Mastitis is a common disease that affects women during lactation,posing a threat to the health of both mothers and infants.Recent studies have shown that insufficient nutrient intake increase the risk of mastitis.Phlo...Mastitis is a common disease that affects women during lactation,posing a threat to the health of both mothers and infants.Recent studies have shown that insufficient nutrient intake increase the risk of mastitis.Phlorizin(PHZ)is one of the nutrients present in apples.This study uses lipopolysaccharide(LPS)-induced mastitis mice and LPS+ATP-stimulated mouse mammary epithelial cells(mMECs)as research objects to explore the effect and mechanism of PHZ on mastitis.Different from in vitro beliefs,our findings demonstrated that PHZ significantly reduced inflammation and protected the blood-milk barrier(BMB)in vivo.Additionally,we observed that oral administration of PHZ regulated the intestinal flora and exhibited prebiotic functions.However,the anti-inflammatory effect of PHZ was not solely dependent on the intestinal flora,as antibiotic disruption of the intestinal flora does not completely abolish the improvement of mastitis by PHZ.Further mechanistic research revealed that the anti-inflammatory properties of PHZ were attributed to its metabolism into phloretin(PHT).Moreover,our results demonstrated that PHT reduced inflammation and protected the BMB by promoting autophagy to prevent the pyroptosis of mMECs.This study provides a theoretical basis for reducing inflammation in lactating women by consuming fruits,such as apples,that contain PHZ.展开更多
Cr(Ⅵ)-based compounds pollution have attracted global concern due to serious harm to humans and environment.Hence,it is crucial to exploit an effective technique to eliminate Cr(Ⅵ)in water.Herein,we in-situ grown Bi...Cr(Ⅵ)-based compounds pollution have attracted global concern due to serious harm to humans and environment.Hence,it is crucial to exploit an effective technique to eliminate Cr(Ⅵ)in water.Herein,we in-situ grown BiOI on graphitic carbon nitride to prepare the BiOI/g-C_(3)N_(4)(BCN)direct Z-scheme heterojunction by solid phase engineering method at room temperature.Experimental result shown the photocatalytic activity of pure BiOI were obviously enhanced by constructing Z-scheme BCN heterostructure,and BCN-3 heterostructure exhibited the optimal photocatalytic degradation of RhB with 98%yield for 2.5 h and reduction of Cr(Ⅵ)with more than 99%yield for 1.5 h at pH=2.Stability test shows BCN-3 still kept more than 98%reduction efficiency after 6 cycles.In addition,we also studied the reduction mechanism that shown the.O_(2)^(-)radicals essentially helped to reduce the Cr(Ⅵ)in aqueous solution under illumination,verified the direct Z-scheme charge transfer path by X-ray photoelectron spectroscopy(XPS)and the free radical trapping experiment.The work open a new way for rationally designing photocatalyst heterostructure to reduce Cr(Ⅵ)to Cr(Ⅲ).展开更多
In order to study the influence of parameters on durability of marine concrete structures, the parameter＇s sensitivity analysis was studied in this paper. With the Fick＇s 2nd law of diffusion and the deterministic s...In order to study the influence of parameters on durability of marine concrete structures, the parameter＇s sensitivity analysis was studied in this paper. With the Fick＇s 2nd law of diffusion and the deterministic sensitivity analysis method （DSA）, the sensitivity factors of apparent surface chloride content, apparent chloride diffusion coefficient and its time dependent attenuation factor were analyzed. The results of the analysis show that the impact of design variables on concrete durability was different. The values of sensitivity factor of chloride diffusion coefficient and its time dependent attenuation factor were higher than others. Relative less error in chloride diffusion coefficient and its time dependent attenuation coefficient induces a bigger error in concrete durability design and life prediction. According to probability sensitivity analysis （PSA）, the influence of mean value and variance of concrete durability design variables on the durability failure probability was studied. The results of the study provide quantitative measures of the importance of concrete durability design and life prediction variables. It was concluded that the chloride diffusion coefficient and its time dependent attenuation factor have more influence on the reliability of marine concrete structural durability. In durability design and life prediction of marine concrete structures, it was very important to reduce the measure and statistic error of durability design variables.展开更多
