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Discrete biological modeling for the immune response to dengue virus
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作者 khaled a.al-utaibi M.Muzamil +3 位作者 Ayesha Sohail Fatima Alam Alessandro Nutini Sadiq M.Sait 《International Journal of Modeling, Simulation, and Scientific Computing》 EI 2022年第1期214-234,共21页
Dengue infection affects more than half of the world’s population,with 1 billion symp-tomatic cases identified per year and several distinct genetic serotypes:DENV 1–4.Transmitted via the mosquito bite,the dengue vi... Dengue infection affects more than half of the world’s population,with 1 billion symp-tomatic cases identified per year and several distinct genetic serotypes:DENV 1–4.Transmitted via the mosquito bite,the dengue virus infects Langerhans cells.Monocytes,B lymphocytes,and mast cells infected with dengue virus produce various cytokines although it is not clear which ones are predominant during DHF disease.A mathemat-ical model of the Dengue virus infection is developed according to complex dynamics determined by many factors.Starting from a state of equilibrium that we could define as“virus-free”asymptotically stable with a viral reproduction number lower than one which means a very effective action of the innate immune system:it stops the infectious process,the mathematical analysis of stability in the presence of the virus demonstrates that the proposed model is dynamically influenced.Dengue fever affects more than half of the world’s population,with 1 billion symptomatic cases and multiple genetic serotypes confirmed each year,which simulates a network of interactions between the various populations involved without considering the speeds of the processes in question which are indicated in a separate computation.In this research,a hybrid approach of petri nets is utilized to connect the discrete models of dengue. 展开更多
关键词 MODELING scientific computing DENV CYTOKINES petri nets infected cell
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Artificial intelligence to link environmental endocrine disruptors(EEDs)with bone diseases
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作者 khaled a.al-utaibi M.Idreest +3 位作者 Ayesha Sohail Fatima Arift Alessandro Nutini Sadiq M.Sait 《International Journal of Modeling, Simulation, and Scientific Computing》 EI 2022年第3期187-206,共20页
Our endocrine system is not only complex,but is also enormously sensitive to the imbalances caused by the environmental stressors,extreme weather situation,and other geographical factors.The endocrine disruptions are ... Our endocrine system is not only complex,but is also enormously sensitive to the imbalances caused by the environmental stressors,extreme weather situation,and other geographical factors.The endocrine disruptions are associated with the bone diseases.Osteoporosis is a bone disorder that occurs when bone mineral density and bone mass decrease.It affects women and men of all races and ethnic groups,causing bone weakness and the risk of fractures.Environmental stresses are referred to physical,chemical,and biological factors that can impact species productivity.This research aims to examine the impact of environmental stresses on bone diseases like osteoporosis and low bone mass(LBM)in the United States(US).For this purpose,we use an artificial neural network model to evaluate the correlation between the data.A multilayer neural network model is constructed using the Levenberg–Marquardt training algorithm,and its performance is evaluated by mean absolute error and coefficient of correlation.The data of osteoporosis and LBM cases in the US are divided into three groups,including gender group,age group,and race/ethnicity group.Each group shows a positive correlation with environmental stresses and thus the endocrinology. 展开更多
关键词 Endocrine disruptors OSTEOPOROSIS LBM environmental stresses spatial ANNs
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