Background. Vitiligo is an acquired depigmentation disorder of great cosmetic importance, affecting 1% of the general population. Photochemotherapy is the most commonly used treatment modalityinextensivevitiligo,butis...Background. Vitiligo is an acquired depigmentation disorder of great cosmetic importance, affecting 1% of the general population. Photochemotherapy is the most commonly used treatment modalityinextensivevitiligo,butisassociatedwithmanyshortand long-term side-effects. Recently, narrow-band ultraviolet B (NBUVB) therapy has been reported to be an effective and safe therapeutic option in patients with vitiligo. We studied the efficacy and safety of NBUVB (311 nm) therapy in Indian patients with generalized vitiligo. Methods. Fourteen patients (six males and eight females), aged 12- 56 years, with generalized vitiligo, were treated thrice weekly with NBUVB radiation therapy for a maximum period of 1 year. Results. At the end of 1 year, 10 patients (71.4% ) had marked to complete repigmentation and two each (14.3% ) had moderate or mild repigmentation. Repigmentation sites showed an excellent color match. The response to therapy was correlated with the sites of involvement, duration of disease, and compliance to therapy. Adverse events were limited and transient. Conclusion. NBUVB therapy is effective and safe in Indian patients with vitiligo. Long- term follow up is required, however, to establish the stability of repigmentation.展开更多
A pot culture experiment was carried out for the Screening of 11 popular genotypes against to Meloidogyne incognita and Fusarium chlamydosporum wilt complex on Coleus forskohlii. Genotype viz., yellow tubers and Rabak...A pot culture experiment was carried out for the Screening of 11 popular genotypes against to Meloidogyne incognita and Fusarium chlamydosporum wilt complex on Coleus forskohlii. Genotype viz., yellow tubers and Rabakavi local showed resistant reaction, Orange tuber and Nimbanur local showed moderately resistant reaction. Rest of the seven genotvDes showed suscentible reactions.展开更多
We present the case of a 33-year-old nonatopic woman with multiple episodes of anaphylaxis after ingestion of different fruits. The fruits implicated were apple, banana and lychee: all of which belong to different and...We present the case of a 33-year-old nonatopic woman with multiple episodes of anaphylaxis after ingestion of different fruits. The fruits implicated were apple, banana and lychee: all of which belong to different and botanically disparate plant families. The reaction to apple and banana was confirmed by prick testing. There was no history of allergy to other agents that are known to have cross reactions with fruits, viz. latex or pollen. As such patients often do not present to dermatologists, we wish to highlight the rare but potentially fatal clinical entity of type I allergy to fruits without concomitant allergy to other common airborne/contact allergens. We also discuss the possible explanation of type I reaction to apparently unrelated fruits and the allergens involved in such reactions.展开更多
Background. We undertook this study in order to determine the pattern and prevalence of childhood psoriasis in northern India and to highlight the differences and similarities with previous studies. Materials and meth...Background. We undertook this study in order to determine the pattern and prevalence of childhood psoriasis in northern India and to highlight the differences and similarities with previous studies. Materials and methods. In this retrospective epidemiologic study, the data from 419 children (less than 14 years of age) with psoriasis registered at the Psoriasis Clinic between January 1990 and December 2002 were included. Results. The 419 children registered at the Psoriasis Clinic constituted 0.3%of the dermatology outpatients and 12.5%of the total psoriasis patients seen over a period of 13 years in the department. There were 219 (52.3%) boys and 200 (47.7%) girls, with a male to female ratio of 1.09:1. The age of onset ranged from 4 days to 14 years. The mean age of onset was 8.1 ±2.1 years in boys and 9.3 ±2.3 years in girls. The peak age of onset in boys was in the 6-10-year age group, whereas the majority of girls showed an onset of psoriasis between the ages of 10 and 14 years. A positive family history was present in only 19 (4.5%) patients. The extensors of the legs were the most common initial site affected [105 (25%) cases], followed by the scalp [87 (20.7%)]. Classical plaque psoriasis was the most frequent clinical presentation [254 (60.6%) patients], followed by plantar psoriasis [54 (12.8%)]. Nail involvement was observed in 130 (31%) cases. All types of nail changes described in psoriasis were seen in these patients. Pitting was the most common nail change, followed by ridging and discoloration. Five children (1.1%) (three