To evaluate the relationship between the α2-Heremans Schmidt glycoprotein (A HSG) gene polymorphism and endometriosis. Case-control study. Department of Obs tetrics and Gynecology, Seoul National University Hospital,...To evaluate the relationship between the α2-Heremans Schmidt glycoprotein (A HSG) gene polymorphism and endometriosis. Case-control study. Department of Obs tetrics and Gynecology, Seoul National University Hospital, Korea. Seventy-nine women with endometriosis and 105 women without endometriosis. Determination of AHSG gene polymorphism. Prevalence of AHSG genotypes or alleles. The allele freq uencies of AHSG 1 and AHSG 2 were found to be 0.69 and 0.31, respectively. The p roportion of noncarriers of the AHSG 2 allele was significantly higher in women with endometriosis than in women without (55.7%vs. 39.0%). Women not carrying the AHSG 2 allele were found to have twice the risk of endometriosis than those carrying at least one copy of this allele. No significant difference was noted i n the distribution of the AHSG alleles or AHSG genotypes between early stage end ometriosis and late stage endometriosis. Endometriosis is associated with the AH SG gene polymorphism in Korean women.展开更多
Am J Hypertens,2019,32(3):308-316.已有研究报道过血管疾病与青光眼有关,至于血压与青光眼之间的关系目前尚未达成一致。本研究在一个美国成年人群中调查血压与青光眼之间是否存在一种非线性的关系。方法:从2005-2008年美国国家健康...Am J Hypertens,2019,32(3):308-316.已有研究报道过血管疾病与青光眼有关,至于血压与青光眼之间的关系目前尚未达成一致。本研究在一个美国成年人群中调查血压与青光眼之间是否存在一种非线性的关系。方法:从2005-2008年美国国家健康和营养检查调查数据中.展开更多
Objective: To evaluate the effects of hormone replacement therapy (HRT) on oxidative DNA damage in postmenopausal women. Materials and Methods: Eighty- one postmenopausal women who received HRT were recruited, and 8- ...Objective: To evaluate the effects of hormone replacement therapy (HRT) on oxidative DNA damage in postmenopausal women. Materials and Methods: Eighty- one postmenopausal women who received HRT were recruited, and 8- hydroxy- de- oxyguanosine (8- OHdG) levels were measured in the urine and compared with those of agema- tched control (n = 40). The HRT group received either conjugate estrogens or tibolone. Clinical characteristics and urinary 8- OHdG levels were correlated and compared between the two groups. Results: The urinary level of 8- OHdG was lower in the HRT group, compared to controls, with a borderline significance (7.13 ± 3.58 μ g/g creatinine vs. 9.32 ± 7.29 μ g/g creatinine, p = 0.079) (mean ± S.D.). There was no significant difference in urinary 8- OHdG levels among different HRT duration subgroups. After correcting for age, HRT showed a significant effect on the urinary level of 8- OHdG, and the HRT group showed a lower urinary level of 8- OHdG, compared to controls (p = 0.029). Conclusion: Postmenopausal women receiving HRT may have a lower level of DNA oxidative damage than those not receiving HRT. Further larger- scale, prospective controlled investigations are necessary to confirm these results.展开更多
文摘To evaluate the relationship between the α2-Heremans Schmidt glycoprotein (A HSG) gene polymorphism and endometriosis. Case-control study. Department of Obs tetrics and Gynecology, Seoul National University Hospital, Korea. Seventy-nine women with endometriosis and 105 women without endometriosis. Determination of AHSG gene polymorphism. Prevalence of AHSG genotypes or alleles. The allele freq uencies of AHSG 1 and AHSG 2 were found to be 0.69 and 0.31, respectively. The p roportion of noncarriers of the AHSG 2 allele was significantly higher in women with endometriosis than in women without (55.7%vs. 39.0%). Women not carrying the AHSG 2 allele were found to have twice the risk of endometriosis than those carrying at least one copy of this allele. No significant difference was noted i n the distribution of the AHSG alleles or AHSG genotypes between early stage end ometriosis and late stage endometriosis. Endometriosis is associated with the AH SG gene polymorphism in Korean women.
文摘Objective: To evaluate the effects of hormone replacement therapy (HRT) on oxidative DNA damage in postmenopausal women. Materials and Methods: Eighty- one postmenopausal women who received HRT were recruited, and 8- hydroxy- de- oxyguanosine (8- OHdG) levels were measured in the urine and compared with those of agema- tched control (n = 40). The HRT group received either conjugate estrogens or tibolone. Clinical characteristics and urinary 8- OHdG levels were correlated and compared between the two groups. Results: The urinary level of 8- OHdG was lower in the HRT group, compared to controls, with a borderline significance (7.13 ± 3.58 μ g/g creatinine vs. 9.32 ± 7.29 μ g/g creatinine, p = 0.079) (mean ± S.D.). There was no significant difference in urinary 8- OHdG levels among different HRT duration subgroups. After correcting for age, HRT showed a significant effect on the urinary level of 8- OHdG, and the HRT group showed a lower urinary level of 8- OHdG, compared to controls (p = 0.029). Conclusion: Postmenopausal women receiving HRT may have a lower level of DNA oxidative damage than those not receiving HRT. Further larger- scale, prospective controlled investigations are necessary to confirm these results.
