目的通过Meta分析的方法确定ABCB1 3435T>C(rs1045642)和2677T>G/A(rs2032582)与抗抑郁药物疗效之间的相关性。方法计算机检索Pubmed、Embase、Cochrane Library和中国知网全文数据库,检索的时间范围从建库至2017年8月14日。筛选...目的通过Meta分析的方法确定ABCB1 3435T>C(rs1045642)和2677T>G/A(rs2032582)与抗抑郁药物疗效之间的相关性。方法计算机检索Pubmed、Embase、Cochrane Library和中国知网全文数据库,检索的时间范围从建库至2017年8月14日。筛选研究ABCB1基因多态性与抗抑郁药物疗效之间相关性的文献。采用Stata软件对数据进行统计分析,以合并比值比(OR)和95%置信区间(95%CI)确定相关性。结果共纳入8篇文献。合并结果显示,3435T>C与抗抑郁药物治疗抑郁症的应答率无关(CC+CT vs TT:OR=0.90,95%CI 0.53-1.52;CC vs CT+TT:OR=0.95,95%CI 0.61-1.47);与抗抑郁药物治疗抑郁症的缓解率也无关(CC+CT vs TT:OR=0.59,95%CI 0.28-1.24;CC vs CT+TT:OR=0.55,95%CI 0.22-1.42)。对于2677T>G/A,该SNP对抗抑郁药物治疗抑郁症的应答率无显著影响(GG+GT vs TT:OR=1.03,95%CI 0.36-2.93;GG vs GT+TT:OR=1.04,95%CI 0.64-1.68),在显性模型下,2677T>G/A与抗抑郁药物治疗抑郁症的缓解率有显著关联(GG+GT vs TT,OR=0.23,95%CI 0.07-0.75),但在隐性模型下无显著关联(GG vs GT+TT:OR=0.7,95%CI 0.32-1.51)。结论 ABCB1基因多态性3435T>C(rs1045642)对抗抑郁药物疗效无显著影响,2677T>G/A可能影响抗抑郁药物治疗抑郁症的缓解率。展开更多
Observation results of abnormal acoustic-gravity waves before a Beijing earthquake （ML =3.0） are presented. During this period, abnormalities of earth surface tilt variations were also recorded. The cross-correlatio...Observation results of abnormal acoustic-gravity waves before a Beijing earthquake （ML =3.0） are presented. During this period, abnormalities of earth surface tilt variations were also recorded. The cross-correlations between the both values are high, which reach maximal values of 0.5 in the area close to the epicenter. The correlations decrease with increasing distances from the epicenter. It was proposed that generation of the anomalous waves may be associated with the pressure and wind perturbations in the air flow caused by slowly shaking mountains during slow surface motion preceding the earthquake in Beijing. Based on the wind velocity data taken from a 350 m meteorological tower in Beijing, the propagation of ducted acoustic-gravity waves in a two-layer model of the atmosphere was numerically simulated. It is shown that characteristic periods, amplitudes and velocities of the simulated phases which were assumed from non-stationary air flow relative to mountains are approximate to the observed phases. A consistency between the simulated results and observation data indicates that a slow surface motion may be a possible source of the anomalous acoustic-gravity waves observed prior to the earthquake.展开更多
文摘目的通过Meta分析的方法确定ABCB1 3435T>C(rs1045642)和2677T>G/A(rs2032582)与抗抑郁药物疗效之间的相关性。方法计算机检索Pubmed、Embase、Cochrane Library和中国知网全文数据库,检索的时间范围从建库至2017年8月14日。筛选研究ABCB1基因多态性与抗抑郁药物疗效之间相关性的文献。采用Stata软件对数据进行统计分析,以合并比值比(OR)和95%置信区间(95%CI)确定相关性。结果共纳入8篇文献。合并结果显示,3435T>C与抗抑郁药物治疗抑郁症的应答率无关(CC+CT vs TT:OR=0.90,95%CI 0.53-1.52;CC vs CT+TT:OR=0.95,95%CI 0.61-1.47);与抗抑郁药物治疗抑郁症的缓解率也无关(CC+CT vs TT:OR=0.59,95%CI 0.28-1.24;CC vs CT+TT:OR=0.55,95%CI 0.22-1.42)。对于2677T>G/A,该SNP对抗抑郁药物治疗抑郁症的应答率无显著影响(GG+GT vs TT:OR=1.03,95%CI 0.36-2.93;GG vs GT+TT:OR=1.04,95%CI 0.64-1.68),在显性模型下,2677T>G/A与抗抑郁药物治疗抑郁症的缓解率有显著关联(GG+GT vs TT,OR=0.23,95%CI 0.07-0.75),但在隐性模型下无显著关联(GG vs GT+TT:OR=0.7,95%CI 0.32-1.51)。结论 ABCB1基因多态性3435T>C(rs1045642)对抗抑郁药物疗效无显著影响,2677T>G/A可能影响抗抑郁药物治疗抑郁症的缓解率。
基金supported by the National Natural Science Foundation of China(11174320,11304352)
文摘Observation results of abnormal acoustic-gravity waves before a Beijing earthquake （ML =3.0） are presented. During this period, abnormalities of earth surface tilt variations were also recorded. The cross-correlations between the both values are high, which reach maximal values of 0.5 in the area close to the epicenter. The correlations decrease with increasing distances from the epicenter. It was proposed that generation of the anomalous waves may be associated with the pressure and wind perturbations in the air flow caused by slowly shaking mountains during slow surface motion preceding the earthquake in Beijing. Based on the wind velocity data taken from a 350 m meteorological tower in Beijing, the propagation of ducted acoustic-gravity waves in a two-layer model of the atmosphere was numerically simulated. It is shown that characteristic periods, amplitudes and velocities of the simulated phases which were assumed from non-stationary air flow relative to mountains are approximate to the observed phases. A consistency between the simulated results and observation data indicates that a slow surface motion may be a possible source of the anomalous acoustic-gravity waves observed prior to the earthquake.