girls and two boys) had psoriatic arthropathy. Precipitating factors that brought about the onset of the disease or were associated with exacerbation could be recalled in only 28 (6.6%) patients. Koebnerization was observed in 27.9%of patients. Pruritus was the most frequent symptom, reported by 365 (87.1%) children. Twenty-seven (6.4%) children had other concurrent mucocutaneous diseases (vitiligo, pityriasis alba, alopecia areata, ichthyosis vulgaris, halo nevus, aphthous stomatitis, urticaria, pityriasis versicolor, nummular eczema, salmon patch, and verrucous epidermal nevus). Eighteen children had systemic disorders, including seizures, bronchial asthma, mitral regurgitation, scleroderma, Down’s syndrome, high arched palate, cholelithiasis, anterior mongoloid slant, and prognathism; however, these conditions were possibly chance findings only and no correlation with the age of onset or severity of the disease was found. Conclusions. Our findings differ from those of previous studies in showing a delayed onset, equal sex distribution, less frequent facial involvement, uncommon guttate lesions, more frequent involvement of the soles, and a less frequent history of familial occurrence.展开更多
Background:Vitiligo of the lips is a common concern of great psychologic consequence.Medical therapies are often ineffective due mainly to the absence of hair follicles.The transfer of melanocytes or melanocyte-bearin...Background:Vitiligo of the lips is a common concern of great psychologic consequence.Medical therapies are often ineffective due mainly to the absence of hair follicles.The transfer of melanocytes or melanocyte-bearing skin by a surgical procedure may repigment this condition.Only a few surgical modalities have been successful in this “difficult to treat”site.Objective:To assess the effectiveness of autologous melanocy tetransfer by epidermal grafts for lip vitiligo and to review the literature on the surgical correction of lip vitiligo.Methods:Twenty-six vitiligo patients(20 women and six men;age range,13-43 years;mean,26.8 years)having 31 affected lips with stable disease were included in the study.The suction blisters were raised using our own modified device on the lateral aspectof the thigh.The roofs of the blisters were transferred to the dermabraded recipient area.The dressing,together with the grafts,was removed on day 8.Patients were given photochemotherapy for 6 weeks.In addition,meta-analysis of the published literature on the surgical management of lip vitiligo was also performed.Results:Complete repigmentation was observed in 27 of the 31 lip areas(87%)in 23 of 25 patients(92%)in whom a follow-up for 6 months or more was available.Complications observed were persistent hyperpigmentation in12 lips and reactivation of herpes in one patient.Minimal Hyperpigmentation was seen in most of the remaining lips.The results of the meta-analysis revealed that the success rate varies from 32.5%to 100%with various surgical procedures.Conclusion:Autologous melanocyte transfer is an effective and safe therapeutic option for stable vitiligo of the lips.It is cosmetically more acceptable,as there is no abnormal keratinization,which is a problem associated with dermo-epidermal grafts.展开更多
文摘Background. Vitiligo is an acquired depigmentation disorder of great cosmetic importance, affecting 1% of the general population. Photochemotherapy is the most commonly used treatment modalityinextensivevitiligo,butisassociatedwithmanyshortand long-term side-effects. Recently, narrow-band ultraviolet B (NBUVB) therapy has been reported to be an effective and safe therapeutic option in patients with vitiligo. We studied the efficacy and safety of NBUVB (311 nm) therapy in Indian patients with generalized vitiligo. Methods. Fourteen patients (six males and eight females), aged 12- 56 years, with generalized vitiligo, were treated thrice weekly with NBUVB radiation therapy for a maximum period of 1 year. Results. At the end of 1 year, 10 patients (71.4% ) had marked to complete repigmentation and two each (14.3% ) had moderate or mild repigmentation. Repigmentation sites showed an excellent color match. The response to therapy was correlated with the sites of involvement, duration of disease, and compliance to therapy. Adverse events were limited and transient. Conclusion. NBUVB therapy is effective and safe in Indian patients with vitiligo. Long- term follow up is required, however, to establish the stability of repigmentation.
文摘A pot culture experiment was carried out for the Screening of 11 popular genotypes against to Meloidogyne incognita and Fusarium chlamydosporum wilt complex on Coleus forskohlii. Genotype viz., yellow tubers and Rabakavi local showed resistant reaction, Orange tuber and Nimbanur local showed moderately resistant reaction. Rest of the seven genotvDes showed suscentible reactions.
