Achieving precise,localized drug delivery within the brain remains a major challenge due to the restrictive nature of the blood-brain barrier and the risk of systemic toxicity.Here,we present a fully soft neural inter...Achieving precise,localized drug delivery within the brain remains a major challenge due to the restrictive nature of the blood-brain barrier and the risk of systemic toxicity.Here,we present a fully soft neural interface incorporating a thermo-pneumatic peristaltic micropump integrated with asymmetrically tapered microchannels for targeted,on-demand wireless drug delivery.All structural and functional components are fabricated from soft materials,ensuring mechanical compatibility with brain tissue.The system employs sequential actuation of microheaters to generate unidirectional airflow that drives drug infusion from an on-board reservoir.The nozzle-diffuser geometry of the microchannels minimizes backflow while enabling controlled,continuous delivery without mechanical valves.Fluid dynamics simulations guided the optimization of the microfluidic design,resulting in robust forward flow with minimal reflux.Benchtop validation in brain-mimicking phantoms confirmed consistent and programmable drug infusion.This platform represents a significant advancement in neuropharmacological research and therapeutic delivery for central nervous system disorders.展开更多
Epidermal electronic systems feature physical properties that approximate those of the skin,to enable intimate,long-lived skin interfaces for physiological measurements,human–machine interfaces and other applications...Epidermal electronic systems feature physical properties that approximate those of the skin,to enable intimate,long-lived skin interfaces for physiological measurements,human–machine interfaces and other applications that cannot be addressed by wearable hardware that is commercially available today.A primary challenge is power supply;the physical bulk,large mass and high mechanical modulus associated with conventional battery technologies can hinder efforts to achieve epidermal characteristics,and near-field power transfer schemes offer only a limited operating distance.Here we introduce an epidermal,farfield radio frequency(RF)power harvester built using a modularized collection of ultrathin antennas,rectifiers and voltage doublers.These components,separately fabricated and tested,can be integrated together via methods involving soft contact lamination.Systematic studies of the individual components and the overall performance in various dielectric environments highlight the key operational features of these systems and strategies for their optimization.The results suggest robust capabilities for battery-free RF power,with relevance to many emerging epidermal technologies.展开更多
Surface electromyography(sEMG)sensors play a critical role in diagnosing muscle conditions and enabling prosthetic device control,especially for lower extremity robotic legs.However,challenges arise when utilizing suc...Surface electromyography(sEMG)sensors play a critical role in diagnosing muscle conditions and enabling prosthetic device control,especially for lower extremity robotic legs.However,challenges arise when utilizing such sensors on residual limbs within a silicon liner worn by amputees,where dynamic pressure,narrow space,and perspiration can negatively affect sensor performance.Existing commercial sEMG sensors and newly developed sensors are unsuitable due to size and thickness,or susceptible to damage in this environment.In this paper,our sEMG sensors are tailored for amputees wearing sockets,prioritizing breathability,durability,and reliable recording performance.By employing porous PDMS and Silbione substrates,our design achieves exceptional permeability and adhesive properties.The serpentine electrode pattern and design are optimized to improve stretchability,durability,and effective contact area,resulting in a higher signal-to-noise ratio(SNR)than conventional electrodes.Notably,our proposed sensors wirelessly enable to control of a robotic leg for amputees,demonstrating its practical feasibility and expecting to drive forward neuro-prosthetic control in the clinical research field near future.展开更多
The use of water-based chemistry in photolithography during semiconductor fabrication is desirable due to its cost-effectiveness and minimal environmental impact,especially considering the large scale of semiconductor...The use of water-based chemistry in photolithography during semiconductor fabrication is desirable due to its cost-effectiveness and minimal environmental impact,especially considering the large scale of semiconductor production.Despite these benefits,limited research has reported successful demonstrations of water-based photopatterning,particularly for intrinsically water-soluble materials such as Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)due to significant challenges in achieving selective dissolution during the developing process.In this paper,we propose amethod for the direct patterning of PEDOT:PSS in water by introducing an amphiphilic Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)(PEO-PPO-PEO,P123)block copolymer to the PEDOT:PSS film.The addition of the block copolymer enhances the stretchability of the composite film and reduces the hydrophilicity of the film surface,allowing for water absorption only after UV exposure through a photoinitiated reaction with benzophenone.We apply this technique to fabricate tactile and wearable biosensors,both of which benefit fromthe mechanical stretchability and transparency of PEDOT:PSS.Our method represents a promising solution for water-based photopatterning of hydrophilic materials,with potential for wider applications in semiconductor fabrication.展开更多
基金supported by the National Research Foundation of Korea(NRF)funded by Ministry of Science and ICT(RS-2023-00234581)the Technology Innovation Program(RS-2025-08672969)funded by the Ministry of Trade Industry and Energy(MOTIE,Korea).
