Objective:Baicalein has been reported to have wide therapeutic effects that act through its antiinflammatory activity.This study examines the effect and mechanism of baicalein on sepsis-induced cardiomyopathy(SIC).Met...Objective:Baicalein has been reported to have wide therapeutic effects that act through its antiinflammatory activity.This study examines the effect and mechanism of baicalein on sepsis-induced cardiomyopathy(SIC).Methods:A thorough screening of a small library of natural products,comprising 100 diverse compounds,was conducted to identify the most effective drug against lipopolysaccharide(LPS)-treated H9C2 cardiomyocytes.The core target proteins and their associated signaling pathways involved in baicalein's efficacy against LPS-induced myocardial injury were predicted by network pharmacology.Results:Baicalein was identified as the most potent protective agent in LPS-exposed H9C2 cardiomyocytes.It exhibited a dose-dependent inhibitory effect on cell injury and inflammation.In the LPSinduced septic mouse model,baicalein demonstrated a significant capacity to mitigate LPS-triggered myocardial deficits,inflammatory responses,and ferroptosis.Network pharmacological analysis and experimental confirmation suggested that hypoxia-inducible factor 1 subunit a(HIF1-a)is likely to be the crucial factor in mediating the impact of baicalein against LPS-induced myocardial ferroptosis and injury.By combining microRNA(miRNA)screening in LPS-treated myocardium with miRNA prediction targeting HIF1-a,we found that miR-299b-5p may serve as a regulator of HIF1-a.The reduction in miR-299b-5p levels in LPS-treated myocardium,compared to the control group,was reversed by baicalein treatment.The reverse transcription quantitative polymerase chain reaction,Western blotting,and dual-luciferase reporter gene analyses together identified HIF1-a as the target of miR-299b-5p in cardiomyocytes.Conclusion:Baicalein mitigates SIC at the miRNA level,suggesting the therapeutic potential of it in treating SIC through the regulation of miR-299b-5p/HIF1-a/ferroptosis pathway.展开更多
BACKGROUND Cardiopulmonary bypass(CPB)is a life-support technology widely used in surgery.Review articles reflect research advances in a certain topic or field within a certain period of time.AIM To perform a bibliome...BACKGROUND Cardiopulmonary bypass(CPB)is a life-support technology widely used in surgery.Review articles reflect research advances in a certain topic or field within a certain period of time.AIM To perform a bibliometric analysis of the review articles that focused on CPB for cardiovascular surgery.METHODS This study was based on a bibliometric analysis.Data were acquired from the Web of Science and basic bibliometric parameters were analyzed and visualized using VOSviewer and Excel.RESULTS We identified 141 review articles on CPB.Generally,the number of publications increased,and most of them were published in the 2010s(n=57,40.4%)and the 2020s(n=45,31.9%).There were 113(80.1%)narrative review articles,21(14.9%)meta-analysis studies and 7(5.0%)systematic review papers.The United States(n=25,17.7%)and China(n=21,14.9%)were the leading countries in terms of publication number.The articles were published in 98 different journals.The Journal of Cardiothoracic and Vascular Anesthesia(n=14,10.0%)and Perfusion-United Kingdom(n=11,7.8%)were preferred by the authors.The high-frequency keywords included inflammatory response,children,acute kidney injury,meta-analysis and off-pump,except for CPB and cardiac surgery.Inflammatory response had the closest relationship with CPB during cardiac surgery.The complications of CPB,including inflammatory response,kidney injury and ischemia,caught lots of concern.CONCLUSION The rapid increase of review papers shows that the research on CPB in cardiac surgery is increasingly being emphasized by scholars and clinical staff worldwide.Meta-analysis has been widely conducted to analyze clinical controversies and further guide clinical practice.Strategies to improving the outcomes of patients undergoing cardiac surgery with CPB are the hot spots in this field.展开更多
The Solar Close Observations and Proximity Experiments(SCOPE)mission will send a spacecraft into the solar atmosphere at a low altitude of just 5 R☉from the solar center.It aims to elucidate the mechanisms behind sol...The Solar Close Observations and Proximity Experiments(SCOPE)mission will send a spacecraft into the solar atmosphere at a low altitude of just 5 R☉from the solar center.It aims to elucidate the mechanisms behind solar eruptions and coronal heating,and to directly measure the coronal magnetic field.The mission will perform in situ measurements of the current sheet between coronal mass ejections and their associated solar flares,and energetic particles produced by either reconnection or fast-mode shocks driven by coronal mass ejections.This will help to resolve the nature of reconnections in current sheets,and energetic particle acceleration regions.To investigate coronal heating,the mission will observe nano-flares on scales smaller than 70 km in the solar corona and regions smaller than 40 km in the photosphere,where magnetohydrodynamic waves originate.To study solar wind acceleration mechanisms,the mission will also track the process of ion charge-state freezing in the solar wind.A key achievement will be the observation of the coronal magnetic field at unprecedented proximity to the solar photosphere.The polar regions will also be observed at close range,and the inner edge of the solar system dust disk may be identified for the first time.This work presents the detailed background,science,and mission concept of SCOPE and discusses how we aim to address the questions mentioned above.展开更多
