Objective: The management of early-stage (cT1/2N0) oral squamous cell carcinoma (OSCC) remains a controversial issue. The aim of this study was to compare the clinical outcomes of neck observation (OBS) and elective n...Objective: The management of early-stage (cT1/2N0) oral squamous cell carcinoma (OSCC) remains a controversial issue. The aim of this study was to compare the clinical outcomes of neck observation (OBS) and elective neck dissection (END) in treating patients with cT1/2N0 OSCC. Methods: A total of 232 patients with cT1/2N0 OSCC were included in this retrospective study. Of these patients, 181 were treated with END and 51 with OBS. The survival curves of 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were plotted using the Kaplan-Meier method for each group, and compared using the Log-rank test. Results: There was no significant difference in 5-year OS and DSS rates between END and OBS groups (OS: 89.0% vs. 88.2%, P=0.906; DSS: 92.3% vs. 92.2%, P=0.998). However, the END group had a higher 5-year RFS rate than the OBS group (90.1% vs. 76.5%, P=0.009). Patients with occult metastases in OBS group (7/51) had similar 5-year OS rate (57.1% vs. 64.1%, P=0.839) and DSS rate (71.4% vs. 74.4%, P=0.982) to those in END group (39/181). In the regional recurrence patients, the 5-year OS rate (57.1% vs. 11.1%, P=0.011) and DSS rate (71.4% vs. 22.2%, P=0.022) in OBS group (7/51) were higher than those in END group (9/181). Conclusions: The results indicated that OBS policy could obtain the same 5-year OS and DSS as END. Under close follow-up, OBS policy may be an available treatment option for patients with clinical T1/2N0 OSCC.展开更多
In this work,cathode materials of spent lithium-ion ternary batteries are recovered and used as metal precursor to prepare multi-metal oxides MnO_(x)(SY)and GdMnO_(3)(SY)via combustion method and sol-gel method,respec...In this work,cathode materials of spent lithium-ion ternary batteries are recovered and used as metal precursor to prepare multi-metal oxides MnO_(x)(SY)and GdMnO_(3)(SY)via combustion method and sol-gel method,respectively.Furthermore,a series of MnO_(x)(SY)-n and GdMnO_(3)(SY)-n(n=0.05,0.10,1.00,4.00,n represents the dilute HNO_(3) concentration)catalysts are fabricated by acid treatment of MnO_(x)(SY)and GdMnO_(3)(SY)samples and catalytic activities of oxygenated VOCs oxidation over all the prepared catalysts are investigated.Catalytic evaluation results show that acid-treated MnO_(x)(SY)-0.10 and GdMnO_(3)(SY)-0.05 samples perform the optimum VOCs removal efficiency respectively,which may be attributed to their obvious enhancement of physicochemical properties.In detail,Mn O_(x)(SY)-0.10 and GdMnO_(3)(SY)-0.05 samples exhibit the larger specific surface area,bigger amount of surface high-valence metal ions(Mn^(4+),Co^(3+),Ni^(3+)),more abundant adsorbed oxygen species and better low-temperature reducibility,which can play a crucial role in the significant improvement of VOCs oxidation.In situ DRIFTS results imply that the possible main intermediates are-OCO,-COO and-C-O species produced during VOCs oxidation.Possible by-products are further determined via TD/GC-MS analysis.展开更多
We use the couple dipole method to investigate the scanning near-field optical microscopy metallic tip-nanoparticle near-field interaction. Dependences of the local field intensity inside the nanoparticle on the nanos...We use the couple dipole method to investigate the scanning near-field optical microscopy metallic tip-nanoparticle near-field interaction. Dependences of the local field intensity inside the nanoparticle on the nanosized tip shape,the tip open angle and the illumination angle are revealed. In combination with the previous results, we establish a complete model to understand the tip-nanoparticle near-field coupling mechanism.展开更多
Diamonds on the Earth mainly occur in volcanic rocks such as kimberlites and lamproites^([1-8]),but can also be found in ultrahigh-pressure metamorphic rocks^([9-10]),meteorites^([11])and alluvial deposits^([12]).In r...Diamonds on the Earth mainly occur in volcanic rocks such as kimberlites and lamproites^([1-8]),but can also be found in ultrahigh-pressure metamorphic rocks^([9-10]),meteorites^([11])and alluvial deposits^([12]).In recent years,diamonds have been recovered from ophiolites^([13-16])and alkalic dolerites^([17-18]).The discovery of ophiolitic diamonds and alkalic dolerites diamonds has drawn significant research interests to explore the origin of this new class of diamond source and to infer the evolution of their hosting rocks[^(19-21)].This new type of diamond had been initially considered as a result of contamination.However,more and more evidences either directly or indirectly demonstrate that these diamonds are of natural origin^([16,18,19,22-24]).During a geological survey from 2012 to 2015,the geologists from Nanjing Centre of China Geological Survey discovered a large number of yellow microdiamonds in the Langan area in northern Anhui Province^([18,25-29]).The diamond-bearing rocks of these microdiamonds mainly include dolerite and olivine basalt.From 2016 to 2018,four microdiamonds in basic rocks were recovered again in the prospecting work for primary diamond deposits in the Tashan and Zhangji areas in Xuzhou,which is geographically close to Langan[30].All these microdiamonds are similar in colour and shape to ophiolite type diamonds^([31]),and show different characteristics of kimberlite and lamproite type diamonds.Cai,et al.