Railway bridges are continuously loaded by railway trains;therefore, it is important to understand the nonlinear seismic response of the Vehicle-Bridge Interaction (VBI) system under strong earthquakes. For this purpo...Railway bridges are continuously loaded by railway trains;therefore, it is important to understand the nonlinear seismic response of the Vehicle-Bridge Interaction (VBI) system under strong earthquakes. For this purpose, the nonlinear behavior of the pier was introduced into the in-house VBI solvers. The nonlinear the seismic response of the VBI system was comprehensively evaluated using this model, and the effect of the vehicle dynamics on seismic performance of the bridge was identified. It was found that the seismic responses of most simply-supported bridges were reduced in the presence of railway trains due to the out-of-phase motion of the vehicle-bridge system. Meanwhile, the nonlinear behavior of the pier can reduce the vehicle’s seismic responses. Therefore, ignoring the nonlinear behavior of the pier during strong earthquakes can significantly overestimate the seismic response of the vehicle.展开更多
In natural language processing(NLP),managing multiple downstream tasks through fine-tuning pre-trained models often requires maintaining separate task-specific models,leading to practical inefficiencies.To address thi...In natural language processing(NLP),managing multiple downstream tasks through fine-tuning pre-trained models often requires maintaining separate task-specific models,leading to practical inefficiencies.To address this challenge,we introduce AdaptForever,a novel approach that enables continuous mastery of NLP tasks through the integration of elastic and mutual learning strategies with a stochastic expert mechanism.Our method freezes the pre-trained model weights while incorporating adapters enhanced with mutual learning capabilities,facilitating effective knowledge transfer from previous tasks to new ones.By combining Elastic Weight Consolidation(EWC)for knowledge preservation with specialized regularization terms,AdaptForever successfully maintains performance on earlier tasks while acquiring new capabilities.Experimental results demonstrate that AdaptForever achieves superior performance across a continuous sequence of NLP tasks compared to existing parameter-efficient methods,while effectively preventing catastrophic forgetting and enabling positive knowledge transfer between tasks.展开更多
Welding high-entropy alloy(HEA)to Mg alloy has gained increasing attention for multi-metal structure design,while intrinsic sluggish diffusion kinetics of HEA confines diffusion-controlled interfacial reactions and mak...Welding high-entropy alloy(HEA)to Mg alloy has gained increasing attention for multi-metal structure design,while intrinsic sluggish diffusion kinetics of HEA confines diffusion-controlled interfacial reactions and makes it challenging to establish robust metallurgical bonding.This study investigated welding of FeCoCrNiMn HEA to commercial AZ31 as a model combination to pioneer thisfield.Interfacial phase separation phenomenon was observed,with the diffusion accelerated by in-situ engineering a submicron-scale thick(∼400–500 nm)HEA nearby the interface into nanocrystalline-structure during friction stir welding.Abundant grain boundaries generated in this nanocrystalline-interlayer serve as diffusion short-circuits and energetically preferred nucleation-sites,which promoted Al in AZ31 to diffuse into HEA and triggered quick separation into body-centered cubic AlNi-type and tetragonal FeCr-type intermetallics.HEA and AZ31 were thus metallurgically bonded by these interfacial intermetallics.The joint shows exceptional strength in tensile lap-shear testing with fracture largely occurred within AZ31 rather than right along interface as commonly reported previously for dissimilar joints.展开更多
Thickness of the intermetallic compounds(IMC)layer at the interface has a significant effect on the mechanical properties of Mg/Al dissimilar joints.However,the thickness of IMC layer can be only obtained by metallurg...Thickness of the intermetallic compounds(IMC)layer at the interface has a significant effect on the mechanical properties of Mg/Al dissimilar joints.However,the thickness of IMC layer can be only obtained by metallurgical microscopy,which is destructive and has to break down the weld.Therefore,it is crucial to find a reliable approach that can non-destructively predict the thickness of IMC layer in practical application.In the current study,Mg alloy and Al alloy were friction stir butt welded(FSW)under different tool rotation speeds(TRS)to obtain different thicknesses of IMC layers.As the TRS increased from 400 rpm to 1000 rpm,thickness of the IMC layer increased from 0.4μm to 1.3μm,the peak welding temperatures increased from 259℃to 402℃,and the Z-axis downforces decreased from10.5 kN to 3.2 k N during welding process.Higher TRS would generally induce higher welding heat input,which promotes the growth of the IMC layer and the softening of base materials.The IMC layer formed through solid-state diffusion and transformation instead of eutectic reaction according to the welding temperature history and interfacial microstructure,and its evolution process was clearly observed by plan view.In order to incorporate the effect of dramatic change of welding temperature which is the characteristic feature of FSW,Psd Voigt function was used to fit the welding temperature histories.A new prediction formula was then established to predict thicknesses of IMC layers with considering sharp welding temperature change.Predicted thicknesses gave good agreement with measured thicknesses obtained experimentally under different welding parameters,which confirmed the accuracy and reliability of the new prediction formula.Based on this prediction formula,the time period of temperature higher than 200℃during welding was found critical for the thickening of interfacial IMC layers.展开更多
BACKGROUNDGastric cancer(GC)has a high prevalence and mortality overall.GEN1 is associatedwith abnormal centrosome amplification,DNA damage and increasedapoptosis.To date,little is known about the function and mechani...BACKGROUNDGastric cancer(GC)has a high prevalence and mortality overall.GEN1 is associatedwith abnormal centrosome amplification,DNA damage and increasedapoptosis.To date,little is known about the function and mechanism of GEN1 inGC.AIMTo explore the cellular processes associated with GC will help to elucidate themechanism of the occurrence and development of GC and discover potentialtherapeutic targets.METHODSThe detection of GEN1 expression at mRNA and protein levels was done by realtimequantitative polymerase chain reaction and western blotting.The function ofGEN1 was verified by loss-of-function experiments in AGS cells.The genes coexpressedwith GEN1 were searched from the stomach adenocarcinomas(STAD)data in The Cancer Genome Atlas database.Kyoto Encyclopedia of Genes andGenomes(KEGG)enrichment analysis of the genes co-expressed with GEN1 tofurther identify the pathways involved in GEN1.Rescue experiments usingferroptosis inhibitor ferrostatin-1 and chemotherapeutic sensitivity assays withcisplatin were also performed.RESULTSSignificant up-regulation of GEN1 was observed in GC cell lines AGS and MGC-803.Inhibition of GEN1 induced cell apoptosis and decreased cell proliferation,cycle progression,migration in AGS cells.There were 264 genes co-expressedwith GEN1 in STAD cohort(r>0.4,P<0.001).KEGG enrichment analysis showed that GEN1 might be