局限期小细胞肺癌(limited-stage small cell lung cancer,LS-SCLC)是一种侵袭性强、预后差的恶性肿瘤。长期以来,依托泊苷联合铂类化疗联合同步胸腔放疗是其标准一线治疗方案,但多数患者仍面临复发与耐药。本文系统梳理近年来该领域的...局限期小细胞肺癌(limited-stage small cell lung cancer,LS-SCLC)是一种侵袭性强、预后差的恶性肿瘤。长期以来,依托泊苷联合铂类化疗联合同步胸腔放疗是其标准一线治疗方案,但多数患者仍面临复发与耐药。本文系统梳理近年来该领域的重大进展,旨在展现从传统放化疗向精准整合治疗转变的新格局。放疗技术持续优化,手术在严格筛选的早期患者中价值被重新确立;免疫治疗实现里程碑突破,ADRIATIC研究证实放化疗后Durvalumab巩固治疗可显著延长中位生存期(55.9 vs 33.4个月);同时,基于分子分型的靶向治疗亦显示出潜力。本文阐明多模式治疗策略的优化方向,强调分子分型与生物标志物在个体化治疗中的指导意义,以期为临床实践提供参考,并为未来研究提供框架,从而整体提升LS-SCLC患者的生存预后。展开更多
Dendrobium officinale polysaccharides(DOP),as a natural active ingredient,has exhibited strong immunomodulatory and antioxidant effects.Selenium nanoparticles(SeNPs)also possess various biological activities,but the u...Dendrobium officinale polysaccharides(DOP),as a natural active ingredient,has exhibited strong immunomodulatory and antioxidant effects.Selenium nanoparticles(SeNPs)also possess various biological activities,but the unstable properties limit their applications.This research focused on modification of SeNPs by DOP to form stable complexes(DOP-SeNPs),and the analysis of structural characterization and gut microbiota-mediated immune regulation mechanisms.The results showed that DOP-SeNPs were prepared through hydrogen bond interaction and presented uniform particle size distribution(average particle size of about 100 nm)and good stability.Animal experiments demonstrated that DOP-SeNPs significantly protected the immune organs in cyclophosphamide-induced immune injury mice.Besides,DOP-SeNPs effectively regulated the gut microbiota diversity including promoting the enrichments of probiotics such as Lactobacillus and Lachnospiraceae NK4Al36 group compared with model group,and improved the lymphocyte subsets proportions through the regulation of metabolic pathways including biosynthesis of various antibiotics,protein digestion and absorption,chemical carcinogenesis-DNA adducts.In conclusion,DOP-SeNPs presented stable structure characteristics and improved the immune functions of immune-injured mice by influencing the gut microbiota metabolism.These results will provide a certain theoretical basis and data support for the applications of DOP and the nano-selenium complex in functional food industry.展开更多
文摘局限期小细胞肺癌(limited-stage small cell lung cancer,LS-SCLC)是一种侵袭性强、预后差的恶性肿瘤。长期以来,依托泊苷联合铂类化疗联合同步胸腔放疗是其标准一线治疗方案,但多数患者仍面临复发与耐药。本文系统梳理近年来该领域的重大进展,旨在展现从传统放化疗向精准整合治疗转变的新格局。放疗技术持续优化,手术在严格筛选的早期患者中价值被重新确立;免疫治疗实现里程碑突破,ADRIATIC研究证实放化疗后Durvalumab巩固治疗可显著延长中位生存期(55.9 vs 33.4个月);同时,基于分子分型的靶向治疗亦显示出潜力。本文阐明多模式治疗策略的优化方向,强调分子分型与生物标志物在个体化治疗中的指导意义,以期为临床实践提供参考,并为未来研究提供框架,从而整体提升LS-SCLC患者的生存预后。
基金supported by the Young Doctor Research Fund of Yantai University(No.SM22B184).
文摘Dendrobium officinale polysaccharides(DOP),as a natural active ingredient,has exhibited strong immunomodulatory and antioxidant effects.Selenium nanoparticles(SeNPs)also possess various biological activities,but the unstable properties limit their applications.This research focused on modification of SeNPs by DOP to form stable complexes(DOP-SeNPs),and the analysis of structural characterization and gut microbiota-mediated immune regulation mechanisms.The results showed that DOP-SeNPs were prepared through hydrogen bond interaction and presented uniform particle size distribution(average particle size of about 100 nm)and good stability.Animal experiments demonstrated that DOP-SeNPs significantly protected the immune organs in cyclophosphamide-induced immune injury mice.Besides,DOP-SeNPs effectively regulated the gut microbiota diversity including promoting the enrichments of probiotics such as Lactobacillus and Lachnospiraceae NK4Al36 group compared with model group,and improved the lymphocyte subsets proportions through the regulation of metabolic pathways including biosynthesis of various antibiotics,protein digestion and absorption,chemical carcinogenesis-DNA adducts.In conclusion,DOP-SeNPs presented stable structure characteristics and improved the immune functions of immune-injured mice by influencing the gut microbiota metabolism.These results will provide a certain theoretical basis and data support for the applications of DOP and the nano-selenium complex in functional food industry.