(2019)reported the petrological characteristics of the diamondiferous rocks^([17,21,30]).In this paper,the morphology,infrared spectrum,and carbon isotope compositions of microdiamonds were analysed and discussed by Fourier infrared spectroscopy and carbon isotope test.The types of microdiamonds found in the North China Craton,the age of mantle occurrence,and the source of carbon isotopes were revealed.In the past,many deposits of macro-diamonds,mostly of TypeⅠa orⅡa,were found in the North China Craton,and they have been extensively studied.Microdiamonds recovered from the alkalic dolerites of the North China Craton were studied by FTIR and carbon isotopic.These diamonds are usually light yellow to yellow,with a few colourless,and cubic,octahedral or rhomboidal dodecahedron,and octahedron in shape.The surface characteristics of diamonds,such as dissolution,can be observed.The overall N concentration is not high,with an average of 173×10^(-6).The infrared spectra show that most of these diamonds are TypeⅠb,and C centres are found at 1344 cm^(-1).Three diamond samples are classified as TypeⅠa/Ⅰb,because of A centres and C centres in these diamonds.Two diamonds are classified as typeⅠaAB because B,B′and A centres are found co-existing.FTIR microscopic measurements from the core to the edge of the TypeⅠaAB diamond suggest a mantle residence time of approximately 550 Ma.The C isotopic analysis reveals that these diamonds are strongly depleted in 13 C.These lowδ^(13) C values of dolerites-hosted diamonds overlap with the lower ends of peridotitic diamonds and metamorphic diamonds,and the upper end of the ophiolitic diamonds.Additionally,the reason for the strong deficitδ^(13) C shown by the carbon isotope should be studied in the future.展开更多
This study presents a breakthrough in flexible strain sensor technology with the development of an ultrahigh sensitivity and wide-range sensor,addressing the critical challenge of reconciling sensitivity with measurem...This study presents a breakthrough in flexible strain sensor technology with the development of an ultrahigh sensitivity and wide-range sensor,addressing the critical challenge of reconciling sensitivity with measurement range.Inspired by the structure of bamboo slips,we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric electrode.The resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%.The integration of patterned liquid metal enables customisable tuning of the sensor’s response,while the porous fabric structure ensures superior comfort and air permeability for the wearer.Our design not only optimises the sensor’s performance but also enhances the electrical stability that is essential for practical applications.Through systematic investigation,we reveal the intrinsic mechanisms governing the sensor’s response,offering valuable insights for the design of wearable strain sensors.The sensor’s exceptional performance across a spectrum of applications,from micro-strain to large-strain detection,highlights its potential for a wide range of real-world uses,demonstrating a significant advancement in the field of flexible electronics.展开更多
This study aims to investigate the effect of a magnetic field on nitrous oxide(N2O)emission from a sequencing batch reactor treating low-strength domestic wastewater at low temperature(10℃).After running for 124 days...This study aims to investigate the effect of a magnetic field on nitrous oxide(N2O)emission from a sequencing batch reactor treating low-strength domestic wastewater at low temperature(10℃).After running for 124 days in parallel,results indicated that the conversion rate of N2O for a magnetic field-sequencing batch reactor(MF-SBR)decreased by34.3%compared to that of a conventional SBR(C-SBR).Meanwhile,the removal efficiencies for total nitrogen(TN)and ammonia nitrogen(NH4-N)of the MF-SBR were 22.4%and 39.5%higher than those of the C-SBR.High-throughput sequencing revealed that the abundances of AOB(Nitrosomonas),NOB(Nitrospira)and denitrifiers(Zoogloea),which could reduce N2O to N2,were promoted significantly in the MF-SBR.Enzyme activities(Nir)and gene abundances(nos Z nir S and nir K)for denitrification in the MF-SBR were also notably higher compared to C-SBR.Our study shows that application of a magnetic field is a useful approach for inhibiting the generation of N2O and promoting the nitrogen removal efficiency by affecting the microbial characteristics of sludge in an SBR treating domestic wastewater at low temperature.展开更多
Flexible high-temperature electronics is a compliant form of high-temperature electronics to expand the application areas of conventional flexible one.In aerospace applications,electronic devices are not only required...Flexible high-temperature electronics is a compliant form of high-temperature electronics to expand the application areas of conventional flexible one.In aerospace applications,electronic devices are not only required to be deformable but also to be able to withstand extreme temperatures.The disadvantages of current flexible electronics,such as high cost,large differences between components,and even requiring independent debugging,are acceptable.展开更多
