body-center cubic,face-center cubic,or hexagonal close-packed lattice.Here,we report a class of compounds stabilized at high pressure with Rubik’s cubic Fermi surface.展开更多
It is well known that atoms of the same element in different valence states show very different chemical behaviors.Calcium is a typical divalent metal,sharing or losing both of its valence electrons when forming compo...It is well known that atoms of the same element in different valence states show very different chemical behaviors.Calcium is a typical divalent metal,sharing or losing both of its valence electrons when forming compounds.Attempts have been made to synthesize compounds of monovalent calcium ions for decades,but with very little success(e.g.,in clusters).Pressure can result in substantial changes in the properties of atoms and chemical bonding,creating an extensive variety of unique materials with special valence states.In this study,using the ab initio evolutionary algorithm USPEX,we search for stable calcium-chlorine(Ca-Cl)system compounds at pressures up to 100 GPa.Besides the expected compound CaCl_(2),we predict three new compounds with monovalent Ca to be stable at high pressures,namely,CaCl,Ca_(5)Cl_(6),and Ca_(3)Cl_(4).According to our calculations,CaCl is stable at pressures above 18 GPa and is predicted to undergo a transition from nonmagnetic Fm-3m-CaCl to ferromagnetic Pm-3m-CaCl at 40 GPa.Ca_(5)Cl_(6)and Ca_(3)Cl_(4)are stable at pressures above 37 and 73 GPa,with space groups P-1 and R-3,respectively.Following these predictions,we successfully synthesized Pm-3m-CaCl in laser-heated diamond anvil cell experiments.The emergence of the unusual valence state at high pressures reveals exciting opportunities for creating entirely new materials in sufficiently large quantities for a variety of potential applications.展开更多
Objective:This study investigates the preventive and therapeutic effects of medical radiation protection spray(Bergmann)compared to triethanolamine cream in patients undergoing radiotherapy following breast cancer sur...Objective:This study investigates the preventive and therapeutic effects of medical radiation protection spray(Bergmann)compared to triethanolamine cream in patients undergoing radiotherapy following breast cancer surgery.Methods:Ninety patients with breast cancer who received postoperative radiotherapy between July 2018 and July 2021 were randomly divided into the Bergmann treatment(experimental)group and the triethanolamine cream treatment(control)group,with 45 patients in each group.Radiodermatitis severity was assessed using the RTOG radiodermatitis grading standards.Results:The radiation dose required to develop grade I radiodermatitis was significantly higher in the experimental group compared to the control group,at(36.13±1.17 Gy)and(25.38±0.63 Gy),respectively.At a radiation dose of 30 Gy,the proportion of grade I radiodermatitis cases in the experimental group was significantly lower than in the control group(P=0.002).At radiation doses of 40 Gy and 50 Gy,the proportion of grade II radiodermatitis cases in the experimental group was also significantly lower than in the control group(P<0.001).No cases of grade III or higher radiodermatitis were observed in the experimental group,while three cases of grade III radiodermatitis occurred in the control group,although the difference was not statistically significant.No patients in the experimental group discontinued treatment due to radiodermatitis or mucosal reactions,whereas two patients in the control group interrupted treatment due to these reactions but eventually completed therapy.Conclusion:Bergmann spray effectively prevents radiodermatitis in patients undergoing radiotherapy after breast cancer surgery and is more effective than triethanolamine cream in treating skin lesions.Its ease of use improves the quality of life for patients undergoing radiotherapy and ensures successful treatment completion.Bergmann is suitable for clinical promotion and application.展开更多
