In this study,we investigated the separation of iron and scandium from Sc-bearing red mud.The red mud object of our study contained 31.11 wt%total iron(TFe),0.0045 wt%Sc,hematite(Fe_(2)O_(3))and ferrosilite(FeO·S...In this study,we investigated the separation of iron and scandium from Sc-bearing red mud.The red mud object of our study contained 31.11 wt%total iron(TFe),0.0045 wt%Sc,hematite(Fe_(2)O_(3))and ferrosilite(FeO·SiO_(2))as the main Fe-bearing minerals.The Sc-bearing red mud was treated by a novel deep reduction roasting and magnetic separation process that includes the addition of coke and CaO to extract Fe and enriching Sc from the Sc-bearing red mud.The addition of coke and CaO enhances the transformation of hematite(Fe_(2)O_(3))to metallic iron(Fe~0)and magnetite(Fe_(3)O_(4))as well as the transformation of ferrosilite into metallic iron(Fe~0).The test results show that utilizing the new process a Fe concentrate with a TFe content of 81.22 wt%and Fe recovery of 92.96%was obtained.Furthermore,magnetic separation tailings with Sc content of 0.0062 wt%and Sc recovery of 98.65%were also obtained.The test results were achieved under the following process conditions:roasting temperature of 1373 K,roasting time of 45 min,calcium oxide dosage of 20 wt%,coke dosage of 25 wt%,grinding fineness of90%<0.04 mm,and magnetic field intensity of 0.24 T.The major minerals in the Fe concentrate are metallic iron(Fe~0)and magnetite(Fe_(3)O_(4)).The main minerals in the magnetic separation tailings with a low TFe content of 2.62%are CaO·SiO_(2),Na_(2)O·SiO_(2),FeO·SiO_(2),Ca_(3)Fe_(2)Si_(3)O_(12),CaAl_(2)SiO_6 and CaFe(SiO_(3))_(2).展开更多
Anthocyanin is one of water-soluble natural pigments widely existing in flowers, fruits, stems, leaves and seeds of plants, and it is the major factor conferring pink or red to the petals of Rosa rugose. MYB TFs play ...Anthocyanin is one of water-soluble natural pigments widely existing in flowers, fruits, stems, leaves and seeds of plants, and it is the major factor conferring pink or red to the petals of Rosa rugose. MYB TFs play an important role in the anthocyanin synthesis in plants. This work aimed to clone the MYB gene related to anthocyanin synthesis in the petals of Rosa rugose, and explore the relationship between them to lay a good foundation for gene engineering improvement of R. rugose. Based on the transcriptional data, a full-length cDNA sequence of MYB Gene, RrMYB113 (GenBank accession Nos MG720012), was cloned at the first time from the petals of Rosa rugose “Zi zhi” with RT-PCR and RACE methods. The full-length cDNA is 885 bp with an open reading frame of 654 bp, encoding 216 amino acids. The derived RrMYB113 protein has a molecular weight of 25,297.64 Da, a calculated pI of 9.61, a R2R3-MYB domain and bHLH binding domain, and it also has the signature motifs ((A/S/G)NDV and KPRPR(T/S)), thus belonging to Sg6 R2R3-MYB subfamily. In the secondary structure of RrMYB113 protein, there is 37.04% α-helix, 39.81% random coil, 14.81% extended peptide chain, and 8.33% β-corner. There is no transmembrane domain and no signal peptide cleavage site, seventeen Ser phosphorylation sites, fifteen Thr phosphorylation sites, four Tyr phosphorylation sites, and no O-glycosylation sites. The expression of RrMYB113 increased with the color deepening in petals, and it expressed at a higher level in petals than in other tissues of R. rugose “Zi zhi”. These results are meaningful to reveal that RrMYB113 might be an important regulator in anthocyanin biosynthesis and coloration in the petals of R. rugose.展开更多
R2R3-MYB transcription factor plays an important role in plant anthocyanin synthesis. Based on the transcriptional database of Rosa rugosa, one MYB transcription factor related to floral color, RrMYB6, was cloned. By ...R2R3-MYB transcription factor plays an important role in plant anthocyanin synthesis. Based on the transcriptional database of Rosa rugosa, one MYB transcription factor related to floral color, RrMYB6, was cloned. By using bioinformatics analysis method, cloning MYB gene and analyzing its function in anthocyanin biosynthesis regulation, we hope to lay a solid foundation for new color variety breeding of R. rugosa. Using the R. rugosa “Zi zhi” as the material, we obtained the total length of cDNA of RrMYB6 by RT-PCR and RACE. By analyzing its bioinformatics, we found that the formula of the protein was C1491H2368N452O470S17, molecular