AIM To explore the protective effects and mechanisms of naringenin(NRG) on hepatic injury induced by isoniazid(INH) and rifampicin(RIF).METHODS Male mice were randomly divided into four groups and treated for 14 d as ...AIM To explore the protective effects and mechanisms of naringenin(NRG) on hepatic injury induced by isoniazid(INH) and rifampicin(RIF).METHODS Male mice were randomly divided into four groups and treated for 14 d as follows: normal control group was administered intragastrically with normal saline solution alone; model group was administered intragastrically with INH(100 mg/kg) and RIF(100 mg/kg); lowand high-dosage NRG pretreatment groups were administered intragastrically with different doses of NRG(50 or 100 mg/kg) 2 h before INH and RIF challenge. Mice were killed 16 h after the last dose of drug treatment to determine activity of serum transaminases. Oxidative stress was evaluated by measuring hepatic glutathione(GSH) and superoxide dismutase(SOD) and malondialdehyde(MDA) levels. Histopathological changes in hepatic tissue were observed under the optical microscope. Hepatocyte apoptosis was measured by TUNEL assay and caspase-3 activation. Expression of Bcl-2 and Bax in liver was determined by western blot.RESULTS Both low- and high-dosage NRG pretreatment obviously alleviated serum levels of alanine aminotransferase and aspartate aminotransferase, liver index, hepatic MDA content, and increased hepatic GSH content and SOD activity compared with the INH and RIF-treated group(44.71 ± 8.15 U/L, 38.22 ± 6.64 U/L vs 58.15 ± 10.54 U/L; 98.36 ± 14.78 U/L, 92.41 ± 13.59 U/L vs 133.05 ± 19.36 U/L; 5.34% ± 0.26%, 4.93% ± 0.25% vs 5.71% ± 0.28%; 2.76 ± 0.67 nmol/mgprot, 2.64 ± 0.64 nmol/mgprot vs 4.49 ± 1.12 nmol/mgprot; 5.91 ± 1.31 mg/gprot, 6.42 ± 1.42 mg/gprot vs 3.11 ± 0.73 mg/gprot; 137.31 ± 24.62 U/mgprot, 148.83 ± 26.75 U/mgprot vs 102.34 ± 19.22 U/mgprot; all P < 0.01 or 0.05). Histopathological evaluation showed obvious necrosis and inflammatory cell infiltration in liver of mice administered INH and RIF; however, mice pretreated with NRG showed minor hepatic injury. In addition, INH and RIF resulted in hepatocyte apoptosis, and NRG pretreatment dramatically suppressed INHand RIF-induced hepatocytes apoptosis. Furthermore, NRG-mediated anti-apoptotic effects seemed to be in connection with its regulation of Bax and Bcl-2 protein expression in hepatic tissue.CONCLUSION NRG might attenuate INH- and RIF-induced hepatic injury via suppression of oxidative stress and hepatocyte apoptosis.展开更多
Social influence analysis （SIA） is a vast research field that has attracted research interest in many areas. In this paper, we present a survey of representative and state-of-the-art work in models, methods, and eva...Social influence analysis （SIA） is a vast research field that has attracted research interest in many areas. In this paper, we present a survey of representative and state-of-the-art work in models, methods, and eval- uation aspects related to SIA. We divide SIA models into two types： microscopic and macroscopic models. Microscopic models consider human interactions and the structure of the influence process, whereas macroscopic models consider the same transmission probability and identical influential power for all users. We analyze social influence methods including influence maximization, influence minimization, flow of influence, and individual influence. In social influence evaluation, influence evaluation metrics are introduced and social influence evaluation models are then analyzed. The objectives of this paper are to provide a comprehensive analysis, aid in understanding social behaviors, provide a theoretical basis for influencing public opinion, and unveil future research directions and potential applications.展开更多
Background:N6-methyladenosine(m^(6)A)is an abundant post-transcriptional RNA modification that affects various biological processes.The fat mass and obesity-associated(FTO)protein,a demethylase encoded by the FTO gene...Background:N6-methyladenosine(m^(6)A)is an abundant post-transcriptional RNA modification that affects various biological processes.The fat mass and obesity-associated(FTO)protein,a demethylase encoded by the FTO gene,has been found to regulate adipocyte development in an m^(6)A-dependent manner in multiple species.However,the effects of the m^(6)A methylation and FTO demethylation functions on chicken adipogenesis remain unclear.This study aims to explore the association between m^(6)A modification and chicken adipogenesis and the underlying mechanism by which FTO affects chicken preadipocyte development.Results:The association between m^(6)A modification and chicken lipogenesis was assessed by treating chicken pread-ipocytes with different doses of methyl donor betaine and methylation inhibitor cycloleucine.The results showed that betaine significantly increased methylation levels and inhibited lipogenesis,and the inverse effect was found in preadipocytes after cycloleucine treatment.Overexpression of FTO significantly inhibited m^(6)A levels and promoted proliferation and differentiation of chicken preadipocytes.Silencing FTO showed opposite results.Mechanistically,FTO overexpression increased the expression of catenin beta 1(CTNNB1)by improving RNA stability in an m^(6)A-dependent manner,and we proved that FTO could directly target CTNNB1.Furthermore,CTNNB1 may be a positive regulator of adipogenesis in chicken preadipocytes.Conclusions:m^(6)A methylation of RNA was negatively associated with adipogenesis of chicken preadipocytes.FTO could regulate CTNNB1 expression in a demethylation manner to promote lipogenesis.展开更多
The statistical model for community detection is a promising research area in network analysis.Most existing statistical models of community detection are designed for networks with a known type of community structure...The statistical model for community detection is a promising research area in network analysis.Most existing statistical models of community detection are designed for networks with a known type of community structure,but in many practical situations,the types of community structures are unknown.To cope with unknown community structures,diverse types should be considered in one model.We propose a model that incorporates the latent interaction pattern,which is regarded as the basis of constructions of diverse community structures by us.The interaction pattern can parameterize various types of community structures in one model.A collapsed Gibbs sampling inference is proposed to estimate the community assignments and other hyper-parameters.With the Pitman-Yor process as a prior,our model can automatically detect the numbers and sizes of communities without a known type of community structure beforehand.Via Bayesian inference,our model can detect some hidden interaction patterns that offer extra information for network analysis.Experiments on networks with diverse community structures demonstrate that our model outperforms four state-of-the-art models.展开更多
