The development of sustainable and non-invasive method for delivering drugs to the brain is crucial for the effective treatment of Parkinson’s disease(PD).In this study,nanoparticles were formulated by using poly(eth...The development of sustainable and non-invasive method for delivering drugs to the brain is crucial for the effective treatment of Parkinson’s disease(PD).In this study,nanoparticles were formulated by using poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)(PEG-b-PPG-b-PEG)to facilitate an efficient intranasal delivery of rotigotine directly into the brain.It was found that the intranasal route enabled more effective accumulation of rotigotine in the brain than conventional intravenous administration,demonstrating its feasibility as an innovative delivery approach for PD treatment.Furthermore,the behavioral test,brain histology and immunochemistry analyses demonstrated a significant improvement in the symptoms of PD-like neurodegeneration in mice treated with intranasally delivered rotigotine-loaded nanoparticles.These outcomes affirm an outstanding therapeutic efficacy of the nano-formulation for intranasal delivery,highlighting its potential for the effective treatment of neurodegenerative disorders,particularly PD.展开更多
Parkinson's disease(PD)is a prevalent age-related neurodegenerative disorder marked by the progressive loss of dopaminergic neurons and the formation of Lewy bodies.Traditionally viewed as primarily a dopaminergic...Parkinson's disease(PD)is a prevalent age-related neurodegenerative disorder marked by the progressive loss of dopaminergic neurons and the formation of Lewy bodies.Traditionally viewed as primarily a dopaminergic disorder,recent research has highlighted the significant role of neuroinflammation and the complex interplay between glial cells,particularly astrocytes and microglia,in PD pathogenesis.This review explores the multifaceted roles of astrocytes,microglia and oligodendrocytes in PD,focusing on their involvement in maintaining glutamate and ion homeostasis,energy metabolism,and the inflammatory response.We discuss the dual nature of these glial cells,which can both support and harm neuronal health under different conditions.We also examine the molecular mechanisms underlying glial cell communication,including cytokines,chemokines,extracellular vesicles,gap junctions,and neurotransmitter systems.Finally,we propose potential therapeutic strategies targeting these glial interactions to modulate neuroinflammation and protect neurons,offering new avenues for PD treatment.Understanding the diverse functions and interactions of glial cells in the central nervous system is crucial for developing effective interventions for PD and other neurodegenerative diseases.展开更多
基金fnancial support from the National Natural Science Foundation of China(82130059,82222033,82172003)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘The development of sustainable and non-invasive method for delivering drugs to the brain is crucial for the effective treatment of Parkinson’s disease(PD).In this study,nanoparticles were formulated by using poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)(PEG-b-PPG-b-PEG)to facilitate an efficient intranasal delivery of rotigotine directly into the brain.It was found that the intranasal route enabled more effective accumulation of rotigotine in the brain than conventional intravenous administration,demonstrating its feasibility as an innovative delivery approach for PD treatment.Furthermore,the behavioral test,brain histology and immunochemistry analyses demonstrated a significant improvement in the symptoms of PD-like neurodegeneration in mice treated with intranasally delivered rotigotine-loaded nanoparticles.These outcomes affirm an outstanding therapeutic efficacy of the nano-formulation for intranasal delivery,highlighting its potential for the effective treatment of neurodegenerative disorders,particularly PD.
基金support from the National Natural Science Foundation of China(82222033 and 82172003)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Parkinson's disease(PD)is a prevalent age-related neurodegenerative disorder marked by the progressive loss of dopaminergic neurons and the formation of Lewy bodies.Traditionally viewed as primarily a dopaminergic disorder,recent research has highlighted the significant role of neuroinflammation and the complex interplay between glial cells,particularly astrocytes and microglia,in PD pathogenesis.This review explores the multifaceted roles of astrocytes,microglia and oligodendrocytes in PD,focusing on their involvement in maintaining glutamate and ion homeostasis,energy metabolism,and the inflammatory response.We discuss the dual nature of these glial cells,which can both support and harm neuronal health under different conditions.We also examine the molecular mechanisms underlying glial cell communication,including cytokines,chemokines,extracellular vesicles,gap junctions,and neurotransmitter systems.Finally,we propose potential therapeutic strategies targeting these glial interactions to modulate neuroinflammation and protect neurons,offering new avenues for PD treatment.Understanding the diverse functions and interactions of glial cells in the central nervous system is crucial for developing effective interventions for PD and other neurodegenerative diseases.