weight was 34690.97 Da, the theoretical pI was 8.74. In addition, it belonged to unstable protein with an unstable index at 50.59, and it was also a hydrophilic protein with the total average hydrophobic index at -0.847. In the secondary structure of RrMYB6 protein, the Alpha helix accounted for 32.35%, random coil was 47.39%, extended strand was 11.11%, and beta turn was 9.15%. The sequence analysis showed that RrMYB6 had a typical R2R3-MYB domain and bHLH binding domain, and it also had an N1, C1, C2 inhibitory motif, belonging to the Sg4 subfamily MYB protein. What’s more, evolutionary analysis indicated that the RrMYB6 protein was closely related with the MYB protein in Rosacea family, while it was far from those in other families. The expression analysis showed that RrMYB6 protein decreased with the color of petals deeping, and its expression was the lowest in the petals while the highest in stamens. According to the above results, it was speculated that RrMYB6 was involved in regulating the anthocyanin synthesis of R. rugosa, which belonged to negative regulatory mechanism.展开更多
HA121-28,a promising multikinase inhibitor,mainly targets rearranged during transfection(RET)fusions and selectively targets vascular endothelial growth factor receptor-2,endothelial growth factor receptor,and fibrobl...HA121-28,a promising multikinase inhibitor,mainly targets rearranged during transfection(RET)fusions and selectively targets vascular endothelial growth factor receptor-2,endothelial growth factor receptor,and fibroblast growth factor receptor 1-3.The safety,pharmacokinetics,and efficacy of HA121-28 were assessed in advanced solid tumors(phase 1,ClinicalTrials.gov NCT03994484)and advanced RET fusion-positive non-small-cell lung cancer(RET-TKI naive NSCLC,phase 2,ClinicalTrials.gov NCT05117658).HA121-28 was administered orally in doses range from 25 to 800 mg under the 21-day on/7-day off scheme for a 28-day cycle in phase 1 trial.The recommended dose identified in phase 1(450 mg)was administered for patients during phase 2.The primary endpoints were the maximum tolerated dose(MTD)in phase 1 and the objective response rate(ORR)in phase 2.162 patients were enrolled in phase 1 and 48 in phase 2.A total of 600 mg once daily was set as MTD.Across 100-800 mg,the exposure of HA121-28 increased in a dose-dependent manner.Consistent between both trials,diarrhea,rash,and prolonged QTc interval,were the most reported treatment-emergent adverse events.40.0%(phase 1)and 62.5%(phase 2)patients experienced grade≥3 treatment-related adverse events,respectively.The overall ORR was 26.8%and the median progression-free survival(PFS)was 5.5 months among 97 NSCLC patients with advanced RET fusion receiving a dose at≥450 mg once daily.HA121-28 showed encouraging efficacy in advanced RET fusion NSCLC and its toxicity was tolerable in most patients.Nevertheless,cardiotoxicity is a notable concern that warrants careful attention.展开更多
In 2022,gastric cancer(GC)ranked as the fifth most common cancer and the third leading cause of cancer death in China,with 358,672 new cases and 260,372 deaths,accounting for 37.0%and 39.4%of global cases,respectively...In 2022,gastric cancer(GC)ranked as the fifth most common cancer and the third leading cause of cancer death in China,with 358,672 new cases and 260,372 deaths,accounting for 37.0%and 39.4%of global cases,respectively[1].Previous studies have shown that 25.9%and 36.5%of GC patients in China were diagnosed at stages III and IV,respectively,with 5-year overall survival(OS)rates of 33.0%for stage III and 5.5%for stage IV[2,3].展开更多
Single-photon detectors are ubiquitous devices in quantum-photonic-based communication,computation,metrology,and sensing.In these applications,N-fold coincidence photon counting is often needed,for example,to characte...Single-photon detectors are ubiquitous devices in quantum-photonic-based communication,computation,metrology,and sensing.In these applications,N-fold coincidence photon counting is often needed,for example,to characterize entanglement.However,N-fold coincidence photon counting typically requires N individual singlephoton detectors and associated bias and readout electronics,and these resources could become prohibitive if N goes large and the detectors need to work at cryogenic temperatures.Here,to break this limit on N,we propose a device architecture based on N cascaded photosensitive superconducting