Objective: To explore the real experience and nursing needs of patients with gynecological malignant tumors during their illness, in order to provide reference for the formulation of clinical nursing paths for this po...Objective: To explore the real experience and nursing needs of patients with gynecological malignant tumors during their illness, in order to provide reference for the formulation of clinical nursing paths for this population. Methods: Using descriptive phenomenological research method, 9 cases of gynecological malignant tumor patients treated in a tertiary A hospital in Baoding City, Hebei Province were selected according to the objective sampling method. Semi-structured in-depth interviews were conducted on them, and the interview data were analyzed by Colaizzi 7-step method. Results: Four themes were extracted: the disturbing and beneficial effects of the disease on life, the lack of knowledge about gynecological malignancies, the attitude towards the disease, and the nursing needs of women in reproductive health. Conclusion: Medical workers can take a variety of ways to carry out health education in the community and hospital, choose effective pain management for patients, help patients with gynecological malignant tumor to establish a mature psychological defense mechanism and positive coping style, so that they pay attention to disease prevention awareness, get sufficient social support, so as to improve the quality of life and comfort of patients with gynecological malignant tumor.展开更多
OBJECTIVE: To evaluate the effects of Xuebijing (XBJ) injection in heat stroke (HS) rats and to inves- tigate the mechanisms underlying these effects. METHODS: Sixty anesthetized rats were random- ized into three grou...OBJECTIVE: To evaluate the effects of Xuebijing (XBJ) injection in heat stroke (HS) rats and to inves- tigate the mechanisms underlying these effects. METHODS: Sixty anesthetized rats were random- ized into three groups and intravenously injected twice daily for 3 days with 4 mL XBJ (XBJ group) or phosphate buffered saline (HS and Sham groups) per kg body weight. HS was initiated in the HS and XBJ groups by placing rats in a simulated climate chamber (ambient temperature 40℃:, humidity 60% ). Rectal temperature, aterial pressure, and heart rate were monitored and recorded. Time to HS onset and survival were determined, and serum concentrations of tumor necrosis factor (TNF)-α, in-terleukin (IL)-1β, IL-6, alanine-aminotransferase (ALT), and aspartate-aminotransferase (AST) were measured. Hepatic tissue was harvested for patho- logical examination and electron microscopic ex- amination. Kupffer cells (KCs) were separated from liver at HS initiation, and the concentrations of se- creted TNF-α, IL-1β3 and IL-6 were measured. RESULTS: Time to HS onset and survival were signif- icantly longer in the XBJ than in the HS group. Moreover, the concentrations of TNF-α, IL-1β, IL-6, ALT and AST were lower and liver injury was milder in the XBJ than in the HS group. Heat-stress in- duced structural changes in KCs and hepatic cells were more severe in the HS than in the XBJ group and the concentrations of TNF-α, IL-1β and IL-6 se- creted by KCs were lower in the XBJ than in the HS group. CONCLUSION: XBJ can alleviate HS-induced sys- temic inflammatory response syndrome and liver injury in rats, and improve outcomes. These protec- tive effects may be due to the ability of XBJ to inhib- it cytokine secretion by KCs.展开更多
Background:Intracranial infection after craniotomy is one of the most serious postoperative complications,especially multidrug-resistant(MDR)or extensively drug-resistant(XDR)bacterial meningitis,and strongly affects ...Background:Intracranial infection after craniotomy is one of the most serious postoperative complications,especially multidrug-resistant(MDR)or extensively drug-resistant(XDR)bacterial meningitis,and strongly affects the prognosis of patients.Current treatment experience regarding these infections is scarce.Case presentation:We report a case of severe intracranial infection of XDR Acinetobacter baumannii(A.baumannii)that was treated by intravenous(IV)injection,sequential intraventricular(IVT)injection of tigecycline and polymyxin B,and other anti-infective drugs.Good results were obtained,and the patient was eventually discharged from the hospital.This case is characterized by intracranial infection.Conclusions:The polymyxin B IV+IVT pathway is an ideal treatment strategy for XDR A.baumannii.The tigecycline IVT pathway is also a safe treatment option.展开更多
文摘Paclitaxel is one of the commonly used drugs in postoperative chemotherapy for ovarian cancer patients. However, affected by drug dosage and individual differences in the course of medication, patients will have different degrees of adverse reactions, which will cause damage to the patient’s body once they occur. This paper retrospectively analyzed the clinical data of patients with severe allergic reactions such as fecal incontinence and numbness of hands and feet caused by the use of paclitaxel liposome during postoperative chemotherapy in a case of ovarian cancer admitted to our hospital. The causes and corresponding treatment measures were analyzed, in order to provide the reference for medical staff to take effective countermeasures in advance in the future.