Background:Individuals with unresectable stageⅢnon-small cell lung cancer(NSCLC)who receive complete concurrent chemoradiotherapy(cCRT)can benefit from long-term survival.Although neoadjuvant chemoim-munotherapy(NACI...Background:Individuals with unresectable stageⅢnon-small cell lung cancer(NSCLC)who receive complete concurrent chemoradiotherapy(cCRT)can benefit from long-term survival.Although neoadjuvant chemoim-munotherapy(NACIT)have achieved breakthroughs in treating unresectable stageⅢNSCLC,patients who have received induction chemoimmunotherapy are considered poor candidates for cCRT due to concerns about tolerability.Oral vinorelbine chemotherapy is widely used in clinical settings because of its safety,even for frail patients.The objective of this trial was to assess the efficacy and safety of oral vinorelbine plus concurrent radiotherapy(RT)for individuals with unresectable stageⅢNSCLC following NACIT who were not candidates for concurrent intravenous chemotherapy.Methods:This was a single-arm,phase 2 trial.The primary endpoint was the objective response rate(ORR),while the secondary endpoints consisted of the disease control rate(DCR),safety,overall survival(OS),as well as progression-free survival(PFS).Results:Between March 10,2023 and April 24,2025,46 individuals with unresectable stageⅢNSCLC were administered oral vinorelbine plus thoracic RT.Patients were treated with oral vinorelbine(60 mg/m^(2)once a week for 2 weeks as induction therapy before thoracic RT)and 30 mg/m^(2)per week with concurrent RT(59.4-60.2 Gy)over 5.5 weeks.The median age of the patients was 62.5 years,with 42 being male(91.3%).The ORR was 52.1%(95%confidence interval[CI],35.1%-65.9%),with 24 partial responders.A 95.7%DCR(85.5%-98.8%)was observed,and 20 patients had stable disease.The median follow-up was 22.5 months;the median PFS was 18.0 months and the median OS was not reached.The most commonly observed adverse events(AEs)included leukopenia(grade 1,26.1%),anemia(grade 1,17.4%),neutropenia(grade 1,10.9%),acute esophagitis(grade 2,17.4%),and treatment-related pneumonitis(grade 1-2,60.9%).No grade 3 or 4 treatment-related AEs were recorded.Conclusion:In individuals with unresectable stageⅢNSCLC who had received NACIT and were not candidates for concurrent intravenous chemotherapy with RT,the oral vinorelbine plus concurrent RT demonstrated promising antitumor efficacy with acceptable toxicity profiles.展开更多
Halide electrolytes,renowned for their excellent electrochemical stability and wide voltage window,exhibit significant potential in the development of high energy density solid-state batteries featuring high voltage c...Halide electrolytes,renowned for their excellent electrochemical stability and wide voltage window,exhibit significant potential in the development of high energy density solid-state batteries featuring high voltage cathode materials.In this study,we present the development and synthesis of a 0.6Li_(2)S-ZrCl_(4)solid electrolyte,demonstrating an ion conductivity of 1.9×10^(–3)S/cm at 25°C.Under a pressure of 500 MPa,the relative density of the electrolyte can reach 97.37%,showcasing its commendable compressibility.0.6Li_(2)S-ZrCl_(4)served as the electrolyte,and we assembled batteries utilizing a LiCoO_(2)(LCO)positive electrode,Li_(9.54)Si_(1.74)P_(1.44)S_(11.7)Cl_(0.3)(LSPSCl)coating,and Li-In negative electrode for laboratory testing.At 25°C,this all-solid-state battery demonstrated an impressive discharge capacity retention rate of86.99%(with a final discharge specific capacity of 110.5 m Ah/g)after 250 cycles at 24 m A/g and 100 MPa stack pressure.Upon substituting the positive electrode material with LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)(NMC811)and assembling an all-solid-state battery,it demonstrated a discharge capacity retention rate of 74.17%after200 cycles at 3.6 m A/g and 100 MPa stack pressure in an environment at 25°C(with a final discharge specific capacity of 103.3 m A/g).Our findings hold significant implications for the design of novel superionic conductors,thereby contributing to the advancement of all-solid-state battery technology.展开更多
