Gene expression patterns of tumor cells can be inferred from features of circulating cell-free DNA(cfDNA),such as histone modifications and fragmentation patterns at promoters.However,the direct relationship between c...Gene expression patterns of tumor cells can be inferred from features of circulating cell-free DNA(cfDNA),such as histone modifications and fragmentation patterns at promoters.However,the direct relationship between cfDNA patterns and tumor-specific chromatin accessibility has not yet been experimentally established,limiting its current application to cancer diagnosis alone.展开更多
基金supported by Beijing Natural Science Foundation(Z190022)the National Natural Science Foundation of China(81972680,82141102,52271254,82072748,82141102,and 82072748)+3 种基金a start-up fund from Tsinghua University-Peking University Joined Center for Life Science,Guangxi One Thousand Young and Middle-Aged College and University Backone Teachers Cultivation Program,the CAMS Innovation Fund for Medical Sciences(2021-12M-1-002 and 2023-12M-2-002)the National High Level Hospital Clinical Research Funding(2022-PUMCH-D-001,2022-PUMCH-A-082)the National Key Research and Development Program of China(2020YFA0803702)the Science Foundation of Peking University Cancer Hospital(PY202330).
文摘Gene expression patterns of tumor cells can be inferred from features of circulating cell-free DNA(cfDNA),such as histone modifications and fragmentation patterns at promoters.However,the direct relationship between cfDNA patterns and tumor-specific chromatin accessibility has not yet been experimentally established,limiting its current application to cancer diagnosis alone.
