Misfoldedα-synuclein(α-syn)hallmarks the neuropathological characteristics of Parkinson's disease(PD)and acts as a"pathological seed"that promotes the progression of the disease[1].About 15%of PD patie...Misfoldedα-synuclein(α-syn)hallmarks the neuropathological characteristics of Parkinson's disease(PD)and acts as a"pathological seed"that promotes the progression of the disease[1].About 15%of PD patients have a family history,5%-10%have a monogenic disorder with a Mendelian pattern of inheritance[2],and>90 independent risk signals identified by genome-wide association studies(GWASs)can be used to explain the non-monogenic risk of PD[3].展开更多
结直肠癌(colorectal cancer,CRC)是全球高发恶性肿瘤,老年人群的发病率和死亡率居高,随着老龄化的加剧,老年CRC患者也逐年增多。世界卫生组织(World Health Organization,WHO)等机构调查^([1-2])显示,65岁及以上人群CRC的发病率远超其...结直肠癌(colorectal cancer,CRC)是全球高发恶性肿瘤,老年人群的发病率和死亡率居高,随着老龄化的加剧,老年CRC患者也逐年增多。世界卫生组织(World Health Organization,WHO)等机构调查^([1-2])显示,65岁及以上人群CRC的发病率远超其他年龄段,严重影响老年人健康与生活。目前,手术仍是CRC主要治疗手段,部分患者则因病情或手术需要接受永久/临时性造口(人工肛门)。展开更多
In 316L austenitic stainless steel,the presence of ferrite phase severely affects the non-magnetic properties.316L austenitic stainless steel with low-alloy type(L-316L)and high-alloy type(H-316L)has been studied.The ...In 316L austenitic stainless steel,the presence of ferrite phase severely affects the non-magnetic properties.316L austenitic stainless steel with low-alloy type(L-316L)and high-alloy type(H-316L)has been studied.The microstructure and solidification kinetics of the two as-cast grades were in situ observed by high temperature confocal laser scanning microscopy(HT-CLSM).There are significant differences in the as-cast microstructures of the two 316L stainless steel compositions.In L-316L steel,ferrite morphology appears as the short rods with a ferrite content of 6.98%,forming a dual-phase microstructure consisting of austenite and ferrite.Conversely,in H-316L steel,the ferrite appears as discontinuous network structures with a content of 4.41%,forming a microstructure composed of austenite and sigma(σ)phase.The alloying elements in H-316L steel exhibit a complex distribution,with Ni and Mo enriching at the austenite grain boundaries.HT-CLSM experiments provide the real-time observation of the solidification processes of both 316L specimens and reveal distinct solidification modes:L-316L steel solidifies in an FA mode,whereas H-316L steel solidifies in an AF mode.These differences result in ferrite and austenite predominantly serving as the nucleation and growth phases,respectively.The solidification mode observed by experiments is similar to the thermodynamic calculation results.The L-316L steel solidified in the FA mode and showed minimal element segregation,which lead to a direct transformation of ferrite to austenite phase(δ→γ)during phase transformation after solidification.Besides,the H-316L steel solidified in the AF mode and showed severe element segregation,which lead to Mo enrichment at grain boundaries and transformation of ferrite into sigma and austenite phases through the eutectoid reaction(δ→σ+γ).展开更多
Tectonic activities significantly impact deep reservoir properties via sedimentary and diagenetic processes,and this is particularly true for lacustrine rift basins.The tectonic-sedimentary-diageneticreservoir system ...Tectonic activities significantly impact deep reservoir properties via sedimentary and diagenetic processes,and this is particularly true for lacustrine rift basins.The tectonic-sedimentary-diageneticreservoir system is crucial in deep reservoir exploration.This study examined the first member and upper submember of the second member of the Dongying Formation in the Bodong Low Uplift in the Bohai Bay Basin(East China),documenting the petrologic features and physical properties of reservoirs in different tectonic sub-units through integrated analysis of log and rock data,along with core observation.A mechanism for deep reservoir formation in lacustrine rift basins was developed to elucidate the sedimentary and diagenetic processes in