Moso bamboo(Phyllostachys edulis)forests are a vital resource in subtropical China,known for their high carbon(C)sequestration capacity.However,the dynamic processes of C fluxes within each component(canopy,culm,and s...Moso bamboo(Phyllostachys edulis)forests are a vital resource in subtropical China,known for their high carbon(C)sequestration capacity.However,the dynamic processes of C fluxes within each component(canopy,culm,and soil)and their individual contributions,particularly during on-and off-years,remain unclear.A 2-year field experiment was conducted to investigate the dynamics of C fluxes from the canopy,culm,and soil(partitioned into heterotrophic,rhizome,and stump respiration)and their contributions to net ecosystem productivity(NEP)in a representative Moso bamboo forest in the subtropical region of China.The average annual NEP of the Moso bamboo forest was 7.31±2.76 t C·ha^(-1).Specifically,the canopy's annual net C uptake was 17.30±3.23 tC·ha^(-1),accounting for 237%of NEP.In contrast,C emissions from heterotrophs,culms,rhizomes,and stumps were 5.37±1.20,2.18±1.05,1.29±0.04,and 1.15±0.33 t C·ha^(-1),accounting for73%,30%,18%,and16%of NEP,respectively.The NEP,net cumulative C uptake in the canopy,and C emissions from the respiration of heterotrophs and stumps were all significantly higher during on-years when compared to off-years,whereas C emissions from bamboo culms displayed opposite trends.These findings offer a new approach for quantifying the C budgets of Moso bamboo forests and provide valuable insights into the C cycling processes in forest ecosystems.展开更多
BACKGROUND Helicobacter pylori(H.pylori)infection is highly prevalent worldwide,and rising antibiotic resistance has reduced the efficacy of standard therapy,underscoring the need for simplified and better-tolerated r...BACKGROUND Helicobacter pylori(H.pylori)infection is highly prevalent worldwide,and rising antibiotic resistance has reduced the efficacy of standard therapy,underscoring the need for simplified and better-tolerated regimens.AIM To evaluate the efficacy,safety,and optimal dosing of vonoprazan(VPZ)-amoxicillin(AMO)dual therapy in a non-inferiority randomized trial for H.pylori eradication.METHODS In this multi-center,randomized trial conducted at 17 hospitals in Sichuan Province,China,1717 adults with confirmed infection were assigned(1:1:1)to 14-day regimens:(1)VPZ 20 mg BID+AMO 0.5 g QID;(2)0.75 g QID;or(3)1.0 g TID.The primary endpoint was the eradication rate based on intention-to-treat(ITT)and per-protocol(PP)analyses;secondary endpoints included adverse events(AEs)and treatment compliance.RESULTS Eradication rates were consistently high(92.35%-97.43%).In the 0.5 g QID group,ITT and PP eradication rates were 93.3%(95%CI:91.2-95.1)and 97.4%(95%CI:95.7-98.5),respectively,with no significant differences among groups(P>0.05).Compliance ranged from 98.1%to 98.3%,and AEs were infrequent(5.2%-7.5%),predominantly mild gastrointestinal symptoms,which occurred least often in the 0.5 g QID group.CONCLUSION VPZ-AMO dual therapy achieved excellent eradication,safety,and patient compliance.All regimens were similarly effective,whereas the 0.5 g QID dosing strategy offered the most favorable balance of efficacy and tolerability,supporting its use as a first-line option in high-prevalence settings.展开更多
The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic fie...The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C.展开更多
As one of the payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is aimed at imaging the Sun and the inner corona up to 2.5 R⊙(mean solar radius)in both the...As one of the payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is aimed at imaging the Sun and the inner corona up to 2.5 R⊙(mean solar radius)in both the Lyα(121.6 nm)and visible wavebands with high temporo-spatial resolution,mainly targeting solar flares,coronal mass ejections(CMEs)and filaments/prominences.LST observations allow us to trace solar eruptive phenomena from the disk center to the inner corona,to study the relationships between eruptive prominences/filaments,solar flares and CMEs,to explore the dynamical processes and evolution of solar eruptions,to diagnose solar winds,and to derive physical parameters of the solar atmosphere.LST is actually an instrument suite,which consists of a Solar Disk Imager(SDI),a Solar Corona Imager(SCI),a White-light Solar Telescope(WST)and two Guide Telescopes(GTs).This is the first paper in a series of LST-related papers.In this paper,we introduce the scientific objectives,present an overview of the LST payload and describe the planned observations.The detailed design and data along with potential diagnostics are described in the second(Paper II)and third(Paper III)papers,respectively,appearing in this issue.展开更多
As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SD...As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload.展开更多
The hot deformation behavior and microstructure evolution of 6082 aluminum alloy fabricated through squeeze casting(SC)under different pressures were studied.The alloy was subjected to hot compression tests and 3D hot...The hot deformation behavior and microstructure evolution of 6082 aluminum alloy fabricated through squeeze casting(SC)under different pressures were studied.The alloy was subjected to hot compression tests and 3D hot processing maps were established.The microstructure evolution was studied by optical microscope(OM),scanning electron microscope(SEM),and electron backscattered diffraction(EBSD).It is found that more dynamic recrystallization(DRX)grains are generated during the deformation of the specimen fabricated under higher SC pressure.At high temperature the effect of SC pressure on microstructure evolution weakens due to the dissolution of second phase particles.In addition,uneven second phase particles in specimens fabricated under higher SC pressure compressed with low temperature and middle strain rate would result in flow localization instability.Finally,the optimum deformation conditions for the 6082 aluminum alloy fabricated by SC were obtained at the temperatures of 430−500℃ and the strain rates of 0.01−1 s^(−1).展开更多