nanowires and one wider nanowire that functions as a current reservoir.We show that by strategically designing the device,the network of these superconducting nanowires can work in a synergic manner as an n-photon detector,where n can be from 1 to N,depending on the bias conditions.We therefore name the devices of this type superconducting nanowire multi-photon detectors(SNMPDs).In addition to its simple one-port bias and readout circuitry,the coincidences are counted internally in the detector,eliminating the need for external multi-channel,time-correlated pulse counters.We believe that the SNMPDs proposed in this work could open avenues towards conveniently measuring high-order temporal correlations of light and characterizing multi-photon entanglement.展开更多
Superconducting nanowire single-photon detectors(SNSPDs)have become a mainstream photon-counting technology that has been widely applied in various scenarios.So far,most multi-channel SNSPD systems,either reported in ...Superconducting nanowire single-photon detectors(SNSPDs)have become a mainstream photon-counting technology that has been widely applied in various scenarios.So far,most multi-channel SNSPD systems,either reported in literature or commercially available,are polarization sensitive,that is,the system detection efficiency(SDE)of each channel is dependent on the state of polarization of the to-be-detected photons.Here,we reported an eight-channel system with fractal SNSPDs working in the wavelength range of 930 to 940 nm,which are all featured with low polarization sensitivity.In a close-cycled Gifford-McMahon cryocooler system with the base temperature of 2.2 K,we installed and compared the performance of two types of devices:(1)SNSPD,composed of a single,continuous nanowire and(2)superconducting nanowire avalanche photodetector(SNAP),composed of 16 cascaded units of two nanowires electrically connected in parallel.The highest SDE among the eight channels reaches 96+^(4)_(-5%),with the polarization sensitivity of 1.02 and a dark-count rate of 13 counts per second.The average SDE for eight channels for all states of polarization is estimated to be 90±5%.It is concluded that both the SNSPDs and the SNAPs can reach saturated,high SDE at the wavelength of interest,and the SNSPDs show lower dark-count(false-count)rates,whereas the SNAPs show better properties in the time domain.With the adoption of this system,we showcased the measurements of the second-order photon-correlation functions of light emission from a singlephoton source based on a semiconductor quantum dot and from a pulsed laser.It is believed that this work will provide new choices of systems with single-photon detectors combining the merits of high SDE,low polarization sensitivity,and low noise that can be tailored for different applications.展开更多
Silicon sub-bandgap photodetectors can detect light at the infrared telecommunication wavelengths but with relatively weak photo-response.In this work,we demonstrate the enhancement of sub-bandgap photodetection in si...Silicon sub-bandgap photodetectors can detect light at the infrared telecommunication wavelengths but with relatively weak photo-response.In this work,we demonstrate the enhancement of sub-bandgap photodetection in silicon by helium-ion implantation,without afecting the transparency that is an important benefcial feature of this type of photodetectors.With an implantation dose of 1×10^(13)ions/cm^(2),the minimal detectable optical power can be improved from−33.2 to−63.1 dBm,or,by 29.9 dB,at the wavelength of 1550 nm,and the photo-response at the same optical power(−10 dBm)can be enhanced by approximately 18.8 dB.Our work provides a method for strategically modifying the intrinsic trade-of between transparency and strong photo-responses of this type of photodetectors.展开更多
基金Project supported by the Sichuan Science and Technology Program(2022YFS0462,2021YJ0057,2021YFG0268)the China Postdoctoral Science Foundation(2014M560734)。
