目的探讨双能量虚拟去钙成像(VNCa)CT对中轴性脊柱关节炎相关骶髂关节炎病人骨髓水肿的诊断价值。材料与方法这项前瞻性研究连续收集2016年4月—2017年12月期间47例受试者[年龄14~41岁,平均27岁(男28例,年龄14~37岁,平均24岁;女19例,年...目的探讨双能量虚拟去钙成像(VNCa)CT对中轴性脊柱关节炎相关骶髂关节炎病人骨髓水肿的诊断价值。材料与方法这项前瞻性研究连续收集2016年4月—2017年12月期间47例受试者[年龄14~41岁,平均27岁(男28例,年龄14~37岁,平均24岁;女19例,年龄17~41岁,平均29岁)],行双能CT和3.0 T MRI检查。展开更多
It is difficult to achieve Al/Cu dissimilar welds with good mechanical properties for medium-thick plates due to the inherent high heat generation rate at the shoulder-workpiece contact interface in conventional frict...It is difficult to achieve Al/Cu dissimilar welds with good mechanical properties for medium-thick plates due to the inherent high heat generation rate at the shoulder-workpiece contact interface in conventional friction stir welding.Thus,doubleside friction stir welding is innovatively applied to join 12-mm medium-thick 6061-T6 aluminum alloy and pure copper dissimilar plates,and the effect of welding speeds on the joint microstructure and mechanical properties of Al/Cu welds is systematically analyzed.It reveals that a sound Al/Cu joint without macroscopic defects can be achieved when the welding speed is lower than 180 mm/min,while a nonuniform relatively thick intermetallic compound(IMC)layer is formed at the Al/Cu interface,resulting in lots of local microcracks within the first-pass weld under the plunging force of the tool during friction stir welding of the second-pass,and seriously deteriorates the mechanical properties of the joint.With the increase of welding speed to more than 300 mm/min void defects appear in the joint,but the joint properties are still better than the welds performed at low welding speed conditions since a continuous uniform thin IMCs layer is formed at the Al/Cu interface.The maximum tensile strength and elongation of Al/Cu weld are,respectively,135.11 MPa and 6.06%,which is achieved at the welding speed of 400 mm/min.In addition,due to the influence of welding distortion of the first-pass weld,the secondpass weld is more prone to form void defects than the first-pass weld when the same plunge depth is applied on both sides.The double-side friction stir welding is proved to be a good method for dissimilar welding of medium-thick Al/Cu plates.展开更多
Fatigue crack growth behaviors were investigated by three-point bending tests for TA19 alloy fabricated by laser metal deposition and four kinds of heat-treated samples.The crack growth resistance of the TA19 samples ...Fatigue crack growth behaviors were investigated by three-point bending tests for TA19 alloy fabricated by laser metal deposition and four kinds of heat-treated samples.The crack growth resistance of the TA19 samples in the near-threshold regime and Paris regime was evaluated through the experimental characterization and theoretical analysis of the interaction between fatigue crack andα/βphase inter-face,columnar prior-βgrain boundary and colony boundary.The results show that in the near-threshold regime,the fatigue crack propagation threshold and resistance increase with the increase of widths of lamellarαp phases and colonies,and the decrease of the number ofαlaths with an angle(ϕ)relative to the applied stress direction ranging from 75°to 90°.In the Paris regime,the fatigue cracking path can be deflected at colony boundaries or columnar prior-βgrain boundaries.The larger the deflection angle,the more tortuous the cracking path and the lower the fatigue crack growth rate.The angle(γ)of the columnar prior-βgrain growth direction relative to the build direction affects not onlyϕof differentαvariants,but also the fatigue cracking path deflection angle(θij)at columnar prior-βgrain boundaries.An optimal combination ofγ=0°-15°-0°-15°for several adjacent columnar prior-βgrains is derived from the theoretical analysis,and that can effectively avoidϕbeing in the range from 75°to 90°and makeθij as large as possible.Such findings provide a guide for the selection of scanning strategies and process parameters to additively manufacture Ti alloys with high fatigue damage tolerance.展开更多
Tumor cells escape host immune surveillance bydown-regulation of MHC and/or co-stimulatorymolecules.Anti-tumor immune responses are mediated primarily by T cells.A deficiency in either MHC or co-stimulatory molecules ...Tumor cells escape host immune surveillance bydown-regulation of MHC and/or co-stimulatorymolecules.Anti-tumor immune responses are mediated primarily by T cells.A deficiency in either MHC or co-stimulatory molecules on tumor cells is associated with a failure to induce anti-tumor immunity.展开更多