The Full-disk vector Magneto Graph(FMG)instrument will carry out polarization observations at one wavelength position of the Fe I 5324.179?spectral line.This paper describes how to choose this single wavelength positi...The Full-disk vector Magneto Graph(FMG)instrument will carry out polarization observations at one wavelength position of the Fe I 5324.179?spectral line.This paper describes how to choose this single wavelength position,the relevant data-processing and the magnetic field calibrations based on the measured polarization signals at one single wavelength position.It is found that solar radial Doppler velocity,which can cause the spectral line to shift,is a disadvantageous factor for the linear calibration at one wavelength position.Observations at two symmetric wavelength positions may significantly reduce the wavelength shift effect(~75%),but simulations show that such polarization signals located at the solar limbs(e.g.,beyond the longitude range of±30°)are not free from the effect completely.In future work,we plan to apply machine learning techniques to calibrate vector magnetic fields,or employ full Stokes parameter profile inversion techniques to obtain accurate vector magnetic fields,in order to complement the linear calibration at the single wavelength position.展开更多
Objective:To investigate the safety and efficacy of nimotuzumab combined with radiotherapy for elderly patients with non-resectable esophageal carcinoma(EC).Methods:Eligible patients were aged 70 years or older and ha...Objective:To investigate the safety and efficacy of nimotuzumab combined with radiotherapy for elderly patients with non-resectable esophageal carcinoma(EC).Methods:Eligible patients were aged 70 years or older and had treatment-naive,histologically proven inoperable locally advanced EC.Enrolled patients received radiotherapy with a total dose of 50-60 Gy in 25-30 fractions,concurrent with weekly infusion of nimotuzumab.The primary end point was the rate of more than grade 3 toxicities.Results:From June 2011 to July 2016,46 patients with stageⅡ-IV EC with a median age of 76.5 years were enrolled.There were 10,28 and 8 patients with stageⅡ,III and IV disease,respectively.The common acute toxicities included esophagitis(grade 1-2,75.4%;grade 3,8.7%),pneumonitis(grade 1,4.3%;grade 2,6.5%;grade3,2.2%),leukopenia(grade 1-2,60.9%;grade 3-4,4.4%),gastrointestinal reaction(grade 1-2,17.3%;grade 3,2.2%),thrombocytopenia(grade 1-2,21.7%;grade 3,2.2%),and radiothermitis(grade 1-2,39.2%).The incidence of grade 3-4 adverse effects was 17.4%.No grade 5 toxicities were observed.Clinical complete response,partial response,stable disease,and progressive disease were observed in 1(2.2%),31(67.4%),12(26.1%),and 2(4.3%)patients,respectively.The median overall survival(OS)and progression-free survival(PFS)were 17 and 10 months,respectively.The 2-,3-,and 5-year OS and PFS rates were 30.4%,21.7%,19.6%,and 26.1%,19.6%,19.6%,respectively.Conclusions:Nimotuzumab combined with radiotherapy is a safe and effective therapy for elderly patients who are not surgical candidates.Further studies are warranted to confirm its therapeutic effects in elderly EC patients.展开更多
As one of the most important vegetables,tomato (Solanum lycopersicum) is extensively produced and consumed worldwide and substantially contributes to human nutrition and health (The Tomato Genome Consortium,2012).Alth...As one of the most important vegetables,tomato (Solanum lycopersicum) is extensively produced and consumed worldwide and substantially contributes to human nutrition and health (The Tomato Genome Consortium,2012).Although red tomatoes are the most common,pink tomatoes are more popular in Asia,particularly in China and Japan,because of their better taste (Ballester et al.,2010;Zhu et al.,2018).Compared with red tomatoes,pink tomatoes fail to accumulate the yellow-colored flavonoid pigment,naringenin chalcone (NarCh),in their peels,resulting in a colorless peel phenotype (Adato et al,2009;Ballester et al.,2010).展开更多
基金supported by Natural Science Foundation Project of Ningxia Hui Autonomous Region(No.2021AAC03327)Hunan Provincial Natural Science Foundation(No.2021JJ31058)+2 种基金Shanghai Pujiang Program(No.23PJ1403300)Shanghai Science and Technology Commission(No.23ZR1440700)National Natural Science Foundation of China(No.82000797,82102244,31971077,and 82070255)。
