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具有病灶治愈功能的淫羊藿苷洗脱涂层修饰血管支架 被引量:1
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作者 柯佑 黄楠 +4 位作者 熊开琴 马青 周楠 吴钰 涂秋芬 《表面技术》 EI CAS CSCD 北大核心 2024年第18期219-230,共12页
目的开发一种ICA洗脱涂层,以聚乳酸-羟基乙酸共聚物(PLGA)为药物递送载体,实现靶向治疗。方法利用超声雾化喷涂技术在血管支架表面构建ICA洗脱涂层,利用傅里叶变换红外吸收光谱仪(FTIR)、水接触角(WCA)检测仪和场发射扫描电子显微镜(SEM... 目的开发一种ICA洗脱涂层,以聚乳酸-羟基乙酸共聚物(PLGA)为药物递送载体,实现靶向治疗。方法利用超声雾化喷涂技术在血管支架表面构建ICA洗脱涂层,利用傅里叶变换红外吸收光谱仪(FTIR)、水接触角(WCA)检测仪和场发射扫描电子显微镜(SEM)等表征手段对涂层的材料学性质进行检测;通过紫外分光光度计(UV-Vis)检测药物释放行为;通过体外溶血率和血小板的黏附与激活实验验证该涂层的血液相容性;通过体外细胞实验进一步评价该涂层的细胞相容性。结果研究结果显示,涂层构建成功,且ICA的装载并未对PLGA涂层的力学性能产生影响,同时实现了ICA体外至少28 d的持续释放。血液相容性的评价结果显示,该涂层有效减少了血小板的黏附和聚集,且该涂层能够抑制SMCs的异常增殖,促进ECs的黏附、增殖,有效调控巨噬细胞向组织修复型转变。结论ICA洗脱支架涂层显示出潜在的抗血栓、抗炎、促内皮和抑制平滑肌细胞异常增殖的特性,有望为心血管疾病患者提供一种安全和有效的治疗选择。 展开更多
关键词 淫羊藿苷 药物洗脱涂层 促内皮 抗炎 抗血栓
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Deep Reinforcement Learning for automated scheduling of mining earthwork equipment with spatio-temporal safety constraints
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作者 Yanan LU ke you +4 位作者 Yuxiang WANG Ying LIU Cheng ZHOU Yutian JIANG Zhangang WU 《Frontiers of Engineering Management》 2025年第1期39-58,共20页
Large-scale machinery operated in a coordinat-ed manner in earthworks for mining constitutes high safety risks.Efficient scheduling of such machinery,factoring in safety constraints,could save time and significantly i... Large-scale machinery operated in a coordinat-ed manner in earthworks for mining constitutes high safety risks.Efficient scheduling of such machinery,factoring in safety constraints,could save time and significantly improve the overall safety.This paper develops a model of automated equipment scheduling in mining earthworks and presents a scheduling algorithm based on deep rein-forcement learning with spatio-temporal safety constraints.The algorithm not only performed well on safety parame-ters,but also outperformed randomized instances of various sizes set against real mining applications.Further,the study reveals that responsiveness to spatio-temporal safety constraints noticeably increases as the scheduling size increases.This method provides important noticeable improvements to safe automated scheduling in mining. 展开更多
关键词 deep reinforcement learning mining earthwork automated scheduling spatio-temporal safety constraints
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