Objective:To explore the effect of hydromorphone hydrochloride postoperative analgesia on the inflammatory cytokines, S-100β, and NSE in elderly patients after total hip replacement (THR).Methods: A total of 100 pati...Objective:To explore the effect of hydromorphone hydrochloride postoperative analgesia on the inflammatory cytokines, S-100β, and NSE in elderly patients after total hip replacement (THR).Methods: A total of 100 patients who were admitted in our hospital from January, 2015 to July, 2016 for THR were included in the study and randomized into the observation group and the control group with 50 cases in each group. After operation, the patients in the two groups were immediately given patient-controlled analgesia. The patients in the observation group were given hydromorphone hydrochloride (0.3 mg) + dexamethasone (5 mg) + normal saline (100 mL), while the patients in the control group were given sufentanil (150 μg) + dexamethasone (5 mg) + normal saline (100 mL). The morning fasting peripheral venous blood before operation, 24 h and 3 d after operation in the two groups was collected. ELISA was used to detect the serum CRP, IL-6, and TNF-α, and the plasma S-100β and NSE levels.Results:The serum CRP, TNF-α, and IL-6 levels 24 h and 3 d after operation in the two groups were significantly elevated when compared with before operation, and were reduced 3d after operation. CRP, TNF-α, and IL-6 levels at each timing point after operation in the observation group were significantly lower than those in the control group. The plasma S-100βand NSE levels 24 h and 3 d after operation in the two groups were significantly elevated when compared with before operation, and were reduced 3 d after operation. The plasma S-100β and NSE levels at each timing point after operation in the observation group were significantly lower than those in the control group.Conclusions:Hydromorphone hydrochloride can relieve the postoperative pain in elderly patients with THR, effectively alleviate the inflammatory reaction, reduce the plasma S-100β and NSE levels, and alleviate the cerebral injury, whose pathogenesis remains a further deep study.展开更多
Objective:To explore the effect of hydromorphone hydrochloride postoperative analgesia on the stress reaction and hemorheology in elderly patients after total hip replacement (THR). Methods:A total of 70 patients who ...Objective:To explore the effect of hydromorphone hydrochloride postoperative analgesia on the stress reaction and hemorheology in elderly patients after total hip replacement (THR). Methods:A total of 70 patients who were admitted in our hospital from June, 2015 to June, 2016 for THR were included in the study and randomized into the observation group and the control group with 35 cases in each group. After operation, the patients in the two groups were immediately given patient-controlled analgesia. The patients in the observation group were given hydromorphone hydrochloride, while the patients in the control group were given sufentanil. The peripheral venous blood before operation, 12 and 24 h after operation in the two groups was collected. RIA was used to detect BG and Cor. ELISA was used to detect NE. The peripheral venous blood before operation, 24 and 72 h after operation was collected. The full automatic hematology analyzer was used to detect the plasma PV, BV, and RWBV. Results:Cor and NE levels in the observation group, and BG, Cor, and NE levels in the control group 12 and 24 h after operation were significantly elevated when compared with before operation (P<0.05), but the above indicators at each timing point in the control group were significantly higher than those in the observation group (P<0.05). PV, BV (low-shear, middle-shear, and high-shear), and RWBV (low-shear, middle-shear, and high-shear) levels 24 and 72 h after operation in the two groups were significantly elevated when compared with before operation (P<0.05), but the above indicators at each timing point in the control group were significantly higher than those in the observation group (P<0.05). Conclusions:Application of hydromorphone hydrochloride in the postoperative analgesia in elderly patients with THR has a preferable analgesia effect, can effectively alleviate the postoperative stress reaction, stabilize the hemorheology, and contribute to the rehabilitation.展开更多
Dear Editor,Although progressive respiratory failure is the primary cause of death in patients with COVID-19,thromboembolic complications further increased the mortality rates.Endothelial dysfunction,a pro-inflammator...Dear Editor,Although progressive respiratory failure is the primary cause of death in patients with COVID-19,thromboembolic complications further increased the mortality rates.Endothelial dysfunction,a pro-inflammatory and pro-coagulant state characterized by increased interaction with leukocytes and platelets,is reported to play a key role in COVID-19-associated thrombosis;1 however,its underlying mechanism remains unclear.展开更多