文摘Objective:Baicalein has been reported to have wide therapeutic effects that act through its antiinflammatory activity.This study examines the effect and mechanism of baicalein on sepsis-induced cardiomyopathy(SIC).Methods:A thorough screening of a small library of natural products,comprising 100 diverse compounds,was conducted to identify the most effective drug against lipopolysaccharide(LPS)-treated H9C2 cardiomyocytes.The core target proteins and their associated signaling pathways involved in baicalein's efficacy against LPS-induced myocardial injury were predicted by network pharmacology.Results:Baicalein was identified as the most potent protective agent in LPS-exposed H9C2 cardiomyocytes.It exhibited a dose-dependent inhibitory effect on cell injury and inflammation.In the LPSinduced septic mouse model,baicalein demonstrated a significant capacity to mitigate LPS-triggered myocardial deficits,inflammatory responses,and ferroptosis.Network pharmacological analysis and experimental confirmation suggested that hypoxia-inducible factor 1 subunit a(HIF1-a)is likely to be the crucial factor in mediating the impact of baicalein against LPS-induced myocardial ferroptosis and injury.By combining microRNA(miRNA)screening in LPS-treated myocardium with miRNA prediction targeting HIF1-a,we found that miR-299b-5p may serve as a regulator of HIF1-a.The reduction in miR-299b-5p levels in LPS-treated myocardium,compared to the control group,was reversed by baicalein treatment.The reverse transcription quantitative polymerase chain reaction,Western blotting,and dual-luciferase reporter gene analyses together identified HIF1-a as the target of miR-299b-5p in cardiomyocytes.Conclusion:Baicalein mitigates SIC at the miRNA level,suggesting the therapeutic potential of it in treating SIC through the regulation of miR-299b-5p/HIF1-a/ferroptosis pathway.
文摘BACKGROUND Cardiopulmonary bypass(CPB)is a life-support technology widely used in surgery.Review articles reflect research advances in a certain topic or field within a certain period of time.AIM To perform a bibliometric analysis of the review articles that focused on CPB for cardiovascular surgery.METHODS This study was based on a bibliometric analysis.Data were acquired from the Web of Science and basic bibliometric parameters were analyzed and visualized using VOSviewer and Excel.RESULTS We identified 141 review articles on CPB.Generally,the number of publications increased,and most of them were published in the 2010s(n=57,40.4%)and the 2020s(n=45,31.9%).There were 113(80.1%)narrative review articles,21(14.9%)meta-analysis studies and 7(5.0%)systematic review papers.The United States(n=25,17.7%)and China(n=21,14.9%)were the leading countries in terms of publication number.The articles were published in 98 different journals.The Journal of Cardiothoracic and Vascular Anesthesia(n=14,10.0%)and Perfusion-United Kingdom(n=11,7.8%)were preferred by the authors.The high-frequency keywords included inflammatory response,children,acute kidney injury,meta-analysis and off-pump,except for CPB and cardiac surgery.Inflammatory response had the closest relationship with CPB during cardiac surgery.The complications of CPB,including inflammatory response,kidney injury and ischemia,caught lots of concern.CONCLUSION The rapid increase of review papers shows that the research on CPB in cardiac surgery is increasingly being emphasized by scholars and clinical staff worldwide.Meta-analysis has been widely conducted to analyze clinical controversies and further guide clinical practice.Strategies to improving the outcomes of patients undergoing cardiac surgery with CPB are the hot spots in this field.
基金supported by the National Key R&D Program of China (2022YFF0503800)National Natural Science Foundation of China grants (12073073, 11933009, 12273107 and U2031141)+6 种基金grants associated with the Yunnan Revitalization Talent Support Programthe Foundation of the Chinese Academy of Sciences (Light of West China Program)the Yunling Scholar Project of Yunnan Provincethe Yunnan Province Scientist Workshop of Solar Physicsthe Applied Basic Research of Yunnan Province grants (202101AT070018 and 2019FB005)supported by the National Natural Science Foundation of China grants (12273107 and U2031141)the Yunnan Key Laboratory of Solar Physics and Space Science (202205AG070009)
文摘The Solar Close Observations and Proximity Experiments(SCOPE)mission will send a spacecraft into the solar atmosphere at a low altitude of just 5 R☉from the solar center.It aims to elucidate the mechanisms behind solar eruptions and coronal heating,and to directly measure the coronal magnetic field.The mission will perform in situ measurements of the current sheet between coronal mass ejections and their associated solar flares,and energetic particles produced by either reconnection or fast-mode shocks driven by coronal mass ejections.This will help to resolve the nature of reconnections in current sheets,and energetic particle acceleration regions.To investigate coronal heating,the mission will observe nano-flares on scales smaller than 70 km in the solar corona and regions smaller than 40 km in the photosphere,where magnetohydrodynamic waves originate.To study solar wind acceleration mechanisms,the mission will also track the process of ion charge-state freezing in the solar wind.A key achievement will be the observation of the coronal magnetic field at unprecedented proximity to the solar photosphere.The polar regions will also be observed at close range,and the inner edge of the solar system dust disk may be identified for the first time.This work presents the detailed background,science,and mission concept of SCOPE and discusses how we aim to address the questions mentioned above.