文摘BACKGROUND Endoscopic full-thickness resection(EFTR)is increasingly used for treating gastrointestinal stromal tumors(GISTs)in the stomach.AIM To compare the efficacy,tolerability,and clinical outcomes of EFTR vs surgical resection(SR)for gastric GISTs.METHODS We collected clinical data from patients diagnosed with GISTs who underwent either EFTR or SR at our hospital from October 2011 to July 2024.Patients were matched in a 1:1 ratio based on baseline characteristics and tumor clinical-pathological features using propensity score matching.We analyzed perioperative outcomes and follow-up data.The primary outcome measure was progressionfree survival(PFS).RESULTS Out of 912 patients,573 met the inclusion criteria.After matching,each group included 95 patients.The EFTR group demonstrated statistically significant advantages over the SR group in average operative time(P<0.001),length of hospital stay(P<0.001),time to resume liquid diet(P<0.001),incidence of adverse events(P=0.031),and hospitalization costs(P<0.001).The en bloc resection rate was significantly different,with SR group at 100%and EFTR group at 93.7%(P=0.038).The median follow-up was 2451.50 days.Recurrence occurred in 3 patients in the EFTR group and 4 patients in the SR group,with no statistically significant difference(P=1.000).Factors associated with PFS included age,tumor size,high-risk category in the modified National Institutes of Health(NIH)risk score,and resection status.Resection status was identified as an independent prognostic factor for PFS(P=0.0173,hazard ratios=0.0179,95%CI:0.000655-0.491).Notably,there was no statistically significant difference in PFS between the two groups.CONCLUSION This study is a non-inferiority design.The EFTR group significantly outperformed the SR group in terms of operative time,length of hospital stay,time to resume a liquid diet,incidence of adverse events,and hospitalization costs,demonstrating its higher economic efficiency and better tolerability.Additionally,although the en bloc resection rate was lower in the EFTR group compared to the SR group,there were no significant differences in tumor recurrence rates and progression-free survival between the two groups.This study found no statistical difference in the primary endpoint of postoperative recurrence rates between the two groups.However,due to sample size limitations,this result requires further validation in larger-scale studies.The current results should be viewed as exploratory evidence.
基金supported by the National Natural Science Foundation of China(Grant Nos.52175096,51775243,11902124),the fellowship of China Postdoctoral Science Foundation(Grant No.2021T140279)111 Project(Grant No.B18027).
文摘In practical mechanical fault detection and diagnosis,it is difficult and expensive to collect enough large-scale supervised data to train deep networks.Transfer learning can reuse the knowledge obtained from the source task to improve the performance of the target task,which performs well on small data and reduces the demand for high computation power.However,the detection performance is significantly reduced by the direct transfer due to the domain difference.Domain adaptation(DA)can transfer the distribution information from the source domain to the target domain and solve a series of problems caused by the distribution difference of data.In this survey,we review various current DA strategies combined with deep learning(DL)and analyze the principles,advantages,and disadvantages of each method.We also summarize the application of DA combined with DL in the field of fault diagnosis.This paper provides a summary of the research results and proposes future work based on analysis of the key technologies.
文摘The application of artificial intelligence(AI)technology in the medical field has experienced a long history of development.In turn,some long-standing points and challenges in the medical field have also prompted diverse research teams to continue to explore AI in depth.With the development of advanced technologies such as the Internet of Things(IoT),cloud computing,big data,and 5G mobile networks,AI technology has been more widely adopted in the medical field.In addition,the in-depth integration of AI and IoT technology enables the gradual improvement of medical diagnosis and treatment capabilities so as to provide services to the public in a more effective way.In this work,we examine the technical basis of IoT,cloud computing,big data analysis and machine learning involved in clinical medicine,combined with concepts of specific algorithms such as activity recognition,behavior recognition,anomaly detection,assistant decision-making system,to describe the scenario-based applications of remote diagnosis and treatment collaboration,neonatal intensive care unit,cardiology intensive care unit,emergency first aid,venous thromboembolism,monitoring nursing,image-assisted diagnosis,etc.We also systematically summarize the application of AI and IoT in clinical medicine,analyze the main challenges thereof,and comment on the trends and future developments in this field.