associated with the cell cycle,Fanconi anemia pathway,homologous recombination,oocytemeiosis and cellular senescence in GC.Furthermore,CCNA2,CCNB1,CCNB2,cyclin-dependent kinase(CDK)1,CDK2 and polo-like kinase 1 protein levels were lower in GEN1-knockdown AGS cells,manifesting that GEN1 wasassociated with the cell cycle pathway in AGS cells.Downregulation of GEN1 decreased adenosine triphosphatecontent and elevated reactive oxygen species in AGS cells,suggesting that GEN1 silencing led to mitochondrialdysfunction in AGS cells.In addition,GEN1 silencing caused an overt decrease in FTH1 and GPX4 protein levelsand a significant elevation in ACSL4 protein levels,implying that GEN1 silencing promoted AGS cell ferroptosis.Treatment with ferrostatin-1 rescued cell viability loss induced by GEN1 knockdown,confirming ferroptosis as akey death mechanism.Additionally,GEN1-deficient AGS cells showed enhanced sensitivity to cisplatin,with asignificantly reduced half-maximal inhibitory concentration compared to control cells.CONCLUSIONGEN1 promotes GC cell proliferation and migration while suppressing apoptosis and ferroptosis.Targeting GEN1not only disrupts mitochondrial function and cell cycle progression but also sensitizes GC cells to ferroptosis andchemotherapy.These findings highlight GEN1 as a potential therapeutic target for enhancing treatment efficacy ingastric cancer.展开更多
With the advancements in parameter-efficient transfer learning techniques,it has become feasible to leverage large pre-trained language models for downstream tasks under low-cost and low-resource conditions.However,ap...With the advancements in parameter-efficient transfer learning techniques,it has become feasible to leverage large pre-trained language models for downstream tasks under low-cost and low-resource conditions.However,applying this technique to multimodal knowledge transfer introduces a significant challenge:ensuring alignment across modalities while minimizing the number of additional parameters required for downstream task adaptation.This paper introduces UniTrans,a framework aimed at facilitating efficient knowledge transfer across multiple modalities.UniTrans leverages Vector-based Cross-modal Random Matrix Adaptation to enable fine-tuning with minimal parameter overhead.To further enhance modality alignment,we introduce two key components:the Multimodal Consistency Alignment Module and the Query-Augmentation Side Network,specifically optimized for scenarios with extremely limited trainable parameters.Extensive evaluations on various cross-modal downstream tasks demonstrate that our approach surpasses state-of-the-art methods while using just 5%of their trainable parameters.Additionally,it achieves superior performance compared to fully fine-tuned models on certain benchmarks.展开更多
BACKGROUND The increasing number of type 2 diabetes mellitus(T2DM)patients leads to higher rates of morbidity and mortality related to lung cancer.AIM To investigate the utility of the proliferating cell nuclear antig...BACKGROUND The increasing number of type 2 diabetes mellitus(T2DM)patients leads to higher rates of morbidity and mortality related to lung cancer.AIM To investigate the utility of the proliferating cell nuclear antigen Ki-67 in patients with lung adenocarcinoma in situ(AIS)complicated by T2DM.METHODS One hundred patients with AIS and T2DM(group A),100 patients with AIS alone(group B),and 60 patients with benign lung lesions(group C)admitted to the Department of Thoracic Surgery and Endocrinology of the First Affiliated Hospital of Soochow University from November 2021 to December 2022 were enrolled.Ki-67 expression was compared among the groups.RESULTS Group A had significantly higher levels of fasting plasma glucose(FPG),total cholesterol(TC),total triglyceride,low-density lipoprotein cholesterol,glycosylated hemoglobin(HbA1c),and insulin than groups B and C(P<0.01).Meanwhile,group B had higher insulin levels than group C(P<0.01).Group A exhibited a significantly higher average Ki-67 positivity rate than group B(P<0.01).The Ki-67 positivity rate in group A was 86.87%,while the positivity rate in group B was 77%.Ki-67 was positively correlated with FPG(P<0.01)and HbA1c levels(P<0.01).Ki-67,FBG,insulin,HbA1c,high-density lipoprotein cholesterol and TC were independent factors for patients with AIS complicated by T2DM.Chen K et al.Ki67 in patients with AIS complicated by T2DM WJD https://www.wjgnet.com 2 February 15,2025 Volume 16 Issue 2 CONCLUSION Ki-67 expression was higher in patients with AIS complicated by T2DM than in patients with AIS alone.Therefore,detecting the Ki-67 level might assist in the diagnosis of AIS in patients with T2DM.展开更多
A series of suction-controlled triaxial tests was conducted on Nanyang expansive clay to investigate the effects of dry density and suction on dilatancy and strength.The suction of the soil samples was controlled usin...A series of suction-controlled triaxial tests was conducted on Nanyang expansive clay to investigate the effects of dry density and suction on dilatancy and strength.The suction of the soil samples was controlled using a vapour equilibrium technique,with four suction levels ranging from 3.29 MPa to 198.14 MPa,where water retention is dominated by adsorption.The experimental results show that the tested soil exhibits a brittle failure mode under high suction,significantly distinguishing the hydro-mechanical behaviour of the soil at high suction from that observed at low suction.This brittle failure mode significantly increases the contribution of suction to peak strength compared to residual strength,causes the soil to fail before reaching the critical state,a phenomenon not observed in soils under high suction,and results in dilatancy caused by damage to the soil particle aggregates rather than particle rearrangement.The dilatancy data obtained from the triaxial tests reveal that significant soil dilatancy occurs during shear after reaching peak strength,with the maximum dilatancy angle increasing with suction and decreasing with confining pressure.However,the initial dry density has a negligible impact on the soil's dilatancy under high suction levels.This observation further supports that,for unsaturated soils under high suction levels,dilatancy is attributed to damage to soil particle aggregates rather than the rearrangement of soil particles.展开更多
Understanding the connection between brain and behavior in animals requires precise monitoring of their behaviors in three-dimensional(3-D)space.However,there is no available three-dimensional behavior capture system ...Understanding the connection between brain and behavior in animals requires precise monitoring of their behaviors in three-dimensional(3-D)space.However,there is no available three-dimensional behavior capture system that focuses on rodents.Here,we present MouseVenue3D,an automated and low-cost system for the efficient capture of 3-D skeleton trajectories in markerless rodents.We improved the most time-consuming step in 3-D behavior capturing by developing an automatic calibration module.Then,we validated this process in behavior recognition tasks,and showed that 3-D behavioral data achieved higher accuracy than 2-D data.Subsequently,MouseVenue3D was combined with fast high-resolution miniature two-photon microscopy for synchronous neural recording and behavioral tracking in the freely-moving mouse.Finally,we successfully decoded spontaneous neuronal activity from the 3-D behavior of mice.Our findings reveal that subtle,spontaneous behavior modules are strongly correlated with spontaneous neuronal activity patterns.展开更多