文摘We present the case of a 33-year-old nonatopic woman with multiple episodes of anaphylaxis after ingestion of different fruits. The fruits implicated were apple, banana and lychee: all of which belong to different and botanically disparate plant families. The reaction to apple and banana was confirmed by prick testing. There was no history of allergy to other agents that are known to have cross reactions with fruits, viz. latex or pollen. As such patients often do not present to dermatologists, we wish to highlight the rare but potentially fatal clinical entity of type I allergy to fruits without concomitant allergy to other common airborne/contact allergens. We also discuss the possible explanation of type I reaction to apparently unrelated fruits and the allergens involved in such reactions.
文摘Background. We undertook this study in order to determine the pattern and prevalence of childhood psoriasis in northern India and to highlight the differences and similarities with previous studies. Materials and methods. In this retrospective epidemiologic study, the data from 419 children (less than 14 years of age) with psoriasis registered at the Psoriasis Clinic between January 1990 and December 2002 were included. Results. The 419 children registered at the Psoriasis Clinic constituted 0.3%of the dermatology outpatients and 12.5%of the total psoriasis patients seen over a period of 13 years in the department. There were 219 (52.3%) boys and 200 (47.7%) girls, with a male to female ratio of 1.09:1. The age of onset ranged from 4 days to 14 years. The mean age of onset was 8.1 ±2.1 years in boys and 9.3 ±2.3 years in girls. The peak age of onset in boys was in the 6-10-year age group, whereas the majority of girls showed an onset of psoriasis between the ages of 10 and 14 years. A positive family history was present in only 19 (4.5%) patients. The extensors of the legs were the most common initial site affected [105 (25%) cases], followed by the scalp [87 (20.7%)]. Classical plaque psoriasis was the most frequent clinical presentation [254 (60.6%) patients], followed by plantar psoriasis [54 (12.8%)]. Nail involvement was observed in 130 (31%) cases. All types of nail changes described in psoriasis were seen in these patients. Pitting was the most common nail change, followed by ridging and discoloration. Five children (1.1%) (three girls and two boys) had psoriatic arthropathy. Precipitating factors that brought about the onset of the disease or were associated with exacerbation could be recalled in only 28 (6.6%) patients. Koebnerization was observed in 27.9%of patients. Pruritus was the most frequent symptom, reported by 365 (87.1%) children. Twenty-seven (6.4%) children had other concurrent mucocutaneous diseases (vitiligo, pityriasis alba, alopecia areata, ichthyosis vulgaris, halo nevus, aphthous stomatitis, urticaria, pityriasis versicolor, nummular eczema, salmon patch, and verrucous epidermal nevus). Eighteen children had systemic disorders, including seizures, bronchial asthma, mitral regurgitation, scleroderma, Down’s syndrome, high arched palate, cholelithiasis, anterior mongoloid slant, and prognathism; however, these conditions were possibly chance findings only and no correlation with the age of onset or severity of the disease was found. Conclusions. Our findings differ from those of previous studies in showing a delayed onset, equal sex distribution, less frequent facial involvement, uncommon guttate lesions, more frequent involvement of the soles, and a less frequent history of familial occurrence.
文摘Background:Vitiligo of the lips is a common concern of great psychologic consequence.Medical therapies are often ineffective due mainly to the absence of hair follicles.The transfer of melanocytes or melanocyte-bearing skin by a surgical procedure may repigment this condition.Only a few surgical modalities have been successful in this “difficult to treat”site.Objective:To assess the effectiveness of autologous melanocy tetransfer by epidermal grafts for lip vitiligo and to review the literature on the surgical correction of lip vitiligo.Methods:Twenty-six vitiligo patients(20 women and six men;age range,13-43 years;mean,26.8 years)having 31 affected lips with stable disease were included in the study.The suction blisters were raised using our own modified device on the lateral aspectof the thigh.The roofs of the blisters were transferred to the dermabraded recipient area.The dressing,together with the grafts,was removed on day 8.Patients were given photochemotherapy for 6 weeks.In addition,meta-analysis of the published literature on the surgical management of lip vitiligo was also performed.Results:Complete repigmentation was observed in 27 of the 31 lip areas(87%)in 23 of 25 patients(92%)in whom a follow-up for 6 months or more was available.Complications observed were persistent hyperpigmentation in12 lips and reactivation of herpes in one patient.Minimal Hyperpigmentation was seen in most of the remaining lips.The results of the meta-analysis revealed that the success rate varies from 32.5%to 100%with various surgical procedures.Conclusion:Autologous melanocyte transfer is an effective and safe therapeutic option for stable vitiligo of the lips.It is cosmetically more acceptable,as there is no abnormal keratinization,which is a problem associated with dermo-epidermal grafts.