文摘In this study,we investigated the separation of iron and scandium from Sc-bearing red mud.The red mud object of our study contained 31.11 wt%total iron(TFe),0.0045 wt%Sc,hematite(Fe_(2)O_(3))and ferrosilite(FeO·SiO_(2))as the main Fe-bearing minerals.The Sc-bearing red mud was treated by a novel deep reduction roasting and magnetic separation process that includes the addition of coke and CaO to extract Fe and enriching Sc from the Sc-bearing red mud.The addition of coke and CaO enhances the transformation of hematite(Fe_(2)O_(3))to metallic iron(Fe~0)and magnetite(Fe_(3)O_(4))as well as the transformation of ferrosilite into metallic iron(Fe~0).The test results show that utilizing the new process a Fe concentrate with a TFe content of 81.22 wt%and Fe recovery of 92.96%was obtained.Furthermore,magnetic separation tailings with Sc content of 0.0062 wt%and Sc recovery of 98.65%were also obtained.The test results were achieved under the following process conditions:roasting temperature of 1373 K,roasting time of 45 min,calcium oxide dosage of 20 wt%,coke dosage of 25 wt%,grinding fineness of90%<0.04 mm,and magnetic field intensity of 0.24 T.The major minerals in the Fe concentrate are metallic iron(Fe~0)and magnetite(Fe_(3)O_(4)).The main minerals in the magnetic separation tailings with a low TFe content of 2.62%are CaO·SiO_(2),Na_(2)O·SiO_(2),FeO·SiO_(2),Ca_(3)Fe_(2)Si_(3)O_(12),CaAl_(2)SiO_6 and CaFe(SiO_(3))_(2).
文摘Anthocyanin is one of water-soluble natural pigments widely existing in flowers, fruits, stems, leaves and seeds of plants, and it is the major factor conferring pink or red to the petals of Rosa rugose. MYB TFs play an important role in the anthocyanin synthesis in plants. This work aimed to clone the MYB gene related to anthocyanin synthesis in the petals of Rosa rugose, and explore the relationship between them to lay a good foundation for gene engineering improvement of R. rugose. Based on the transcriptional data, a full-length cDNA sequence of MYB Gene, RrMYB113 (GenBank accession Nos MG720012), was cloned at the first time from the petals of Rosa rugose “Zi zhi” with RT-PCR and RACE methods. The full-length cDNA is 885 bp with an open reading frame of 654 bp, encoding 216 amino acids. The derived RrMYB113 protein has a molecular weight of 25,297.64 Da, a calculated pI of 9.61, a R2R3-MYB domain and bHLH binding domain, and it also has the signature motifs ((A/S/G)NDV and KPRPR(T/S)), thus belonging to Sg6 R2R3-MYB subfamily. In the secondary structure of RrMYB113 protein, there is 37.04% α-helix, 39.81% random coil, 14.81% extended peptide chain, and 8.33% β-corner. There is no transmembrane domain and no signal peptide cleavage site, seventeen Ser phosphorylation sites, fifteen Thr phosphorylation sites, four Tyr phosphorylation sites, and no O-glycosylation sites. The expression of RrMYB113 increased with the color deepening in petals, and it expressed at a higher level in petals than in other tissues of R. rugose “Zi zhi”. These results are meaningful to reveal that RrMYB113 might be an important regulator in anthocyanin biosynthesis and coloration in the petals of R. rugose.
文摘R2R3-MYB transcription factor plays an important role in plant anthocyanin synthesis. Based on the transcriptional database of Rosa rugosa, one MYB transcription factor related to floral color, RrMYB6, was cloned. By using bioinformatics analysis method, cloning MYB gene and analyzing its function in anthocyanin biosynthesis regulation, we hope to lay a solid foundation for new color variety breeding of R. rugosa. Using the R. rugosa “Zi zhi” as the material, we obtained the total length of cDNA of RrMYB6 by RT-PCR and RACE. By analyzing its bioinformatics, we found that the formula of the protein was C1491H2368N452O470S17, molecular weight was 34690.97 Da, the theoretical pI was 8.74. In addition, it belonged to unstable protein with an unstable index at 50.59, and it was also a hydrophilic protein with the total average hydrophobic index at -0.847. In the secondary structure of RrMYB6 protein, the Alpha helix accounted for 32.35%, random coil was 47.39%, extended strand was 11.11%, and beta turn was 9.15%. The sequence analysis showed that RrMYB6 had a typical R2R3-MYB domain and bHLH binding domain, and it also had an N1, C1, C2 inhibitory motif, belonging to the Sg4 subfamily MYB protein. What’s more, evolutionary analysis indicated that the RrMYB6 protein was closely related with the MYB protein in Rosacea family, while it was far from those in other families. The expression analysis showed that RrMYB6 protein decreased with the color of petals deeping, and its expression was the lowest in the petals while the highest in stamens. According to the above results, it was speculated that RrMYB6 was involved in regulating the anthocyanin synthesis of R. rugosa, which belonged to negative regulatory mechanism.
