Atomistic simulations are carried out to investigate the nano-indentation of single crystal Cu and the sliding of the Cu-Zn alloy.As the contact zone is extended due to adhesive interaction between the contact atoms,t...Atomistic simulations are carried out to investigate the nano-indentation of single crystal Cu and the sliding of the Cu-Zn alloy.As the contact zone is extended due to adhesive interaction between the contact atoms,the contact area on a nanoscale is redefined.A comparison of contact area and contact force between molecular dynamics(MD)and contact theory based on Greenwood-Williamson(GW)model is made.Lower roughness causes the adhesive interaction to weaken,showing the better consistency between the calculated results by MD and those from the theoretical model.The simulations of the sliding show that the substrate wear decreases with the mol%of Zn increasing,due to the fact that the diffusion movements of Zn atoms in substrate are blocked during the sliding because of the hexagonal close packed(hcp)structure of Zn.展开更多
Ultra-compact spectrometers have attracted significant attention for their potential applications in portable systems for biomedical analysis,environmental monitoring,spectral analysis,and astronomical observation.In ...Ultra-compact spectrometers have attracted significant attention for their potential applications in portable systems for biomedical analysis,environmental monitoring,spectral analysis,and astronomical observation.In this work,we propose a miniaturized InGaAs-based extended short-wave infrared(eSWIR)spectrometer based on a single n-graded-p junction with voltage-tunable optical response characteristics in the range from 1600to 2100 nm.We combine this unique optical characteristic with a regression algorithm to realize the reconstruction of an unknown spectrum.The spectrometer achieves a high responsivity of 0.73 A/W at 1650 nm,and a low dark current density of 3.91×10^(-5)A/cm^2 at 200 K,corresponding to a calculated detectivity of1.69×10^(11)cm·Hz^(1/2)/W.Such spectrometers compatible with standard Ⅲ-Ⅴprocesses can offer a pathway to greatly promote the development of miniaturized spectrometers.展开更多
Chimeric antigen receptor T(CAR-T)cells have emerged as novel and promising immune therapies for the treatment of multiple types of cancer in patients with hematological malignancies.There are several key components c...Chimeric antigen receptor T(CAR-T)cells have emerged as novel and promising immune therapies for the treatment of multiple types of cancer in patients with hematological malignancies.There are several key components critical for development and application of CAR-T therapy.First,the design of CAR vectors can considerably affect several aspects of the physiological functions of these T cells.Moreover,despite the wide use of g-retrovirus and lentivirus in mediating gene transfer into T cells,optimal CAR delivery systems are also being developed and evaluated.In addition,several classes of mouse models have been used to evaluate the efficacies of CART cells;however,each model has its own limitations.Clinically,although surprising complete remission(CR)rates were observed in acute lymphoblastic leukemia(ALL),lymphoma,and multiple myeloma(MM),there is still a lack of specific targets for acute myeloid leukemia(AML).Leukemia relapse remains a major challenge,and its mechanism is presently under investigation.Cytokine release syndrome(CRS)and neurotoxicity are life-threatening adverse effects that need to be carefully treated.Several factors that compromise the activities of anti-solid cancer CAR-T cells have been recognized,and further improvements targeting these factors are the focus of the development of novel CAR-T cells.Overcoming the current hurdles will lead to optimal responses of CAR-T cells,thus paving the way for their wide clinical application.展开更多
Objective:To quantify coronavirus diseases 2019(COVID-19)pneumonia and to explore whether quantitative computer tomography(CT)could be used to assess severity on admission.Materials and methods:From January 17 to Febr...Objective:To quantify coronavirus diseases 2019(COVID-19)pneumonia and to explore whether quantitative computer tomography(CT)could be used to assess severity on admission.Materials and methods:From January 17 to February 9,2020,38 hospitalized patients with COVID-19 pneumonia were consecutively enrolled in our hospitals.All clinical data and the chest CT on admission were retrospectively reviewed and analyzed.Firstly,a quantitative method based on multi-scale convolutional neural networks was used to assess the infected lung segments