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ATRX镶嵌性/异质性表达的弥漫性胶质瘤
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作者 Purkait S Miller C a +2 位作者 kumar a 陈达阳 王行富 《临床与实验病理学杂志》 CAS CSCD 北大核心 2016年第9期1070-1070,共1页
本组评估176例胶质瘤免疫组化标记ATRX,将其分为阳性、阴性和镶嵌性/混杂性三种染色模式,其中5例混杂性染色进一步行二代测序。着重探讨不同级别和亚型的胶质瘤中ATRX的表达及与其他标志性遗传学改变之间的联系,识别和了解镶嵌性/... 本组评估176例胶质瘤免疫组化标记ATRX,将其分为阳性、阴性和镶嵌性/混杂性三种染色模式,其中5例混杂性染色进一步行二代测序。着重探讨不同级别和亚型的胶质瘤中ATRX的表达及与其他标志性遗传学改变之间的联系,识别和了解镶嵌性/异质性染色的胶质瘤的突变状态。免疫组化显示ATRX阴性大多见于Ⅱ/Ⅲ级的星形细胞、少突一星形细胞肿瘤和继发性胶质母细胞瘤,而在原发性胶质母细胞瘤和少突胶质细胞瘤中罕见。 展开更多
关键词 胶质瘤 镶嵌性 异质性 弥漫性 继发性胶质母细胞瘤 原发性胶质母细胞瘤 免疫组化标记 星形细胞肿瘤
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Variability in growth characteristics for different genotypes of Eucalyptus tereticornis (SM.) 被引量:1
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作者 kumar a Luna RK +1 位作者 Parveen kumar V 《Journal of Forestry Research》 SCIE CAS CSCD 2010年第4期487-491,525,共6页
Eighteen clones of Eucalyptus tereticornis (Sm.) were evaluated for three years by adopting randomized block design for various growth parameters at Hoshiarpur, Punjab, India and compared with two checks. Significan... Eighteen clones of Eucalyptus tereticornis (Sm.) were evaluated for three years by adopting randomized block design for various growth parameters at Hoshiarpur, Punjab, India and compared with two checks. Significant variations were recorded for height, diameter at breast height (DBH) and clear bole height (CBH). The broad sense heritability was low to moderate for both height and CBH. The genetic gain for height and CBH increased substantially pe se with the increase in age of trees. The average genetic gain for thres years was recorded maximum for height (159.60%) followed by DBH (110.97%) and CBH (70.34%). Clone 17 attained maximum DBH over other genotypes for second and third year followed by clones 14 and 11. Clone 5 showed an upward trend for DBH and maintained its superiority for CBH as the age of the tree increased. Similarly, clone 11 changed its ranking from 9th to 8th to 3rd for DBH and from 9th to 4th to 2nd for CBH, respectively for the age of one, two and three years. Nonetheless, clones 6 and 10 per- formed poorly for all the characters studied. Clones 17, 14 and 5 were found to be the most promising clones for commercial deployment. 展开更多
关键词 Eucalyptus tereticornis CLONES HERITABILITY genetic advance genetic gain
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Dengue fever presenting as acute liver failure-a case report
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作者 Rajat Jhamb Bineeta Kashyap +1 位作者 Ranga GS kumar a 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2011年第4期323-324,共2页
Dengue fever(DF) and dengue haemorrhagic fever(DHF) are important mosquito-borne viral diseases of humans and recognized as important emerging infectious diseases in the tropics and subtopics.Compared to nine reportin... Dengue fever(DF) and dengue haemorrhagic fever(DHF) are important mosquito-borne viral diseases of humans and recognized as important emerging infectious diseases in the tropics and subtopics.Compared to nine reporting countries in the 1950s,today the geographic distribution includes more than 100 countries worldwide.Dengue viral infections are known to present a diverse clinical spectrum,ranging from asymptomatic illness to fatal dengue shock syndrome. Mild hepatic dysfunction in dengue haemorrhagic fever is usual.However,its presentation as acute liver failure(ALF) is unusual.We report a patient with dengue shock syndrome who presented with acute liver failure and hepatic encephalopathy in a recent outbreak of dengue fever in Delhi,India. 展开更多
关键词 Arboviral DENGUE Haemorrhagic FEVER HEPATIC disfunction MOSQUITO borne disease
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Genetic divergence for growth and wood parameters in different clones of Dalbergia sissoo Roxb
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作者 kumar a Bhatt a +2 位作者 Ravichandran S Pande PK Dobhal S 《Journal of Forestry Research》 SCIE CAS CSCD 2012年第2期285-288,共4页