基金funded by Sun Yat-sen University clinical research 5010 program(84000-31630002)Cancer Innovative Research Program of Sun Yat-sen University Cancer Center(CIRP-SYSUCC-0004)+4 种基金the National Natural Science Foundation of China(82073396)CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-I2M-5-036)the Guangdong Basic and Applied Basic Research Foundation(2021A1515110697)the Guangzhou Key Research and Development Plan(202206010141)CSPC ZhongQi Pharmaceutical Technology(Shijiazhuang)Co.
文摘HA121-28,a promising multikinase inhibitor,mainly targets rearranged during transfection(RET)fusions and selectively targets vascular endothelial growth factor receptor-2,endothelial growth factor receptor,and fibroblast growth factor receptor 1-3.The safety,pharmacokinetics,and efficacy of HA121-28 were assessed in advanced solid tumors(phase 1,ClinicalTrials.gov NCT03994484)and advanced RET fusion-positive non-small-cell lung cancer(RET-TKI naive NSCLC,phase 2,ClinicalTrials.gov NCT05117658).HA121-28 was administered orally in doses range from 25 to 800 mg under the 21-day on/7-day off scheme for a 28-day cycle in phase 1 trial.The recommended dose identified in phase 1(450 mg)was administered for patients during phase 2.The primary endpoints were the maximum tolerated dose(MTD)in phase 1 and the objective response rate(ORR)in phase 2.162 patients were enrolled in phase 1 and 48 in phase 2.A total of 600 mg once daily was set as MTD.Across 100-800 mg,the exposure of HA121-28 increased in a dose-dependent manner.Consistent between both trials,diarrhea,rash,and prolonged QTc interval,were the most reported treatment-emergent adverse events.40.0%(phase 1)and 62.5%(phase 2)patients experienced grade≥3 treatment-related adverse events,respectively.The overall ORR was 26.8%and the median progression-free survival(PFS)was 5.5 months among 97 NSCLC patients with advanced RET fusion receiving a dose at≥450 mg once daily.HA121-28 showed encouraging efficacy in advanced RET fusion NSCLC and its toxicity was tolerable in most patients.Nevertheless,cardiotoxicity is a notable concern that warrants careful attention.
基金approved by the Independent Ethics Committee of Chinese PLA General Hospital(C2021-102-01)Changzhi People’s Hospital(LSPJ2022006)+17 种基金Fujian Provincial Cancer Hospital(2022-016-01)Cancer Hospital of Shandong First Medical University(SDZLEC2022-042-01)The First People’s Hospital of Changde City(2022-016-01)Jilin Cancer Hospital(202201-011-01)Linyi People’s Hospital(2022-lunlishencha-10)Liaoning Cancer Hospital and Institute(20220205)Shanxi Province Cancer Hospital(YW2022009)Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital(L2022-Y010-002)Harbin Medical University Cancer Hospital(2022-91)Anhui Provincial Cancer Hospital,The First Affiliated Hospital of University of Science and Technology of China(2022-lunlishencha-08)The Fourth Hospital of Hebei Medical University(2022044)Binzhou Medical University Hospital(2022-001-01)Central Hospital Affiliated to Shandong Medical University(jizhongxinlunlilinshen2022-011-01)Qingdao Central Hospital,University of Health and Rehabilitation Science([Y]SY202200401)Liaocheng People’s Hospital(2022006)Suining Central Hospital(2022-lunliyijian-sy002-01)Yanan University Xianyang Hospital(YDXYEC-YWPJ-2022-5)conducted in accordance with the Declaration of Helsinki and Good Clinical Practices.Written informed consent was obtained from all patients before enrollment.
