CAR-T cell therapy demonstrates tremendous potential for tumor treatment,yet faces challenges in solid tumor therapy due to immune suppression,T-cell exhaustion,and cytokine release syndrome(CRS)induced by the tumor m...CAR-T cell therapy demonstrates tremendous potential for tumor treatment,yet faces challenges in solid tumor therapy due to immune suppression,T-cell exhaustion,and cytokine release syndrome(CRS)induced by the tumor microenvironment(TME).Traditional Chinese medicine(TCM)holds substantial potential to enhance CAR-T efficacy and mitigate adverse reactions due to its multi-targeted advantages.TCM active ingredients and formulations can synergistically amplify CAR-T anti-tumor effects while reducing adverse events through multiple mechanisms,including reversing T-cell exhaustion,prolonging CAR-T cell persistence,improving TME hypoxia and fibrosis,modulating gut microbiota,and suppressing CRS.This benefits patient treatment and recovery.Combining TCM with CAR-T therapy can increase objective response rates,prolong cell persistence,and reduce CRS incidence.Future efforts will focus on exploring the precise mechanisms and standardized protocols for TCM-enhanced CAR-T treatment through high-quality clinical trials and multi-omics technologies,driving its clinical translation and application.展开更多
文摘CAR-T cell therapy demonstrates tremendous potential for tumor treatment,yet faces challenges in solid tumor therapy due to immune suppression,T-cell exhaustion,and cytokine release syndrome(CRS)induced by the tumor microenvironment(TME).Traditional Chinese medicine(TCM)holds substantial potential to enhance CAR-T efficacy and mitigate adverse reactions due to its multi-targeted advantages.TCM active ingredients and formulations can synergistically amplify CAR-T anti-tumor effects while reducing adverse events through multiple mechanisms,including reversing T-cell exhaustion,prolonging CAR-T cell persistence,improving TME hypoxia and fibrosis,modulating gut microbiota,and suppressing CRS.This benefits patient treatment and recovery.Combining TCM with CAR-T therapy can increase objective response rates,prolong cell persistence,and reduce CRS incidence.Future efforts will focus on exploring the precise mechanisms and standardized protocols for TCM-enhanced CAR-T treatment through high-quality clinical trials and multi-omics technologies,driving its clinical translation and application.