Printing of metal bottom back electrodes of flexible organic solar cells（FOSCs） at low temperature is of great significance to realize the full-solution fabrication technology. However, this has been difficult to ac...Printing of metal bottom back electrodes of flexible organic solar cells（FOSCs） at low temperature is of great significance to realize the full-solution fabrication technology. However, this has been difficult to achieve because often the interfacial properties of those printed electrodes, including conductivity, roughness, work function,optical and mechanical flexibility, cannot meet the device requirement at the same time. In this work, we fabricate printed Ag and Cu bottom back cathodes by a low-temperature solution technique named polymer-assisted metal deposition（PAMD） on flexible PET substrates. Branched polyethylenimine（PEI） and ZnO thin films are used as the interface modification layers（IMLs） of these cathodes. Detailed experimental studies on the electrical, mechanical, and morphological properties, and simulation study on the optical properties of these IMLs are carried out to understand and optimize the interface of printed cathodes. We demonstrate that the highest power conversion efficiency over 3.0% can be achieved from a full-solution processed OFSC with the device structure being PAMDAg/PEI/P3 HT：PC61BM/PH1000. This device also acquires remarkable stability upon repeating bending tests.展开更多
Facile fabrication of highly conductive and self-encapsulated graphene electronics is in urgent demand for carbon-based integrated circuits,field effect transistors,optoelectronic devices,and flexible sensors.The curr...Facile fabrication of highly conductive and self-encapsulated graphene electronics is in urgent demand for carbon-based integrated circuits,field effect transistors,optoelectronic devices,and flexible sensors.The current fabrication of these electronic devices is mainly based on layer-by-layer techniques(separate circuit preparation and encapsulation procedures),which show multistep fabrication procedures,complicated renovation/repair procedures,and poor electrical property due to graphene oxidation and exfoliation.Here,we propose a laser-guided interfacial writing(LaserIW)technique based on self-confined,nickel-catalyzed graphitization to directly fabricate highly conductive,embedded graphene electronics inside multilayer structures.展开更多
基金supported by grants from National Natural Science Foundation of China (No. 81372884 and No. 81672679)5010 Project of Clinical Study, Sun Yat-sen University (No. 2010018)
文摘Objective: The management of early-stage (cT1/2N0) oral squamous cell carcinoma (OSCC) remains a controversial issue. The aim of this study was to compare the clinical outcomes of neck observation (OBS) and elective neck dissection (END) in treating patients with cT1/2N0 OSCC. Methods: A total of 232 patients with cT1/2N0 OSCC were included in this retrospective study. Of these patients, 181 were treated with END and 51 with OBS. The survival curves of 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were plotted using the Kaplan-Meier method for each group, and compared using the Log-rank test. Results: There was no significant difference in 5-year OS and DSS rates between END and OBS groups (OS: 89.0% vs. 88.2%, P=0.906; DSS: 92.3% vs. 92.2%, P=0.998). However, the END group had a higher 5-year RFS rate than the OBS group (90.1% vs. 76.5%, P=0.009). Patients with occult metastases in OBS group (7/51) had similar 5-year OS rate (57.1% vs. 64.1%, P=0.839) and DSS rate (71.4% vs. 74.4%, P=0.982) to those in END group (39/181). In the regional recurrence patients, the 5-year OS rate (57.1% vs. 11.1%, P=0.011) and DSS rate (71.4% vs. 22.2%, P=0.022) in OBS group (7/51) were higher than those in END group (9/181). Conclusions: The results indicated that OBS policy could obtain the same 5-year OS and DSS as END. Under close follow-up, OBS policy may be an available treatment option for patients with clinical T1/2N0 OSCC.
基金supported by the National Natural Science Foundation of China(Grant numbers 21876107,21607103)。
文摘In this work,cathode materials of spent lithium-ion ternary batteries are recovered and used as metal precursor to prepare multi-metal oxides MnO_(x)(SY)and GdMnO_(3)(SY)via combustion method and sol-gel method,respectively.Furthermore,a series of MnO_(x)(SY)-n and GdMnO_(3)(SY)-n(n=0.05,0.10,1.00,4.00,n represents the dilute HNO_(3) concentration)catalysts are fabricated by acid treatment of MnO_(x)(SY)and GdMnO_(3)(SY)samples and catalytic activities of oxygenated VOCs oxidation over all the prepared catalysts are investigated.Catalytic evaluation results show that acid-treated MnO_(x)(SY)-0.10 and GdMnO_(3)(SY)-0.05 samples perform the optimum VOCs removal efficiency respectively,which may be attributed to their obvious enhancement of physicochemical properties.In detail,Mn O_(x)(SY)-0.10 and GdMnO_(3)(SY)-0.05 samples exhibit the larger specific surface area,bigger amount of surface high-valence metal ions(Mn^(4+),Co^(3+),Ni^(3+)),more abundant adsorbed oxygen species and better low-temperature reducibility,which can play a crucial role in the significant improvement of VOCs oxidation.In situ DRIFTS results imply that the possible main intermediates are-OCO,-COO and-C-O species produced during VOCs oxidation.Possible by-products are further determined via TD/GC-MS analysis.
基金Supported by the Start-Up Grant of Zhejiang University of Technology,the Zhejiang Provincial Key Laboratory of Information Processing,Communication and Networking,the Zhejiang University,and the National Natural Science Foundation of China under Grant No 61605171
文摘We use the couple dipole method to investigate the scanning near-field optical microscopy metallic tip-nanoparticle near-field interaction. Dependences of the local field intensity inside the nanoparticle on the nanosized tip shape,the tip open angle and the illumination angle are revealed. In combination with the previous results, we establish a complete model to understand the tip-nanoparticle near-field coupling mechanism.