The community structures of phytoplankton are important factors and indicators of lake water quality. Harmful algal blooms severely impact water supply, recreational activities and wildlife habitat. This study aimed t...The community structures of phytoplankton are important factors and indicators of lake water quality. Harmful algal blooms severely impact water supply, recreational activities and wildlife habitat. This study aimed to examine the phytoplankton composition and variations using microscopy, and identify harmful Cyanobacteria in weekly samples taken from four sites at Harsha Lake in southwest Ohio. Over the course of the summer in 2015, the phytoplankton of Harsha Lake consisted mainly of 13 taxa belonging to Bacillariophyta, Chlorophyta, Cryptophyta, Cyanobacteria, Dinophyta and Euglenophyta. Their significant successions started with Bacillariophyta and/or Chlorophyta, then bloomed with Cyanobacteria and ended with Chlorophyta and/or Dinophyta. Cyanobacteria members: Microcystis, Planktothrix, Dolichospermum, Aphanizomenon, Cylindrospermopsis, and Oscillatoria from the Cyanophyceae were identified to be dominant genera. These organisms varied spatially and temporally in similar patterns along with the variations of nutrients and formed the summer bloom with the total biomasses ranging from 0.01 to 114.89 mg L-1 with mean of 22.88 mg L-1. M. aeruginosa and P. rubescens were revealed as the microcystin producers, while A. circinalis and Aphanizomenon sp. were identified as a saxitoxin producer through cloning and sequencing PCR products of mcyA, mcyE and sxtA genes. The biomasses of phytoplankton, Cyanobacteria and Microcystis were positively correlated to nutrients, especially to total nitrogen. The total ELISA measurement for microcystin positively correlated with Cyanobacteria (R2 = 0.66, P Microcystis (R2 = 0.64, P 2 = 0.59, P < 0.0001). The basic information on the occurrence and biomasses of Cyanobacteria and total phytoplankton, and the analysis for toxic species, which were the first report for the inland water in Ohio, USA, will document the succession patterns of phytoplankton and toxin production over a season and provide data to predict risk occurrence to both human and ecological factors.展开更多
Lithium sulfur batteries are one of the most promising alternative electrochemical systems,but their practical applications are largely hindered by the serious shuttling problems and sluggish redox kinetics.Here,the c...Lithium sulfur batteries are one of the most promising alternative electrochemical systems,but their practical applications are largely hindered by the serious shuttling problems and sluggish redox kinetics.Here,the conductive and polar niobium nitride(NbN)is in-situ introduced onto graphene with ultrasmall size and high dispersion,and their composite is used to construct an efficient lithium polysulfide blocking layer.The graphene helps to construct highly conductive pathways,and niobium nitride serves as the sulfiphilic sites to chemically adsorb the migrating lithium polysulfides and catalyze their redox conversion.Hence,the cells with the Nb N/G interlayers exhibit a long cycle life with a lower capacity decay of 0.096%/cycle at 1 C for 300 cycles and high rate capability of 937 m Ah g^-1 at 2 C.Further coupling with a sulfur/carbon nanofiber electrode,the cell with an ultra-high sulfur loading of 10.8 mg cm^-2 delivers an areal capacity of 12.5 m Ah cm^-2 at 0.1 C.展开更多
The precise control of the shape of transversely stiffened suspended cable systems is crucial. However, existing form-finding methods primarily rely on iterative calculations that treat loads as fixed known conditions...The precise control of the shape of transversely stiffened suspended cable systems is crucial. However, existing form-finding methods primarily rely on iterative calculations that treat loads as fixed known conditions. These methods are inefficient and fail to accurately control shape results. In this study, we propose a form-finding method that analyzes the load response of models under different sag and stress levels, taking into account the construction process. To analyze the system, a structural finite element model was established in ANSYS, and geometric nonlinear analysis was conducted using the Newton-Raphson method. The form-finding analysis results demonstrate that the proposed method achieves precise control of shape, with a maximum shape error ranging from 0.33% to 0.98%. Furthermore, the relationships between loads and tension forces are influenced by the deformed shape of the structures, exhibiting significant geometric nonlinear characteristics. Meanwhile, the load response analysis reveals that the stress level of the self-equilibrium state in the transversely stiffened suspended cable system is primarily governed by strength criteria, while shape is predominantly controlled by stiffness criteria. Importantly, by simulating the initial tensioning process as an initial condition, this method solves for a counterweight that satisfies the requirements and achieves a self-equilibrium state with the desired shape. The shape of the self-equilibrium state is precisely controlled by simulating the construction process. Overall, this work presents a new method for analyzing the form-finding process of large-span transversely stiffened suspended cable system, considering the construction process which was often overlooked in previous studies.展开更多
To tackle with the security lack in the password-authenticated key exchange protocol, this paper proposes a two-party password-authenticated key exchange protocol based on a verifier. In the proposed protocol, a user ...To tackle with the security lack in the password-authenticated key exchange protocol, this paper proposes a two-party password-authenticated key exchange protocol based on a verifier. In the proposed protocol, a user stores his password in plaintext, and the server stores a verifier for the user’s password, using DL difficult problem and DH difficult problem, through the session between user and server to establish a session key. The security discussion result shows that the proposed protocol provides forward secrecy, and can effectively defend against server compromising fake attacks, dictionary attacks and middleman attacks. Protocol efficiency comparisons reveal our protocol is more reasonable.展开更多
Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the pr...Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.展开更多
Vertebrate neurons are highly dynamic cells that undergo several alterations in their functioning and physiologies in adaptation to various external stimuli.In particular,how these neurons respond to physical exercise...Vertebrate neurons are highly dynamic cells that undergo several alterations in their functioning and physiologies in adaptation to various external stimuli.In particular,how these neurons respond to physical exercise has long been an area of active research.Studies of the vertebrate locomotor system’s adaptability suggest multiple mechanisms are involved in the regulation of neuronal activity and properties during exercise.In this brief review,we highlight recent results and insights from the field with a focus on the following mechanisms:(a)alterations in neuronal excitability during acute exercise;(b)alterations in neuronal excitability after chronic exercise;(c)exercise-induced changes in neuronal membrane properties via modulation of ion channel activity;(d)exercise-enhanced dendritic plasticity;and(e)exercise-induced alterations in neuronal gene expression and protein synthesis.Our hope is to update the community with a cellular and molecular understanding of the recent mechanisms underlying the adaptability of the vertebrate locomotor system in response to both acute and chronic physical exercise.展开更多