文摘In 2022,gastric cancer(GC)ranked as the fifth most common cancer and the third leading cause of cancer death in China,with 358,672 new cases and 260,372 deaths,accounting for 37.0%and 39.4%of global cases,respectively[1].Previous studies have shown that 25.9%and 36.5%of GC patients in China were diagnosed at stages III and IV,respectively,with 5-year overall survival(OS)rates of 33.0%for stage III and 5.5%for stage IV[2,3].
基金National Natural Science Foundation of China(11527808,61505141)Natural Science Foundation of Tianjin City(15JCYBJC52500,19JCYBJC16900)。
文摘Single-photon detectors are ubiquitous devices in quantum-photonic-based communication,computation,metrology,and sensing.In these applications,N-fold coincidence photon counting is often needed,for example,to characterize entanglement.However,N-fold coincidence photon counting typically requires N individual singlephoton detectors and associated bias and readout electronics,and these resources could become prohibitive if N goes large and the detectors need to work at cryogenic temperatures.Here,to break this limit on N,we propose a device architecture based on N cascaded photosensitive superconducting nanowires and one wider nanowire that functions as a current reservoir.We show that by strategically designing the device,the network of these superconducting nanowires can work in a synergic manner as an n-photon detector,where n can be from 1 to N,depending on the bias conditions.We therefore name the devices of this type superconducting nanowire multi-photon detectors(SNMPDs).In addition to its simple one-port bias and readout circuitry,the coincidences are counted internally in the detector,eliminating the need for external multi-channel,time-correlated pulse counters.We believe that the SNMPDs proposed in this work could open avenues towards conveniently measuring high-order temporal correlations of light and characterizing multi-photon entanglement.
基金supported by National Natural Science Foundation of China(62071322).
文摘Superconducting nanowire single-photon detectors(SNSPDs)have become a mainstream photon-counting technology that has been widely applied in various scenarios.So far,most multi-channel SNSPD systems,either reported in literature or commercially available,are polarization sensitive,that is,the system detection efficiency(SDE)of each channel is dependent on the state of polarization of the to-be-detected photons.Here,we reported an eight-channel system with fractal SNSPDs working in the wavelength range of 930 to 940 nm,which are all featured with low polarization sensitivity.In a close-cycled Gifford-McMahon cryocooler system with the base temperature of 2.2 K,we installed and compared the performance of two types of devices:(1)SNSPD,composed of a single,continuous nanowire and(2)superconducting nanowire avalanche photodetector(SNAP),composed of 16 cascaded units of two nanowires electrically connected in parallel.The highest SDE among the eight channels reaches 96+^(4)_(-5%),with the polarization sensitivity of 1.02 and a dark-count rate of 13 counts per second.The average SDE for eight channels for all states of polarization is estimated to be 90±5%.It is concluded that both the SNSPDs and the SNAPs can reach saturated,high SDE at the wavelength of interest,and the SNSPDs show lower dark-count(false-count)rates,whereas the SNAPs show better properties in the time domain.With the adoption of this system,we showcased the measurements of the second-order photon-correlation functions of light emission from a singlephoton source based on a semiconductor quantum dot and from a pulsed laser.It is believed that this work will provide new choices of systems with single-photon detectors combining the merits of high SDE,low polarization sensitivity,and low noise that can be tailored for different applications.
基金supported by the National Key Research and Development Program of China(No.2019YFB2203600)the Open Project Program of Wuhan National Laboratory for Optoelectronics(No.2020WNLOKF003).
文摘Silicon sub-bandgap photodetectors can detect light at the infrared telecommunication wavelengths but with relatively weak photo-response.In this work,we demonstrate the enhancement of sub-bandgap photodetection in silicon by helium-ion implantation,without afecting the transparency that is an important benefcial feature of this type of photodetectors.With an implantation dose of 1×10^(13)ions/cm^(2),the minimal detectable optical power can be improved from−33.2 to−63.1 dBm,or,by 29.9 dB,at the wavelength of 1550 nm,and the photo-response at the same optical power(−10 dBm)can be enhanced by approximately 18.8 dB.Our work provides a method for strategically modifying the intrinsic trade-of between transparency and strong photo-responses of this type of photodetectors.