文摘Objectives:To retrospectively analyze the clinical results of the treatment of pulmonary multifocal adenocarcinoma presenting as ground glass opacity(GGO)by surgery and thermal ablation.Methods:87 GGO-type pulmonary adenocarcinomas of 48 patients(14 males and 34 females;mean age:59.7 years old±9.9,range:33-79 years old)had been treated from March 2015 to March 2019.Treatment means included 43 wedge resections,7 segmentectomy,17 lobectomies,and 20 thermal ablations.The indication selected for treatment means,safety,and local tumor progression rate were evaluated.Results:No operation-related death occurred in all patients.42 times of surgery were performed and 67 carcinomas were resected in 42 patients.23 times of single-port Video-assisted thoracoscopic surgery(VATS),8 times of two-port VATS and 11 times of three-port VATS were performed in total.There were 2 cases of air leak(exceeding 1 week),1 case of chylothorax and 1 case of massive pleural effusion.Time duration of surgery was between 60 and 300 mins(mean:167 mins).Intraoperative blood loss was between 5 and 300 mL(mean:44 mL).Time of chest drainage was between 2 and 23 d(mean 4.9 d).Chest drainage volume was between 14 and 4633 mL(mean:872 mL).Post-operation LOS(length of stay)was between 3 and 25 d(mean:6.2 d).15 times of thermal ablation were performed(1 case of air leak)and 20 carcinomas were ablated in 14 patients.The ablation time was between 30 and 120 min(mean:43 min);post-operation LOS was between 1 and 10 d(mean:3.5 d).During the mean follow-up period(16 months±13)(range:5-60 months),no local tumor progression occurred.Conclusions:Surgery and thermal ablation are safe and effective options for the treatment of pulmonary multifocal GGO-type adenocarcinoma.
基金supported by the Key Research and Development Program of Guangdong Province(No.2020B1111350001)the National Key Research and Development Program of China(Nos.2021YFC3200700 and 2021YFC3200702)。
文摘The dissolved oxygen content in water is an important indicator for assessing the quality of the water environment,and maintaining a certain amount of dissolved oxygen is essential for the healthy development of the ecological environment.When a water body is anoxic,the activity of anaerobic microorganisms increases and organic matter is decomposed to produce a large number of blackening and odorizing substances,resulting in black and odorous water bodies,which is a very common and typical phenomenon in China.Presently,there is still a relatively universal occurrence of illicitly connected stormwater and sewage pipes in the urban drainage pipe network in China,which makes oxygen-consuming substances be directly discharged into rivers through stormwater pipes and consume the dissolved oxygen in the water bodies,resulting in an oxygen deficiency of the water.This induces seasonal or year-round black and stink phenomena in urban rivers.Hence,identifying high oxygen-consuming substances,which lays the foundation for the subsequent removal of oxygen-consuming substances,is essential.Through a series of comparisons of water quality indicators and analysis of organic characteristics,it was found that the oxygen consumption capacity of domestic sewage was higher than that of industrial wastewater in the selected area of this study,and the oxygen-consuming substances of domestic sewage were small molecular amino acids.By comparing 20 conventional free amino acids,it was found that seven of them consumed oxygen easily,and compared with chemical oxygen consumption,biological oxygen consumption was in a leading position.
基金supported by the National Key Research and Development Program of China(No.2023YFB2604600).
文摘Vibration measurements can be used to evaluate the operation status of power equipment and are widely applied in equipment quality inspection and fault identification.Event-sensing technology can sense the change in surface light intensity caused by object vibration and provide a visual description of vibration behavior.Based on the analysis of the principle underlying the transformation of vibration behavior into event flow data by an event sensor,this paper proposes an algorithm to reconstruct event flow data into a relationship correlating vibration displacement and time to extract the amplitude-frequency characteristics of the vibration signal.A vibration measurement test platform is constructed,and feasibility and effectiveness tests are performed for the vibration motor and other power equipment.The results show that event-sensing technology can effectively perceive the surface vibration behavior of power and provide a wide dynamic range.Furthermore,the vibration measurement and visualization algorithm for power equipment constructed using this technology offers high measurement accuracy and efficiency.The results of this study provide a new noncontact and visual method for locating vibrations and performing amplitude-frequency analysis on power equipment.