文摘Diamonds on the Earth mainly occur in volcanic rocks such as kimberlites and lamproites^([1-8]),but can also be found in ultrahigh-pressure metamorphic rocks^([9-10]),meteorites^([11])and alluvial deposits^([12]).In recent years,diamonds have been recovered from ophiolites^([13-16])and alkalic dolerites^([17-18]).The discovery of ophiolitic diamonds and alkalic dolerites diamonds has drawn significant research interests to explore the origin of this new class of diamond source and to infer the evolution of their hosting rocks[^(19-21)].This new type of diamond had been initially considered as a result of contamination.However,more and more evidences either directly or indirectly demonstrate that these diamonds are of natural origin^([16,18,19,22-24]).During a geological survey from 2012 to 2015,the geologists from Nanjing Centre of China Geological Survey discovered a large number of yellow microdiamonds in the Langan area in northern Anhui Province^([18,25-29]).The diamond-bearing rocks of these microdiamonds mainly include dolerite and olivine basalt.From 2016 to 2018,four microdiamonds in basic rocks were recovered again in the prospecting work for primary diamond deposits in the Tashan and Zhangji areas in Xuzhou,which is geographically close to Langan[30].All these microdiamonds are similar in colour and shape to ophiolite type diamonds^([31]),and show different characteristics of kimberlite and lamproite type diamonds.Cai,et al.(2019)reported the petrological characteristics of the diamondiferous rocks^([17,21,30]).In this paper,the morphology,infrared spectrum,and carbon isotope compositions of microdiamonds were analysed and discussed by Fourier infrared spectroscopy and carbon isotope test.The types of microdiamonds found in the North China Craton,the age of mantle occurrence,and the source of carbon isotopes were revealed.In the past,many deposits of macro-diamonds,mostly of TypeⅠa orⅡa,were found in the North China Craton,and they have been extensively studied.Microdiamonds recovered from the alkalic dolerites of the North China Craton were studied by FTIR and carbon isotopic.These diamonds are usually light yellow to yellow,with a few colourless,and cubic,octahedral or rhomboidal dodecahedron,and octahedron in shape.The surface characteristics of diamonds,such as dissolution,can be observed.The overall N concentration is not high,with an average of 173×10^(-6).The infrared spectra show that most of these diamonds are TypeⅠb,and C centres are found at 1344 cm^(-1).Three diamond samples are classified as TypeⅠa/Ⅰb,because of A centres and C centres in these diamonds.Two diamonds are classified as typeⅠaAB because B,B′and A centres are found co-existing.FTIR microscopic measurements from the core to the edge of the TypeⅠaAB diamond suggest a mantle residence time of approximately 550 Ma.The C isotopic analysis reveals that these diamonds are strongly depleted in 13 C.These lowδ^(13) C values of dolerites-hosted diamonds overlap with the lower ends of peridotitic diamonds and metamorphic diamonds,and the upper end of the ophiolitic diamonds.Additionally,the reason for the strong deficitδ^(13) C shown by the carbon isotope should be studied in the future.
基金support from the National Key R&D Program of China(2021YFB3200700)the National Natural Science Foundation of China(Grant No.0214100221,51925503).
文摘This study presents a breakthrough in flexible strain sensor technology with the development of an ultrahigh sensitivity and wide-range sensor,addressing the critical challenge of reconciling sensitivity with measurement range.Inspired by the structure of bamboo slips,we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric electrode.The resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%.The integration of patterned liquid metal enables customisable tuning of the sensor’s response,while the porous fabric structure ensures superior comfort and air permeability for the wearer.Our design not only optimises the sensor’s performance but also enhances the electrical stability that is essential for practical applications.Through systematic investigation,we reveal the intrinsic mechanisms governing the sensor’s response,offering valuable insights for the design of wearable strain sensors.The sensor’s exceptional performance across a spectrum of applications,from micro-strain to large-strain detection,highlights its potential for a wide range of real-world uses,demonstrating a significant advancement in the field of flexible electronics.
基金supported by the Major Science and Technology Program for Water Pollution Control and Treatment(No.2017ZX07202-001-002)
文摘This study aims to investigate the effect of a magnetic field on nitrous oxide(N2O)emission from a sequencing batch reactor treating low-strength domestic wastewater at low temperature(10℃).After running for 124 days in parallel,results indicated that the conversion rate of N2O for a magnetic field-sequencing batch reactor(MF-SBR)decreased by34.3%compared to that of a conventional SBR(C-SBR).Meanwhile,the removal efficiencies for total nitrogen(TN)and ammonia nitrogen(NH4-N)of the MF-SBR were 22.4%and 39.5%higher than those of the C-SBR.High-throughput sequencing revealed that the abundances of AOB(Nitrosomonas),NOB(Nitrospira)and denitrifiers(Zoogloea),which could reduce N2O to N2,were promoted significantly in the MF-SBR.Enzyme activities(Nir)and gene abundances(nos Z nir S and nir K)for denitrification in the MF-SBR were also notably higher compared to C-SBR.Our study shows that application of a magnetic field is a useful approach for inhibiting the generation of N2O and promoting the nitrogen removal efficiency by affecting the microbial characteristics of sludge in an SBR treating domestic wastewater at low temperature.
基金financially supported by the National Key R&D Program of China (No.2021YFB3200700)the National Natural Science Foundation of China (Nos.52205593 and 51925503)Xplorer Prize (2020-1036)。
文摘Flexible high-temperature electronics is a compliant form of high-temperature electronics to expand the application areas of conventional flexible one.In aerospace applications,electronic devices are not only required to be deformable but also to be able to withstand extreme temperatures.The disadvantages of current flexible electronics,such as high cost,large differences between components,and even requiring independent debugging,are acceptable.