The fabrication of advanced graphene-based microwave absorbing materials with thin thickness,wide bandwidth,strong absorption strength,and low filling ratio remains a huge challenge.In this paper,nitrogen-doped reduce...The fabrication of advanced graphene-based microwave absorbing materials with thin thickness,wide bandwidth,strong absorption strength,and low filling ratio remains a huge challenge.In this paper,nitrogen-doped reduced graphene oxide/tricobalt tetraoxide(NRGO/Co_(3)O_(4))composite aerogels were syn-thesized by a three-step method of solvothermal reaction,high-temperature calcination,and hydrother-mal self-assembly.The results showed that the attained NRGO/Co_(3)O_(4)composite aerogels had a unique three-dimensional porous network structure,extremely low bulk density,and good compression recov-ery.Furthermore,the effect of the addition amounts of flower-like Co_(3)O_(4)on the complex dielectric con-stant and microwave absorption properties of NRGO/Co_(3)O_(4)composite aerogels was investigated.When the addition amount of Co_(3)O_(4)was equal to 15 mg,the prepared binary composite aerogel showed the strongest absorption strength of-62.78 dB and a wide absorption bandwidth of 5.5 GHz at a thin thick-ness of 2.13 mm and a low filling ratio of 15 wt.%.It was worth noting that the maximum absorption bandwidth could reach 6.32 GHz(11.68-18 GHz,spanning the entire Ku-band)at a thickness of 2.24 mm.In addition,the possible microwave absorption mechanism of NRGO/Co_(3)O_(4)composite aerogels was also proposed.Therefore,this paper will provide a new and simple strategy for preparing RGO-based porous nanocomposites as lightweight,efficient,and broadband microwave absorbers.展开更多
Failure of oocyte activation,including polyspermy and defects in pronuclear(PN)formation,triggers early embryonic developmental arrest.Many studies have shown that phospholipase C zeta 1(PLCZ1)mutations cause failure ...Failure of oocyte activation,including polyspermy and defects in pronuclear(PN)formation,triggers early embryonic developmental arrest.Many studies have shown that phospholipase C zeta 1(PLCZ1)mutations cause failure of PN formation following intracytoplasmic sperm injection(ICSI);however,whether PLCZ1 mutation is associated with polyspermy during in vitro fertilization(IVF)remains unknown.Whole-exome sequencing(WES)was performed to identify candidate mutations in couples with primary infertility.Sanger sequencing was used to validate the mutations.Multiple PLCZ1-mutated sperm were injected into human and mouse oocytes to explore whether PN formation was induced.Assisted oocyte activation(AOA)after ICSI was performed to overcome the failure of oocyte activation.We identified three PLCZ1 mutations in three patients who experienced polyspermy during IVF cycles,including a novel missense mutation c.1154C>T,p.R385Q.PN formation failure was observed during the ICSI cycle.However,injection of multiple PLCZ1-mutated sperm induced PN formation,suggesting that the Ca2+oscillations induced by the sperm exceeded the necessary threshold for PN formation.AOA after ICSI enabled normal fertilization,and all patients achieved successful pregnancies.These findings expand the mutational spectrum of PLCZ1 and suggest an important role for PLCZ1 in terms of blocking polyspermy.Furthermore,this study may benefit genetic diagnoses in cases of abnormal fertilization and provide potential appropriate therapeutic measures for these patients with sperm-derived polyspermy.展开更多
BACKGROUND Endoscopic submucosal dissection(ESD)is a less invasive local treatment for diseases throughout the gastrointestinal tract.AIM To develop an integrated management protocol and analyze its effects on surgica...BACKGROUND Endoscopic submucosal dissection(ESD)is a less invasive local treatment for diseases throughout the gastrointestinal tract.AIM To develop an integrated management protocol and analyze its effects on surgical outcomes and mental health of patients after ESD.METHODS The study population consisted of patients undergoing ESD before implementation of integrated management and those undergoing ESD by the same pool of surgeons after implementation of integrated management.RESULTS The management group exhibited shortened fasting time and length of hospital stay compared to the control group(P<0.05).The management group exhibited a higher incidence rate of postoperative complications than the control group(3 cases vs 11 cases;P=0.043).The management group exhibited a lower uncertainty score for disease knowledge compared to the control group 12 h after surgery(P<0.05).The management group gave more scores on the domains of patient familiarity to the responsible nurses,professional skills of responsible nurses,and general evaluation compared to the control group.The management group had a higher total score of patient satisfaction towards the responsible nurses in term of health care than the control group(P<0.01).The management group exhibited lower Self-Rating Anxiety Scale and Self-Rating Depression Scale scores compared to the control group 12 h after surgery(P<0.01).CONCLUSION The study demonstrates that integrated management could improve surgical outcomes and mental health of patients undergoing ESD.展开更多
BACKGROUND Many scholars have performed several clinical studies have investigated the association between chronic periodontitis(CP)and chronic kidney disease(CKD).However,there are still differences between these res...BACKGROUND Many scholars have performed several clinical studies have investigated the association between chronic periodontitis(CP)and chronic kidney disease(CKD).However,there are still differences between these research results,and there is no unified conclusion.Therefore,a systematic review is required to understand this issue fully.AIM To explore the correlation between CP and CKD.METHODS Literature on the correlation between CP and CKD,as well as the clinical attachment level(CAL)and pocket probing depth(PPD)of CKD and non-CKD,were retrieved from PubMed,Embase,the Cochrane Library,and Web of Science repositories until January 2024.After the effective data were extracted,data processing and statistics were performed using Stata 12.0.RESULTS Of the 22 studies,13 were related to CP and CKD,and 9 reported CAL and PPD in patients with CKD and healthy controls.Meta-analysis of the correlation between CP and CKD revealed that CKD probability in people with CP was 1.54 times that of healthy individuals[relative risk=1.54,95%confidence interval(CI):1.40-1.70],and CP incidence in patients with CKD was 1.98 times that of healthy individuals[overall risk(OR)=1.98,95%CI:1.53-2.57].Meta-analysis of CAL and PPD evaluations between CKD patients and healthy individuals showed that CAL and PPD levels were higher in CKD patients[standard mean difference(SMD)of CAL=0.65,95%CI:0.29-1.01;SMD of PPD=0.33,95%CI:0.02-0.63].CONCLUSION A bidirectional association exists between CP and CKD.CKD risk is increased in CP patients and vice versa.Periodontal tissue or tooth loss risks increase over time in CKD patients.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.51678490)the Natural Science Foundation of Sichuan Province(Grant No.2024NSFSC0161).