The wood analysis for different parameters was carried out in a clonal seed orchard ofDalbergia sissoo Roxb. established during 1997 at Hoshiarpur, Punjab, India. Twelve clones with higher index value were subjected t... The wood analysis for different parameters was carried out in a clonal seed orchard ofDalbergia sissoo Roxb. established during 1997 at Hoshiarpur, Punjab, India. Twelve clones with higher index value were subjected to Euclidean Cluster Analysis based on wood and growth parameters to group into seven clusters. Cluster I and II contained four and three clones, respectively, and remaining clusters bad just one clone each. Clone originated from Barielly, Uttar Pradesh of cluster VII was found to be the most divergent clone. Cluster II with three clones main- tained greater inter cluster distance with other clusters. The divergence analysis has confirmed that the clones planted in the clonal seed orchard are sufficiently divergent and seed harvested from the orchard would maintain high diversity. 展开更多
关键词 Dalbergia sissoo Roxb. seed orchard wood and growthtraits genetic divergence HYBRIDIZATION
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Ectomycorrhizal fungi associated with Pinus gerardiana in Kinnaur district of Himachal Pradesh,India
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作者 Tapwal a Kapoor KS +1 位作者 Thakur Y kumar a 《Studies in Fungi》 2021年第1期425-436,共12页
Investigations on the diversity of ectomycorrhizal macrofungi associated with Pinus gerardiana in Kinnaur district of Himachal Pradesh revealed the associations of 22 ectomycorrhizal fungi belonging to 12 genera in 11... Investigations on the diversity of ectomycorrhizal macrofungi associated with Pinus gerardiana in Kinnaur district of Himachal Pradesh revealed the associations of 22 ectomycorrhizal fungi belonging to 12 genera in 11 families.The dominant genus was Geastrum(4 species),followed by Russula and Suillus(3 species each);Boletus,Ramaria and Scleroderma(2 species each)and rest of the genera were represented by one species each.Among these,Scleroderma polyrhizum had the highest frequency of occurrence and was recorded in most of the sites.Maximum diversity was recorded beyond 2500m above mean sea level.Morpho-anatomical study of mycorrhizal roots revealed typical ectomycorrhizal association exhibiting well-developed mantle and hartig net. 展开更多
关键词 Chilgoza Pine ECTOMYCORRHIZA Kinnaur Macro-fungi
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创伤性寰枢椎滑脱伴移位型齿状突骨折:采用“关节重塑”技术实现后路完全复位 被引量:3
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作者 kumar a varshney g +2 位作者 singh pk 葛苏 马向阳 《中国骨科临床与基础研究杂志》 2018年第1期58-59,共2页
寰枢椎脱位(atlantocaxial dislocation,AAD)是在先天性和创伤性情况下,寰枢关节常见的一种不正常关系,寰枢椎滑脱(atlantoaxial spondyloptosis,AAS)是指寰椎侧块小关节面完全移位,两个关节面之间无接触,是寰枢椎不稳定的一种罕见表现... 寰枢椎脱位(atlantocaxial dislocation,AAD)是在先天性和创伤性情况下,寰枢关节常见的一种不正常关系,寰枢椎滑脱(atlantoaxial spondyloptosis,AAS)是指寰椎侧块小关节面完全移位,两个关节面之间无接触,是寰枢椎不稳定的一种罕见表现,属于最严重的寰枢椎脱位之一。由于寰枢关节面交锁,传统的后路手术方式或单纯凭借颅骨牵引均无法使寰枢椎完全复位。“关节操作”技术最初由Goel等提出,通过术中C1~C2撑开及进行寰枢关节操作实现颅颈交界区的重新对位。但单独使用该技术并不能达到关节复位,因此需要联合关节重塑技术(通过在C1关节面前下方边缘及C2关节面钻孔以辅助骨刀插入,获得撑开及部分复位),使寰枢关节复位到正常的解剖位置。作者对1例创伤性AAS伴移位型齿状突骨折患儿采取单纯后路手术,通过“关节操作”和“关节重塑”技术实现完全复位,效果良好。 展开更多
关键词 寰枢关节 关节复位 齿状突骨折 后路手术 枢椎滑脱 移位型 创伤性 dislocation
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患者肠道微生物群失调与肠上皮屏障功能障碍 被引量:67
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作者 Kim S Goel R +10 位作者 kumar a Qi Y Lobaton G Hosaka K Mohammed M Handberg EM Richards EM Pepine CJ Raizada MK 刘青 叶鹏 《中华高血压杂志》 CAS CSCD 北大核心 2018年第9期864-864,共1页
最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预... 最近的证据表明,在动物模型中,肠道病理学和微生物组与高血压之间存在联系。然而,这种关联在人类中是否存在尚不清楚。因此,该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化,结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。 展开更多
关键词 肠道微生物 高血压患者 微生物群 功能障碍 上皮屏障 失调 动物模型 屏障功能
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因拒食而由家庭成员对其鼻饲四年的精神分裂症和强迫症共病患者一例(英文) 被引量:3
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作者 Sachdeva a Chandra M +3 位作者 Saxena a Beniwal R Kandpal M kumar a 《上海精神医学》 CSCD 2015年第4期252-255,共4页
在许多精神障碍中(包括强迫症和精神分裂症),拒食是常见的表现。当突然出现拒食时,这可能需要急诊处理;一旦变成慢性,它就成为一种难以改变的根深蒂固的行为。对拒食患者的诊断可能有难度,尤其是对有共病问题、智力受损或对自身状况缺... 在许多精神障碍中(包括强迫症和精神分裂症),拒食是常见的表现。当突然出现拒食时,这可能需要急诊处理;一旦变成慢性,它就成为一种难以改变的根深蒂固的行为。对拒食患者的诊断可能有难度,尤其是对有共病问题、智力受损或对自身状况缺乏自知力的患者。鼻饲是一种有效的短期干预方法,当患者重新进食时即可中止这一干预。然而,在某些情况下,患者可能变得依赖于鼻饲。我们介绍一个病例,报告一名患有精神分裂症、强迫症、边缘智力以及癫痫的患者由于拒绝进食而由其家庭成员用鼻饲管喂食超过三年。 展开更多
关键词 拒食 共病精神障碍 精神分裂症 强迫症 边缘智力 癫痫 病例报告 印度
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