基金supported by the Beijing Xisike Clinical Oncology Research Foundation(grant number:Y-pierrefabre202101-0119)the National High Level Hospital Clinical Research Funding and the Cooperation Fund of CHCAMS Beijing&Langfang&SZCH(grant number:CFA202502021).
文摘Background:Individuals with unresectable stageⅢnon-small cell lung cancer(NSCLC)who receive complete concurrent chemoradiotherapy(cCRT)can benefit from long-term survival.Although neoadjuvant chemoim-munotherapy(NACIT)have achieved breakthroughs in treating unresectable stageⅢNSCLC,patients who have received induction chemoimmunotherapy are considered poor candidates for cCRT due to concerns about tolerability.Oral vinorelbine chemotherapy is widely used in clinical settings because of its safety,even for frail patients.The objective of this trial was to assess the efficacy and safety of oral vinorelbine plus concurrent radiotherapy(RT)for individuals with unresectable stageⅢNSCLC following NACIT who were not candidates for concurrent intravenous chemotherapy.Methods:This was a single-arm,phase 2 trial.The primary endpoint was the objective response rate(ORR),while the secondary endpoints consisted of the disease control rate(DCR),safety,overall survival(OS),as well as progression-free survival(PFS).Results:Between March 10,2023 and April 24,2025,46 individuals with unresectable stageⅢNSCLC were administered oral vinorelbine plus thoracic RT.Patients were treated with oral vinorelbine(60 mg/m^(2)once a week for 2 weeks as induction therapy before thoracic RT)and 30 mg/m^(2)per week with concurrent RT(59.4-60.2 Gy)over 5.5 weeks.The median age of the patients was 62.5 years,with 42 being male(91.3%).The ORR was 52.1%(95%confidence interval[CI],35.1%-65.9%),with 24 partial responders.A 95.7%DCR(85.5%-98.8%)was observed,and 20 patients had stable disease.The median follow-up was 22.5 months;the median PFS was 18.0 months and the median OS was not reached.The most commonly observed adverse events(AEs)included leukopenia(grade 1,26.1%),anemia(grade 1,17.4%),neutropenia(grade 1,10.9%),acute esophagitis(grade 2,17.4%),and treatment-related pneumonitis(grade 1-2,60.9%).No grade 3 or 4 treatment-related AEs were recorded.Conclusion:In individuals with unresectable stageⅢNSCLC who had received NACIT and were not candidates for concurrent intravenous chemotherapy with RT,the oral vinorelbine plus concurrent RT demonstrated promising antitumor efficacy with acceptable toxicity profiles.
基金financially supported by Natural Science Foundation of Hebei Province(Nos.B2020203037,F2021203097)Science Research Project of Hebei Education Department(No.JZX2024022)National Natural Science Foundation of China(Nos.52022088,51971245)。
文摘Halide electrolytes,renowned for their excellent electrochemical stability and wide voltage window,exhibit significant potential in the development of high energy density solid-state batteries featuring high voltage cathode materials.In this study,we present the development and synthesis of a 0.6Li_(2)S-ZrCl_(4)solid electrolyte,demonstrating an ion conductivity of 1.9×10^(–3)S/cm at 25°C.Under a pressure of 500 MPa,the relative density of the electrolyte can reach 97.37%,showcasing its commendable compressibility.0.6Li_(2)S-ZrCl_(4)served as the electrolyte,and we assembled batteries utilizing a LiCoO_(2)(LCO)positive electrode,Li_(9.54)Si_(1.74)P_(1.44)S_(11.7)Cl_(0.3)(LSPSCl)coating,and Li-In negative electrode for laboratory testing.At 25°C,this all-solid-state battery demonstrated an impressive discharge capacity retention rate of86.99%(with a final discharge specific capacity of 110.5 m Ah/g)after 250 cycles at 24 m A/g and 100 MPa stack pressure.Upon substituting the positive electrode material with LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)(NMC811)and assembling an all-solid-state battery,it demonstrated a discharge capacity retention rate of 74.17%after200 cycles at 3.6 m A/g and 100 MPa stack pressure in an environment at 25°C(with a final discharge specific capacity of 103.3 m A/g).Our findings hold significant implications for the design of novel superionic conductors,thereby contributing to the advancement of all-solid-state battery technology.
基金sponsored by the National Natural Science Foundation of China(Grant Nos.32125027,31930075)Zhejiang A&F University Research and Development Fund(No.2022LFR006).