文摘Railway bridges are continuously loaded by railway trains;therefore, it is important to understand the nonlinear seismic response of the Vehicle-Bridge Interaction (VBI) system under strong earthquakes. For this purpose, the nonlinear behavior of the pier was introduced into the in-house VBI solvers. The nonlinear the seismic response of the VBI system was comprehensively evaluated using this model, and the effect of the vehicle dynamics on seismic performance of the bridge was identified. It was found that the seismic responses of most simply-supported bridges were reduced in the presence of railway trains due to the out-of-phase motion of the vehicle-bridge system. Meanwhile, the nonlinear behavior of the pier can reduce the vehicle’s seismic responses. Therefore, ignoring the nonlinear behavior of the pier during strong earthquakes can significantly overestimate the seismic response of the vehicle.
基金supported by the National Key R&D Program of China(No.2023YFB3308601)Sichuan Science and Technology Program(2024NSFJQ0035,2024NSFSC0004)the Talents by Sichuan provincial Party Committee Organization Department.
文摘In natural language processing(NLP),managing multiple downstream tasks through fine-tuning pre-trained models often requires maintaining separate task-specific models,leading to practical inefficiencies.To address this challenge,we introduce AdaptForever,a novel approach that enables continuous mastery of NLP tasks through the integration of elastic and mutual learning strategies with a stochastic expert mechanism.Our method freezes the pre-trained model weights while incorporating adapters enhanced with mutual learning capabilities,facilitating effective knowledge transfer from previous tasks to new ones.By combining Elastic Weight Consolidation(EWC)for knowledge preservation with specialized regularization terms,AdaptForever successfully maintains performance on earlier tasks while acquiring new capabilities.Experimental results demonstrate that AdaptForever achieves superior performance across a continuous sequence of NLP tasks compared to existing parameter-efficient methods,while effectively preventing catastrophic forgetting and enabling positive knowledge transfer between tasks.
基金supported by the National Natural Science Foundation of China[Grant numbers:52475385,52305392]the China Postdoctoral Science Foundation(Grant No.2022M722048).
文摘Welding high-entropy alloy(HEA)to Mg alloy has gained increasing attention for multi-metal structure design,while intrinsic sluggish diffusion kinetics of HEA confines diffusion-controlled interfacial reactions and makes it challenging to establish robust metallurgical bonding.This study investigated welding of FeCoCrNiMn HEA to commercial AZ31 as a model combination to pioneer thisfield.Interfacial phase separation phenomenon was observed,with the diffusion accelerated by in-situ engineering a submicron-scale thick(∼400–500 nm)HEA nearby the interface into nanocrystalline-structure during friction stir welding.Abundant grain boundaries generated in this nanocrystalline-interlayer serve as diffusion short-circuits and energetically preferred nucleation-sites,which promoted Al in AZ31 to diffuse into HEA and triggered quick separation into body-centered cubic AlNi-type and tetragonal FeCr-type intermetallics.HEA and AZ31 were thus metallurgically bonded by these interfacial intermetallics.The joint shows exceptional strength in tensile lap-shear testing with fracture largely occurred within AZ31 rather than right along interface as commonly reported previously for dissimilar joints.
基金supported by the National Natural Science Foundation of China(No.52075330)the Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2019QNA15)the Foundation of National Facility for Translational Medicine(Shanghai)(No.TMSK-2020-107)。
文摘Thickness of the intermetallic compounds(IMC)layer at the interface has a significant effect on the mechanical properties of Mg/Al dissimilar joints.However,the thickness of IMC layer can be only obtained by metallurgical microscopy,which is destructive and has to break down the weld.Therefore,it is crucial to find a reliable approach that can non-destructively predict the thickness of IMC layer in practical application.In the current study,Mg alloy and Al alloy were friction stir butt welded(FSW)under different tool rotation speeds(TRS)to obtain different thicknesses of IMC layers.As the TRS increased from 400 rpm to 1000 rpm,thickness of the IMC layer increased from 0.4μm to 1.3μm,the peak welding temperatures increased from 259℃to 402℃,and the Z-axis downforces decreased from10.5 kN to 3.2 k N during welding process.Higher TRS would generally induce higher welding heat input,which promotes the growth of the IMC layer and the softening of base materials.The IMC layer formed through solid-state diffusion and transformation instead of eutectic reaction according to the welding temperature history and interfacial microstructure,and its evolution process was clearly observed by plan view.In order to incorporate the effect of dramatic change of welding temperature which is the characteristic feature of FSW,Psd Voigt function was used to fit the welding temperature histories.A new prediction formula was then established to predict thicknesses of IMC layers with considering sharp welding temperature change.Predicted thicknesses gave good agreement with measured thicknesses obtained experimentally under different welding parameters,which confirmed the accuracy and reliability of the new prediction formula.Based on this prediction formula,the time period of temperature higher than 200℃during welding was found critical for the thickening of interfacial IMC layers.
文摘BACKGROUNDGastric cancer(GC)has a high prevalence and mortality overall.GEN1 is associatedwith abnormal centrosome amplification,DNA damage and increasedapoptosis.To date,little is known about the function and mechanism of GEN1 inGC.AIMTo explore the cellular processes associated with GC will help to elucidate themechanism of the occurrence and development of GC and discover potentialtherapeutic targets.METHODSThe detection of GEN1 expression at mRNA and protein levels was done by realtimequantitative polymerase chain reaction and western blotting.The function ofGEN1 was verified by loss-of-function experiments in AGS cells.The genes coexpressedwith GEN1 were searched from the stomach adenocarcinomas(STAD)data in The Cancer Genome Atlas database.Kyoto Encyclopedia of Genes andGenomes(KEGG)enrichment analysis of the genes co-expressed with GEN1 tofurther identify the pathways involved in GEN1.Rescue experiments usingferroptosis inhibitor ferrostatin-1 and chemotherapeutic sensitivity assays withcisplatin were also performed.RESULTSSignificant up-regulation of GEN1 was observed in GC cell lines AGS and MGC-803.Inhibition of GEN1 induced cell apoptosis and decreased cell proliferation,cycle progression,migration in AGS cells.There were 264 genes co-expressedwith GEN1 in STAD cohort(r>0.4,P<0.001).KEGG enrichment analysis showed that GEN1 might be associated with the cell cycle,Fanconi anemia pathway,homologous recombination,oocytemeiosis and cellular senescence in GC.Furthermore,CCNA2,CCNB1,CCNB2,cyclin-dependent kinase(CDK)1,CDK2 and polo-like kinase 1 protein levels were lower in GEN1-knockdown AGS cells,manifesting that GEN1 wasassociated with the cell cycle pathway in AGS cells.Downregulation of GEN1 decreased adenosine triphosphatecontent and elevated reactive oxygen species in AGS cells,suggesting that GEN1 silencing led to mitochondrialdysfunction in AGS cells.In addition,GEN1 silencing caused an overt decrease in FTH1 and GPX4 protein levelsand a significant elevation in ACSL4 protein levels,implying that GEN1 silencing promoted AGS cell ferroptosis.Treatment with ferrostatin-1 rescued cell viability loss induced by GEN1 knockdown,confirming ferroptosis as akey death mechanism.Additionally,GEN1-deficient AGS cells showed enhanced sensitivity to cisplatin,with asignificantly reduced half-maximal inhibitory concentration compared to control cells.CONCLUSIONGEN1 promotes GC cell proliferation and migration while suppressing apoptosis and ferroptosis.Targeting GEN1not only disrupts mitochondrial function and cell cycle progression but also sensitizes GC cells to ferroptosis andchemotherapy.These findings highlight GEN1 as a potential therapeutic target for enhancing treatment efficacy ingastric cancer.