complex tectonic settings.The results show that tectonic activities result in the occurrence of provenances in multiple directions and the existence of reservoirs at varying burial depths,as well as the significant diversity in sedimentary and diagenetic processes.The grain sizes of the sandstones,influenced by transport pathways rather than the topography of the sedimentary area,exhibit spatial complexity due to tectonic frameworks,which determine the initial pore content of reservoirs.However,the burial depth,influenced by subsequent tectonic subsidence,significantly impacts pore evolution during diagenesis.Based on the significant differences of reservoirs in slope zone,low uplift and depression zone,we establish different tectonic-diagenetic models in deep complex tectonic units of lacustrine rift basins.展开更多
背景混合痔术后便秘是常见且影响患者生活质量的并发症,常规的术后护理措施往往无法有效缓解这一问题.多学科协作的多元素干预措施通过围手术期的饮食指导、药物干预及家属参与,能综合改善患者的术后恢复情况.本研究假设,实施多学科协...背景混合痔术后便秘是常见且影响患者生活质量的并发症,常规的术后护理措施往往无法有效缓解这一问题.多学科协作的多元素干预措施通过围手术期的饮食指导、药物干预及家属参与,能综合改善患者的术后恢复情况.本研究假设,实施多学科协作干预能够显著缩短便秘患者术后恢复时间、降低并发症发生率、提高患者的生活质量与满意度,为临床护理提供新思路.目的探讨基于多学科协作的多元素干预措施在混合痔术后便秘患者中的应用效果.方法选取2024-01/2024-12在瑞安市人民医院接受混合痔手术治疗的111例便秘患者,随机分为观察组(n=62)和对照组(n=49).对照组接受常规术后便秘防治措施,包括术后常规指导及对症通便治疗.观察组在对照组基础上,实施多学科协作的多元素干预措施,包括围手术期超前饮食干预、指导家属合理饮食搭配、术后排便药物干预等.比较两组患者的一般临床资料、术后临床症状恢复情况、便秘症状评分(Constipation Symptom Score,CSS)、简明健康状况调查问卷36条评分(Short Form 36 Health Survey,SF-36)评估生活质量、术后并发症发生情况及治疗满意度.结果与对照组相比,观察组患者首次排便时间、疼痛消失时间、出血消失时间、水肿消失时间及创面愈合时间均显著缩短(P<0.05);干预后及术后三个月CSS评分显著降低(P<0.05);干预后及术后三个月SF-36评分显著提高(P<0.05);术后出血、感染和便秘发生率显著降低(P<0.05);治疗总满意度显著提高(P<0.05).结论基于多学科协作的多元素干预能有效改善混合痔术后便秘患者的临床症状、提高生活质量、降低并发症发生率,并提升患者满意度,值得临床推广应用.展开更多
Abnormal wound scarring often leads to functional impairments and cosmetic deformities,primarily driven by the prolonged activation of the TGF-β/Smad signaling pathway.Addressing this challenge,we developed a biomime...Abnormal wound scarring often leads to functional impairments and cosmetic deformities,primarily driven by the prolonged activation of the TGF-β/Smad signaling pathway.Addressing this challenge,we developed a biomimetic scaffold aimed at facilitating rapid and scarless wound healing.This highly in-tegrated 3D-printed dermal scaffold comprised modified recombinant human type III collagen(rhCOLIII-MA),gelatin methacrylate(GelMA),and liposomes encapsulating SB431542 to target TGF-β1(Lip@SB).The rhCOLIII-MA/GelMA(CG)scaffold retained inherent biomaterial characteristics,exhibited tailored physicochemical properties,and demonstrated favorable biocompatibility.Moreover,the Lip@SB-loaded CG scaffold(CGL)effectively promoted in vitro wound healing,while enabling controlled release of SB431542 to inhibit pathological collagen deposition.In a full-thickness skin defect rat model,the CGL dermal scaffold combined with split-thickness skin graft(STSG)minimized scar contraction,stimulated functional neovascularization,and enhanced graft aesthetics comparable to normal skin.Remarkably,the performance of the CGL scaffold surpassed that of commercially available anti-scarring alternatives.This innovative strategy presents a straightforward approach toward scarless skin regeneration and holds promise in alleviating the prolonged,painful postoperative rehabilitation.展开更多
The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analys...The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.展开更多
BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram ...BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.展开更多
基金supported by the National Natural Science Foundation of China(31871049 and 32170984).
文摘Misfoldedα-synuclein(α-syn)hallmarks the neuropathological characteristics of Parkinson's disease(PD)and acts as a"pathological seed"that promotes the progression of the disease[1].About 15%of PD patients have a family history,5%-10%have a monogenic disorder with a Mendelian pattern of inheritance[2],and>90 independent risk signals identified by genome-wide association studies(GWASs)can be used to explain the non-monogenic risk of PD[3].