文摘Moso bamboo(Phyllostachys edulis)forests are a vital resource in subtropical China,known for their high carbon(C)sequestration capacity.However,the dynamic processes of C fluxes within each component(canopy,culm,and soil)and their individual contributions,particularly during on-and off-years,remain unclear.A 2-year field experiment was conducted to investigate the dynamics of C fluxes from the canopy,culm,and soil(partitioned into heterotrophic,rhizome,and stump respiration)and their contributions to net ecosystem productivity(NEP)in a representative Moso bamboo forest in the subtropical region of China.The average annual NEP of the Moso bamboo forest was 7.31±2.76 t C·ha^(-1).Specifically,the canopy's annual net C uptake was 17.30±3.23 tC·ha^(-1),accounting for 237%of NEP.In contrast,C emissions from heterotrophs,culms,rhizomes,and stumps were 5.37±1.20,2.18±1.05,1.29±0.04,and 1.15±0.33 t C·ha^(-1),accounting for73%,30%,18%,and16%of NEP,respectively.The NEP,net cumulative C uptake in the canopy,and C emissions from the respiration of heterotrophs and stumps were all significantly higher during on-years when compared to off-years,whereas C emissions from bamboo culms displayed opposite trends.These findings offer a new approach for quantifying the C budgets of Moso bamboo forests and provide valuable insights into the C cycling processes in forest ecosystems.
基金Supported by Project Fund of the Health Commission of Sichuan Province,No.19PJ290。
文摘BACKGROUND Helicobacter pylori(H.pylori)infection is highly prevalent worldwide,and rising antibiotic resistance has reduced the efficacy of standard therapy,underscoring the need for simplified and better-tolerated regimens.AIM To evaluate the efficacy,safety,and optimal dosing of vonoprazan(VPZ)-amoxicillin(AMO)dual therapy in a non-inferiority randomized trial for H.pylori eradication.METHODS In this multi-center,randomized trial conducted at 17 hospitals in Sichuan Province,China,1717 adults with confirmed infection were assigned(1:1:1)to 14-day regimens:(1)VPZ 20 mg BID+AMO 0.5 g QID;(2)0.75 g QID;or(3)1.0 g TID.The primary endpoint was the eradication rate based on intention-to-treat(ITT)and per-protocol(PP)analyses;secondary endpoints included adverse events(AEs)and treatment compliance.RESULTS Eradication rates were consistently high(92.35%-97.43%).In the 0.5 g QID group,ITT and PP eradication rates were 93.3%(95%CI:91.2-95.1)and 97.4%(95%CI:95.7-98.5),respectively,with no significant differences among groups(P>0.05).Compliance ranged from 98.1%to 98.3%,and AEs were infrequent(5.2%-7.5%),predominantly mild gastrointestinal symptoms,which occurred least often in the 0.5 g QID group.CONCLUSION VPZ-AMO dual therapy achieved excellent eradication,safety,and patient compliance.All regimens were similarly effective,whereas the 0.5 g QID dosing strategy offered the most favorable balance of efficacy and tolerability,supporting its use as a first-line option in high-prevalence settings.
基金supported by the Strategic Priority Research Program on Space Science, Chinese Academy of Sciences (Grant Nos. XDA15320100, XDA15320102, XDA15320103, XDA15320104, XDA15320300 and XDA15052200)supported by the National Natural Science Foundation of China (Grant Nos. 11427803, U1731241, U1631242 and 11820101002)
文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C.
基金supported by the National Natural Science Foundation of China (Grant Nos.11427803 and U1731241)the CAS Strategic Pioneer Program on Space Science (Grant Nos.XDA04061003, XDA04076100, XDA15052200, XDA15320103 and XDA15320301)
文摘As one of the payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is aimed at imaging the Sun and the inner corona up to 2.5 R⊙(mean solar radius)in both the Lyα(121.6 nm)and visible wavebands with high temporo-spatial resolution,mainly targeting solar flares,coronal mass ejections(CMEs)and filaments/prominences.LST observations allow us to trace solar eruptive phenomena from the disk center to the inner corona,to study the relationships between eruptive prominences/filaments,solar flares and CMEs,to explore the dynamical processes and evolution of solar eruptions,to diagnose solar winds,and to derive physical parameters of the solar atmosphere.LST is actually an instrument suite,which consists of a Solar Disk Imager(SDI),a Solar Corona Imager(SCI),a White-light Solar Telescope(WST)and two Guide Telescopes(GTs).This is the first paper in a series of LST-related papers.In this paper,we introduce the scientific objectives,present an overview of the LST payload and describe the planned observations.The detailed design and data along with potential diagnostics are described in the second(Paper II)and third(Paper III)papers,respectively,appearing in this issue.
基金supported by Chinese Academy of Sciences (CAS)supported by the National Natural Science Foundation of China (Grant Nos. 11427803, U1731241, U1731114 and U1531106)the CAS Strategic Pioneer Program on Space Science (Grant Nos. XDA04076100, XDA15052200, XDA15320103 and XDA15320301)
文摘As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload.