文摘With the advancements in parameter-efficient transfer learning techniques,it has become feasible to leverage large pre-trained language models for downstream tasks under low-cost and low-resource conditions.However,applying this technique to multimodal knowledge transfer introduces a significant challenge:ensuring alignment across modalities while minimizing the number of additional parameters required for downstream task adaptation.This paper introduces UniTrans,a framework aimed at facilitating efficient knowledge transfer across multiple modalities.UniTrans leverages Vector-based Cross-modal Random Matrix Adaptation to enable fine-tuning with minimal parameter overhead.To further enhance modality alignment,we introduce two key components:the Multimodal Consistency Alignment Module and the Query-Augmentation Side Network,specifically optimized for scenarios with extremely limited trainable parameters.Extensive evaluations on various cross-modal downstream tasks demonstrate that our approach surpasses state-of-the-art methods while using just 5%of their trainable parameters.Additionally,it achieves superior performance compared to fully fine-tuned models on certain benchmarks.
文摘BACKGROUND The increasing number of type 2 diabetes mellitus(T2DM)patients leads to higher rates of morbidity and mortality related to lung cancer.AIM To investigate the utility of the proliferating cell nuclear antigen Ki-67 in patients with lung adenocarcinoma in situ(AIS)complicated by T2DM.METHODS One hundred patients with AIS and T2DM(group A),100 patients with AIS alone(group B),and 60 patients with benign lung lesions(group C)admitted to the Department of Thoracic Surgery and Endocrinology of the First Affiliated Hospital of Soochow University from November 2021 to December 2022 were enrolled.Ki-67 expression was compared among the groups.RESULTS Group A had significantly higher levels of fasting plasma glucose(FPG),total cholesterol(TC),total triglyceride,low-density lipoprotein cholesterol,glycosylated hemoglobin(HbA1c),and insulin than groups B and C(P<0.01).Meanwhile,group B had higher insulin levels than group C(P<0.01).Group A exhibited a significantly higher average Ki-67 positivity rate than group B(P<0.01).The Ki-67 positivity rate in group A was 86.87%,while the positivity rate in group B was 77%.Ki-67 was positively correlated with FPG(P<0.01)and HbA1c levels(P<0.01).Ki-67,FBG,insulin,HbA1c,high-density lipoprotein cholesterol and TC were independent factors for patients with AIS complicated by T2DM.Chen K et al.Ki67 in patients with AIS complicated by T2DM WJD https://www.wjgnet.com 2 February 15,2025 Volume 16 Issue 2 CONCLUSION Ki-67 expression was higher in patients with AIS complicated by T2DM than in patients with AIS alone.Therefore,detecting the Ki-67 level might assist in the diagnosis of AIS in patients with T2DM.
基金support from the China Scholarship Council(CSC)-University of Technology Sydney joint scholarship and the National Key R&D Program of China(Grant No.2016YFC0800200)is gratefully acknowledged.
文摘A series of suction-controlled triaxial tests was conducted on Nanyang expansive clay to investigate the effects of dry density and suction on dilatancy and strength.The suction of the soil samples was controlled using a vapour equilibrium technique,with four suction levels ranging from 3.29 MPa to 198.14 MPa,where water retention is dominated by adsorption.The experimental results show that the tested soil exhibits a brittle failure mode under high suction,significantly distinguishing the hydro-mechanical behaviour of the soil at high suction from that observed at low suction.This brittle failure mode significantly increases the contribution of suction to peak strength compared to residual strength,causes the soil to fail before reaching the critical state,a phenomenon not observed in soils under high suction,and results in dilatancy caused by damage to the soil particle aggregates rather than particle rearrangement.The dilatancy data obtained from the triaxial tests reveal that significant soil dilatancy occurs during shear after reaching peak strength,with the maximum dilatancy angle increasing with suction and decreasing with confining pressure.However,the initial dry density has a negligible impact on the soil's dilatancy under high suction levels.This observation further supports that,for unsaturated soils under high suction levels,dilatancy is attributed to damage to soil particle aggregates rather than the rearrangement of soil particles.
基金the Key Area R&D Program of Guangdong Province,China(2018B030338001 and 2018B030331001)the National Key R&D Program of China(2018YFA0701403)+11 种基金the National Natural Science Foundation of China(31500861,31630031,91732304,and 31930047)Chang Jiang Scholars Program,the International Big Science Program Cultivating Project of the Chinese Academy of Science(CAS172644KYS820170004)the Strategic Priority Research Program of the CAS(XDB32030100)the Youth Innovation Promotion Association of the CAS(2017413)the CAS Key Laboratory of Brain Connectome and Manipulation(2019DP173024)Shenzhen Government Basic Research Grants(JCYJ20170411140807570,JCYJ20170413164535041)the Science,Technology and Innovation Commission of Shenzhen Municipality(JCYJ20160429185235132)a Helmholtz-CAS Joint Research grant(GJHZ1508)Guangdong Provincial Key Laboratory of Brain Connectome and Behavior(2017B030301017)the Ten Thousand Talent Program,the Guangdong Special Support Program,Key Laboratory of Shenzhen Institute of Advanced Technology(2019DP173024)the Shenzhen Key Science and Technology Infrastructure Planning Project(ZDKJ20190204002).
文摘Understanding the connection between brain and behavior in animals requires precise monitoring of their behaviors in three-dimensional(3-D)space.However,there is no available three-dimensional behavior capture system that focuses on rodents.Here,we present MouseVenue3D,an automated and low-cost system for the efficient capture of 3-D skeleton trajectories in markerless rodents.We improved the most time-consuming step in 3-D behavior capturing by developing an automatic calibration module.Then,we validated this process in behavior recognition tasks,and showed that 3-D behavioral data achieved higher accuracy than 2-D data.Subsequently,MouseVenue3D was combined with fast high-resolution miniature two-photon microscopy for synchronous neural recording and behavioral tracking in the freely-moving mouse.Finally,we successfully decoded spontaneous neuronal activity from the 3-D behavior of mice.Our findings reveal that subtle,spontaneous behavior modules are strongly correlated with spontaneous neuronal activity patterns.