文摘结直肠癌(colorectal cancer,CRC)是全球高发恶性肿瘤,老年人群的发病率和死亡率居高,随着老龄化的加剧,老年CRC患者也逐年增多。世界卫生组织(World Health Organization,WHO)等机构调查^([1-2])显示,65岁及以上人群CRC的发病率远超其他年龄段,严重影响老年人健康与生活。目前,手术仍是CRC主要治疗手段,部分患者则因病情或手术需要接受永久/临时性造口(人工肛门)。
基金support of the Research Project Supported by Shanxi Scholarship Council of China(2022-040)"Chunhui Plan"Collaborative Research Project by the Ministry of Education of China(HZKY20220507)+2 种基金National Natural Science Foundation of China(52104338)Applied Fundamental Research Programs of Shanxi Province(202303021221036)Shandong Postdoctoral Science Foundation(SDCX-ZG-202303027,SDBX2023054).
文摘In 316L austenitic stainless steel,the presence of ferrite phase severely affects the non-magnetic properties.316L austenitic stainless steel with low-alloy type(L-316L)and high-alloy type(H-316L)has been studied.The microstructure and solidification kinetics of the two as-cast grades were in situ observed by high temperature confocal laser scanning microscopy(HT-CLSM).There are significant differences in the as-cast microstructures of the two 316L stainless steel compositions.In L-316L steel,ferrite morphology appears as the short rods with a ferrite content of 6.98%,forming a dual-phase microstructure consisting of austenite and ferrite.Conversely,in H-316L steel,the ferrite appears as discontinuous network structures with a content of 4.41%,forming a microstructure composed of austenite and sigma(σ)phase.The alloying elements in H-316L steel exhibit a complex distribution,with Ni and Mo enriching at the austenite grain boundaries.HT-CLSM experiments provide the real-time observation of the solidification processes of both 316L specimens and reveal distinct solidification modes:L-316L steel solidifies in an FA mode,whereas H-316L steel solidifies in an AF mode.These differences result in ferrite and austenite predominantly serving as the nucleation and growth phases,respectively.The solidification mode observed by experiments is similar to the thermodynamic calculation results.The L-316L steel solidified in the FA mode and showed minimal element segregation,which lead to a direct transformation of ferrite to austenite phase(δ→γ)during phase transformation after solidification.Besides,the H-316L steel solidified in the AF mode and showed severe element segregation,which lead to Mo enrichment at grain boundaries and transformation of ferrite into sigma and austenite phases through the eutectoid reaction(δ→σ+γ).
基金funded by the Open Fund of Key Laboratory of Marine Geology and Environment,Chinese Academy of Sciences(Grant No.MGE2020KG10)the Open Fund of Key Laboratory of Submarine Geosciences,Ministry of Natural Resources(Grant No.KLSG 2208)+2 种基金the Natural Science Basic Research Program of Shaanxi(Grant No.2024JC-YBMS-227,2023-JC-QN-0287)the Postgraduate Innovation and Practice Ability Development Fund of Xi'an Shiyou University(No.YCS23113046)the National Natural Science Foundation of China(Grant No.41802128,42076219)。
文摘Tectonic activities significantly impact deep reservoir properties via sedimentary and diagenetic processes,and this is particularly true for lacustrine rift basins.The tectonic-sedimentary-diageneticreservoir system is crucial in deep reservoir exploration.This study examined the first member and upper submember of the second member of the Dongying Formation in the Bodong Low Uplift in the Bohai Bay Basin(East China),documenting the petrologic features and physical properties of reservoirs in different tectonic sub-units through integrated analysis of log and rock data,along with core observation.A mechanism for deep reservoir formation in lacustrine rift basins was developed to elucidate the sedimentary and diagenetic processes in complex tectonic settings.The results show that tectonic activities result in the occurrence of provenances in multiple directions and the existence of reservoirs at varying burial depths,as well as the significant diversity in sedimentary and diagenetic processes.The grain sizes of the sandstones,influenced by transport pathways rather than the topography of the sedimentary area,exhibit spatial complexity due to tectonic frameworks,which determine the initial pore content of reservoirs.However,the burial depth,influenced by subsequent tectonic subsidence,significantly impacts pore evolution during diagenesis.Based on the significant differences of reservoirs in slope zone,low uplift and depression zone,we establish different tectonic-diagenetic models in deep complex tectonic units of lacustrine rift basins.