基金Supported by National Natural Science Foundation of China,No.31502059Education Department of Hubei Province,No.B2016039+1 种基金Medical School of Yangtze University,No.YXYQ201406Clinical and Molecular Immunology Research Center of Yangtze University
文摘AIM To explore the protective effects and mechanisms of naringenin(NRG) on hepatic injury induced by isoniazid(INH) and rifampicin(RIF).METHODS Male mice were randomly divided into four groups and treated for 14 d as follows: normal control group was administered intragastrically with normal saline solution alone; model group was administered intragastrically with INH(100 mg/kg) and RIF(100 mg/kg); lowand high-dosage NRG pretreatment groups were administered intragastrically with different doses of NRG(50 or 100 mg/kg) 2 h before INH and RIF challenge. Mice were killed 16 h after the last dose of drug treatment to determine activity of serum transaminases. Oxidative stress was evaluated by measuring hepatic glutathione(GSH) and superoxide dismutase(SOD) and malondialdehyde(MDA) levels. Histopathological changes in hepatic tissue were observed under the optical microscope. Hepatocyte apoptosis was measured by TUNEL assay and caspase-3 activation. Expression of Bcl-2 and Bax in liver was determined by western blot.RESULTS Both low- and high-dosage NRG pretreatment obviously alleviated serum levels of alanine aminotransferase and aspartate aminotransferase, liver index, hepatic MDA content, and increased hepatic GSH content and SOD activity compared with the INH and RIF-treated group(44.71 ± 8.15 U/L, 38.22 ± 6.64 U/L vs 58.15 ± 10.54 U/L; 98.36 ± 14.78 U/L, 92.41 ± 13.59 U/L vs 133.05 ± 19.36 U/L; 5.34% ± 0.26%, 4.93% ± 0.25% vs 5.71% ± 0.28%; 2.76 ± 0.67 nmol/mgprot, 2.64 ± 0.64 nmol/mgprot vs 4.49 ± 1.12 nmol/mgprot; 5.91 ± 1.31 mg/gprot, 6.42 ± 1.42 mg/gprot vs 3.11 ± 0.73 mg/gprot; 137.31 ± 24.62 U/mgprot, 148.83 ± 26.75 U/mgprot vs 102.34 ± 19.22 U/mgprot; all P < 0.01 or 0.05). Histopathological evaluation showed obvious necrosis and inflammatory cell infiltration in liver of mice administered INH and RIF; however, mice pretreated with NRG showed minor hepatic injury. In addition, INH and RIF resulted in hepatocyte apoptosis, and NRG pretreatment dramatically suppressed INHand RIF-induced hepatocytes apoptosis. Furthermore, NRG-mediated anti-apoptotic effects seemed to be in connection with its regulation of Bax and Bcl-2 protein expression in hepatic tissue.CONCLUSION NRG might attenuate INH- and RIF-induced hepatic injury via suppression of oxidative stress and hepatocyte apoptosis.
文摘Social influence analysis （SIA） is a vast research field that has attracted research interest in many areas. In this paper, we present a survey of representative and state-of-the-art work in models, methods, and eval- uation aspects related to SIA. We divide SIA models into two types： microscopic and macroscopic models. Microscopic models consider human interactions and the structure of the influence process, whereas macroscopic models consider the same transmission probability and identical influential power for all users. We analyze social influence methods including influence maximization, influence minimization, flow of influence, and individual influence. In social influence evaluation, influence evaluation metrics are introduced and social influence evaluation models are then analyzed. The objectives of this paper are to provide a comprehensive analysis, aid in understanding social behaviors, provide a theoretical basis for influencing public opinion, and unveil future research directions and potential applications.
基金funded by the Natural Scientific Foundation of China(U1901206)Local Innovative and Research Teams Project of Guangdong Province(2019BT02N630)+4 种基金the Science and Technology Program of Guangdong province,China(2020B1212060060)the Science and Technology Program of Guangzhou,China(202103000084)the Construction Project of Modern Agricultural Science and Technology Innovation Alliance in Guangdong Province(2021KJ128)National Key R&D Program of China(2021YFD1300100)China Agriculture Research System(CARS-41-G03).
文摘Background:N6-methyladenosine(m^(6)A)is an abundant post-transcriptional RNA modification that affects various biological processes.The fat mass and obesity-associated(FTO)protein,a demethylase encoded by the FTO gene,has been found to regulate adipocyte development in an m^(6)A-dependent manner in multiple species.However,the effects of the m^(6)A methylation and FTO demethylation functions on chicken adipogenesis remain unclear.This study aims to explore the association between m^(6)A modification and chicken adipogenesis and the underlying mechanism by which FTO affects chicken preadipocyte development.Results:The association between m^(6)A modification and chicken lipogenesis was assessed by treating chicken pread-ipocytes with different doses of methyl donor betaine and methylation inhibitor cycloleucine.The results showed that betaine significantly increased methylation levels and inhibited lipogenesis,and the inverse effect was found in preadipocytes after cycloleucine treatment.Overexpression of FTO significantly inhibited m^(6)A levels and promoted proliferation and differentiation of chicken preadipocytes.Silencing FTO showed opposite results.Mechanistically,FTO overexpression increased the expression of catenin beta 1(CTNNB1)by improving RNA stability in an m^(6)A-dependent manner,and we proved that FTO could directly target CTNNB1.Furthermore,CTNNB1 may be a positive regulator of adipogenesis in chicken preadipocytes.Conclusions:m^(6)A methylation of RNA was negatively associated with adipogenesis of chicken preadipocytes.FTO could regulate CTNNB1 expression in a demethylation manner to promote lipogenesis.
基金Project supported by Beijing Natural Science Foundation,China(Grant Nos.L181010 and 4172054)the National Key R&D Program of China(Grant No.2016YFB0801100)the National Basic Research Program of China(Grant No.2013CB329605)。
文摘The statistical model for community detection is a promising research area in network analysis.Most existing statistical models of community detection are designed for networks with a known type of community structure,but in many practical situations,the types of community structures are unknown.To cope with unknown community structures,diverse types should be considered in one model.We propose a model that incorporates the latent interaction pattern,which is regarded as the basis of constructions of diverse community structures by us.The interaction pattern can parameterize various types of community structures in one model.A collapsed Gibbs sampling inference is proposed to estimate the community assignments and other hyper-parameters.With the Pitman-Yor process as a prior,our model can automatically detect the numbers and sizes of communities without a known type of community structure beforehand.Via Bayesian inference,our model can detect some hidden interaction patterns that offer extra information for network analysis.Experiments on networks with diverse community structures demonstrate that our model outperforms four state-of-the-art models.