基金financially supported by the National Natural Science Foundation of China (Nos.52090043,51725504)the Key Research and Development Program of Hubei Province,China (No.2020BAB040)the Fundamental Research Funds for the Central Universities,China (No.2021GCRC003)。
文摘The hot deformation behavior and microstructure evolution of 6082 aluminum alloy fabricated through squeeze casting(SC)under different pressures were studied.The alloy was subjected to hot compression tests and 3D hot processing maps were established.The microstructure evolution was studied by optical microscope(OM),scanning electron microscope(SEM),and electron backscattered diffraction(EBSD).It is found that more dynamic recrystallization(DRX)grains are generated during the deformation of the specimen fabricated under higher SC pressure.At high temperature the effect of SC pressure on microstructure evolution weakens due to the dissolution of second phase particles.In addition,uneven second phase particles in specimens fabricated under higher SC pressure compressed with low temperature and middle strain rate would result in flow localization instability.Finally,the optimum deformation conditions for the 6082 aluminum alloy fabricated by SC were obtained at the temperatures of 430−500℃ and the strain rates of 0.01−1 s^(−1).
基金supported by the Strategic Priority Research Program on Space Science, the Chinese Academy of Sciences (Grant Nos. XDA15320302, XDA15052200 and XDA15320102)the National Natural Science Foundation of China (Grant Nos. 11773038, 11703042, U1731241, 11427901, 11427803, 11473039 and U1831107)the 13th Fiveyear Informatization Plan of the Chinese Academy of Sciences (Grant No. XXH13505-04)
文摘The Full-disk vector Magneto Graph(FMG)instrument will carry out polarization observations at one wavelength position of the Fe I 5324.179?spectral line.This paper describes how to choose this single wavelength position,the relevant data-processing and the magnetic field calibrations based on the measured polarization signals at one single wavelength position.It is found that solar radial Doppler velocity,which can cause the spectral line to shift,is a disadvantageous factor for the linear calibration at one wavelength position.Observations at two symmetric wavelength positions may significantly reduce the wavelength shift effect(~75%),but simulations show that such polarization signals located at the solar limbs(e.g.,beyond the longitude range of±30°)are not free from the effect completely.In future work,we plan to apply machine learning techniques to calibrate vector magnetic fields,or employ full Stokes parameter profile inversion techniques to obtain accurate vector magnetic fields,in order to complement the linear calibration at the single wavelength position.
基金supported by Wu Jieping Medical Foundation,the National Key Projects of Research and Development of China(No.2016YFC0904600)。
文摘Objective:To investigate the safety and efficacy of nimotuzumab combined with radiotherapy for elderly patients with non-resectable esophageal carcinoma(EC).Methods:Eligible patients were aged 70 years or older and had treatment-naive,histologically proven inoperable locally advanced EC.Enrolled patients received radiotherapy with a total dose of 50-60 Gy in 25-30 fractions,concurrent with weekly infusion of nimotuzumab.The primary end point was the rate of more than grade 3 toxicities.Results:From June 2011 to July 2016,46 patients with stageⅡ-IV EC with a median age of 76.5 years were enrolled.There were 10,28 and 8 patients with stageⅡ,III and IV disease,respectively.The common acute toxicities included esophagitis(grade 1-2,75.4%;grade 3,8.7%),pneumonitis(grade 1,4.3%;grade 2,6.5%;grade3,2.2%),leukopenia(grade 1-2,60.9%;grade 3-4,4.4%),gastrointestinal reaction(grade 1-2,17.3%;grade 3,2.2%),thrombocytopenia(grade 1-2,21.7%;grade 3,2.2%),and radiothermitis(grade 1-2,39.2%).The incidence of grade 3-4 adverse effects was 17.4%.No grade 5 toxicities were observed.Clinical complete response,partial response,stable disease,and progressive disease were observed in 1(2.2%),31(67.4%),12(26.1%),and 2(4.3%)patients,respectively.The median overall survival(OS)and progression-free survival(PFS)were 17 and 10 months,respectively.The 2-,3-,and 5-year OS and PFS rates were 30.4%,21.7%,19.6%,and 26.1%,19.6%,19.6%,respectively.Conclusions:Nimotuzumab combined with radiotherapy is a safe and effective therapy for elderly patients who are not surgical candidates.Further studies are warranted to confirm its therapeutic effects in elderly EC patients.
基金supported by the National Key Research and Development Program of China (2017YFD0101900)the National Natural Science Foundation of China(31601759)+1 种基金the Key Research and Development Program of Guangdong Province (2018B020202006)the Ministry of Agriculture of China (2016ZX08009-003-001)
文摘As one of the most important vegetables,tomato (Solanum lycopersicum) is extensively produced and consumed worldwide and substantially contributes to human nutrition and health (The Tomato Genome Consortium,2012).Although red tomatoes are the most common,pink tomatoes are more popular in Asia,particularly in China and Japan,because of their better taste (Ballester et al.,2010;Zhu et al.,2018).Compared with red tomatoes,pink tomatoes fail to accumulate the yellow-colored flavonoid pigment,naringenin chalcone (NarCh),in their peels,resulting in a colorless peel phenotype (Adato et al,2009;Ballester et al.,2010).