and this was compared with the semi-quantitative method.Secondly,the quantitative method was tested with laboratory results and the pneumonia severity index(PSI)by correlation analyses.Thirdly,both quantitative and semi-quantitative parameters between patients with different PSI were compared.Results:Thirty cases were finally enrolled:16(53.33%)of them were male,and the mean age was 48 years old.The interval from onset symptoms to first chest CT scan was 8 days.The proportion of ground glass opacity(GGO),consolidation and the total lesion based on the quantitative method was positively correlated with the semi-quantitative CT score(P<0.001 for all;rs=0.88,0.87,0.90),CRP(P=0.0278,0.0168,0.0078;rs=0.40,0.43,0.48)and ESR(P=0.0296,0.0408,0.0048;rs=0.46,0.44,0.58),respectively,and was negatively correlated with the lymphocyte count(P=0.0222,0.0024,0.0068;rs=-0.42,-0.53,-0.48).There was a positive correlation trend between the proportion of total infection and the pneumonia severity index(P=0.0994;rs=0.30)and a tendency that patients with severe COVID-19 pneumonia had higher percentage of consolidation and total infection(P=0.0903,0.0989).Conclusions:Quantitative CT may have potential in assessing the severity of COVID-19 pneumonia on admission.展开更多
Objective:To explore the clinical and radiological characteristics of COVID-19 patients with progressive and non-progressive CT manifestations.Methods:160 patients with COVID-19 were retrospectively included from Wenz...Objective:To explore the clinical and radiological characteristics of COVID-19 patients with progressive and non-progressive CT manifestations.Methods:160 patients with COVID-19 were retrospectively included from Wenzhou and Wuhan,China.CT features including lesion position,attenuation,form and total scores(0e4)at the segment level were evaluated.Other images signs were also assessed.65 patients were classified as progressive(Group 1)and 95 as non-progressive CT(Group 2)groups according to score changes between the initial and second CT.Results:Symptoms onset-initial CT interval time in group 1[5(2,7)days]were significantly shorter than that in group 2[10(8,14)days](P<0.001).Group 2 had higher radiological scores,with more lobes and segments affected,and other CT signs(P<0.05).In group 1,radiological scores,the number of lobes and segments affected as well as lesions in both peripheral and central distribution,mixed ground grass opacity and consolidation density,and patchy form increased in the second CT(P<0.05).More reticular pattern,subpleural linear opacity and bronchial dilatation were also found(P<0.05).Conclusion:Typically radiological characteristics of progressive CT patients could potentially help to predict changes and increase understanding of the natural history of COVID-19.展开更多
Although chimeric antigen receptor T-cell(CAR-T-cell)therapy has shown excellent efficacy against refractory/relapsed B-cell lymphoma,B-cell acute lymphoblastic leukemia and multiple myeloma,1,2 the complete response ...Although chimeric antigen receptor T-cell(CAR-T-cell)therapy has shown excellent efficacy against refractory/relapsed B-cell lymphoma,B-cell acute lymphoblastic leukemia and multiple myeloma,1,2 the complete response rate of patients with refractory/relapsed B-cell lymphoma receiving conventional CAR-T-cell therapy is approximately 40%to 50%.3–5 There are 3 drawbacks to viral CAR-T-cell therapy.First,random integration of the CAR cassette and lentivirus replication are potential risks for viral CAR-T-cell therapy(Fig.1A).展开更多
基金Project supported by the National Key Research and Development Program of China(Grant No.2018YFC0808800)the Natural Science Foundation of Jiangsu Higher Education Institutions,China(Grant No.17KJA460002)the“Six Talent Peaks”of Jiangsu Province,China(Grant No.GDZB-002)。
文摘Atomistic simulations are carried out to investigate the nano-indentation of single crystal Cu and the sliding of the Cu-Zn alloy.As the contact zone is extended due to adhesive interaction between the contact atoms,the contact area on a nanoscale is redefined.A comparison of contact area and contact force between molecular dynamics(MD)and contact theory based on Greenwood-Williamson(GW)model is made.Lower roughness causes the adhesive interaction to weaken,showing the better consistency between the calculated results by MD and those from the theoretical model.The simulations of the sliding show that the substrate wear decreases with the mol%of Zn increasing,due to the fact that the diffusion movements of Zn atoms in substrate are blocked during the sliding because of the hexagonal close packed(hcp)structure of Zn.