基金National Natural Science Foundation of China(32272955,32172807)。
文摘Mastitis is a common disease that affects women during lactation,posing a threat to the health of both mothers and infants.Recent studies have shown that insufficient nutrient intake increase the risk of mastitis.Phlorizin(PHZ)is one of the nutrients present in apples.This study uses lipopolysaccharide(LPS)-induced mastitis mice and LPS+ATP-stimulated mouse mammary epithelial cells(mMECs)as research objects to explore the effect and mechanism of PHZ on mastitis.Different from in vitro beliefs,our findings demonstrated that PHZ significantly reduced inflammation and protected the blood-milk barrier(BMB)in vivo.Additionally,we observed that oral administration of PHZ regulated the intestinal flora and exhibited prebiotic functions.However,the anti-inflammatory effect of PHZ was not solely dependent on the intestinal flora,as antibiotic disruption of the intestinal flora does not completely abolish the improvement of mastitis by PHZ.Further mechanistic research revealed that the anti-inflammatory properties of PHZ were attributed to its metabolism into phloretin(PHT).Moreover,our results demonstrated that PHT reduced inflammation and protected the BMB by promoting autophagy to prevent the pyroptosis of mMECs.This study provides a theoretical basis for reducing inflammation in lactating women by consuming fruits,such as apples,that contain PHZ.
基金supported by the National Natural Science Foundation of China under Grant(No.51871078)Heilongjiang Science Foundation(No.E2018028)
文摘Cr(Ⅵ)-based compounds pollution have attracted global concern due to serious harm to humans and environment.Hence,it is crucial to exploit an effective technique to eliminate Cr(Ⅵ)in water.Herein,we in-situ grown BiOI on graphitic carbon nitride to prepare the BiOI/g-C_(3)N_(4)(BCN)direct Z-scheme heterojunction by solid phase engineering method at room temperature.Experimental result shown the photocatalytic activity of pure BiOI were obviously enhanced by constructing Z-scheme BCN heterostructure,and BCN-3 heterostructure exhibited the optimal photocatalytic degradation of RhB with 98%yield for 2.5 h and reduction of Cr(Ⅵ)with more than 99%yield for 1.5 h at pH=2.Stability test shows BCN-3 still kept more than 98%reduction efficiency after 6 cycles.In addition,we also studied the reduction mechanism that shown the.O_(2)^(-)radicals essentially helped to reduce the Cr(Ⅵ)in aqueous solution under illumination,verified the direct Z-scheme charge transfer path by X-ray photoelectron spectroscopy(XPS)and the free radical trapping experiment.The work open a new way for rationally designing photocatalyst heterostructure to reduce Cr(Ⅵ)to Cr(Ⅲ).
文摘In order to study the influence of parameters on durability of marine concrete structures, the parameter＇s sensitivity analysis was studied in this paper. With the Fick＇s 2nd law of diffusion and the deterministic sensitivity analysis method （DSA）, the sensitivity factors of apparent surface chloride content, apparent chloride diffusion coefficient and its time dependent attenuation factor were analyzed. The results of the analysis show that the impact of design variables on concrete durability was different. The values of sensitivity factor of chloride diffusion coefficient and its time dependent attenuation factor were higher than others. Relative less error in chloride diffusion coefficient and its time dependent attenuation coefficient induces a bigger error in concrete durability design and life prediction. According to probability sensitivity analysis （PSA）, the influence of mean value and variance of concrete durability design variables on the durability failure probability was studied. The results of the study provide quantitative measures of the importance of concrete durability design and life prediction variables. It was concluded that the chloride diffusion coefficient and its time dependent attenuation factor have more influence on the reliability of marine concrete structural durability. In durability design and life prediction of marine concrete structures, it was very important to reduce the measure and statistic error of durability design variables.