文摘The community structures of phytoplankton are important factors and indicators of lake water quality. Harmful algal blooms severely impact water supply, recreational activities and wildlife habitat. This study aimed to examine the phytoplankton composition and variations using microscopy, and identify harmful Cyanobacteria in weekly samples taken from four sites at Harsha Lake in southwest Ohio. Over the course of the summer in 2015, the phytoplankton of Harsha Lake consisted mainly of 13 taxa belonging to Bacillariophyta, Chlorophyta, Cryptophyta, Cyanobacteria, Dinophyta and Euglenophyta. Their significant successions started with Bacillariophyta and/or Chlorophyta, then bloomed with Cyanobacteria and ended with Chlorophyta and/or Dinophyta. Cyanobacteria members: Microcystis, Planktothrix, Dolichospermum, Aphanizomenon, Cylindrospermopsis, and Oscillatoria from the Cyanophyceae were identified to be dominant genera. These organisms varied spatially and temporally in similar patterns along with the variations of nutrients and formed the summer bloom with the total biomasses ranging from 0.01 to 114.89 mg L-1 with mean of 22.88 mg L-1. M. aeruginosa and P. rubescens were revealed as the microcystin producers, while A. circinalis and Aphanizomenon sp. were identified as a saxitoxin producer through cloning and sequencing PCR products of mcyA, mcyE and sxtA genes. The biomasses of phytoplankton, Cyanobacteria and Microcystis were positively correlated to nutrients, especially to total nitrogen. The total ELISA measurement for microcystin positively correlated with Cyanobacteria (R2 = 0.66, P Microcystis (R2 = 0.64, P 2 = 0.59, P < 0.0001). The basic information on the occurrence and biomasses of Cyanobacteria and total phytoplankton, and the analysis for toxic species, which were the first report for the inland water in Ohio, USA, will document the succession patterns of phytoplankton and toxin production over a season and provide data to predict risk occurrence to both human and ecological factors.
基金financial support from the National Key R&D Program of China(2016YFB0100100 and 2016YFA0200100)the National Natural Science Foundation of China(Nos.51972313,51525206 and 51521091)+1 种基金the Strategic Priority Research Program of Chinese Academy of Science(XDA22010602)China Petrochemical Cooperation(No.218025)。
文摘Lithium sulfur batteries are one of the most promising alternative electrochemical systems,but their practical applications are largely hindered by the serious shuttling problems and sluggish redox kinetics.Here,the conductive and polar niobium nitride(NbN)is in-situ introduced onto graphene with ultrasmall size and high dispersion,and their composite is used to construct an efficient lithium polysulfide blocking layer.The graphene helps to construct highly conductive pathways,and niobium nitride serves as the sulfiphilic sites to chemically adsorb the migrating lithium polysulfides and catalyze their redox conversion.Hence,the cells with the Nb N/G interlayers exhibit a long cycle life with a lower capacity decay of 0.096%/cycle at 1 C for 300 cycles and high rate capability of 937 m Ah g^-1 at 2 C.Further coupling with a sulfur/carbon nanofiber electrode,the cell with an ultra-high sulfur loading of 10.8 mg cm^-2 delivers an areal capacity of 12.5 m Ah cm^-2 at 0.1 C.
文摘The precise control of the shape of transversely stiffened suspended cable systems is crucial. However, existing form-finding methods primarily rely on iterative calculations that treat loads as fixed known conditions. These methods are inefficient and fail to accurately control shape results. In this study, we propose a form-finding method that analyzes the load response of models under different sag and stress levels, taking into account the construction process. To analyze the system, a structural finite element model was established in ANSYS, and geometric nonlinear analysis was conducted using the Newton-Raphson method. The form-finding analysis results demonstrate that the proposed method achieves precise control of shape, with a maximum shape error ranging from 0.33% to 0.98%. Furthermore, the relationships between loads and tension forces are influenced by the deformed shape of the structures, exhibiting significant geometric nonlinear characteristics. Meanwhile, the load response analysis reveals that the stress level of the self-equilibrium state in the transversely stiffened suspended cable system is primarily governed by strength criteria, while shape is predominantly controlled by stiffness criteria. Importantly, by simulating the initial tensioning process as an initial condition, this method solves for a counterweight that satisfies the requirements and achieves a self-equilibrium state with the desired shape. The shape of the self-equilibrium state is precisely controlled by simulating the construction process. Overall, this work presents a new method for analyzing the form-finding process of large-span transversely stiffened suspended cable system, considering the construction process which was often overlooked in previous studies.
文摘To tackle with the security lack in the password-authenticated key exchange protocol, this paper proposes a two-party password-authenticated key exchange protocol based on a verifier. In the proposed protocol, a user stores his password in plaintext, and the server stores a verifier for the user’s password, using DL difficult problem and DH difficult problem, through the session between user and server to establish a session key. The security discussion result shows that the proposed protocol provides forward secrecy, and can effectively defend against server compromising fake attacks, dictionary attacks and middleman attacks. Protocol efficiency comparisons reveal our protocol is more reasonable.
基金supported by the STI 2030-Major Projects 2022ZD0208500(to DY)the National Natural Science Foundation of China,Nos.82072011(to YX),82121003(to DY),82271120(to YS)+2 种基金Sichuan Science and Technology Program,No.2022ZYD0066(to YS)a grant from Chinese Academy of Medical Science,No.2019-12M-5-032(to YS)the Fundamental Research Funds for the Central Universities,No.ZYGX2021YGLH219(to KC)。
文摘Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.
基金supported by grants from the National Natural Science Foundation of China(NSFC)to YD(32171129)from China Postdoctoral Science Foundation to YC(2023M731112)from NSFC to RG(32260216)。
文摘Vertebrate neurons are highly dynamic cells that undergo several alterations in their functioning and physiologies in adaptation to various external stimuli.In particular,how these neurons respond to physical exercise has long been an area of active research.Studies of the vertebrate locomotor system’s adaptability suggest multiple mechanisms are involved in the regulation of neuronal activity and properties during exercise.In this brief review,we highlight recent results and insights from the field with a focus on the following mechanisms:(a)alterations in neuronal excitability during acute exercise;(b)alterations in neuronal excitability after chronic exercise;(c)exercise-induced changes in neuronal membrane properties via modulation of ion channel activity;(d)exercise-enhanced dendritic plasticity;and(e)exercise-induced alterations in neuronal gene expression and protein synthesis.Our hope is to update the community with a cellular and molecular understanding of the recent mechanisms underlying the adaptability of the vertebrate locomotor system in response to both acute and chronic physical exercise.