文摘Objective:To explore the effect of hydromorphone hydrochloride postoperative analgesia on the inflammatory cytokines, S-100β, and NSE in elderly patients after total hip replacement (THR).Methods: A total of 100 patients who were admitted in our hospital from January, 2015 to July, 2016 for THR were included in the study and randomized into the observation group and the control group with 50 cases in each group. After operation, the patients in the two groups were immediately given patient-controlled analgesia. The patients in the observation group were given hydromorphone hydrochloride (0.3 mg) + dexamethasone (5 mg) + normal saline (100 mL), while the patients in the control group were given sufentanil (150 μg) + dexamethasone (5 mg) + normal saline (100 mL). The morning fasting peripheral venous blood before operation, 24 h and 3 d after operation in the two groups was collected. ELISA was used to detect the serum CRP, IL-6, and TNF-α, and the plasma S-100β and NSE levels.Results:The serum CRP, TNF-α, and IL-6 levels 24 h and 3 d after operation in the two groups were significantly elevated when compared with before operation, and were reduced 3d after operation. CRP, TNF-α, and IL-6 levels at each timing point after operation in the observation group were significantly lower than those in the control group. The plasma S-100βand NSE levels 24 h and 3 d after operation in the two groups were significantly elevated when compared with before operation, and were reduced 3 d after operation. The plasma S-100β and NSE levels at each timing point after operation in the observation group were significantly lower than those in the control group.Conclusions:Hydromorphone hydrochloride can relieve the postoperative pain in elderly patients with THR, effectively alleviate the inflammatory reaction, reduce the plasma S-100β and NSE levels, and alleviate the cerebral injury, whose pathogenesis remains a further deep study.
文摘Objective:To explore the effect of hydromorphone hydrochloride postoperative analgesia on the stress reaction and hemorheology in elderly patients after total hip replacement (THR). Methods:A total of 70 patients who were admitted in our hospital from June, 2015 to June, 2016 for THR were included in the study and randomized into the observation group and the control group with 35 cases in each group. After operation, the patients in the two groups were immediately given patient-controlled analgesia. The patients in the observation group were given hydromorphone hydrochloride, while the patients in the control group were given sufentanil. The peripheral venous blood before operation, 12 and 24 h after operation in the two groups was collected. RIA was used to detect BG and Cor. ELISA was used to detect NE. The peripheral venous blood before operation, 24 and 72 h after operation was collected. The full automatic hematology analyzer was used to detect the plasma PV, BV, and RWBV. Results:Cor and NE levels in the observation group, and BG, Cor, and NE levels in the control group 12 and 24 h after operation were significantly elevated when compared with before operation (P<0.05), but the above indicators at each timing point in the control group were significantly higher than those in the observation group (P<0.05). PV, BV (low-shear, middle-shear, and high-shear), and RWBV (low-shear, middle-shear, and high-shear) levels 24 and 72 h after operation in the two groups were significantly elevated when compared with before operation (P<0.05), but the above indicators at each timing point in the control group were significantly higher than those in the observation group (P<0.05). Conclusions:Application of hydromorphone hydrochloride in the postoperative analgesia in elderly patients with THR has a preferable analgesia effect, can effectively alleviate the postoperative stress reaction, stabilize the hemorheology, and contribute to the rehabilitation.
基金supported by grants from the National Natural Science Foundation of China(82070305)(L.Y.),(81730014)(Y.Z.),and(82130014)(D.A.).
文摘Dear Editor,Although progressive respiratory failure is the primary cause of death in patients with COVID-19,thromboembolic complications further increased the mortality rates.Endothelial dysfunction,a pro-inflammatory and pro-coagulant state characterized by increased interaction with leukocytes and platelets,is reported to play a key role in COVID-19-associated thrombosis;1 however,its underlying mechanism remains unclear.
基金supported by the Research Grant Council of Hong Kong(No.PolyUC5015-15G)the Hong Kong Polytechnic University(No.G-SB06)the National Natural Science Foundation of China(Nos.21125316,21434009,51573026)
文摘Printing of metal bottom back electrodes of flexible organic solar cells（FOSCs） at low temperature is of great significance to realize the full-solution fabrication technology. However, this has been difficult to achieve because often the interfacial properties of those printed electrodes, including conductivity, roughness, work function,optical and mechanical flexibility, cannot meet the device requirement at the same time. In this work, we fabricate printed Ag and Cu bottom back cathodes by a low-temperature solution technique named polymer-assisted metal deposition（PAMD） on flexible PET substrates. Branched polyethylenimine（PEI） and ZnO thin films are used as the interface modification layers（IMLs） of these cathodes. Detailed experimental studies on the electrical, mechanical, and morphological properties, and simulation study on the optical properties of these IMLs are carried out to understand and optimize the interface of printed cathodes. We demonstrate that the highest power conversion efficiency over 3.0% can be achieved from a full-solution processed OFSC with the device structure being PAMDAg/PEI/P3 HT：PC61BM/PH1000. This device also acquires remarkable stability upon repeating bending tests.
基金supported by the National Natural Science Foundation of China(51925503,52105576,and 52188102)the Xplorer Prize.
文摘Facile fabrication of highly conductive and self-encapsulated graphene electronics is in urgent demand for carbon-based integrated circuits,field effect transistors,optoelectronic devices,and flexible sensors.The current fabrication of these electronic devices is mainly based on layer-by-layer techniques(separate circuit preparation and encapsulation procedures),which show multistep fabrication procedures,complicated renovation/repair procedures,and poor electrical property due to graphene oxidation and exfoliation.Here,we propose a laser-guided interfacial writing(LaserIW)technique based on self-confined,nickel-catalyzed graphitization to directly fabricate highly conductive,embedded graphene electronics inside multilayer structures.