基金supported by grants from the National Natural Science Foundation of China(81730057,82130062)the Key Project of Military Medical Innovation Program of Chinese PLA(18CXZ026)+1 种基金the Guangdong Clinical Research Center for Critical Care Medicine(2020B1111170005)the Sun Yat?sen University Clinical Research Program 5010(2019002)。
文摘Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis.To provide clinical practice recommendations on the immune function in sepsis,an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was developed.Literature related to the immune monitoring and treatment of sepsis were retrieved from PubMed,Web of Science,and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online questionnaire.Then,the Delphi method was used to form consensus opinions,and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus opinions.This consensus achieved satisfactory results through two rounds of questionnaire survey,with 2 statements rated as perfect consistency,13 as very good consistency,and 9 as good consistency.After summarizing the results,a total of 14 strong recommended opinions,8 weak recommended opinions and 2 non-recommended opinions were produced.Finally,a face-to-face discussion of the consensus opinions was performed through an online meeting,and all judges unanimously agreed on the content of this consensus.In summary,this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.010-63243095)the National Science Foundation of China(Grant Nos.92263101 and 12174200)。
文摘In the quasi-free electron model,the Fermi surface spreads into a sphere in the Brillouin zone,i.e.,the Fermi sphere.The Fermi sphere exists widely in metal systems,no matter whether the crystal is in a body-center cubic,face-center cubic,or hexagonal close-packed lattice.Here,we report a class of compounds stabilized at high pressure with Rubik’s cubic Fermi surface.
基金supported by the National Science Foundation of China(Grant Nos.92263101,12174200,21627802,51722209,and 21273206)the Science Challenge Project(Grant No.TZ2016001)+2 种基金the Key Research Project of Higher Education(Grant Nos.15A140016 and 2010GGJS-110)the National Key R&D Program of China(Grant No.YS2018YFA070119)supported by the Russian Science Foundation(Grant No.24-43-00162)。
文摘It is well known that atoms of the same element in different valence states show very different chemical behaviors.Calcium is a typical divalent metal,sharing or losing both of its valence electrons when forming compounds.Attempts have been made to synthesize compounds of monovalent calcium ions for decades,but with very little success(e.g.,in clusters).Pressure can result in substantial changes in the properties of atoms and chemical bonding,creating an extensive variety of unique materials with special valence states.In this study,using the ab initio evolutionary algorithm USPEX,we search for stable calcium-chlorine(Ca-Cl)system compounds at pressures up to 100 GPa.Besides the expected compound CaCl_(2),we predict three new compounds with monovalent Ca to be stable at high pressures,namely,CaCl,Ca_(5)Cl_(6),and Ca_(3)Cl_(4).According to our calculations,CaCl is stable at pressures above 18 GPa and is predicted to undergo a transition from nonmagnetic Fm-3m-CaCl to ferromagnetic Pm-3m-CaCl at 40 GPa.Ca_(5)Cl_(6)and Ca_(3)Cl_(4)are stable at pressures above 37 and 73 GPa,with space groups P-1 and R-3,respectively.Following these predictions,we successfully synthesized Pm-3m-CaCl in laser-heated diamond anvil cell experiments.The emergence of the unusual valence state at high pressures reveals exciting opportunities for creating entirely new materials in sufficiently large quantities for a variety of potential applications.
基金supported by the Baoding City Self-Financed Fund Project(Project No.2241ZF339).
文摘Objective:This study investigates the preventive and therapeutic effects of medical radiation protection spray(Bergmann)compared to triethanolamine cream in patients undergoing radiotherapy following breast cancer surgery.Methods:Ninety patients with breast cancer who received postoperative radiotherapy between July 2018 and July 2021 were randomly divided into the Bergmann treatment(experimental)group and the triethanolamine cream treatment(control)group,with 45 patients in each group.Radiodermatitis severity was assessed using the RTOG radiodermatitis grading standards.Results:The radiation dose required to develop grade I radiodermatitis was significantly higher in the experimental group compared to the control group,at(36.13±1.17 Gy)and(25.38±0.63 Gy),respectively.At a radiation dose of 30 Gy,the proportion of grade I radiodermatitis cases in the experimental group was significantly lower than in the control group(P=0.002).At radiation doses of 40 Gy and 50 Gy,the proportion of grade II radiodermatitis cases in the experimental group was also significantly lower than in the control group(P<0.001).No cases of grade III or higher radiodermatitis were observed in the experimental group,while three cases of grade III radiodermatitis occurred in the control group,although the difference was not statistically significant.No patients in the experimental group discontinued treatment due to radiodermatitis or mucosal reactions,whereas two patients in the control group interrupted treatment due to these reactions but eventually completed therapy.Conclusion:Bergmann spray effectively prevents radiodermatitis in patients undergoing radiotherapy after breast cancer surgery and is more effective than triethanolamine cream in treating skin lesions.Its ease of use improves the quality of life for patients undergoing radiotherapy and ensures successful treatment completion.Bergmann is suitable for clinical promotion and application.