文摘背景混合痔术后便秘是常见且影响患者生活质量的并发症,常规的术后护理措施往往无法有效缓解这一问题.多学科协作的多元素干预措施通过围手术期的饮食指导、药物干预及家属参与,能综合改善患者的术后恢复情况.本研究假设,实施多学科协作干预能够显著缩短便秘患者术后恢复时间、降低并发症发生率、提高患者的生活质量与满意度,为临床护理提供新思路.目的探讨基于多学科协作的多元素干预措施在混合痔术后便秘患者中的应用效果.方法选取2024-01/2024-12在瑞安市人民医院接受混合痔手术治疗的111例便秘患者,随机分为观察组(n=62)和对照组(n=49).对照组接受常规术后便秘防治措施,包括术后常规指导及对症通便治疗.观察组在对照组基础上,实施多学科协作的多元素干预措施,包括围手术期超前饮食干预、指导家属合理饮食搭配、术后排便药物干预等.比较两组患者的一般临床资料、术后临床症状恢复情况、便秘症状评分(Constipation Symptom Score,CSS)、简明健康状况调查问卷36条评分(Short Form 36 Health Survey,SF-36)评估生活质量、术后并发症发生情况及治疗满意度.结果与对照组相比,观察组患者首次排便时间、疼痛消失时间、出血消失时间、水肿消失时间及创面愈合时间均显著缩短(P<0.05);干预后及术后三个月CSS评分显著降低(P<0.05);干预后及术后三个月SF-36评分显著提高(P<0.05);术后出血、感染和便秘发生率显著降低(P<0.05);治疗总满意度显著提高(P<0.05).结论基于多学科协作的多元素干预能有效改善混合痔术后便秘患者的临床症状、提高生活质量、降低并发症发生率,并提升患者满意度,值得临床推广应用.
基金supported by the National Natural Science Foundation of China(No.82272297).
文摘Abnormal wound scarring often leads to functional impairments and cosmetic deformities,primarily driven by the prolonged activation of the TGF-β/Smad signaling pathway.Addressing this challenge,we developed a biomimetic scaffold aimed at facilitating rapid and scarless wound healing.This highly in-tegrated 3D-printed dermal scaffold comprised modified recombinant human type III collagen(rhCOLIII-MA),gelatin methacrylate(GelMA),and liposomes encapsulating SB431542 to target TGF-β1(Lip@SB).The rhCOLIII-MA/GelMA(CG)scaffold retained inherent biomaterial characteristics,exhibited tailored physicochemical properties,and demonstrated favorable biocompatibility.Moreover,the Lip@SB-loaded CG scaffold(CGL)effectively promoted in vitro wound healing,while enabling controlled release of SB431542 to inhibit pathological collagen deposition.In a full-thickness skin defect rat model,the CGL dermal scaffold combined with split-thickness skin graft(STSG)minimized scar contraction,stimulated functional neovascularization,and enhanced graft aesthetics comparable to normal skin.Remarkably,the performance of the CGL scaffold surpassed that of commercially available anti-scarring alternatives.This innovative strategy presents a straightforward approach toward scarless skin regeneration and holds promise in alleviating the prolonged,painful postoperative rehabilitation.
文摘The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.
基金Supported by the Appropriate Technology Promotion Program in Chongqing,No.2023jstg005.
文摘BACKGROUND Ampullary adenocarcinoma is a rare malignant tumor of the gastrointestinal tract.Currently,only a few cases have been reported,resulting in limited information on survival.AIM To develop a dynamic nomogram using internal and external validation to predict survival in patients with ampullary adenocarcinoma.METHODS Data were sourced from the surveillance,epidemiology,and end results stat database.The patients in the database were randomized in a 7:3 ratio into training and validation groups.Using Cox regression univariate and multivariate analyses in the training group,we identified independent risk factors for overall survival and cancer-specific survival to develop the nomogram.The nomogram was validated with a cohort of patients from the First Affiliated Hospital of the Army Medical University.RESULTS For overall and cancer-specific survival,12(sex,age,race,lymph node ratio,tumor size,chemotherapy,surgical modality,T stage,tumor differentiation,brain metastasis,lung metastasis,and extension)and 6(age;surveillance,epidemiology,and end results stage;lymph node ratio;chemotherapy;surgical modality;and tumor differentiation)independent risk factors,respectively,were incorporated into the nomogram.The area under the curve values at 1,3,and 5 years,respectively,were 0.807,0.842,and 0.826 for overall survival and 0.816,0.835,and 0.841 for cancer-specific survival.The internal and external validation cohorts indicated good consistency of the nomogram.CONCLUSION The dynamic nomogram offers robust predictive efficacy for the overall and cancer-specific survival of ampullary adenocarcinoma.
