Genomic instability remains an enabling feature of cancer and promotes malignant transformation.Alterations of DNA damage response(DDR)pathways allow genomic instability,generate neoantigens,upregulate the expression ...Genomic instability remains an enabling feature of cancer and promotes malignant transformation.Alterations of DNA damage response(DDR)pathways allow genomic instability,generate neoantigens,upregulate the expression of programmed death ligand 1(PD-L1)and interact with signaling such as cyclic GMPe AMP synthase-stimulator of interferon genes(cGASe STING)signaling.Here,we review the basic knowledge of DDR pathways,mechanisms of genomic instability induced by DDR alterations,impacts of DDR alterations on immune system,and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy.展开更多
To the Editor:In recent years,impressive outcomes have been achieved in patients harboring human epidermal growth factor receptor 2(HER2)mutations,which accounts for 1%to 4%of cases in non-small cell lung cancer(NSCLC).
基金supported in part by a grant from National Natural Science Foundation of China(81802255)Shanghai Pujiang Program(17PJD036,China)+6 种基金a grant from Shanghai Municipal Commission of Health and Family Planning Program(20174Y0131,China)National Key Research&Development Project(2016YFC0902300,China)major disease clinical skills enhancement program of three year action plan for promoting clinical skills and clinical innovation in municipal hospitalsShanghai Shen Kang Hospital Development Center Clinical Research Plan of SHDC(16CR1001A,China)“Dream Tutor”Outstanding Young Talents Program(fkyq1901,China)key disciplines of Shanghai Pulmonary Hospital(2017ZZ02012,China)grant of Shanghai Science and Technology Commission(16JC1405900,China)。
文摘Genomic instability remains an enabling feature of cancer and promotes malignant transformation.Alterations of DNA damage response(DDR)pathways allow genomic instability,generate neoantigens,upregulate the expression of programmed death ligand 1(PD-L1)and interact with signaling such as cyclic GMPe AMP synthase-stimulator of interferon genes(cGASe STING)signaling.Here,we review the basic knowledge of DDR pathways,mechanisms of genomic instability induced by DDR alterations,impacts of DDR alterations on immune system,and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy.
基金National Natural Science Foundation of China(Nos.81972167,82172869 and 82002419)Shanghai Shenkang Hospital Development Center(No.SHDC12019133)+1 种基金Clinical Research Foundation of Shanghai Pulmonary Hospital(No.FKLY20008)Shanghai Innovative Collaboration Project(No.2020CXJQ02)
文摘To the Editor:In recent years,impressive outcomes have been achieved in patients harboring human epidermal growth factor receptor 2(HER2)mutations,which accounts for 1%to 4%of cases in non-small cell lung cancer(NSCLC).