基金supported by the Natural Science Research Project of Anhui Educational Committee(No.KJ2021ZD0047)the Joint National-Local Engineering Research Center for Safe and Precise Coal Mining Fund(No.EC2022020)+1 种基金the Anhui Provincial Natural Science Foundation(No.2008085J27)the Anhui Provincial Training Program of Innovation and Entrepreneurship for Undergraduates(No.S202210361156).
文摘The fabrication of advanced graphene-based microwave absorbing materials with thin thickness,wide bandwidth,strong absorption strength,and low filling ratio remains a huge challenge.In this paper,nitrogen-doped reduced graphene oxide/tricobalt tetraoxide(NRGO/Co_(3)O_(4))composite aerogels were syn-thesized by a three-step method of solvothermal reaction,high-temperature calcination,and hydrother-mal self-assembly.The results showed that the attained NRGO/Co_(3)O_(4)composite aerogels had a unique three-dimensional porous network structure,extremely low bulk density,and good compression recov-ery.Furthermore,the effect of the addition amounts of flower-like Co_(3)O_(4)on the complex dielectric con-stant and microwave absorption properties of NRGO/Co_(3)O_(4)composite aerogels was investigated.When the addition amount of Co_(3)O_(4)was equal to 15 mg,the prepared binary composite aerogel showed the strongest absorption strength of-62.78 dB and a wide absorption bandwidth of 5.5 GHz at a thin thick-ness of 2.13 mm and a low filling ratio of 15 wt.%.It was worth noting that the maximum absorption bandwidth could reach 6.32 GHz(11.68-18 GHz,spanning the entire Ku-band)at a thickness of 2.24 mm.In addition,the possible microwave absorption mechanism of NRGO/Co_(3)O_(4)composite aerogels was also proposed.Therefore,this paper will provide a new and simple strategy for preparing RGO-based porous nanocomposites as lightweight,efficient,and broadband microwave absorbers.
基金the General Project of Chongqing Natural Science foundation of China(cstc2021jcyj-msxmX0877)the Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau,2023MSXM054)the General Project of Chongqing Health Center for Women and Children(2020YJMS01 and 2021YJMS05).
文摘Failure of oocyte activation,including polyspermy and defects in pronuclear(PN)formation,triggers early embryonic developmental arrest.Many studies have shown that phospholipase C zeta 1(PLCZ1)mutations cause failure of PN formation following intracytoplasmic sperm injection(ICSI);however,whether PLCZ1 mutation is associated with polyspermy during in vitro fertilization(IVF)remains unknown.Whole-exome sequencing(WES)was performed to identify candidate mutations in couples with primary infertility.Sanger sequencing was used to validate the mutations.Multiple PLCZ1-mutated sperm were injected into human and mouse oocytes to explore whether PN formation was induced.Assisted oocyte activation(AOA)after ICSI was performed to overcome the failure of oocyte activation.We identified three PLCZ1 mutations in three patients who experienced polyspermy during IVF cycles,including a novel missense mutation c.1154C>T,p.R385Q.PN formation failure was observed during the ICSI cycle.However,injection of multiple PLCZ1-mutated sperm induced PN formation,suggesting that the Ca2+oscillations induced by the sperm exceeded the necessary threshold for PN formation.AOA after ICSI enabled normal fertilization,and all patients achieved successful pregnancies.These findings expand the mutational spectrum of PLCZ1 and suggest an important role for PLCZ1 in terms of blocking polyspermy.Furthermore,this study may benefit genetic diagnoses in cases of abnormal fertilization and provide potential appropriate therapeutic measures for these patients with sperm-derived polyspermy.
基金the Ethics Committee of Ningbo Yinzhou No.2 Hospital(No.ZXIRB2022301).
文摘BACKGROUND Endoscopic submucosal dissection(ESD)is a less invasive local treatment for diseases throughout the gastrointestinal tract.AIM To develop an integrated management protocol and analyze its effects on surgical outcomes and mental health of patients after ESD.METHODS The study population consisted of patients undergoing ESD before implementation of integrated management and those undergoing ESD by the same pool of surgeons after implementation of integrated management.RESULTS The management group exhibited shortened fasting time and length of hospital stay compared to the control group(P<0.05).The management group exhibited a higher incidence rate of postoperative complications than the control group(3 cases vs 11 cases;P=0.043).The management group exhibited a lower uncertainty score for disease knowledge compared to the control group 12 h after surgery(P<0.05).The management group gave more scores on the domains of patient familiarity to the responsible nurses,professional skills of responsible nurses,and general evaluation compared to the control group.The management group had a higher total score of patient satisfaction towards the responsible nurses in term of health care than the control group(P<0.01).The management group exhibited lower Self-Rating Anxiety Scale and Self-Rating Depression Scale scores compared to the control group 12 h after surgery(P<0.01).CONCLUSION The study demonstrates that integrated management could improve surgical outcomes and mental health of patients undergoing ESD.
文摘BACKGROUND Many scholars have performed several clinical studies have investigated the association between chronic periodontitis(CP)and chronic kidney disease(CKD).However,there are still differences between these research results,and there is no unified conclusion.Therefore,a systematic review is required to understand this issue fully.AIM To explore the correlation between CP and CKD.METHODS Literature on the correlation between CP and CKD,as well as the clinical attachment level(CAL)and pocket probing depth(PPD)of CKD and non-CKD,were retrieved from PubMed,Embase,the Cochrane Library,and Web of Science repositories until January 2024.After the effective data were extracted,data processing and statistics were performed using Stata 12.0.RESULTS Of the 22 studies,13 were related to CP and CKD,and 9 reported CAL and PPD in patients with CKD and healthy controls.Meta-analysis of the correlation between CP and CKD revealed that CKD probability in people with CP was 1.54 times that of healthy individuals[relative risk=1.54,95%confidence interval(CI):1.40-1.70],and CP incidence in patients with CKD was 1.98 times that of healthy individuals[overall risk(OR)=1.98,95%CI:1.53-2.57].Meta-analysis of CAL and PPD evaluations between CKD patients and healthy individuals showed that CAL and PPD levels were higher in CKD patients[standard mean difference(SMD)of CAL=0.65,95%CI:0.29-1.01;SMD of PPD=0.33,95%CI:0.02-0.63].CONCLUSION A bidirectional association exists between CP and CKD.CKD risk is increased in CP patients and vice versa.Periodontal tissue or tooth loss risks increase over time in CKD patients.