文摘Achieving precise,localized drug delivery within the brain remains a major challenge due to the restrictive nature of the blood-brain barrier and the risk of systemic toxicity.Here,we present a fully soft neural interface incorporating a thermo-pneumatic peristaltic micropump integrated with asymmetrically tapered microchannels for targeted,on-demand wireless drug delivery.All structural and functional components are fabricated from soft materials,ensuring mechanical compatibility with brain tissue.The system employs sequential actuation of microheaters to generate unidirectional airflow that drives drug infusion from an on-board reservoir.The nozzle-diffuser geometry of the microchannels minimizes backflow while enabling controlled,continuous delivery without mechanical valves.Fluid dynamics simulations guided the optimization of the microfluidic design,resulting in robust forward flow with minimal reflux.Benchtop validation in brain-mimicking phantoms confirmed consistent and programmable drug infusion.This platform represents a significant advancement in neuropharmacological research and therapeutic delivery for central nervous system disorders.
基金XF and YM acknowledge the support from the National Basic Research Program of China(Grant No.2015CB351900)the National Natural Science Foundation of China(Grant Nos.11402135 and 11320101001).
文摘Epidermal electronic systems feature physical properties that approximate those of the skin,to enable intimate,long-lived skin interfaces for physiological measurements,human–machine interfaces and other applications that cannot be addressed by wearable hardware that is commercially available today.A primary challenge is power supply;the physical bulk,large mass and high mechanical modulus associated with conventional battery technologies can hinder efforts to achieve epidermal characteristics,and near-field power transfer schemes offer only a limited operating distance.Here we introduce an epidermal,farfield radio frequency(RF)power harvester built using a modularized collection of ultrathin antennas,rectifiers and voltage doublers.These components,separately fabricated and tested,can be integrated together via methods involving soft contact lamination.Systematic studies of the individual components and the overall performance in various dielectric environments highlight the key operational features of these systems and strategies for their optimization.The results suggest robust capabilities for battery-free RF power,with relevance to many emerging epidermal technologies.
基金supported by a Korea Medical Device Development Fund grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health&Welfare,the Ministry of Food and Drug Safety)(Project Number:1711135031,KMDF_PR_20200901_0158-05).
文摘Surface electromyography(sEMG)sensors play a critical role in diagnosing muscle conditions and enabling prosthetic device control,especially for lower extremity robotic legs.However,challenges arise when utilizing such sensors on residual limbs within a silicon liner worn by amputees,where dynamic pressure,narrow space,and perspiration can negatively affect sensor performance.Existing commercial sEMG sensors and newly developed sensors are unsuitable due to size and thickness,or susceptible to damage in this environment.In this paper,our sEMG sensors are tailored for amputees wearing sockets,prioritizing breathability,durability,and reliable recording performance.By employing porous PDMS and Silbione substrates,our design achieves exceptional permeability and adhesive properties.The serpentine electrode pattern and design are optimized to improve stretchability,durability,and effective contact area,resulting in a higher signal-to-noise ratio(SNR)than conventional electrodes.Notably,our proposed sensors wirelessly enable to control of a robotic leg for amputees,demonstrating its practical feasibility and expecting to drive forward neuro-prosthetic control in the clinical research field near future.
基金supported by the Korean government(the Ministry of Science and ICT,the Ministry of Trade,Industry,and Energy,the Ministry of Health&Welfare,and the Ministry of Food and Drug Safety).(Nos.2022R1C1C101007112,RS-2023-00221295,HR22C183201,RS-2020-KD000093,RS-2023-00234581,23-SENS-01).
文摘The use of water-based chemistry in photolithography during semiconductor fabrication is desirable due to its cost-effectiveness and minimal environmental impact,especially considering the large scale of semiconductor production.Despite these benefits,limited research has reported successful demonstrations of water-based photopatterning,particularly for intrinsically water-soluble materials such as Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)due to significant challenges in achieving selective dissolution during the developing process.In this paper,we propose amethod for the direct patterning of PEDOT:PSS in water by introducing an amphiphilic Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)(PEO-PPO-PEO,P123)block copolymer to the PEDOT:PSS film.The addition of the block copolymer enhances the stretchability of the composite film and reduces the hydrophilicity of the film surface,allowing for water absorption only after UV exposure through a photoinitiated reaction with benzophenone.We apply this technique to fabricate tactile and wearable biosensors,both of which benefit fromthe mechanical stretchability and transparency of PEDOT:PSS.Our method represents a promising solution for water-based photopatterning of hydrophilic materials,with potential for wider applications in semiconductor fabrication.