文摘Objective: To explore the real experience and nursing needs of patients with gynecological malignant tumors during their illness, in order to provide reference for the formulation of clinical nursing paths for this population. Methods: Using descriptive phenomenological research method, 9 cases of gynecological malignant tumor patients treated in a tertiary A hospital in Baoding City, Hebei Province were selected according to the objective sampling method. Semi-structured in-depth interviews were conducted on them, and the interview data were analyzed by Colaizzi 7-step method. Results: Four themes were extracted: the disturbing and beneficial effects of the disease on life, the lack of knowledge about gynecological malignancies, the attitude towards the disease, and the nursing needs of women in reproductive health. Conclusion: Medical workers can take a variety of ways to carry out health education in the community and hospital, choose effective pain management for patients, help patients with gynecological malignant tumor to establish a mature psychological defense mechanism and positive coping style, so that they pay attention to disease prevention awareness, get sufficient social support, so as to improve the quality of life and comfort of patients with gynecological malignant tumor.
基金Supported by the National Natural Science Foundation of China(Grant No.81101406,81071529)the Project of Medical Research of PLA BWS12J108
文摘OBJECTIVE: To evaluate the effects of Xuebijing (XBJ) injection in heat stroke (HS) rats and to inves- tigate the mechanisms underlying these effects. METHODS: Sixty anesthetized rats were random- ized into three groups and intravenously injected twice daily for 3 days with 4 mL XBJ (XBJ group) or phosphate buffered saline (HS and Sham groups) per kg body weight. HS was initiated in the HS and XBJ groups by placing rats in a simulated climate chamber (ambient temperature 40℃:, humidity 60% ). Rectal temperature, aterial pressure, and heart rate were monitored and recorded. Time to HS onset and survival were determined, and serum concentrations of tumor necrosis factor (TNF)-α, in-terleukin (IL)-1β, IL-6, alanine-aminotransferase (ALT), and aspartate-aminotransferase (AST) were measured. Hepatic tissue was harvested for patho- logical examination and electron microscopic ex- amination. Kupffer cells (KCs) were separated from liver at HS initiation, and the concentrations of se- creted TNF-α, IL-1β3 and IL-6 were measured. RESULTS: Time to HS onset and survival were signif- icantly longer in the XBJ than in the HS group. Moreover, the concentrations of TNF-α, IL-1β, IL-6, ALT and AST were lower and liver injury was milder in the XBJ than in the HS group. Heat-stress in- duced structural changes in KCs and hepatic cells were more severe in the HS than in the XBJ group and the concentrations of TNF-α, IL-1β and IL-6 se- creted by KCs were lower in the XBJ than in the HS group. CONCLUSION: XBJ can alleviate HS-induced sys- temic inflammatory response syndrome and liver injury in rats, and improve outcomes. These protec- tive effects may be due to the ability of XBJ to inhib- it cytokine secretion by KCs.
基金supported by grants from the National Natural Science Foundation of China(81571940,81741125)the Guangzhou Science and Technology Planning Project of China(201504281714528)PLA Logistics Research Project of China(CWH17L020,17CXZ008,18CXZ030)
文摘Background:Intracranial infection after craniotomy is one of the most serious postoperative complications,especially multidrug-resistant(MDR)or extensively drug-resistant(XDR)bacterial meningitis,and strongly affects the prognosis of patients.Current treatment experience regarding these infections is scarce.Case presentation:We report a case of severe intracranial infection of XDR Acinetobacter baumannii(A.baumannii)that was treated by intravenous(IV)injection,sequential intraventricular(IVT)injection of tigecycline and polymyxin B,and other anti-infective drugs.Good results were obtained,and the patient was eventually discharged from the hospital.This case is characterized by intracranial infection.Conclusions:The polymyxin B IV+IVT pathway is an ideal treatment strategy for XDR A.baumannii.The tigecycline IVT pathway is also a safe treatment option.