基金National Key Research and Development Program of China(2024YFB2807901)Innovation Program for Quantum Science and Technology(2021ZD0302300)+3 种基金Strategic Priority Research Program of Chinese Academy of Sciences(XDB01000000)National Natural Science Foundation of China(61991441,62275117)Shenzhen Excellent Youth Program(RCYX20221008092900001)Synergetic Extreme Condition User Facility(SECUF,https://cstr.cn/31123.02.SECUF)。
文摘Ultra-compact spectrometers have attracted significant attention for their potential applications in portable systems for biomedical analysis,environmental monitoring,spectral analysis,and astronomical observation.In this work,we propose a miniaturized InGaAs-based extended short-wave infrared(eSWIR)spectrometer based on a single n-graded-p junction with voltage-tunable optical response characteristics in the range from 1600to 2100 nm.We combine this unique optical characteristic with a regression algorithm to realize the reconstruction of an unknown spectrum.The spectrometer achieves a high responsivity of 0.73 A/W at 1650 nm,and a low dark current density of 3.91×10^(-5)A/cm^2 at 200 K,corresponding to a calculated detectivity of1.69×10^(11)cm·Hz^(1/2)/W.Such spectrometers compatible with standard Ⅲ-Ⅴprocesses can offer a pathway to greatly promote the development of miniaturized spectrometers.
基金The National Major Scientific and Technological Special Project for“Significant New Drugs Development,”No.SQ2018ZX090201The Strategic Priority Research Program of the Chinese Academy of Sciences,Grant No.XDB19030205,No.XDA12050305+10 种基金Guangdong Provincial Applied Science and Technology Research&Development Program,No.2016B020237006Guangdong Special Support Program,NO.2017TX04R102Frontier and key technology innovation special grant from the Department of Science and Technology of Guangdong province,No.2015B020227003Natural Science Fund of Guangdong Province:Distinguished Young Scholars(Grant No.:2014A030306028)Doctoral Foundation,No.:2017A030310381National Natural Science Foundation of China(NSFC),No.81773301,81700156,81870121,81873847Frontier Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory,No.2018GZR110105003Science and Technology Planning Project of Guangdong Province,China(2017B030314056)Guangzhou Medical University High-level University Construction Research Startup Fund,NO.B195002004013Research Program of Hefei Institute of Stem Cell and Regenerative Medicine,No.2019YF001Guangzhou science and technology plan project,NO.201907010042,201904010473.
文摘Chimeric antigen receptor T(CAR-T)cells have emerged as novel and promising immune therapies for the treatment of multiple types of cancer in patients with hematological malignancies.There are several key components critical for development and application of CAR-T therapy.First,the design of CAR vectors can considerably affect several aspects of the physiological functions of these T cells.Moreover,despite the wide use of g-retrovirus and lentivirus in mediating gene transfer into T cells,optimal CAR delivery systems are also being developed and evaluated.In addition,several classes of mouse models have been used to evaluate the efficacies of CART cells;however,each model has its own limitations.Clinically,although surprising complete remission(CR)rates were observed in acute lymphoblastic leukemia(ALL),lymphoma,and multiple myeloma(MM),there is still a lack of specific targets for acute myeloid leukemia(AML).Leukemia relapse remains a major challenge,and its mechanism is presently under investigation.Cytokine release syndrome(CRS)and neurotoxicity are life-threatening adverse effects that need to be carefully treated.Several factors that compromise the activities of anti-solid cancer CAR-T cells have been recognized,and further improvements targeting these factors are the focus of the development of novel CAR-T cells.Overcoming the current hurdles will lead to optimal responses of CAR-T cells,thus paving the way for their wide clinical application.