文摘目的探讨双能量虚拟去钙成像(VNCa)CT对中轴性脊柱关节炎相关骶髂关节炎病人骨髓水肿的诊断价值。材料与方法这项前瞻性研究连续收集2016年4月—2017年12月期间47例受试者[年龄14~41岁,平均27岁(男28例,年龄14~37岁,平均24岁;女19例,年龄17~41岁,平均29岁)],行双能CT和3.0 T MRI检查。
基金financially supported by the National Natural Science Foundation of China(No.51905309)the Science and Technology Planning Project of State Grid Henan Electric Power Company(No.52170220009Y)。
文摘It is difficult to achieve Al/Cu dissimilar welds with good mechanical properties for medium-thick plates due to the inherent high heat generation rate at the shoulder-workpiece contact interface in conventional friction stir welding.Thus,doubleside friction stir welding is innovatively applied to join 12-mm medium-thick 6061-T6 aluminum alloy and pure copper dissimilar plates,and the effect of welding speeds on the joint microstructure and mechanical properties of Al/Cu welds is systematically analyzed.It reveals that a sound Al/Cu joint without macroscopic defects can be achieved when the welding speed is lower than 180 mm/min,while a nonuniform relatively thick intermetallic compound(IMC)layer is formed at the Al/Cu interface,resulting in lots of local microcracks within the first-pass weld under the plunging force of the tool during friction stir welding of the second-pass,and seriously deteriorates the mechanical properties of the joint.With the increase of welding speed to more than 300 mm/min void defects appear in the joint,but the joint properties are still better than the welds performed at low welding speed conditions since a continuous uniform thin IMCs layer is formed at the Al/Cu interface.The maximum tensile strength and elongation of Al/Cu weld are,respectively,135.11 MPa and 6.06%,which is achieved at the welding speed of 400 mm/min.In addition,due to the influence of welding distortion of the first-pass weld,the secondpass weld is more prone to form void defects than the first-pass weld when the same plunge depth is applied on both sides.The double-side friction stir welding is proved to be a good method for dissimilar welding of medium-thick Al/Cu plates.
基金supported by the National Natural Science Foundation of China(Nos.51771207 and 52171128)the National Science and Technology Major Project(No.J2019-VI-0012-0126)the Fundamental Research Project of Shenyang National Laboratory for Materials Science(No.L2019R18).
文摘Fatigue crack growth behaviors were investigated by three-point bending tests for TA19 alloy fabricated by laser metal deposition and four kinds of heat-treated samples.The crack growth resistance of the TA19 samples in the near-threshold regime and Paris regime was evaluated through the experimental characterization and theoretical analysis of the interaction between fatigue crack andα/βphase inter-face,columnar prior-βgrain boundary and colony boundary.The results show that in the near-threshold regime,the fatigue crack propagation threshold and resistance increase with the increase of widths of lamellarαp phases and colonies,and the decrease of the number ofαlaths with an angle(ϕ)relative to the applied stress direction ranging from 75°to 90°.In the Paris regime,the fatigue cracking path can be deflected at colony boundaries or columnar prior-βgrain boundaries.The larger the deflection angle,the more tortuous the cracking path and the lower the fatigue crack growth rate.The angle(γ)of the columnar prior-βgrain growth direction relative to the build direction affects not onlyϕof differentαvariants,but also the fatigue cracking path deflection angle(θij)at columnar prior-βgrain boundaries.An optimal combination ofγ=0°-15°-0°-15°for several adjacent columnar prior-βgrains is derived from the theoretical analysis,and that can effectively avoidϕbeing in the range from 75°to 90°and makeθij as large as possible.Such findings provide a guide for the selection of scanning strategies and process parameters to additively manufacture Ti alloys with high fatigue damage tolerance.
文摘Tumor cells escape host immune surveillance bydown-regulation of MHC and/or co-stimulatorymolecules.Anti-tumor immune responses are mediated primarily by T cells.A deficiency in either MHC or co-stimulatory molecules on tumor cells is associated with a failure to induce anti-tumor immunity.