文摘Objective:To quantify coronavirus diseases 2019(COVID-19)pneumonia and to explore whether quantitative computer tomography(CT)could be used to assess severity on admission.Materials and methods:From January 17 to February 9,2020,38 hospitalized patients with COVID-19 pneumonia were consecutively enrolled in our hospitals.All clinical data and the chest CT on admission were retrospectively reviewed and analyzed.Firstly,a quantitative method based on multi-scale convolutional neural networks was used to assess the infected lung segments and this was compared with the semi-quantitative method.Secondly,the quantitative method was tested with laboratory results and the pneumonia severity index(PSI)by correlation analyses.Thirdly,both quantitative and semi-quantitative parameters between patients with different PSI were compared.Results:Thirty cases were finally enrolled:16(53.33%)of them were male,and the mean age was 48 years old.The interval from onset symptoms to first chest CT scan was 8 days.The proportion of ground glass opacity(GGO),consolidation and the total lesion based on the quantitative method was positively correlated with the semi-quantitative CT score(P<0.001 for all;rs=0.88,0.87,0.90),CRP(P=0.0278,0.0168,0.0078;rs=0.40,0.43,0.48)and ESR(P=0.0296,0.0408,0.0048;rs=0.46,0.44,0.58),respectively,and was negatively correlated with the lymphocyte count(P=0.0222,0.0024,0.0068;rs=-0.42,-0.53,-0.48).There was a positive correlation trend between the proportion of total infection and the pneumonia severity index(P=0.0994;rs=0.30)and a tendency that patients with severe COVID-19 pneumonia had higher percentage of consolidation and total infection(P=0.0903,0.0989).Conclusions:Quantitative CT may have potential in assessing the severity of COVID-19 pneumonia on admission.
文摘Objective:To explore the clinical and radiological characteristics of COVID-19 patients with progressive and non-progressive CT manifestations.Methods:160 patients with COVID-19 were retrospectively included from Wenzhou and Wuhan,China.CT features including lesion position,attenuation,form and total scores(0e4)at the segment level were evaluated.Other images signs were also assessed.65 patients were classified as progressive(Group 1)and 95 as non-progressive CT(Group 2)groups according to score changes between the initial and second CT.Results:Symptoms onset-initial CT interval time in group 1[5(2,7)days]were significantly shorter than that in group 2[10(8,14)days](P<0.001).Group 2 had higher radiological scores,with more lobes and segments affected,and other CT signs(P<0.05).In group 1,radiological scores,the number of lobes and segments affected as well as lesions in both peripheral and central distribution,mixed ground grass opacity and consolidation density,and patchy form increased in the second CT(P<0.05).More reticular pattern,subpleural linear opacity and bronchial dilatation were also found(P<0.05).Conclusion:Typically radiological characteristics of progressive CT patients could potentially help to predict changes and increase understanding of the natural history of COVID-19.
文摘Although chimeric antigen receptor T-cell(CAR-T-cell)therapy has shown excellent efficacy against refractory/relapsed B-cell lymphoma,B-cell acute lymphoblastic leukemia and multiple myeloma,1,2 the complete response rate of patients with refractory/relapsed B-cell lymphoma receiving conventional CAR-T-cell therapy is approximately 40%to 50%.3–5 There are 3 drawbacks to viral CAR-T-cell therapy.First,random integration of the CAR cassette and lentivirus replication are potential risks for viral CAR-T-cell therapy(Fig.1A).
